The use of in vitro 3D cell models of human airway epithelia (MucilAirTM) in inhalation toxicity

Cellular in Vitro Testing: Methods and Protocols

Volumn , Issue , 2014, Pages 15-33

  Constant, Samuel ^a   Wiszniewski, Ludovic ^a   Huang, Song ^a  

^a Epithelix   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84979951014     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.4032/9789814364980     Document Type: Chapter

References (44)

1. Committee on Toxicity Testing and Assessment of Environmental Agents, Board on Environmental Studies and Toxicology, Institute for Laboratory Animal Research, National Research Council (2007) Toxicity Testing in the 21st Century. A Vision and a Strategy, Washington, DC:National Academies Press.
2. Béru Bé, K., Aufderheide, M., Breheny, D., Clothier, R., Combes, R., Duffin, R., Forbes, B., Gaça, M., Gray, A., Hall, I., Kelly, M., Lethem, M., Liebsch, M., Merolla, L., Morin, J. P., Seagrave, J., Swartz, M. A., Tetley, T. D., Umachandran, M. (2009) In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. Altern Lab Anim 37, 89-141.
3. Roggen, E. L. (2011) In vitro toxicity testing in the twenty-first century. Front Pharmacol 2, 3.
4. International Commission on Radiological Protection (1994) Human respiratory tract model for radiological protection. CRP Publication 66. A report of a task group of the ICRP. Ann ICRP 24, 1-482.
5. Geiser, M., Kreyling, W. G. (2010) Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol 7, 2.
6. Ochs, M., Webel, E. R. (2008) Functional design of the human lung for gas exchange. In Fishman, A. P. (ed.), Fishman's Pulmonary Diseases and Disorders, McGray-Hill Medical.
7. Epstein, M. M. (2004) Do mouse models of allergic asthma mimic clinical disease? Int Arch Allergy Immunol 133, 84-100.
8. Verstraelen, S., Bloemen, K., Nelissen, I., Witters, H., Schoeters, G., Van Den Heuvel, R. (2008) Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization. Toxicol in Vitro 22, 1419-1431.
9. Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., Parks, W. P. (1973) In vitro cultivation of human tumors:establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 51, 1417-1423.
10. Haws, C., Finkbeiner, W. E., Widdicombe, J. H., Wine, J. J. (1994) Calu-3: a human airway epithelial cell line that shows cAMP-dependent Clsecretion. Am J Physiol 266, 493-501.
11. Bur, M., Huwer, H., Muys, L., Lehr, C. M. (2010) Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique. J Aerosol Med Pulm Drug Deliv 23, 119-127.
12. Bissell, M. J., LaBarge, M. A. (2005) Context, tissue plasticity, and cancer:are tumor stem cells also regulated by the microenvironment? Cancer Cell 7, 17-23.
13. Griffith, L. G., Swartz, M. A. (2006) Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7, 211-224.
14. Casati, S., Aeby, P., Basketter, D. A., Cavani, A., Gennari, A., Gerberick, G. F., Griem, P., Hartung, T., Kimber, I., Lepoittevin, J. P., Meade, B. J., Pallardy, M., Rougier, N., Rousset, F., Rubinstenn, G., Sallusto, F., Verheyen, G. R., Zuang, V. (2005) Dendritic cells as a tool for the predictive identification of skin sensitisation hazard Report and recommendations of ECVAM Workshop 51. Altern Lab Anim 33, 47-62.
15. Santegoets, S. J., van den Eertwegh, A. J., van de Loosdrecht, A. A., Scheper, R. J., de Gruijl, T. D. (2008) Human dendritic cell line models for DC differentiation and clinical DC vaccination studies. J Leukoc Biol 84, 1364-1373.
16. Casale, T. B., Stokes, J. R. (2008) Immunomodulators for allergic respiratory disorders. J Allergy Clin Immunol 121, 288-296.
17. Nilsson, C., Larsson, A. K., Höglind, A., Gabrielsson, S., Troye Blomberg, M., Lilja, G. (2004) Low numbers of interleukin-12-producing cord blood mononuclear cells and immunoglobulin E sensitization in early childhood. Clin Exp Allergy 34, 373-380.
18. Wottrich, R., Diabaté, S., Krug, H. F. (2004) Biological effects of ultrafine model particles in human macrophages and epithelial cells in monoand co-culture. Int J Hyg Environ Health 207, 353-361.
19. Crabbé, A., Sarker, S. F., Van Houdt, R., Ott, C. M., Leys, N., Cornelis, P., Nickerson, C. A. (2011) Alveolar epithelium protectsmacrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model. Cell Microbiol 13, 469-481.
20. Lang, D. S., Jörres, R. A., Mücke, M., Siegfried, W., Magnussen, H. (1998) Interactions between human bronchoepithelial cells and lung fibroblasts after ozone exposure in vitro. Toxicol Lett 96-97, 13-24.
21. Mögel, M., Krüger, E., Krug, H. F., Seidel, A. (1998) A new coculturesystem of bronchial epithelial and endothelial cells as a model for studying ozone effects on airway tissue. Toxicol Lett 96-97, 25-32.
22. Wong, C. K., Wang, C. B., Ip, W. K., Tian, Y. P., Lam, C. W. (2005) Role of p38 MAPK and NF-kB for chemokine release in coculture of human eosinophils and bronchial epithelial cells. Clin Exp Immunol 139, 90-100.
23. Ishii, H., Hayashi, S., Hogg, J. C., Fujii, T., Goto, Y., Sakamoto, N., Mukae, H., Vincent, R., van Eeden, S. F. (2005) Alveolar macrophageepithelial cell interaction following exposure to atmospheric particles induces the release ofmediators involved in monocyte mobilization and recruitment. Respir Res 6, 87.
24. Rothen-Rutishauser, B. M., Kiama, S. G., Gehr, P. (2005) A threedimensional cellular model of the human respiratory tract to study the interaction with particles. Am J Respir Cell Mol Biol 32, 281-289.
25. Klein, S. G., Hennen, J., Serchi, T., Blömeke, B., Gutleb, A. C. (2011) Potential of coculture in vitro models to study inflammatory and sensitizing effects of particles on the lung. J Immunol 186, 2238-2244.
26. Fisher, R. L., Smith, M. S., Hasal, S. J., Hasal, K. S., Gandolfi, A. J., Brendel, K. (1994) The use of human lung slices in toxicology. Hum Exp Toxicol 13, 466-471.
27. Martin, C., Uhlig, S., Ullrich, V. (1996) Videomicroscopy of methacholineinduced contraction of individual airways in precision-cut lung slices. Eur Respir J 9, 2479-2487.
28. Switalla, S., Lauenstein, L., Prenzler, F., Knothe, S., Förster, C., Fieguth, H. G., Pfennig, O., Schaumann, F., Martin, C., Guzman, C. A., Ebensen, T., Müller, M., Hohlfeld, J. M., Krug, N., Braun, A., Sewald, K., (2010) Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices. Toxicol Appl Pharmacol 246(3), 107-115.
29. De Kanter, R., Olinga, P., De Jager, M. H., Merema, M. T., Meijer, D. K., Groothius, G. M. (1999) Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney. Toxicol in Vitro 13, 737-744.
30. Wohlsen, A., Martin, C., Vollmer, E., Branscheid, D., Magnussen, H., Becker, W. M., Lepp, U., Uhlig, S. (2003) The early allergic response in small airways of human precision-cut lung slices. Eur Respir J 21, 1024-1032.
31. Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Yuan Hsin, H., Ingber, D. E. (2010) Reconstituting organ-level lung functions on a chip. Science 328, 1662-1668.
32. Vozzi, F., Heinrich, J. M., Bader, A., Ahluwalia, A. D. (2009) Connected culture of murine hepatocytes and HUVEC in a multi-compartmental bioreactor. Tissue Eng Part A 15, 1291-1299.
33. Bérubé, K., Prytherch, Z., Job, C., Hughes, T. (2010) Human primary bronchial lung cell constructs: the new respiratory models. Toxicology 278, 311-318.
34. Crespin, S., Bacchetta,M., Huang, S., Dudez, T.,Wiszniewski, L., Chanson, M. (2011) Approaches to study differentiation and repair of human airway epithelial cells. Methods Mol Biol 742, 173-185.
35. Hofmann, W., Asgharian, B., Winkler-Heil, R. (2002). Inter-subject variability in particle deposition in human lungs. J Aerosol Sci 33, 219-235.
36. Foster, W. M., Langenback, E. G., Bergofsky, E. H. (1982) Lung mucociliary function in man: interdependence of bronchial and tracheal mucus transport velocitieswith lung clearance in bronchial asthma and healthy subjects. Ann Occup Hyg 26, 227-244.
37. Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T. (1998) Evidence for periciliary liquid layer depletion, no abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95, 1005-1015.
38. Dimova, S., Maes, F., Brewster, M. E., Jorissen, M., Noppe, M., Augustijns, P. (2005) High-speed digital imaging method for ciliary beat frequency measurement. J Pharm Pharmacol 57(4), 521-526.
39. Adler S. et al. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol 85, 367-485.
40. Hubatsch, I., Ragnarsson, E. G. E., Artursson, P. (2007) Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers. Nature Prot 2, 2111-2119.
41. Huang, S., Wiszniewski, L., Derouette, J. P., Constant, S. (2009) In vitro organ culture models of asthma. Drug Disc Today: Dis Models 6, 137-144.
42. Huang, S., CaulFuty, M. (2009) A novel in vitro cell model of the human airway epithelium. 3R-Info-Bulletin 41(October 2009).
43. Constant, S., Huang, S., Derouette, J. P.,Wiszniewski, L. (2008) MucilAir:a novel in vitro human 3D airway epithelium model for assessing the potential hazard of nanoparticles and chemical compounds. Toxicol Lett 180, S233.
44. Maier, M. S. V. (2011) Setting occupational exposure limits for unstudied pharmaceutical intermediates using an in vitro parallelogram approach. Toxicol Mech Methods 21, 76-85.