Crocin improves spatial learning and memory deficits in the Morris water maze via attenuating cortical oxidative damage in diabetic rats

Neuroscience Letters

Volumn 642, Issue , 2017, Pages 1-6

  Ahmadi, M ^a   Rajaei, Z ^b   Hadjzadeh, M A ^a   Nemati, H ^a   Hosseini, M ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crocin; Diabetes mellitus; Hyperglycaemia; Morris water maze; Oxidative stress; Spatial memory

Indexed keywords

CROCIN; GLUCOSE; THIOL; CAROTENOID; GLUCOSE BLOOD LEVEL; MALONALDEHYDE; SCAVENGER; THIOL DERIVATIVE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COGNITION; CONTROLLED STUDY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; LEARNING DISORDER; LIPID PEROXIDATION; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPATIAL LEARNING; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; COMPLICATION; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; MEMORY DISORDERS; METABOLISM; SPATIAL MEMORY; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; CAROTENOIDS; CEREBRAL CORTEX; DIABETES MELLITUS, EXPERIMENTAL; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MEMORY DISORDERS; OXIDATIVE STRESS; RATS; RATS, WISTAR; SPATIAL LEARNING; SPATIAL MEMORY; SULFHYDRYL COMPOUNDS; TREATMENT OUTCOME;

EID: 85012302366     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2017.01.049     Document Type: Article

References (42)

1. [1] Brownlee, M., Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001), 813–820.
2. [2] Manschot, S.M., Biessels, G.J., Rutten, G.E., Kessels, R.P., Gispen, W.H., Kappelle, L.J., Peripheral and central neurologic complications in type 2 diabetes mellitus: no association in individual patients. J. Neurol. Sci. 264 (2008), 157–162.
3. [3] Kennedy, J.M., Zochodne, D.W., Impaired peripheral nerve regeneration in diabetes mellitus. J. Peripher. Nerv. Syst. 10 (2005), 144–157.
4. [4] Biessels, G.J., Heide, L.P., Kamal, A., Ageing and diabetes: implications for brain function. Eur. J. Pharmacol. 441 (2002), 1–14.
5. [5] Sima, A.A.F., Kamiya, H., Lia, Z.G., Insulin C-peptide hyperglycemia, and central nervous system complications in diabetes. Eur. J. Pharmacol. 490 (2004), 187–197.
6. [6] Brands, A.M., Biessels, G.J., Kappelle, L.J., de Haan, E.H., de Valk, H.W., Algra, A., Kessels, R.P., Cognitive functioning and brain MR1 in patients with type 1 and type 2 diabetes mellitus: a comparative study. Dement. Geriatr. Cogn. Disord. 23 (2007), 343–350.
7. [7] van Harten, B., de Leeuw, F.E., Weinstein, H.C., Scheltens, P., Biessels, G.J., Brain imaging in patients with diabetes – a systematic review. Diabetes Care 29 (2006), 2539–2548.
8. [8] Biessels, G.J., Staekenborg, S., Brunner, E., Brayne, C., Scheltens, P., Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 5 (2006), 64–74.
9. [9] Kuhad, A., Chopra, K., Effect of sesamol on diabetes-associated cognitive decline in rats. Exp. Brain Res. 185 (2008), 411–420.
10. [10] Kucukatay, V., Agar, A., Gumuslu, S., Yargicoglu, P., Effect of sulfur dioxide on active and passive avoidance in experimental diabetes mellitus: relation to oxidant stress and antioxidant enzymes. Int. J. Neurosci. 117 (2007), 1091–1107.
11. [11] Iwai, T., Suzuki, M., Kobayashi, K., Mori, K., Mogi, Y., Oka, J., The influences of juvenile diabetes on memory and hippocampal plasticity in rats: improving effects of glucagon-like peptide-1. Neurosci. Res. 64 (2009), 67–74.
12. [12] Mastrocola, R., Restivo, F., Vercellinatto, I., Danni, O., Brignardello, E., Aragno, M., Boccuzzi, G., Oxidative and nitrosative stress in brain mitochondria of diabetic rats. J. Endocrinol. 187 (2005), 37–44.
13. [13] Young, I.S., Tate, S., Lightbody, J.H., McMaster, D., Trimble, E.R., The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat. Free Radic. Biol. Med. 18 (1995), 833–840.
14. [14] Fukui, K., Onodera, K., Shinkai, T., Suzuki, S., Urano, S., Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann. N.Y. Acad. Sci. 928 (2001), 168–175.
15. [15] Assimopoulou, A.N., Sinakos, Z., Papageorgiou, V.P., Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother. Res. 19 (2005), 997–1000.
16. [16] Ochiai, T., Ohno, S., Soeda, S., Tanaka, H., Shoyama, Y., Shimeno, H., Crocin prevents the death of rat pheochromocytoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci. Lett. 362 (2004), 61–64.
17. [17] Hadizadeh, F., Mahdavi, M., Emami, S.A., Khashayarmanesh, Z., Hassanzadeh, M., Asili, J., Seifi, M., Nassirli, H., Shariatimoghadam, A., Noorbakhsh, R., Evaluation of ISO method in saffron qualification. Acta Hortic. (ISHS) 739 (2007), 405–409.
18. [18] Hosseinzadeh, H., Sadeghnia, H.R., Ghaeni, F.A., Effects of saffron (Crocus sativus L.) and its active constituent crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytother. Res. 26 (2012), 381–386.
19. [19] Rajaei, Z., Hadjzadeh, M.A., Nemati, H., Hosseini, M., Ahmadi, M., Shafiee, S., Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J. Med. Food 16 (2013), 206–210.
20. [20] Pitsikas, N., Zisopoulou, S., Tarantilis, P.A., Kanakis, C.D., Polissiou, M.G., Sakellaridis, N., Effects of the active constituents of Crocus sativus L., crocins on recognition and spatial rats’ memory. Behav. Brain Res. 183 (2007), 141–146.
21. [21] Abe, K., Saito, H., Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phyhtother. Res. 14 (2000), 149–152.
22. [22] Kakkar, R., Mantha, S.V., Radhi, J., Prasad, K., Kalra, J., Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes. J. Clin. Sci. 94 (1998), 623–632.
23. [23] Low, P.A., Nickander, K.K., Tritschler, H.J., The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 46 (1997), S38–S42.
24. [24] Artola, A., Kamal, A., Ramakers, G.M., Biessels, G.J., Gispen, W.H., Diabetes mellitus concomitantly facilitates the induction of long-term depression and inhibits that of long-term potentiation in hippocampus. Eur. J. Neurosci. 22 (2005), 169–178.
25. [25] Yu, X., Jin, L., Zhang, X., Yu, X., Effects of maternal mild zinc deficiency and zinc supplementation in offspring on spatial memory and hippocampal neuronal ultrastructural changes. Nutrition 29 (2013), 457–461.
26. [26] Biessels, G.J., Kerssen, A., de Haan, E.H., Kappelle, L.J., Cognitive dysfunction and diabetes: implications for primary care. Prim. Care Diabetes 1 (2007), 187–193.
27. [27] Frier, B.M., Cognitive functioning in type 1 diabetes: the diabetes control and complications trial (DCCT) revisited. Diabetologia 54 (2011), 233–236.
28. [28] Schmatz, R., Mazzanti, C.M., Spanevello, R., Stefanello, N., Gutierres, J., Corrêa, M., da Rosa, M.M., Rubin, M.A., Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 610 (2009), 42–48.
29. [29] Kucukatay, V., Hacioglu, G., Ozkaya, G., Agar, A., Yargicoglu, P., The effect of diabetes mellitus on active avoidance learning in rats: the role of nitric oxide. Med. Sci. Monit. 15 (2009), BR88–93.
30. [30] Suge, R., Shimazu, T., Hasegawa, H., Inoue, I., Hayashibe, H., Nagasaka, H., Araki, N., Katayama, S., Nomura, M., Watanabe, S., Cerebral antioxidant enzyme increase associated with learning deficit in type2 diabetes rats. Brain Res. 1481 (2012), 97–106.
31. [31] Jin, Q.H., Shen, H.X., Wang, H., Shou, Q.Y., Liu, Q., Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-kappaB activation in gastric tissues of diabetic gastroparesisrats. Diabetol. Metab. Syndr. 5 (2013), 12–18.
32. [32] Ryan, C.M., Freed, M.I., Rood, J.A., Cobitz, A.R., Waterhouse, B.R., Strachan, M.W., Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 29 (2006), 345–351.
33. [33] Kianbakht, S., Hajiaghaee, R., Anti-hyperglycemic effects of saffron and its active constituents crocin and safranal, in alloxan induced diabetic rats. J. Med. Plants 10 (2011), 82–89.
34. [34] Hawkins, C.L., Davies, M.J., Generation and propagation of radical reactions on proteins. Biochim. Biophys. Acta 1504 (2001), 196–219.
35. [35] Gispen, W.H., Biessels, G.J., Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci. 23 (2000), 542–549.
36. [36] Fukui, K., Omoi, N.O., Hayasaka, T., Shinnkai, T., Suzuki, S., Abe, K., Urano, S., Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann. N. Y. Acad. Sci. 959 (2002), 275–284.
37. [37] Hasanein, P., Shahidi, S., Effects of combined treatment with vitamins C and E onpassive avoidance learning and memory in diabetic rats. Neurobiol. Learn. Mem. 93 (2010), 472–478.
38. [38] Chen, Y., Yang, T., Huang, J., Tian, X., Zhao, C., Cai, L., Feng, L., Zhang, H., Comparative evaluation of the antioxidant capacity of crocetin and crocin in vivo. Chin. Pharmacol. Bull. 26 (2010), 248–251.
39. [39] Ochiai, T., Soeda, S.H., Ohno, S., Tanaka, H., Shoyama, Y., Shimeno, H., Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signalling by increasing glutathione synthesis. Neurochem. Int. 44 (2004), 321–330.
40. [40] Rajaei, Z., Hosseini, M., Alaei, H., Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson‘s disease. Arq Neuropsiquiatr. 74 (2016), 723–729.
41. [41] Appleyard, M.E., Non-cholinergic functions of acetylcholinesterase. Biochem. Soc. Trans. 22 (1994), 749–755.
42. [42] Geromichalos, G.D., Lamari, F.N., Papandreou, M.A., Trafalis, D.T., Margarity, M., Papageorgiou, A., Sinakos, Z., Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. J. Agric. Food Chem. 60 (2012), 6131–6138.