Low nanomolar caffeic acid attenuates high glucose-induced endothelial dysfunction in primary human umbilical-vein endothelial cells by affecting NF-κB and Nrf2 pathways

BioFactors

Volumn 43, Issue 1, 2017, Pages 54-62

  Fratantonio, Deborah ^a   Speciale, Antonio ^a   Canali, Raffaella ^b   Natarelli, Lucia ^b   Ferrari, Daniela ^a   Saija, Antonina ^a   Virgili, Fabio ^b   Cimino, Francesco ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b CREA Research Centre for Food and Nutrition   (Italy)

Author keywords

caffeic acid; cellular adaptive response; endothelial dysfunction; high glucose; Nrf2; oxidative stress

Indexed keywords

CAFFEIC ACID; CELL ADHESION MOLECULE; ENDOTHELIAL ADHESION MOLECULE 1; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; CAFFEIC ACID DERIVATIVE; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; RELA PROTEIN, HUMAN; SELE PROTEIN, HUMAN;

ANTIOXIDANT ASSAY; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; ENDOTHELIAL DYSFUNCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOTAL ANTIOXIDANT ACTIVITY; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; CELL ADHESION; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; PRECLINICAL STUDY;

CAFFEIC ACIDS; CELL ADHESION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; E-SELECTIN; GENE EXPRESSION; GLUCOSE; GLUTATHIONE; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA;

EID: 85012024703     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1312     Document Type: Article

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