메뉴 건너뛰기




Volumn 33, Issue 10, 2013, Pages 1493-1499

Why does brain metabolism not favor burning of fatty acids to provide energy-Reflections on disadvantages of the use of free fatty acids as fuel for brain

Author keywords

ATP generation; fatty acid; mitochondria; neural cells; oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; FATTY ACID; GLUCOSE; OXYGEN; SUPEROXIDE;

EID: 84885023188     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.128     Document Type: Review
Times cited : (306)

References (82)
  • 2
    • 0000202516 scopus 로고
    • Circulation and energy metabolism of the brain
    • Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (eds) Raven Press: New York
    • Clarke DD, Sokoloff L. Circulation and energy metabolism of the brain. In: Siegel GJ, Agranoff BW, Albers RW, Molinoff PB (eds) Basic Neurochemistry. Raven Press: New York, 1994, pp 645-680.
    • (1994) Basic Neurochemistry , pp. 645-680
    • Clarke, D.D.1    Sokoloff, L.2
  • 4
    • 82955168362 scopus 로고    scopus 로고
    • Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation
    • Bélanger M, Allaman I, Magistretti PJ. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 2011; 14: 724-738.
    • (2011) Cell Metab , vol.14 , pp. 724-738
    • Bélanger, M.1    Allaman, I.2    Magistretti, P.J.3
  • 5
    • 84865993166 scopus 로고    scopus 로고
    • Cellular links between neuronal activity and energy homeostasis
    • Shetty PK, Galeffi F, Turner DA. Cellular links between neuronal activity and energy homeostasis. Front Pharmacol 2012; 3: 43.
    • (2012) Front Pharmacol , vol.3 , pp. 43
    • Shetty, P.K.1    Galeffi, F.2    Turner, D.A.3
  • 6
    • 0030894684 scopus 로고    scopus 로고
    • Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor
    • Hu Y, Wilson GS. Rapid changes in local extracellular rat brain glucose observed with an in vivo glucose sensor. J Neurochem 1997; 68: 1745-1752. (Pubitemid 27133086)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.4 , pp. 1745-1752
    • Hu, Y.1    Wilson, G.S.2
  • 7
    • 84863464112 scopus 로고    scopus 로고
    • Brain lactate metabolism: The discoveries and the controversies
    • Dienel GA. Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab 2012; 32: 1107-1138.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1107-1138
    • Dienel, G.A.1
  • 10
    • 51449120723 scopus 로고    scopus 로고
    • Evidence for the mitochondrial lactate oxidation complex in rat neurons: Demonstration of an essential component of brain lactate shuttles
    • Hashimoto T, Hussien R, Cho HS, Kaufer D, Brooks GA. Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles. PLoS One 2008; 3: e2915.
    • (2008) PLoS One , vol.3
    • Hashimoto, T.1    Hussien, R.2    Cho, H.S.3    Kaufer, D.4    Brooks, G.A.5
  • 12
    • 19444376784 scopus 로고    scopus 로고
    • Cerebral ketone body metabolism
    • DOI 10.1007/s10545-005-5518-0
    • Morris AA. Cerebral ketone body metabolism. J Inherit Metab Dis 2005; 28: 109-121. (Pubitemid 40723878)
    • (2005) Journal of Inherited Metabolic Disease , vol.28 , Issue.2 , pp. 109-121
    • Morris, A.A.M.1
  • 13
    • 33750110683 scopus 로고    scopus 로고
    • Fuel metabolism in starvation
    • Cahill Jr. GF. Fuel metabolism in starvation. Annu Rev Nutr 2006; 26: 1-22.
    • (2006) Annu Rev Nutr , vol.26 , pp. 1-22
    • Cahill Jr., G.F.1
  • 14
    • 0015576103 scopus 로고
    • CNS and fatty acid metabolism
    • Spitzer JJ. CNS and fatty acid metabolism. Physiologist 1973; 16: 55-68.
    • (1973) Physiologist , vol.16 , pp. 55-68
    • Spitzer, J.J.1
  • 15
    • 0037707488 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy
    • Ebert D, Haller RG, Walton ME. Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J Neurosci 2003; 23: 5928-5935. (Pubitemid 36807872)
    • (2003) Journal of Neuroscience , vol.23 , Issue.13 , pp. 5928-5935
    • Ebert, D.1    Haller, R.G.2    Walton, M.E.3
  • 17
    • 80053611084 scopus 로고    scopus 로고
    • Fatty acid transport into the brain: Of fatty acid fables and lipid tails
    • Mitchell RW, Hatch GM. Fatty acid transport into the brain: of fatty acid fables and lipid tails. Prostaglandins Leukot Essent Fatty Acids 2011; 85: 293-302.
    • (2011) Prostaglandins Leukot Essent Fatty Acids , vol.85 , pp. 293-302
    • Mitchell, R.W.1    Hatch, G.M.2
  • 20
    • 0025107323 scopus 로고
    • Brain and liver pathology in a patient with carnitine deficiency
    • Kimura S, Amemiya F. Brain and liver pathology in a patient with carnitine deficiency. Brain Dev 1990; 12: 436-439. (Pubitemid 20340535)
    • (1990) Brain and Development , vol.12 , Issue.4 , pp. 436-439
    • Kimura, S.1    Amemiya, F.2
  • 21
    • 0026020414 scopus 로고
    • Fatty acid oxidation and ketogenesis by astrocytes in primary culture
    • Auestad N, Korsak RA, Morrow JW, Edmond J. Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J Neurochem 1991; 56: 1376-1386. (Pubitemid 21902060)
    • (1991) Journal of Neurochemistry , vol.56 , Issue.4 , pp. 1376-1386
    • Auestad, N.1    Korsak, R.A.2    Morrow, J.W.3    Edmond, J.4
  • 22
    • 0023470792 scopus 로고
    • Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
    • DOI 10.1002/jnr.490180407
    • Edmond J, Robbins RA, Bergstrom JD, Cole RA, de Vellis J. Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J Neurosci Res 1987; 18: 551-561. (Pubitemid 18007554)
    • (1987) Journal of Neuroscience Research , vol.18 , Issue.4 , pp. 551-561
    • Edmond, J.1    Robbins, R.A.2    Bergstrom, J.D.3    Cole, R.A.4    De Vellis, J.5
  • 24
    • 61849183130 scopus 로고    scopus 로고
    • L-Carnitine suppresses oleic acid-induced membrane permeability transition of mitochondria
    • Oyanagi E, Yano H, Kato Y, Fujita H, Utsumi K, Sasaki J. L-Carnitine suppresses oleic acid-induced membrane permeability transition of mitochondria. Cell Biochem Funct 2008; 26: 778-786.
    • (2008) Cell Biochem Funct , vol.26 , pp. 778-786
    • Oyanagi, E.1    Yano, H.2    Kato, Y.3    Fujita, H.4    Utsumi, K.5    Sasaki, J.6
  • 25
    • 0035242430 scopus 로고    scopus 로고
    • Free fatty acid effects on mitochondrial permeability: An overview
    • DOI 10.1006/abbi.2000.2195
    • Sultan A, Sokolove PM. Free fatty acid effects on mitochondrial permeability: an overview. Arch Biochem Biophys 2001; 386: 52-61. (Pubitemid 32980176)
    • (2001) Archives of Biochemistry and Biophysics , vol.386 , Issue.1 , pp. 52-61
    • Sultan, A.1    Sokolove, P.M.2
  • 27
    • 35348852575 scopus 로고    scopus 로고
    • A model for fatty acid transport into the brain
    • DOI 10.1007/s12031-007-0050-3
    • Hamilton JA, Brunaldi K. A model for fatty acid transport into the brain. J Mol Neurosci 2007; 33: 12-17. (Pubitemid 47574951)
    • (2007) Journal of Molecular Neuroscience , vol.33 , Issue.1 , pp. 12-17
    • Hamilton, J.A.1    Brunaldi, K.2
  • 28
    • 0031921236 scopus 로고    scopus 로고
    • Fatty acid transport: Difficult or easy?
    • Hamilton JA. Fatty acid transport: difficult or easy? J Lipid Res 1998; 39: 467-481. (Pubitemid 28158391)
    • (1998) Journal of Lipid Research , vol.39 , Issue.3 , pp. 467-481
    • Hamilton, J.A.1
  • 29
    • 69349087207 scopus 로고    scopus 로고
    • Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study
    • Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S et al. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: an in situ cerebral perfusion study. Neurochem Int 2009; 55: 476-482.
    • (2009) Neurochem Int , vol.55 , pp. 476-482
    • Ouellet, M.1    Emond, V.2    Chen, C.T.3    Julien, C.4    Bourasset, F.5    Oddo, S.6
  • 30
    • 0034913792 scopus 로고    scopus 로고
    • Fatty acid uptake and incorporation in brain: Studies with the perfusion model
    • DOI 10.1385/JMN:16:2-3:167
    • Smith QR, Nagura H. Fatty acid uptake and incorporation in brain: studies with the perfusion model. J Mol Neurosci 2001; 16: 167-172. (Pubitemid 32664776)
    • (2001) Journal of Molecular Neuroscience , vol.16 , Issue.2-3 , pp. 167-172
    • Smith, Q.R.1    Nagura, H.2
  • 31
    • 0023930956 scopus 로고
    • Fatty acid transport through the blood-brain barrier
    • Spector R. Fatty acid transport through the blood-brain barrier. J Neurochem 1988; 50: 639-643. (Pubitemid 18042340)
    • (1988) Journal of Neurochemistry , vol.50 , Issue.2 , pp. 639-643
    • Spector, R.1
  • 32
    • 0031105659 scopus 로고    scopus 로고
    • In vivo incorporation from plasma of radiolabeled palmitate and arachidonate into rat brain microvessels
    • DOI 10.1006/mvre.1996.1984
    • Williams WM, Chang MC, Hayakawa T, Grange E, Rapoport SI. In vivo incorporation from plasma of radiolabeled palmitate and arachidonate into rat brain microvessels. Microvasc Res 1997; 53: 163-166. (Pubitemid 27202433)
    • (1997) Microvascular Research , vol.53 , Issue.2 , pp. 163-166
    • Williams, W.M.1    Chang, M.C.J.2    Hayakawa, T.3    Grange, E.4    Rapoport, S.I.5
  • 33
    • 34447533581 scopus 로고    scopus 로고
    • Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: Molecular, biochemical, and physiological evidence
    • Bonen A, Chabowski A, Luiken JJ, Glatz JF. Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence. Physiology (Bethesda) 2007; 22: 15-29.
    • (2007) Physiology (Bethesda) , vol.22 , pp. 15-29
    • Bonen, A.1    Chabowski, A.2    Luiken, J.J.3    Glatz, J.F.4
  • 34
    • 33847127557 scopus 로고    scopus 로고
    • Is membrane transport of FFA mediated by lipid, protein, or both? An unknown protein mediates free fatty acid transport across the adipocyte plasma membrane
    • Kampf JP, Kleinfeld AM. Is membrane transport of FFA mediated by lipid, protein, or both? An unknown protein mediates free fatty acid transport across the adipocyte plasma membrane. Physiology (Bethesda) 2007; 22: 7-14.
    • (2007) Physiology (Bethesda) , vol.22 , pp. 7-14
    • Kampf, J.P.1    Kleinfeld, A.M.2
  • 35
    • 35348853741 scopus 로고    scopus 로고
    • The role of size and charge for blood-brain barrier permeation of drugs and fatty acids
    • DOI 10.1007/s12031-007-0055-y
    • Seelig A. The role of size and charge for blood-brain barrier permeation of drugs and fatty acids. J Mol Neurosci 2007; 33: 32-41. (Pubitemid 47574956)
    • (2007) Journal of Molecular Neuroscience , vol.33 , Issue.1 , pp. 32-41
    • Seelig, A.1
  • 36
    • 79954988524 scopus 로고    scopus 로고
    • Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells
    • Mitchell RW, On NH, Del Bigio MR, Miller DW, Hatch GM. Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. J Neurochem 2011; 117: 735-746.
    • (2011) J Neurochem , vol.117 , pp. 735-746
    • Mitchell, R.W.1    On, N.H.2    Del Bigio, M.R.3    Miller, D.W.4    Hatch, G.M.5
  • 37
    • 84866150126 scopus 로고    scopus 로고
    • Restoration of dietary-fat induced blood-brain barrier dysfunction by anti-inflammatory lipid-modulating agents
    • Pallebage-Gamarallage M, Lam V, Takechi R, Galloway S, Clark K, Mamo J. Restoration of dietary-fat induced blood-brain barrier dysfunction by anti-inflammatory lipid-modulating agents. Lipids Health Dis 2012; 11: 117.
    • (2012) Lipids Health Dis , vol.11 , pp. 117
    • Pallebage-Gamarallage, M.1    Lam, V.2    Takechi, R.3    Galloway, S.4    Clark, K.5    Mamo, J.6
  • 38
    • 80051667284 scopus 로고    scopus 로고
    • The role of free radical generation in increasing cerebrovascular permeability
    • Fraser PA. The role of free radical generation in increasing cerebrovascular permeability. Free Radic Biol Med 2011; 51: 967-977.
    • (2011) Free Radic Biol Med , vol.51 , pp. 967-977
    • Fraser, P.A.1
  • 40
    • 0038037734 scopus 로고    scopus 로고
    • Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
    • DOI 10.1038/nm873
    • Obici S, Feng Z, Arduini A, Conti R, Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 2003; 9: 756-761. (Pubitemid 36749226)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 756-761
    • Obici, S.1    Feng, Z.2    Arduini, A.3    Conti, R.4    Rossetti, L.5
  • 41
    • 0023665017 scopus 로고
    • Fatty acid oxidation in rat brain is limited by the low activity of 3-ketoacyl-coenzyme A thiolase
    • Yang SY, He XY, Schulz H. Fatty acid oxidation in rat brain is limited by the low activity of 3-ketoacyl-coenzyme A thiolase. J Biol Chem 1987; 262: 13027-13032.
    • (1987) J Biol Chem , vol.262 , pp. 13027-13032
    • Yang, S.Y.1    He, X.Y.2    Schulz, H.3
  • 42
    • 0021907294 scopus 로고
    • Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern
    • Bird MI, Munday LA, Saggerson ED, Clark JB. Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. Biochem J 1985; 226: 323-330. (Pubitemid 15127939)
    • (1985) Biochemical Journal , vol.226 , Issue.1 , pp. 323-330
    • Bird, M.I.1    Munday, L.A.2    Saggerson, E.D.3    Clark, J.B.4
  • 43
    • 84876472084 scopus 로고    scopus 로고
    • Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity
    • Ellis JM, Wong GW, Wolfgang MJ. Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol 2013; 33: 1869-1882.
    • (2013) Mol Cell Biol , vol.33 , pp. 1869-1882
    • Ellis, J.M.1    Wong, G.W.2    Wolfgang, M.J.3
  • 44
    • 0032524916 scopus 로고    scopus 로고
    • Comparison of mitochondrial respiratory chain enzyme activities in rodent astrocytes and neurones and a human astrocytoma cell line
    • DOI 10.1016/S0304-3940(98)00284-5, PII S0304394098002845
    • Stewart VC, Land JM, Clark JB, Heales SJ. Comparison of mitochondrial respiratory chain enzyme activities in rodent astrocytes and neurones and a human astrocytoma cell line. Neurosci Lett 1998; 247: 201-203. (Pubitemid 28240132)
    • (1998) Neuroscience Letters , vol.247 , Issue.2-3 , pp. 201-203
    • Stewart, V.C.1    Land, J.M.2    Clark, J.B.3    Heales, S.J.R.4
  • 45
    • 0028793538 scopus 로고
    • Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain
    • Almeida A, Brooks KJ, Sammut I, Keelan J, Davey GP, Clark JB et al. Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Dev Neurosci 1995; 17: 212-218.
    • (1995) Dev Neurosci , vol.17 , pp. 212-218
    • Almeida, A.1    Brooks, K.J.2    Sammut, I.3    Keelan, J.4    Davey, G.P.5    Clark, J.B.6
  • 47
    • 80052361500 scopus 로고    scopus 로고
    • Astrocytic-neuronal crosstalk: Implications for neuroprotection from brain injury
    • Barreto GE, Gonzalez J, Torres Y, Morales L. Astrocytic-neuronal crosstalk: implications for neuroprotection from brain injury. Neurosci Res 2011; 71: 107-113.
    • (2011) Neurosci Res , vol.71 , pp. 107-113
    • Barreto, G.E.1    Gonzalez, J.2    Torres, Y.3    Morales, L.4
  • 48
    • 33748980104 scopus 로고    scopus 로고
    • Interaction of free fatty acids with mitochondria: Coupling, uncoupling and permeability transition
    • DOI 10.1016/j.bbabio.2006.03.024, PII S0005272806000958, Mitochondria: from Molecular Insight to Physiology and Pathology
    • Di Paola M, Lorusso M. Interaction of free fatty acids with mitochondria: coupling, uncoupling and permeability transition. Biochim Biophys Acta 2006; 1757: 1330-1337. (Pubitemid 44442109)
    • (2006) Biochimica et Biophysica Acta - Bioenergetics , vol.1757 , Issue.9-10 , pp. 1330-1337
    • Di Paola, M.1    Lorusso, M.2
  • 49
    • 0027384310 scopus 로고
    • Effect of fatty acids on energy coupling processes in mitochondria
    • DOI 10.1016/0005-2728(93)90004-Y
    • Wojtczak L, Schö nfeld P. Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta 1993; 1183: 41-57. (Pubitemid 23322954)
    • (1993) Biochimica et Biophysica Acta - Bioenergetics , vol.1183 , Issue.1 , pp. 41-57
    • Wojtczak, L.1    Schonfeld, P.2
  • 50
    • 11844255781 scopus 로고    scopus 로고
    • 2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes
    • DOI 10.1016/j.nbd.2004.08.010, PII S0969996104001974
    • Kahlert S, Schö nfeld P, Reiser G. The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2\+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes. Neurobiol Dis 2005; 18: 110-118. (Pubitemid 40092901)
    • (2005) Neurobiology of Disease , vol.18 , Issue.1 , pp. 110-118
    • Kahlert, S.1    Schonfeld, P.2    Reiser, G.3
  • 51
    • 79958826670 scopus 로고    scopus 로고
    • Non-esterified polyunsaturated fatty acids distinctly modulate the mitochondrial and cellular ROS production in normoxia and hypoxia
    • Schö nfeld P, Schluter T, Fischer KD, Reiser G. Non-esterified polyunsaturated fatty acids distinctly modulate the mitochondrial and cellular ROS production in normoxia and hypoxia. J Neurochem 2011; 118: 69-78.
    • (2011) J Neurochem , vol.118 , pp. 69-78
    • Schö Nfeld, P.1    Schluter, T.2    Fischer, K.D.3    Reiser, G.4
  • 52
    • 44849118490 scopus 로고    scopus 로고
    • Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture
    • DOI 10.1093/hmg/ddn066
    • Hein S, Schö nfeld P, Kahlert S, Reiser G. Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture. Hum Mol Genet 2008; 17: 1750-1761. (Pubitemid 351791501)
    • (2008) Human Molecular Genetics , vol.17 , Issue.12 , pp. 1750-1761
    • Hein, S.1    Schonfeld, P.2    Kahlert, S.3    Reiser, G.4
  • 53
    • 0034650995 scopus 로고    scopus 로고
    • X-linked adrenoleukodystrophy enigma: How does the ALD peroxisomal transporter mutation affect CNS glia?
    • DOI 10.1002/(SICI)1098-1136(2000 0115)29:2<186::AID-GLIA13>3.0. CO;2-5
    • Aubourg P, Dubois-Dalcq M. X-linked adrenoleukodystrophy enigma: how does the ALD peroxisomal transporter mutation affect CNS glia? Glia 2000; 29: 186-190. (Pubitemid 30044514)
    • (2000) GLIA , vol.29 , Issue.2 , pp. 186-190
    • Aubourg, P.1    Dubois-Dalcq, M.2
  • 54
    • 0001435689 scopus 로고
    • ON the presence of 3, 7 11,15-tetramethylhexadecanoic acid (PHYTANIC ACID) in the cholesterol esters and other lipoid fractions of the organs in a case of a disease of unknown origin (POSSIBLY HEREDOPATHIA ATACTICA POLYNEURITIFORMIS, REFSUM'S SYNDROME)
    • Klenk E, Kahike W. [ON THE PRESENCE OF 3,7,11,15-TETRAMETHYLHEXADECANOIC ACID (PHYTANIC ACID) IN THE CHOLESTEROL ESTERS AND OTHER LIPOID FRACTIONS OF THE ORGANS IN A CASE OF A DISEASE OF UNKNOWN ORIGIN (POSSIBLY HEREDOPATHIA ATACTICA POLYNEURITIFORMIS, REFSUM'S SYNDROME)]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie 1963; 333: 133-139.
    • (1963) Hoppe-Seyler's Zeitschrift fur Physiologische Chemie , vol.333 , pp. 133-139
    • Klenk, E.1    Kahike, W.2
  • 55
    • 46449087496 scopus 로고    scopus 로고
    • Fatty acids as modulators of the cellular production of reactive oxygen species
    • Schö nfeld P, Wojtczak L. Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med 2008; 45: 231-241.
    • (2008) Free Radic Biol Med , vol.45 , pp. 231-241
    • Schö Nfeld, P.1    Wojtczak, L.2
  • 57
    • 12944319308 scopus 로고    scopus 로고
    • ATP channels in respiratory neurons and their role in the hypoxic facilitation of rhythmic activity
    • DOI 10.1016/j.brainres.2004.11.011, PII S0006899304017949
    • Mironov SL, Hartelt N, Ivannikov MV. Mitochondrial KATP channels in respiratory neurons and their role in the hypoxic facilitation of rhythmic activity. Brain Res 2005; 1033: 20-27. (Pubitemid 40175101)
    • (2005) Brain Research , vol.1033 , Issue.1 , pp. 20-27
    • Mironov, S.L.1    Hartelt, N.2    Ivannikov, M.V.3
  • 59
    • 84874115017 scopus 로고    scopus 로고
    • Marked inhibition of Na\+, K\+-ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: Possible underlying mechanisms of cerebellar ataxia in Refsum disease
    • Busanello EN, Zanatta A, Tonin AM, Viegas CM, Vargas CR, Leipnitz G et al. Marked inhibition of Na\+, K\+-ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease. J Bioenerg Biomembr 2013; 45: 137-144.
    • (2013) J Bioenerg Biomembr , vol.45 , pp. 137-144
    • Busanello, E.N.1    Zanatta, A.2    Tonin, A.M.3    Viegas, C.M.4    Vargas, C.R.5    Leipnitz, G.6
  • 62
    • 0035160270 scopus 로고    scopus 로고
    • Tissue oxygen tension and brain sensitivity to hypoxia
    • DOI 10.1016/S0034-5687(01)00306-1, PII S0034568701003061
    • Erecinska M, Silver IA. Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 2001; 128: 263-276. (Pubitemid 33051004)
    • (2001) Respiration Physiology , vol.128 , Issue.3 , pp. 263-276
    • Erecinska, M.1    Silver, I.A.2
  • 63
    • 84862008999 scopus 로고    scopus 로고
    • Lipid metabolism and toxicity in the heart
    • Goldberg IJ, Trent CM, Schulze PC. Lipid metabolism and toxicity in the heart. Cell Metab 2012; 15: 805-812.
    • (2012) Cell Metab , vol.15 , pp. 805-812
    • Goldberg, I.J.1    Trent, C.M.2    Schulze, P.C.3
  • 64
    • 72249087964 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress, and temporal lobe epilepsy
    • Waldbaum S, Patel M. Mitochondria, oxidative stress, and temporal lobe epilepsy. Epilepsy Res 2010; 88: 23-45.
    • (2010) Epilepsy Res , vol.88 , pp. 23-45
    • Waldbaum, S.1    Patel, M.2
  • 65
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009; 417: 1-13.
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 66
    • 84861542507 scopus 로고    scopus 로고
    • Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants
    • Rodrigues JV, Gomes CM. Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants. Free Radic Biol Med 2012; 53: 12-19.
    • (2012) Free Radic Biol Med , vol.53 , pp. 12-19
    • Rodrigues, J.V.1    Gomes, C.M.2
  • 67
    • 84855794688 scopus 로고    scopus 로고
    • Brown adipose tissue mitochondria oxidizing fatty acids generate high levels of reactive oxygen species irrespective of the uncoupling protein-1 activity state
    • Schö nfeld P, Wojtczak L. Brown adipose tissue mitochondria oxidizing fatty acids generate high levels of reactive oxygen species irrespective of the uncoupling protein-1 activity state. Biochim Biophys Acta 2012; 1817: 410-418.
    • (2012) Biochim Biophys Acta , vol.1817 , pp. 410-418
    • Schö Nfeld, P.1    Wojtczak, L.2
  • 68
    • 77949322975 scopus 로고    scopus 로고
    • Electron transport chain-dependent and-independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation
    • Seifert EL, Estey C, Xuan JY, Harper ME. Electron transport chain-dependent and-independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem 2010; 285: 5748-5758.
    • (2010) J Biol Chem , vol.285 , pp. 5748-5758
    • Seifert, E.L.1    Estey, C.2    Xuan, J.Y.3    Harper, M.E.4
  • 69
    • 77953809888 scopus 로고    scopus 로고
    • Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transferassociated production of reactive oxygen species
    • Schö nfeld P, Wieckowski MR, Lebiedzinska M, Wojtczak L. Mitochondrial fatty acid oxidation and oxidative stress: lack of reverse electron transferassociated production of reactive oxygen species. Biochim Biophys Acta 2010; 1797: 929-938.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 929-938
    • Schö Nfeld, P.1    Wieckowski, M.R.2    Lebiedzinska, M.3    Wojtczak, L.4
  • 70
    • 80051665640 scopus 로고    scopus 로고
    • Neuroprotective strategies involving ROS in Alzheimer disease
    • Dumont M, Beal MF. Neuroprotective strategies involving ROS in Alzheimer disease. Free Radic Biol Med 2011; 51: 1014-1026.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1014-1026
    • Dumont, M.1    Beal, M.F.2
  • 71
    • 67651184281 scopus 로고    scopus 로고
    • NOX enzymes in the central nervous system: From signaling to disease
    • Sorce S, Krause KH. NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal 2009; 11: 2481-2504.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2481-2504
    • Sorce, S.1    Krause, K.H.2
  • 72
    • 84861658605 scopus 로고    scopus 로고
    • Evidence of oxidative stress in very long chain fatty acid-treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins
    • Baarine M, Andreoletti P, Athias A, Nury T, Zarrouk A, Ragot K et al. Evidence of oxidative stress in very long chain fatty acid-treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins. Neurosci 2012; 213: 1-18.
    • (2012) Neurosci , vol.213 , pp. 1-18
    • Baarine, M.1    Andreoletti, P.2    Athias, A.3    Nury, T.4    Zarrouk, A.5    Ragot, K.6
  • 73
    • 84864032314 scopus 로고    scopus 로고
    • Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?
    • Galea E, Launay N, Portero-Otin M, Ruiz M, Pamplona R, Aubourg P et al. Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases? Biochim Biophys Acta 2012; 1822: 1475-1488.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 1475-1488
    • Galea, E.1    Launay, N.2    Portero-Otin, M.3    Ruiz, M.4    Pamplona, R.5    Aubourg, P.6
  • 74
    • 78651427556 scopus 로고    scopus 로고
    • Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it: FADH2/NADH flux ratios determining mitochondrial radical formation were crucial for the eukaryotic invention of peroxisomes and catabolic tissue differentiation
    • Speijer D. Oxygen radicals shaping evolution: why fatty acid catabolism leads to peroxisomes while neurons do without it: FADH2/NADH flux ratios determining mitochondrial radical formation were crucial for the eukaryotic invention of peroxisomes and catabolic tissue differentiation. BioEssays 2011; 33: 88-94.
    • (2011) BioEssays , vol.33 , pp. 88-94
    • Speijer, D.1
  • 75
    • 0023780085 scopus 로고
    • Nonoxidative glucose consumption during focal physiologic neural activity
    • Fox PT, Raichle ME, Mintun MA, Dence C. Nonoxidative glucose consumption during focal physiologic neural activity. Science 1988; 241: 462-464.
    • (1988) Science , vol.241 , pp. 462-464
    • Fox, P.T.1    Raichle, M.E.2    Mintun, M.A.3    Dence, C.4
  • 76
    • 0026643890 scopus 로고
    • Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy
    • Sappey-Marinier D, Calabrese G, Fein G, Hugg JW, Biggins C, Weiner MW. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 1992; 12: 584-592.
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 584-592
    • Sappey-Marinier, D.1    Calabrese, G.2    Fein, G.3    Hugg, J.W.4    Biggins, C.5    Weiner, M.W.6
  • 78
    • 0036154857 scopus 로고    scopus 로고
    • Control of mitochondrial beta-oxidation flux
    • Eaton S. Control of mitochondrial beta-oxidation flux. Prog Lipid Res 2002; 41: 197-239.
    • (2002) Prog Lipid Res , vol.41 , pp. 197-239
    • Eaton, S.1
  • 81
    • 78649817322 scopus 로고    scopus 로고
    • Principles of exercise biochemistry
    • Poortmans JR (ed) Karger: Basel
    • Greenhaff PL, Hultman E, Harris RC. Principles of Exercise Biochemistry. In: Poortmans JR (ed) Medicine and Sport Science. Karger: Basel, 2004, pp 108-151.
    • (2004) Medicine and Sport Science , pp. 108-151
    • Greenhaff, P.L.1    Hultman, E.2    Harris, R.C.3
  • 82
    • 77956631199 scopus 로고    scopus 로고
    • The mitochondria permeability transition pore complex in the brain with interacting proteins-promising targets for protection in neurodegenerative diseases
    • Azarashvili T, Stricker R, Reiser G. The mitochondria permeability transition pore complex in the brain with interacting proteins-promising targets for protection in neurodegenerative diseases. Biol Chem 2010; 391: 619-629.
    • (2010) Biol Chem , vol.391 , pp. 619-629
    • Azarashvili, T.1    Stricker, R.2    Reiser, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.