An update of the evolving epidemic of blaKPC carrying Klebsiella pneumoniae in Sicily, Italy, 2014: Emergence of multiple Non-ST258 Clones

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Bonura, Celestino ^a   Giuffrè, Mario ^a   Aleo, Aurora ^a   Fasciana, Teresa ^a   Di Bernardo, Francesca ^b   Stampone, Tomaso ^c   Giammanco, Anna ^a,d   Palma, Daniela Maria ^b   Mammina, Caterina ^a   Geraci, Daniela Maria ^a   Graziano, Giorgio ^a   Saporito, Laura ^a   Saporito, Maria Antonietta ^b   Sodano, Concetta ^b   Verde, Maria Stella ^b   Baldi, Maria Teresa ^c   Donato, Elisa ^c   Amato, Teresa ^d   Immordino, Rita ^d   Distefano, Salvatore ^d  

^a UNIVERSITY OF PALERMO   (Italy)

^b Di Cristina and Benfratelli'   (Italy)

^c Azienda Ospedaliera Ospedali Riuniti 'Villa Sofia Cervello'   (Italy)

^d UNIVERSITY OF PALERMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; BETA LACTAM; CARBAPENEM; COLISTIN; GENTAMICIN; IMIPENEM; MEROPENEM; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CARBAPENEMASE; MEMBRANE PROTEIN; QUINOLONE DERIVATIVE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CONTROLLED STUDY; EPIDEMIC; GENE; GENE AMPLIFICATION; GENE INACTIVATION; GENETIC RESISTANCE; ITALY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE CARBAPENEMASE PRODUCING KLEBSIELLA PNEUMONIAE; MGRB GENE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PULSED FIELD GEL ELECTROPHORESIS; SEQUENCE ANALYSIS; CELL CLONE; CHEMISTRY; CLASSIFICATION; DRUG EFFECTS; EPIDEMIOLOGICAL MONITORING; GENE EXPRESSION; GENETICS; HOSPITAL; HUMAN; INCIDENCE; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; METABOLISM; MICROBIOLOGY; MULTIDRUG RESISTANCE; MUTATION; PLASMID; TRANSMISSION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CLONE CELLS; COLISTIN; DISEASE OUTBREAKS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; EPIDEMIOLOGICAL MONITORING; FLUOROQUINOLONES; GENE EXPRESSION; HOSPITALS; HUMANS; INCIDENCE; ITALY; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MEMBRANE PROTEINS; MULTILOCUS SEQUENCE TYPING; MUTATION; PLASMIDS;

EID: 84941345225     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132936     Document Type: Article

References (28)

1. Giani T, Pini B, Arena F, Conte V, Bracco S, Migliavacca R, et al. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011. Euro Surveill. 2013; 18(22):pii = 20489. Available: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20489
2. Giani T, D'Andrea MM, Pecile P, Borgianni L, Nicoletti P, Tonelli F, et al. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J Clin Microbiol. 2009; 47:3793-4. doi: 10.1128/JCM.01773-09 PMID: 19759220
3. European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2013. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2014.
4. Monaco M, Giani T, Raffone M, Arena F, Garcia-Fernandez A, Pollini S, et al. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill.2014;19:pii = 20939. Available: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20939
5. Mammina C, Palma DM, Bonura C, Plano MRA, Monastero R, Sodano C, et al. Outbreak of infection with Klebsiella pneumoniae sequence type 258 producing Klebsiella pneumoniae carbapenemase 3 in an intensive care unit in Italy. J Clin Microbiol. 2010; 48:1506-7. doi: 10.1128/JCM.00315-10 PMID: 20200298
6. Agodi A, Barchitta M, Valenti G, Romeo MA, Giaquinta L, Santangelo C, et al. Cross-transmission of Klebsiella pneumoniae in two intensive care units: intra- and inter-hospital spread. J Hosp Infect. 2011; 77:279-80. doi: 10.1016/j.jhin.2010.10.007 PMID: 21277048
7. Giuffrè M, Bonura C, Geraci DM, Saporito L, Catalano R, Di Noto S, et al. Successful control of an outbreak of colonization by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae sequence type 258 in a neonatal intensive care unit, Italy. J Hosp Infect. 2013; 85:233-6. doi: 10.1016/j.jhin.2013. 08.004 PMID: 24074641
8. Mezzatesta ML, Gona F, Caio C, Petrolito V, Sciortino D, Sciacca A, et al Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals. Clin Microbiol Infect. 2011; 17:1444-7. doi: 10.1111/j.1469-0691.2011.03572.x PMID: 21668577
9. Mammina C, Bonura C, Di Bernardo F, Aleo A, Fasciana T, Sodano C, et al. Ongoing spread of colistinresistant Klebsiella pneumoniae in different wards of an acute general hospital, Italy, June to December 2011. Euro Surveill. 2012;17:pii = 20248. Available: http://www.eurosurveillance.org/ViewArticle.aspx? ArticleId=20248.
10. Geraci DM, Bonura C, Giuffrè M, Saporito L, Graziano G, Aleo A, et al. Is the monoclonal spread of the ST258, KPC-3-producing clone being replaced in southern Italy by the dissemination of multiple clones of carbapenem-nonsusceptible, KPC-3-producing Klebsiella pneumoniae? Clin Microbiol Infect. 2015; 21:e15-7. doi: 10.1016/j.cmi.2014.08.022 PMID: 25658574
11. Cannatelli A, Giani T, D'Andrea MM, Di Pilato V, Arena F, Conte V, et al. MgrB inactivation is a common mechanism of colistin resistance in KPC-producing Klebsiella pneumoniae of clinical origin. Antimicrob Agents Chemother. 2014; 58:5696-703. doi: 10.1128/AAC.03110-14 PMID: 25022583
12. Poirel L, Jayol A, Bontron S, Villegas MV, Ozdamar M, Türkoglu S, et al. The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae. J Antimicrob Chemother. 2015; 70:75-80. doi: 10.1093/jac/dku323 PMID: 25190723
13. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Växjö: EUCAST; 2013. Available: http://www.eucast.org/clinical-breakpoints/
14. Tsakris A, Poulou A, Pournaras S, Voulgari E, Vrioni G, Themeli-Digalaki K, et al. A simple phenotypic method for the differentiation of metallo-β-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J Antimicrob Chemother. 2010; 65:1664-71. doi: 10.1093/jac/dkq210 PMID: 20542902
15. Dallenne C, Da Costa A, Decré D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010; 65:490-5. doi: 10.1093/jac/dkp498 PMID: 20071363
16. Hu L, Zhong Q, Shang Y, Wang H, Ning C, Li Y, et al. The prevalence of carbapenemase genes and plasmid-mediated quinolone resistance determinants in carbapenem-resistant Enterobacteriaceae from five teaching hospitals in central China. Epidemiol Infect. 2014; 142:1972-7. doi: 10.1017/S0950268813002975 PMID: 24252194
17. Woodford N, Fagan EJ, Ellington MJ. Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases. J Antimicrob Chemother. 2006; 57:154-5. PMID: 16284100.
18. van Belkum A, Tassios PT, Dijkshoorn L, Haeggman S, Cookson B, Fry NK, et al. Guidelines for the validation and application of typing methods for use in bacterial epidemiology. Clin Microbiol Infect. 2007; 13 Suppl 3:1-46. doi: org/10.1111/j.1469-0691.2007.01786.x. PMID: 17716294
19. Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN. Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol. 2014; 22:686-696. doi: 10.1016/j.tim.2014.09.003 PMID: 25304194
20. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013; 13:785-96. doi: 10.1016/S1473-3099(13)70190-7 PMID: 23969216
21. Mammina C, Aleo A, Bonura C, Calà C, Degl'Innocenti R, Conti A, et al. Multiclonal emergence of carbapenem-resistant Klebsiella pneumoniae in Tuscany, Italy. Int J Antimicrob Agents. 2010; 36:576-8. doi: 10.1016/j.ijantimicag.2010.08.004 PMID: 20869854
22. Castanheira M, Farrell SE, Wanger A, Rolston KV, Jones RN, Mendes RE. Rapid expansion of KPC-2-producing Klebsiella pneumoniae isolates in two Texas hospitals due to clonal spread of ST258 and ST307 lineages. Microb Drug Resist. 2013; 19:295-7. doi: 10.1089/mdr.2012.0238 PMID: 23530541
23. Habeeb MA, Haque A, Nematzadeh S, Iversen A, Giske CG. High prevalence of 16S rRNA methylase RmtB among CTX-M extended-spectrum β-lactamase-producing Klebsiella pneumoniae from Islamabad, Pakistan. Int J Antimicrob Agents. 2013; 41:524-6. doi: 10.1016/j.ijantimicag.2013.02.017 PMID: 23622882
24. Migliavacca R, Caltagirone M, Corbella M, Bitar L, Piazza A, Stronati M, et al. Emergence of the CTXM-15 Klebsiella pneumoniae ST307 clone in Italy. 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Copenhagen, Denmark, 25-28 April, 2015. Available: https://www.escmid.org/escmid-library/online-lecture-library/?search=1¤t-page=1&search-term=Pagani
25. Ageevets VA, Partina IV, Lisitsyna ES, Ilina EN, Lobzin YV, Shlyapnikov SA, et al. Emergence of carbapenemase-producing Gram-negative bacteria in Saint Petersburg, Russia. Int J Antimicrob Agents. 2014; 44:152-5. doi: 10.1016/j.ijantimicag.2014.05.004 PMID: 25059447
26. Ruiz-Garbajosa P, Curiao T, Tato M, Gijón D, Pintado V, Valverde A, et al. Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain. J Antimicrob Chemother. 2013; 68:2487-92. doi: 10.1093/jac/dkt237 PMID: 23788480
27. Tofteland S, Naseer U, Lislevand JH, Sundsfjord A, Samuelsen O. A long-term low-frequency hospital outbreak of KPC-producing Klebsiella pneumoniae involving intergenus plasmid diffusion and a persisting environmental reservoir. PLoS One. 2013; 8:e59015. doi: 10.1371/journal.pone.0059015 PMID: 23536849
28. Gomez-Simmonds A, Greenman M, Sullivan SB, Tanner JP, Sowash MG, Whittier S, et al. Population structure of Klebsiella pneumoniae causing bloodstream infections at a New York City tertiary care hospital: diversification of multidrug-resistant isolates. J Clin Microbiol. 2015 Apr 15. pii: JCM.03455-14. [Epub ahead of print]