Risk factors for infection and predictors of mortality among patients with KPC-producing Klebsiella pneumoniae bloodstream infections in the intensive care unit

Scandinavian Journal of Infectious Diseases

Volumn 46, Issue 9, 2014, Pages 642-648

  Papadimitriou Olivgeris, Matthaios ^a   Marangos, Markos ^a   Christofidou, Myrto ^b   Fligou, Fotini ^a   Bartzavali, Christina ^b   Panteli, Eleftheria S ^a   Vamvakopoulou, Sophia ^b   Filos, Kriton S ^a   Anastassiou, Evangelos D ^a,b  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Bacteraemia; Carbapenemase; Critically ill patients; Resistance epidemiology; Surveillance

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AZTREONAM; CARBAPENEM DERIVATIVE; CARBAPENEMASE; CEPHALOSPORIN DERIVATIVE; COLISTIN; COTRIMOXAZOLE; GENTAMICIN; PENICILLIN DERIVATIVE; QUINOLONE DERIVATIVE; TIGECYCLINE; TOBRAMYCIN; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE;

ADULT; AGE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTEREMIA; BLOODSTREAM INFECTION; CATHETER; CONTROLLED STUDY; DISK DIFFUSION; FEMALE; HOSPITALIZATION; HUMAN; INFECTION RISK; INTENSIVE CARE UNIT; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR TYPING; MORTALITY; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PROGNOSIS; SEPTIC SHOCK; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; TRACHEOSTOMY; AGED; CLASSIFICATION; ENZYMOLOGY; GENETICS; GREECE; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; PULSED FIELD GEL ELECTROPHORESIS; RISK FACTOR; SECRETION (PROCESS); SURVIVAL; UNIVERSITY HOSPITAL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIAL PROTEINS; BETA-LACTAMASES; ELECTROPHORESIS, GEL, PULSED-FIELD; GREECE; HOSPITALS, UNIVERSITY; HUMANS; INTENSIVE CARE UNITS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOLECULAR TYPING; POLYMERASE CHAIN REACTION; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 84906213669     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2014.923106     Document Type: Article

References (28)

1. Schechner V, Kotlovsky T, Kazma M, Mishali H, Schwartz D, Navon-Venezia S, et al. Asymptomatic rectal carriage of bla KPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected? Clin Microbiol Infect 2013; 19: 451-6.
2. Grundmann H, Livermore DM, Giske CG, Canton R, Rossolini GM, Campos J, et al. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill 2010; 15. pii: 19711.
3. Carbonne A, Thiolet JM, Fournier S, Fortineau N, Kassis-Chikhani N, Boytchev I, et al. Control of a multihospital outbreak of KPC-producing Klebsiella pneumoniae type 2 in France, September to October 2009. Euro Surveill 2010; 15. pii: 19734.
4. Woodford N, Zhang J, Warner M, Kaufmann ME, Matos J, Macdonald A, et al. Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom. J Antimicrob Chemother 2008; 62: 1261-4.
5. Giakkoupi P, Papagiannitsis CC, Miriagou V, Pappa O, Polemis M, Tryfinopoulou K, et al. An update of the evolving epidemic of bla KPC-2-carrying Klebsiella pneumoniae in Greece (2009-10). J Antimicrob Chemother 2011; 66: 1510-3.
6. Papadimitriou-Olivgeris M, Marangos M, Fligou F, Christofidou M, Bartzavali C, Anastassiou ED, et al. Risk factors for KPC-producing Klebsiella pneumoniae enteric colonization upon ICU admission. J Antimicrob Chemother 2012; 67: 2976-81.
7. Lubbert C, Becker-Rux D, Rodloff AC, Laudi S, Busch T, Bartels M, et al. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis. Infection 2014 42: 309-16.
8. Papadimitriou-Olivgeris M, Marangos M, Fligou F, Christofidou M, Sklavou C, Vamvakopoulou S, et al. KPC producing Klebsiella pneumoniae enteric colonization acquired during intensive care unit stay: the significance of risk factors for its development and its impact on mortality. Diagn Microbiol Infect Dis 2013; 77: 169-73.
9. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 2013; 13: 785-96.
10. Kontopidou F, Giamarellou H, Katerelos P, Maragos A, Kioumis I, Trikka-Graphakos E, et al. Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect 2014; 20: O117-23.
11. Wiskirchen DE, Crandon JL, Nicolau D P. Impact of various conditions on the efficacy of dual carbapenem therapy against KPC-producing Klebsiella pneumoniae. Int J Antimicrob Agents 2013; 41: 582-5.
12. Lee GC, Burgess D S. Polymyxins and doripenem combination against KPC-producing Klebsiella pneumoniae. J Clin Med Res 2013; 5: 97-100.
13. Hirsch EB, Guo B, Chang KT, Cao H, Ledesma KR, Singh M, et al. Assessment of antimicrobial combinations for Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. J Infect Dis 2013; 207: 786-93.
14. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes J M. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16: 128-40.
15. Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 12th ed. Approved standard M7-A7. Wayne, PA: CLSI; 2011.
16. Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K, et al. Predictors of mortality in patients with bloodstream infections caused by KPCproducing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 2011; 17: 1798-803.
17. Borer A, Saidel-Odes L, Eskira S, Nativ R, Riesenberg K, Livshiz-Riven I, et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenemresistant K pneumoniae. Am J Infect Control 2012; 40: 421-5.
18. Correa L, Martino MD, Siqueira I, Pasternak J, Gales AC, Silva CV, et al. A hospital-based matched case-control study to identify clinical outcome and risk factors associated with carbapenem-resistant Klebsiella pneumoniae infection. BMC Infect Dis 2013; 13: 80.
19. Daikos GL, Vryonis E, Psichogiou M, Tzouvelekis LS, Liatis S, Petrikkos P, et al. Risk factors for bloodstream infection with Klebsiella pneumoniae producing VIM-1 metallo- beta-lactamase. J Antimicrob Chemother 2010; 65: 784-8.
20. Tuon FF, Rocha JL, Toledo P, Arend LN, Dias CH, Leite TM, et al. Risk factors for KPC-producing Klebsiella pneumoniae bacteremia. Braz J Infect Dis 2012; 16: 416-9.
21. Daikos GL, Petrikkos P, Psichogiou M, Kosmidis C, Vryonis E, Skoutelis A, et al. Prospective observational study of the impact of VIM-1 metallo-beta-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections. Antimicrob Agents Chemother 2009; 53: 1868-73.
22. Crusio R, Rao S, Changawala N, Paul V, Tiu C, van Ginkel J, et al. Epidemiology and outcome of infections with carbapenem- resistant Gram-negative bacteria treated with polymyxin B-based combination therapy. Scand J Infect Dis 2014; 46: 1-8.
23. Qureshi ZA, Paterson DL, Potoski BA, Kilayko MC, Sandovsky G, Sordillo E, et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother 2012; 56: 2108-13.
24. Tumbarello M, Viale P, Viscoli C, Trecarichi EM, Tumietto F, Marchese A, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 2012; 55: 943-50.
25. Lee GC, Burgess D S. Treatment of Klebsiella pneumoniae carbapenemase (KPC) infections: a review of published case series and case reports. Ann Clin Microbiol Antimicrob 2012; 11: 32.
26. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 2012; 25: 682-707.
27. Carmeli Y, Akova M, Cornaglia G, Daikos GL, Garau J, Harbarth S, et al. Controlling the spread of carbapenemaseproducing Gram-negatives: therapeutic approach and infection control. Clin Microbiol Infect 2010; 16: 102-11.
28. Tzouvelekis LS, Miriagou V, Kotsakis SD, Spyridopoulou K, Athanasiou E, Karagouni E, et al. KPC-producing, multidrug- resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen. Antimicrob Agents Chemother 2013; 57: 5144-6.