Endotoxin neutralization by an O-antigen specific monoclonal antibody: A potential novel therapeutic approach against Klebsiella pneumoniae ST258

Virulence

Volumn 8, Issue 7, 2017, Pages 1203-1215

  Szijártó, Valéria ^a   Guachalla, Luis M ^a   Hartl, Katharina ^a   Varga, Cecília ^a   Badarau, Adriana ^a   Mirkina, Irina ^a   Visram, Zehra C ^a   Stulik, Lukas ^a   Power, Christine A ^a   Nagy, Eszter ^a   Nagy, Gábor ^a  

^a Arsanis Biosciences GmbH   (Austria)

Author keywords

carbapenem resistant Klebsiella; endotoxin neutralization; Klebsiella pneumoniae ST258; monoclonal antibody; protective efficacy

Indexed keywords

ENDOTOXIN; MONOCLONAL ANTIBODY; BACTERIUM ANTIBODY; O ANTIGEN;

AFFINITY CHROMATOGRAPHY; ANIMAL MODEL; ARTICLE; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; INFECTION CONTROL; INTERFEROMETRY; KLEBSIELLA PNEUMONIAE; MOUSE; NONHUMAN; SIZE EXCLUSION CHROMATOGRAPHY; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; KLEBSIELLA INFECTION; LEPORIDAE; MALE; MICROBIOLOGY; PASSIVE IMMUNIZATION; RAT; SERODIAGNOSIS; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ENDOTOXINS; FEMALE; HUMANS; IMMUNIZATION, PASSIVE; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; O ANTIGENS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 85012881020     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.1080/21505594.2017.1279778     Document Type: Article

References (43)

1. Livermore DM. Current epidemiology and growing resistance of gram-negative pathogens. Korean J Intern Med 2012; 27(2):128-42; PMID:22707882; http://dx.doi.org/10.3904/kjim.2012.27.2.128
2. Capone A, Giannella M, Fortini D, Giordano A, Meledandri M, Ballardini M, Venditti M, Bordi E, Capozzi D, Balice MP, et al. High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality. Clin Microbiol Infect 2013; 19(1):E23-30; PMID:23137235; http://dx.doi.org/10.1111/1469-0691.12070
3. Weterings V, Zhou K, Rossen JW, van Stenis D, Thewessen E, Kluytmans J, Veenemans J. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread. Eur J Clin Microbiol Infect Dis 2015; 34(8):1647-55;PMID:26067658; http://dx.doi.org/10.1007/s10096-015-2401-2
4. Mammina C, Bonura C, Di Bernardo F, Aleo A, Fasciana T, Sodano C, Saporito MA, Verde MS, Tetamo R, Palma DM. Ongoing spread of colistin-resistant Klebsiella pneumoniae in different wards of an acute general hospital, Italy, June to December 2011. Euro Surveill 2012; 17(33):pii: 20248; PMID:22913977
5. Czaplewski L, Bax R, Clokie M, Dawson M, Fairhead H, Fischetti VA, Foster S, Gilmore BF, Hancock RE, Harper D, et al. Alternatives to antibiotics-a pipeline portfolio review. Lancet Infect Dis 2016;16(2):239-51;PMID:26795692; http://dx.doi.org/10.1016/S1473-3099(15)00466-1
6. Oleksiewicz MB, Nagy G, Nagy E. Anti-bacterial monoclonal antibodies: back to the future? Arch.Biochem Biophys 2012; 526(2):124-31; PMID:22705202; http://dx.doi.org/10.1016/j.abb.2012.06.001
7. Ter Meulen J. Monoclonal antibodies in infectious diseases: clinical pipeline in 2011. Infect Dis Clin North Am 2011; 25(4):789-802; PMID:22054756; http://dx.doi.org/10.1016/j.idc.2011.07.006
8. Casadevall A, Scharff MD. Return to the past: the case for antibody-based therapies in infectious diseases. Clin Infect Dis 1995; 21(1):150-61; PMID:7578724; http://dx.doi.org/10.1093/clinids/21.1.150
9. Diago-Navarro E, Chen L, Passet V, Burack S, Ulacia-Hernando A, Kodiyanplakkal RP, Levi MH, Brisse S, Kreiswirth BN, Fries BC, et al. Carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits. J Infect Dis 2014; 210(5):803-13
10. Tzouvelekis LS, Miriagou V, Kotsakis SD, Spyridopoulou K, Athanasiou E, Karagouni E, Tzelepi E, Daikos GL. KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen. Antimicrob Agents Chemother 2013; 57(10):5144-6; PMID:23856769; http://dx.doi.org/10.1128/AAC.01052-13
11. Siu LK, Lin JC, Gomez E, Eng R, Chiang T. Virulence and plasmid transferability of kpc Klebsiella pneumoniae at the veterans affairs healthcare system of new jersey. Microb Drug Resist 2012; 18(4):380-4; PMID:22533374;http://dx.doi.org/10.1089/mdr.2011.0241
12. Borer A, Saidel-Odes L, Eskira S, Nativ R, Riesenberg K, Livshiz-Riven I, Schlaeffer F, Sherf M, Peled N. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant k pneumoniae. Am J Infect Control 2012; 40(5):421-5; PMID:21906844;http://dx.doi.org/10.1016/j.ajic.2011.05.022
13. Schechner V, Kotlovsky T, Kazma M, Mishali H, Schwartz D, Navon-Venezia S, Schwaber MJ, Carmeli Y. Asymptomatic rectal carriage of blakpc producing carbapenem-resistant enterobacteriaceae: who is prone to become clinically infected? Clin Microbiol Infect 2013; 19(5):451-6; PMID:22563800; http://dx.doi.org/10.1111/j.1469-0691.2012.03888.x
14. Gasink LB, Edelstein PH, Lautenbach E, Synnestvedt M, Fishman NO. Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing k. pneumoniae. Infect Control Hosp Epidemiol 2009; 30(12):1180-5; PMID:19860564; http://dx.doi.org/10.1086/648451
15. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL. Carbapenemases in Klebsiella pneumoniae and other enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 2012; 25(4):682-707; PMID:23034326; http://dx.doi.org/10.1128/CMR.05035-11
16. Trautmann M, Ruhnke M, Rukavina T, Held TK, Cross AS, Marre R, Whitfield C. O-Antigen seroepidemiology of klebsiella clinical isolates and implications for immunoprophylaxis of klebsiella infections. Clin Diagn Lab Immunol 1997; 4(5):550-5; PMID:9302204
17. Rukavina T, Tícac B, Susa M, Jendrike N, Jonjíc S, Lucin P, Marre R, Doríc M, Trautmann M. Protective effect of antilipopolysaccharide monoclonal antibody in experimental klebsiella infection. Infect Immun 1997; 65(5):1754-60; PMID:9125558
18. Donta ST, Peduzzi P, Cross AS, Sadoff J, Haakenson C, Cryz SJ, Jr, Kauffman C, Bradley S, Gafford G, Elliston D, et al. Immunoprophylaxis against klebsiella and pseudomonas aeruginosa infections. the federal hyperimmune immunoglobulin trial study group. J Infect Dis 1996; 174(3):537-43;PMID:8769611;http://dx.doi.org/10.1093/infdis/174.3.537
19. Chen L, Mathema B, Pitout JD, DeLeo FR, Kreiswirth BN. Epidemic Klebsiella pneumoniae st258 is a hybrid strain. MBio 2014; 5(3):e01355-14; http://dx.doi.org/10.1128/mBio.01355-14
20. DeLeo FR, Chen L, Porcella SF, Martens CA, Kobayashi SD, Porter AR, Chavda KD, Jacobs MR, Mathema B, Olsen RJ, et al. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc Natl Acad Sci U.S.A 2014; 111(13):4988-93;PMID:24639510; http://dx.doi.org/10.1073/pnas.1321364111
21. Wyres KL, Gorrie C, Edwards DJ, Wertheim HF, Hsu LY, Van Kinh N, Zadoks R, Baker S, Holt KE. Extensive capsule locus variation and large-scale genomic recombination within the Klebsiella pneumoniae clonal group 258. Genome Biol Evol 2015; 7(5):1267-79; PMID:25861820; http://dx.doi.org/10.1093/gbe/evv062
22. Bowers JR, Kitchel B, Driebe EM, MacCannell DR, Roe C, Lemmer D, de Man T, Rasheed JK, Engelthaler DM, Keim P, et al. Genomic analysis of the emergence and rapid global dissemination of the clonal group 258 Klebsiella pneumoniae pandemic. PLoS One 2015; 10(7):e0133727; PMID:26196384; http://dx.doi.org/10.1371/journal.pone.0133727
23. Szijarto V, Guachalla LM, Hartl K, Varga C, Banerjee P, Stojkovic K, Kaszowska M, Nagy E, Lukasiewicz J, Nagy G. Both clades of the epidemic KPC-producing Klebsiella pneumoniae clone ST258 share a modified galactan O-antigen type. Int J Med Microbiol 2016; 306(2):89-98; PMID:26723873;http://dx.doi.org/10.1016/j.ijmm.2015.12.002
24. Geraci DM, Bonura C, Giuffrè M, Saporito L, Graziano G, Aleo A, Fasciana T, Di Bernardo F, Stampone T, Palma DM, et al. Is the monoclonal spread of the ST258, KPC-3-producing clone being replaced in Southern Italy by the dissemination of multiple clones of carbapenem-nonsusceptible, KPC-3-producing Klebsiella pneumoniae? Clin Microbiol Infect 2015; 21(3):e15-7; PMID:25658574;http://dx.doi.org/10.1016/j.cmi.2014.08.022
25. Bonura C, Giuffrè M, Aleo A, Fasciana T, Di Bernardo F, Stampone T, Giammanco A,; MDR-GN Working Group, Palma DM, Mammina C. An update of the evolving epidemic of blakpc carrying Klebsiella pneumoniae in Sicily, Italy, 2014: emergence of multiple Non-ST258 clones. PLoS One 2015; 10(7):e0132936; PMID:26177547; http://dx.doi.org/10.1371/journal.pone.0132936
26. Fraenkel-Wandel Y, Raveh-Brawer D, Wiener-Well Y, Yinnon AM, Assous MV. Mortality Due to BlaKPC Klebsiella pneumoniae bacteraemia. J Antimicrob Chemother 2016; 71(4):1083-7; PMID:26661396; http://dx.doi.org/10.1093/jac/dkv414
27. Baraniak A, Grabowska A, Izdebski R, Fiett J, Herda M, Bojarska K, Żabicka D, Kania-Pudło M, Młynarczyk G, Żak-Puławska Z, et al. Molecular characteristics of KPC-producing enterobacteriaceae at the early stage of their dissemination in Poland, 2008-2009. Antimicrob Agents Chemother 2011; 55(12):5493-9; PMID:21930889; http://dx.doi.org/10.1128/AAC.05118-11
28. Fodah RA, Scott JB, Tam HH, Yan P, Pfeffer TL, Bundschuh R, Warawa JM. Correlation of Klebsiella pneumoniae comparative genetic analyses with virulence profiles in a murine respiratory disease model. PLoS One 2014; 9(9):e107394; PMID:25203254; http://dx.doi.org/10.1371/journal.pone.0107394
29. Szijarto V, Guachalla LM, Visram ZC, Hartl K, Varga C, Mirkina I, Zmajkovic J, Badarau A, Zauner G, Pleban C, et al. Bactericidal monoclonal antibodies specific to the lipopolysaccharide O antigen from multidrug-resistant escherichia coli clone ST131-O25b:H4 elicit protection in mice. Antimicrob Agents Chemother 2015; 59(6):3109-16;PMID:25779571;http://dx.doi.org/10.1128/AAC.04494-14
30. Galanos C, Freudenberg MA, Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci U.S.A 1979; 76(11):5939-43; PMID:293694; http://dx.doi.org/10.1073/pnas.76.11.5939
31. Muller-Loennies S, MacKenzie CR, Patenaude SI, Evans SV, Kosma P, Brade H, Brade L, Narang S. Characterization of high affinity monoclonal antibodies specific for chlamydial lipopolysaccharide. Glycobiology 2000; 10(2):121-30; PMID:10642603
32. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 2013; 13(9):785-96; PMID:23969216
33. Conte V, Monaco M, Giani T, D'Ancona F, Moro ML, Arena F, D'Andrea MM, Rossolini GM, Pantosti A, et al. Molecular epidemiology of KPC-producing Klebsiella pneumoniae from invasive infections in Italy: increasing diversity with predominance of the ST512 clade II sublineage. J Antimicrob Chemother 2016; 71(12):3386-91; PMID:27585968
34. Chiang TT, Yang YS, Yeh KM, Chiu SK, Wang NC, Lin TY, Huang LY, Chang FY, Siu LK, Lin JC, et al. quantification and comparison of virulence and characteristics of different variants of carbapenemase-producing Klebsiella pneumoniae clinical isolates from Taiwan and the United States. J Microbiol Immunol Infect 2016; 49(1):83-90; PMID:26514941
35. Muschel LH, Muto T. Bactericidal reaction of mouse serum. Science 1956; 123(3185):62-4; PMID:13281484
36. Nagy G, Dobrindt U, Hacker J, Emödy L. Oral immunization with an RfaH mutant elicits protection against salmonellosis in mice. Infect Immun 2004; 72(7):4297-301; PMID:15213179
37. Dubrovskaya Y, Chen TY, Scipione MR, Esaian D, Phillips MS, Papadopoulos J, Mehta SA. Risk factors for treatment failure of polymyxin B monotherapy for carbapenem-resistant Klebsiella pneumoniae infections. Antimicrob Agents Chemother 2013; 57(11):5394-7; PMID:23959321
38. Papadimitriou-Olivgeris M, Marangos M, Christofidou M, Fligou F, Bartzavali C, Panteli ES, Vamvakopoulou S, Filos KS, Anastassiou ED. Risk factors for infection and predictors of mortality among patients with KPC-producing Klebsiella pneumoniae bloodstream infections in the intensive care unit. Scand J Infect Dis 2014; 46(9):642-8; PMID:25017796
39. Tumbarello M, Trecarichi EM, De Rosa FG, Giannella M, Giacobbe DR, Bassetti M, Losito AR, Bartoletti M, Del Bono V, Corcione S, et al. Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study. J Antimicrob Chemother 2015; 70(7):2133-43; PMID:25900159
40. Hurley JC. Towards clinical applications of anti-endotoxin antibodies; a Re-Appraisal of the disconnect. Toxins.(Basel) 2013; 5(12):2589-620; PMID:24351718
41. Mackenzie CR, Muller-Loennies S. Determination of antibody affinity by surface plasmon resonance. In Anticarbohydrate Antibodies, 403-29. Springer, 2012.
42. Muller-Loennies S, Brade L, MacKenzie CR, Di Padova FE, Brade H, et al. Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5. J Biol Chem 2003; 278(28):25618-27
43. Gomery K, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV. Antibody WN1 222-5 mimics toll-like receptor 4 binding in the recognition of LPS. Proc Natl Acad Sci U.S.A 2012; 109(51):20877-82