Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Science

Volumn 355, Issue 6326, 2017, Pages 756-760

  Williams, Pete A ^a   Harder, Jeffrey M ^a   Foxworth, Nicole E ^a   Cochran, Kelly E ^a   Philip, Vivek M ^a   Porciatti, Vittorio ^b   Smithies, Oliver ^c   John, Simon W M ^a,d,e  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL PROTEIN; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NMNAT1 PROTEIN, MOUSE;

AGING POPULATION; CELLS AND CELL COMPONENTS; EYE; MITOCHONDRION; RODENT; SENSORY SYSTEM DISORDER; VISION; VITAMIN; VULNERABILITY;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE THERAPY; GLAUCOMA; INTRAOCULAR PRESSURE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN MODIFICATION; RNA SEQUENCE; VITAMIN SUPPLEMENTATION; ANIMAL; CELL AGING; DEFICIENCY; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; NERVE CELL; NEURODEGENERATIVE DISEASES; PATHOLOGY; RETINA GANGLION CELL;

MUS;

AGING; ANIMALS; CELL AGING; GENETIC THERAPY; GLAUCOMA; MICE; MITOCHONDRIA; NAD; NEURODEGENERATIVE DISEASES; NEURONS; NIACINAMIDE; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; RETINAL GANGLION CELLS;

EID: 85013149487     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aal0092     Document Type: Article

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