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Volumn 2, Issue , 2011, Pages 165-177

Bioreactor Engineering

Author keywords

Biological system; Bioprocess optimization; Bioreactor design; Bioreactor engineering; Bioreactor operation strategy; Fluid mixing; Oxygen transfer; Scale up; Shear stress

Indexed keywords


EID: 85012818757     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-08-088504-9.00097-0     Document Type: Chapter
Times cited : (25)

References (55)
  • 2
    • 85012822736 scopus 로고    scopus 로고
    • Bioreactors, cell culture, commercial production
    • John Wiley and Sons, Hoboken, NJ, M.C. Flickinger (Ed.)
    • Zhou T.C., Zhou W.W., Hu W.W., Zhong J.J. Bioreactors, cell culture, commercial production. Encyclopedia of Industrial Biotechnology 2010, 2:913-939. John Wiley and Sons, Hoboken, NJ. M.C. Flickinger (Ed.).
    • (2010) Encyclopedia of Industrial Biotechnology , vol.2 , pp. 913-939
    • Zhou, T.C.1    Zhou, W.W.2    Hu, W.W.3    Zhong, J.J.4
  • 3
    • 0032949506 scopus 로고    scopus 로고
    • Reactor design for large scale suspension animal cell culture
    • Varley J., Birch J. Reactor design for large scale suspension animal cell culture. Cytotechnology 1999, 29:177.
    • (1999) Cytotechnology , vol.29 , pp. 177
    • Varley, J.1    Birch, J.2
  • 4
    • 0027394438 scopus 로고
    • High density cultivation of plant cells in a new aeration-agitation type fermentor, Maxblend Fermentor®
    • Yokoi H., Koga J., Yamamura K., et al. High density cultivation of plant cells in a new aeration-agitation type fermentor, Maxblend Fermentor®. Journal of Fermentation and Bioengineering 1993, 75:48-53.
    • (1993) Journal of Fermentation and Bioengineering , vol.75 , pp. 48-53
    • Yokoi, H.1    Koga, J.2    Yamamura, K.3
  • 5
    • 0029837454 scopus 로고    scopus 로고
    • A novel internally illuminated stirred tank photobioreactor for large- scale cultivation of photosynthetic cells
    • Ogbonna J.C., Yada H., Masui H., Tanaka H. A novel internally illuminated stirred tank photobioreactor for large- scale cultivation of photosynthetic cells. Journal of Fermentation and Bioengineering 1996, 82:61-67.
    • (1996) Journal of Fermentation and Bioengineering , vol.82 , pp. 61-67
    • Ogbonna, J.C.1    Yada, H.2    Masui, H.3    Tanaka, H.4
  • 6
    • 0028449103 scopus 로고
    • Mixing in the transition flow regime with helical ribbon agitators
    • Cheng J., Carreau P.J. Mixing in the transition flow regime with helical ribbon agitators. Canadian Journal of Chemical Engineering 1994, 72:418-430.
    • (1994) Canadian Journal of Chemical Engineering , vol.72 , pp. 418-430
    • Cheng, J.1    Carreau, P.J.2
  • 7
    • 0026220295 scopus 로고
    • Culture of insect cells in a helical ribbon impeller bioreactor
    • Kamen A.A., Tom R.L., Caron A.W., et al. Culture of insect cells in a helical ribbon impeller bioreactor. Biotechnology and Bioengineering 1991, 38:619-628.
    • (1991) Biotechnology and Bioengineering , vol.38 , pp. 619-628
    • Kamen, A.A.1    Tom, R.L.2    Caron, A.W.3
  • 8
    • 0030570945 scopus 로고    scopus 로고
    • A novel centrifugal impeller bioreactor. I. Fluid circulation, mixing, and liquid velocity profiles
    • Wang S.J., Zhong J.J. A novel centrifugal impeller bioreactor. I. Fluid circulation, mixing, and liquid velocity profiles. Biotechnology and Bioengineering 1996, 51:511-519.
    • (1996) Biotechnology and Bioengineering , vol.51 , pp. 511-519
    • Wang, S.J.1    Zhong, J.J.2
  • 10
    • 0025382589 scopus 로고
    • Gas dispersion performance in fermenter operation
    • Nienow A.W. Gas dispersion performance in fermenter operation. Chemical Engineering Progress 1990, 86:61-71.
    • (1990) Chemical Engineering Progress , vol.86 , pp. 61-71
    • Nienow, A.W.1
  • 14
    • 0032924570 scopus 로고    scopus 로고
    • Disposable bioreactor for cell culture using wave-induced agitation
    • Singh V. Disposable bioreactor for cell culture using wave-induced agitation. Cytotechnology 1999, 30:149-158.
    • (1999) Cytotechnology , vol.30 , pp. 149-158
    • Singh, V.1
  • 15
    • 36248985213 scopus 로고    scopus 로고
    • Upstream processes in antibody production: Evaluation of critical parameters
    • Jain E., Kumar A. Upstream processes in antibody production: Evaluation of critical parameters. Biotechnology Advances 2008, 26:46-72.
    • (2008) Biotechnology Advances , vol.26 , pp. 46-72
    • Jain, E.1    Kumar, A.2
  • 20
    • 0031647064 scopus 로고    scopus 로고
    • Influence of impeller type on mass transfer in fermentation vessels
    • Junker B.H., Stanik M., Barna C., et al. Influence of impeller type on mass transfer in fermentation vessels. Bioprocess Engineering 1998, 19:403-413.
    • (1998) Bioprocess Engineering , vol.19 , pp. 403-413
    • Junker, B.H.1    Stanik, M.2    Barna, C.3
  • 23
    • 0035226724 scopus 로고    scopus 로고
    • Biochemical engineering of the production of plant-specific secondary metabolites by cell suspension cultures
    • Zhong J.J. Biochemical engineering of the production of plant-specific secondary metabolites by cell suspension cultures. Advances in Biochemical Engineering/Biotechnology 2001, 72:1-26.
    • (2001) Advances in Biochemical Engineering/Biotechnology , vol.72 , pp. 1-26
    • Zhong, J.J.1
  • 27
    • 0035947520 scopus 로고    scopus 로고
    • Indirect measurement of water content in an aseptic solid substrate cultivation pilot-scale bioreactor
    • Lillo M.P.Y., Perez-Correa R., Agosin E., Latrille E. Indirect measurement of water content in an aseptic solid substrate cultivation pilot-scale bioreactor. Biotechnology and Bioengineering 2001, 76:44-51.
    • (2001) Biotechnology and Bioengineering , vol.76 , pp. 44-51
    • Lillo, M.P.Y.1    Perez-Correa, R.2    Agosin, E.3    Latrille, E.4
  • 28
    • 0035809236 scopus 로고    scopus 로고
    • On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy
    • Ducommun P., Kadouri A., von Stockar U., Marison I.W. On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy. Biotechnology and Bioengineering 2002, 77:316-323.
    • (2002) Biotechnology and Bioengineering , vol.77 , pp. 316-323
    • Ducommun, P.1    Kadouri, A.2    von Stockar, U.3    Marison, I.W.4
  • 29
    • 0242380880 scopus 로고    scopus 로고
    • Measurement of metabolic heat in a production-scale bioreactor by continuous and dynamic calorimetry
    • Turker M. Measurement of metabolic heat in a production-scale bioreactor by continuous and dynamic calorimetry. Chemical Engineering Communications 2003, 190:573-598.
    • (2003) Chemical Engineering Communications , vol.190 , pp. 573-598
    • Turker, M.1
  • 30
    • 2942756043 scopus 로고    scopus 로고
    • Serial 13C-based flux analysis of an L-phenylalanine-producing E. coli strain using the sensor reactor
    • Wahl A., El Massaoudi M., Schipper D., et al. Serial 13C-based flux analysis of an L-phenylalanine-producing E. coli strain using the sensor reactor. Biotechnology Progress 2004, 20:706-714.
    • (2004) Biotechnology Progress , vol.20 , pp. 706-714
    • Wahl, A.1    El Massaoudi, M.2    Schipper, D.3
  • 31
    • 0035037896 scopus 로고    scopus 로고
    • A networks-of-zones analysis of mixing and mass transfer in three industrial bioreactors
    • Zahradnik J., Mann R., Fialova M., et al. A networks-of-zones analysis of mixing and mass transfer in three industrial bioreactors. Chemical Engineering Science 2001, 56:485-492.
    • (2001) Chemical Engineering Science , vol.56 , pp. 485-492
    • Zahradnik, J.1    Mann, R.2    Fialova, M.3
  • 32
    • 0035866509 scopus 로고    scopus 로고
    • A kinetic and mass transfer model to simulate the growth of baker's yeast in industrial bioreactors
    • Di Serio M., Tesser R., Santacesaria E. A kinetic and mass transfer model to simulate the growth of baker's yeast in industrial bioreactors. Chemical Engineering Journal 2001, 82:347-354.
    • (2001) Chemical Engineering Journal , vol.82 , pp. 347-354
    • Di Serio, M.1    Tesser, R.2    Santacesaria, E.3
  • 33
    • 0344223519 scopus 로고    scopus 로고
    • A special reactor design for investigations of mixing time effects in a scaled-down industrial L-lysine fed-batch fermentation process
    • Schilling B.M., Pfefferle W., Bachmann B., et al. A special reactor design for investigations of mixing time effects in a scaled-down industrial L-lysine fed-batch fermentation process. Biotechnology and Bioengineering 1999, 64:599.
    • (1999) Biotechnology and Bioengineering , vol.64 , pp. 599
    • Schilling, B.M.1    Pfefferle, W.2    Bachmann, B.3
  • 34
    • 0034694211 scopus 로고    scopus 로고
    • Studies related to the scale-up of high-cell-density E. coli fed-batch fermentations using multiparameter flow cytometry: Effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration
    • Hewitt C.J., Nebe-Von Caron G., Axelsson B., et al. Studies related to the scale-up of high-cell-density E. coli fed-batch fermentations using multiparameter flow cytometry: Effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration. Biotechnology and Bioengineering 2000, 70:381-390.
    • (2000) Biotechnology and Bioengineering , vol.70 , pp. 381-390
    • Hewitt, C.J.1    Nebe-Von Caron, G.2    Axelsson, B.3
  • 35
    • 0142073266 scopus 로고    scopus 로고
    • Further studies related to the scale-up of high cell density Escherichia coli fed-batch fermentations: the additional effect of a changing microenvironment when using aqueous ammonia to control pH
    • Onyeaka H., Nienow A.W., Hewitt C.J. Further studies related to the scale-up of high cell density Escherichia coli fed-batch fermentations: the additional effect of a changing microenvironment when using aqueous ammonia to control pH. Biotechnology and Bioengineering 2003, 84:474-484.
    • (2003) Biotechnology and Bioengineering , vol.84 , pp. 474-484
    • Onyeaka, H.1    Nienow, A.W.2    Hewitt, C.J.3
  • 37
    • 14244261836 scopus 로고    scopus 로고
    • Low-cost noninvasive optical CO2 sensing system for fermentation and cell culture
    • Ge X., Kostov Y., Rao G. Low-cost noninvasive optical CO2 sensing system for fermentation and cell culture. Biotechnology and Bioengineering 2005, 89:329-334.
    • (2005) Biotechnology and Bioengineering , vol.89 , pp. 329-334
    • Ge, X.1    Kostov, Y.2    Rao, G.3
  • 38
    • 36749028275 scopus 로고    scopus 로고
    • Twenty-four-well plate miniature bioreactor high-throughput system: Assessment for microbial cultivations
    • Isett K., George H., Herber W., Amanullah A. Twenty-four-well plate miniature bioreactor high-throughput system: Assessment for microbial cultivations. Biotechnology and Bioengineering 2007, 98:1017-1028.
    • (2007) Biotechnology and Bioengineering , vol.98 , pp. 1017-1028
    • Isett, K.1    George, H.2    Herber, W.3    Amanullah, A.4
  • 39
    • 58149269805 scopus 로고    scopus 로고
    • Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development
    • Chen A., Chitta R., Chang D., Amanullah A. Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development. Biotechnology and Bioengineering 2009, 102:148-160.
    • (2009) Biotechnology and Bioengineering , vol.102 , pp. 148-160
    • Chen, A.1    Chitta, R.2    Chang, D.3    Amanullah, A.4
  • 40
    • 3042790235 scopus 로고    scopus 로고
    • Membrane-aerated microbioreactor for high-throughput bioprocessing
    • Zanzotto A., Szita N., Boccazzi P., et al. Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnology and Bioengineering 2004, 87:243-254.
    • (2004) Biotechnology and Bioengineering , vol.87 , pp. 243-254
    • Zanzotto, A.1    Szita, N.2    Boccazzi, P.3
  • 41
    • 9144228701 scopus 로고    scopus 로고
    • Membrane-based PDMS microbioreactor for perfused 3D primary rat hepatocyte cultures
    • Ostrovidov S., Jiang J.L., Sakai Y., Fujii T. Membrane-based PDMS microbioreactor for perfused 3D primary rat hepatocyte cultures. Biomedical Microdevices 2004, 6:279-287.
    • (2004) Biomedical Microdevices , vol.6 , pp. 279-287
    • Ostrovidov, S.1    Jiang, J.L.2    Sakai, Y.3    Fujii, T.4
  • 42
    • 12344332390 scopus 로고    scopus 로고
    • A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array
    • Hung P.J., Lee P.J., Sabounchi P., et al. A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array. Lab on a Chip - Miniaturisation for Chemistry and Biology 2005, 5:44-48.
    • (2005) Lab on a Chip - Miniaturisation for Chemistry and Biology , vol.5 , pp. 44-48
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3
  • 43
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    • Hung P.J., Lee P.J., Sabounchi P., et al. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnology and Bioengineering 2005, 89:1-8.
    • (2005) Biotechnology and Bioengineering , vol.89 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3
  • 45
    • 0034213221 scopus 로고    scopus 로고
    • Lactic acid bacteria as a cell factory: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering
    • Kleerebezem M., Hols P., Hugenholtz J. Lactic acid bacteria as a cell factory: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering. Enzyme and Microbial Technology 2000, 26:840-848.
    • (2000) Enzyme and Microbial Technology , vol.26 , pp. 840-848
    • Kleerebezem, M.1    Hols, P.2    Hugenholtz, J.3
  • 46
    • 0036284760 scopus 로고    scopus 로고
    • An expanded role for microbial physiology in metabolic engineering and functional genomics: Moving towards systems biology1
    • Nielsen J., Olsson L. An expanded role for microbial physiology in metabolic engineering and functional genomics: Moving towards systems biology1. FEMS Yeast Research 2002, 2:175-181.
    • (2002) FEMS Yeast Research , vol.2 , pp. 175-181
    • Nielsen, J.1    Olsson, L.2
  • 47
    • 0033662249 scopus 로고    scopus 로고
    • Engineering the plant cell factory for secondary metabolite production
    • Verpoorte R., van der Heijden R., Memelink J. Engineering the plant cell factory for secondary metabolite production. Transgenic Research 2000, 9:323-343.
    • (2000) Transgenic Research , vol.9 , pp. 323-343
    • Verpoorte, R.1    van der Heijden, R.2    Memelink, J.3
  • 48
    • 4444351323 scopus 로고    scopus 로고
    • Plant cell factories in the post-genomic era: New ways to produce designer secondary metabolites
    • Oksman-Caldentey K.M., Inze D. Plant cell factories in the post-genomic era: New ways to produce designer secondary metabolites. Trends in Plant Science 2004, 9:433-440.
    • (2004) Trends in Plant Science , vol.9 , pp. 433-440
    • Oksman-Caldentey, K.M.1    Inze, D.2
  • 49
  • 52
    • 0037283651 scopus 로고    scopus 로고
    • Chloroplast expression of His-tagged GUS-fusions: A general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors
    • Leelavathi S., Reddy V.S. Chloroplast expression of His-tagged GUS-fusions: A general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors. Molecular Breeding 2003, 11:49-58.
    • (2003) Molecular Breeding , vol.11 , pp. 49-58
    • Leelavathi, S.1    Reddy, V.S.2
  • 53
    • 0036250985 scopus 로고    scopus 로고
    • Large scale production of recombinant human lactoferrin in the milk of transgenic cows
    • van Berkel P.H.C., Welling M.M., Geerts M., et al. Large scale production of recombinant human lactoferrin in the milk of transgenic cows. Nature Biotechnology 2002, 20:484-487.
    • (2002) Nature Biotechnology , vol.20 , pp. 484-487
    • van Berkel, P.H.C.1    Welling, M.M.2    Geerts, M.3
  • 54
    • 8844251563 scopus 로고    scopus 로고
    • Purification and characterization of a recombinant version of human alpha-fetoprotein expressed in the milk of transgenic goats
    • Park M.H., Birck-Wilson E., Allard G., et al. Purification and characterization of a recombinant version of human alpha-fetoprotein expressed in the milk of transgenic goats. Protein Expression and Purification 2004, 38:177-183.
    • (2004) Protein Expression and Purification , vol.38 , pp. 177-183
    • Park, M.H.1    Birck-Wilson, E.2    Allard, G.3
  • 55
    • 7244232790 scopus 로고    scopus 로고
    • Purification and characterization of a recombinant version of human alpha-fetoprotein expressed in the milk of transgenic goats
    • Mikus T., Poplstein M., Sedlakova J., et al. Purification and characterization of a recombinant version of human alpha-fetoprotein expressed in the milk of transgenic goats. Transgenic Research 2004, 13:487-498.
    • (2004) Transgenic Research , vol.13 , pp. 487-498
    • Mikus, T.1    Poplstein, M.2    Sedlakova, J.3


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