The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis

American Journal of Rhinology

Volumn 21, Issue 3, 2007, Pages 359-366

  Guo, Qiang Ding ^a   Chun, Quan Zheng ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Chronic sinusitis; MUC5AC; MUC5B; Mucin; Nasal mucosa; Nasal polyp

Indexed keywords

EOSIN; HEMATOXYLIN; MUCIN 5AC; MUCIN 5B;

ARTICLE; CONTROLLED STUDY; EOSINOPHIL; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; MAXILLARY SINUS; NOSE MUCOSA; NOSE POLYP; PATHOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOSINUSITIS;

ENDOSCOPY; EOSINOPHILS; HUMANS; MUCINS; NASAL MUCOSA; NASAL POLYPS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINITIS; RNA, MESSENGER; SINUSITIS;

EID: 34347216756     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2007.21.3037     Document Type: Article

References (31)

1. Ordonez CL, Khashayar R, Wong HH, et al. Mild and moderate asthma is associated with airway goblet cell metaplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 163:517-523, 2001.
2. Takeyama K, Fahy JV, and Nadel JA. Relationship of epidermal growth factor receptors to airway goblet cell production in human bronchi. Am J Respir Crit Care Med 163:511-516, 2001.
3. Sharma P, Dudus L, Nielsen PA, et al. MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol 19:30-37, 1998.
4. Lamblin G, Degroote S, Perini JM, et al. Human airway mucin glycosylation: A combinatory of carbohydrate determinants which vary in cystic fibrosis. Glycoconj J 18:661-684, 2001.
5. Li JD, Dohrman AF, Gallup M, et al. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci USA 94:967-972, 1997.
6. Li JD, Feng W, Gallup M, et al. Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sci USA 95:5718-5723, 1998.
7. Majima Y, Sakakura Y, Matsubara T, et al. Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis. Clin Otolaryngol Allied Sci 11:55-60, 1986.
8. Groneberg DA, Eynott PR, Lim S, et al. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 40:367-373, 2002.
9. Voynow JA, Selby DM, and Rose MC. Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals. Lung 176:345-354, 1998.
10. Kim DH, Chu HS, Lee JY, et al. Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 130:747-752, 2004.
11. Mahfouz ME, Elsheikh MN, and Ghoname NF. Molecular profile of the antrochoanal polyp: Up-regulation of basic fibroblast growth factor and transforming growth factor beta in maxillary sinus mucosa. Am J Rhinol 20:466-470, 2006.
12. Pena MT, Aujla PK, Patel KM, et al. Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls. Ann Otol Rhinol Laryngol 114:958-965, 2005.
13. Ali MS, Hutton DA, Wilson JA, et al. Major secretory mucin expression in chronic sinusitis. Otolaryngol Head Neck Surg 133:423-428, 2005.
14. Viswanathan H, Brownlee IA, Pearson JP, et al. MUC5B secretion is up-regulated in sinusitis compared with controls. Am J Rhinol 20:554-557, 2006.
15. Temann UA, Prasad B, Gallup MW, et al. A novel role for murine IL-4 in vivo: Induction of MUC5AC gene expression and mucin hypersecretion. Am J Respir Cell Mol Biol 471-478, 1997.
16. Longphre M, Li D, Gallup M, et al. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J Clin Invest 104:1375-1382, 1999.
17. Borchers MT, Carty MP, and Leikauf GD. Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol 276:L549-L555, 1999.
18. Borchers MT, Wert SE, and Leikauf GD. Acrolein-induced MUC5ac expression in rat airways. Am J Physiol 274:L573-L581, 1998.
19. Voynow JA, Young LR, Wang Y, et al. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 276:L835-L843, 1999.
20. Takeyama K, Dabbagh K, Jeong Shim J, et al. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: Role of neutrophils. J Immunol 164:1546-1552, 2000.
21. Kohri K, Ueki IF, Shim JJ, et al. Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor. Eur Respir J 20:1263-1270, 2002.
22. Hovenberg HW, Davies JR, and Carlstedt I. Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from the goblet cells. Biochem J 318:319-324, 1996.
23. Burgel PR, Escudier E, Coste A, et al. Relation of epidermal growth factor receptor expression to goblet cells hyperplasia in nasal polyps. J Allergy Clin Immunol 106: 705-712, 2000.
24. Kim CH, Song KS, Kim SS, et al. Expression of MUC5AC mRNA in the goblet cells of human nasal mucosa. Laryngoscope 110:2110-2113, 2000.
25. Groneberg DA, Peiser C, Dinh QT, et al. Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope 113:520-524, 2003.
26. Audie JP, Janin A, Porchet N, et al. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 41:1479-1485, 1993.
27. Aust MR, Madsen CS, Jennings A, et al. Mucin mRNA expression in normal and vasomotor inferior turbinates. Am J Rhinol 11:293-302, 1997.
28. Kawano H, Paparella MM, Ho SB, et al. Identification of MUC5B mucin gene in human middle ear with chronic otitis media. Laryngoscope 110:668-673, 2000.
29. Sasaki M, Yamato T, Nakanuma Y, et al. Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder. Pathol Int 49:38-44, 1999.
30. Afdhal NH, Offner GD, Murray FE, et al. Isolation and characterization of peptides from the protein core of bovine gallbladder mucin. Gastroenterology 98:1633-1641, 1990.
31. Audie JP, Tetaert D, Pigny P, et al. Mucin gene expression in the human endocervix. Hum Reprod 10:98-102, 1995.