Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate

ACS Synthetic Biology

Volumn 6, Issue 2, 2017, Pages 201-205

  Edgar, Steven ^a   Li, Fu Shuang ^c   Qiao, Kangjian ^a   Weng, Jing Ke ^b,c   Stephanopoulos, Gregory ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; PACLITAXEL; TERPENE; ISOMERASE; TAXA-4(5),11(12)-DIENE SYNTHASE;

ARTICLE; BIOSYNTHESIS; CATALYST; CRYSTAL STRUCTURE; CYCLIZATION; DRUG SELECTIVITY; ENERGY YIELD; ENZYME ACTIVITY; ENZYME ENGINEERING; EPOXIDATION; HYDROXYLATION; PRIORITY JOURNAL; CATALYSIS; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION;

CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; ISOMERASES; OXIDATION-REDUCTION; PACLITAXEL;

EID: 85013188408     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.6b00206     Document Type: Article

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