Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity

Oncotarget

Volumn 8, Issue 3, 2017, Pages 4837-4848

  Cao, Yuan ^a   Shen, Tao ^a   Huang, Xiuqing ^a   Lin, Yajun ^a   Chen, Beidong ^a   Pang, Jing ^a   Li, Guoping ^a   Wang, Que ^a   Zohrabian, Sylvia ^b   Duan, Chao ^c   Ruan, Yang ^d   Man, Yong ^a   Wang, Shu ^a   Li, Jian ^a  

^a Chinese Academy of Medical Sciences   (China)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

^d BEIJING INSTITUTE OF HEART   (China)

Author keywords

AMPK mTOR; Astragalus polysaccharide; Autophagy; Cardiomyocyte; Doxorubicin

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; ASTRAGALUS POLYSACCHARIDE; CASPASE 3; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; SEQUESTOSOME 1; UNCLASSIFIED DRUG; DOXORUBICIN; PLANT EXTRACT; POLYSACCHARIDE; PROTEIN KINASE B; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; C57BL 6 MOUSE; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPERIMENTAL HEART FAILURE; HEART EJECTION FRACTION; HEART FUNCTION; HEART PROTECTION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; HEART FAILURE; HEART FUNCTION TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTRAGALUS PROPINQUUS; AUTOPHAGY; CARDIOTOXICITY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOXORUBICIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HEART FAILURE; HEART FUNCTION TESTS; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; PLANT EXTRACTS; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 85011961628     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13596     Document Type: Article

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