Catabolic defect of branched-chain amino acids promotes heart failure

Circulation

Volumn 133, Issue 21, 2016, Pages 2038-2049

  Sun, Haipeng ^a,b   Olson, Kristine C ^c   Gao, Chen ^b   Prosdocimo, Domenick A ^d   Zhou, Meiyi ^a   Wang, Zhihua ^b   Jeyaraj, Darwin ^d   Youn, Ji Youn ^b   Ren, Shuxun ^b   Liu, Yunxia ^a   Rau, Christoph D ^b   Shah, Svati ^e   Ilkayeva, Olga ^e   Gui, Wen Jun ^f   William, Noelle S ^f   Wynn, R Max ^f   Newgard, Christopher B ^e   Cai, Hua ^b   Xiao, Xinshu ^b   Chuang, David T ^f   Schulze, Paul Christian ^g,h   Lynch, Christopher ^c   Jain, Mukesh K ^d   Wang, Yibin ^a,b   more..

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS AT DALLAS   (United States)

^g NewYork Presbyterian Hospital   (United States)

^h FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

amino acids; heart failure; metabolism; oxidant stress; pathogenesis; remodeling

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); BRANCHED CHAIN ALPHA KETO ACID; BRANCHED CHAIN ALPHA KETO ACID DEHYDROGENASE KINASE; BRANCHED CHAIN AMINO ACID; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 15; PROTEIN KINASE; SUPEROXIDE; UNCLASSIFIED DRUG; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BREATHING; CARDIOMYOPATHY; CATABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART MITOCHONDRION; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; MALE; METABOLIC DISORDER; METABOLOMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSCRIPTOMICS; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; HEART FAILURE; HUMANS; MALE; METABOLISM; METABOLOMICS; MICE; MICE, KNOCKOUT; TRANSCRIPTOME;

EID: 84963636032     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.020226     Document Type: Article

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