Protective effect of Astragalus polysaccharides on liver injury induced by several different chemotherapeutics in mice

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 23, 2014, Pages 10413-10420

  Liu, Wen ^a   Gao, Fang Fang ^a   Li, Qun ^c   Lv, Jia Wei ^b   Wang, Ying ^a   Hu, Peng Chao ^a   Xiang, Qing Ming ^b   Wei, Lei ^a  

^a WUHAN UNIVERSITY   (China)

^b ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

ALT; AST; Astragalus polysaccharides; Cyclophosphamide; Docetaxel; Epirubicin; Hepatotoxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CYCLOPHOSPHAMIDE; DOCETAXEL; EPIRUBICIN; POLYSACCHARIDE; TAXOID;

ANIMAL; ASTRAGALUS (PLANT); DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; LIVER CELL; METABOLISM; MOUSE; PATHOLOGY; PHYTOTHERAPY;

ALANINE TRANSAMINASE; ANIMALS; ANTINEOPLASTIC AGENTS; ASPARTATE AMINOTRANSFERASES; ASTRAGALUS PLANT; CASPASE 3; CYCLOPHOSPHAMIDE; DRUG-INDUCED LIVER INJURY; EPIRUBICIN; HEPATOCYTES; LIVER; MICE; PHYTOTHERAPY; POLYSACCHARIDES; TAXOIDS;

EID: 84921720245     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.23.10413     Document Type: Article

References (40)

1. Anonymous (2003). Astragalus membranaceus. Monograph. Altern Med Rev, 8, 72-7.
2. Al-Sayed E, Martiskainen O, Seif el-Din SH, et al (2014). Hepatoprotective and antioxidant effect of Bauhinia hookeri extract against carbon tetrachloride-induced hepatotoxicity in mice and characterization of its bioactive compounds by HPLC-PDA-ESI-MS/MS. Biomed Res Int, 2014, 245171.
3. Alexandre J, Bleuzen P, Bonneterre J, et al (2000). Factors predicting for efficacy and safety of docetaxel in a compassionate-use cohort of 825 heavily pretreated advanced breast cancer patients. J Clin Oncol, 18, 562-73.
4. Basu A, Bhattacharjee A, Roy SS, et al (2014). Vanadium as a chemoprotectant: effect of vanadium (III)-L-cysteine complex against cyclophosphamide-induced hepatotoxicity and genotoxicity in Swiss albino mice. J Biol Inorg Chem, 19, 981-96.
5. Bissery MC, Nohynek G, Sanderink GJ, et al (1995). Docetaxel (Taxotere): a review of preclinical and clinical experience. Part I: Preclinical experience. Anticancer Drugs, 6, 63-8.
6. Chen X, Ye G, Zhang C, et al (2013). Superior outcome after neoadjuvant chemotherapy with docetaxel, anthracycline, and cyclophosphamide versus docetaxel plus cyclophosphamide: results from the NATT trial in triple negative or HER2 positive breast cancer. Breast Cancer Res Treat, 142, 549-58.
7. de Jonge ME, Huitema AD, Beijnen JH, et al (2006). High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy. Br J Cancer, 94, 1226-30.
8. Ding Y, Zhao L, Mei H, et al (2008). Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. Eur J Pharmacol, 590, 377-86.
9. Dobbs NA, Twelves CJ, Gregory W, et al (2003). Epirubicin in patients with liver dysfunction: development and evaluation of a novel dose modification scheme. Eur J Cancer, 39, 580-6.
10. Fan L, Strasser-Weippl K, Li JJ, et al (2014). Breast cancer in China. Lancet Oncol, 15, e279-89.
11. Fang Y, Wang L, Xia GH, et al (2014). Clinical investigation of efficacy of albumin bound paclitaxel plus platinum compounds as first-line chemotherapy for stage III/IV squamous non-small cell lung cancer. Asian Pac J Cancer Prev, 15, 7453-7.
12. Field KM, Dow C, Michael M (2008). Part I: Liver function in oncology: biochemistry and beyond. Lancet Oncol, 9, 1092-101.
13. Fisher B, Brown AM, Dimitrov NV, et al (1990). Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15. J Clin Oncol, 8, 1483-96.
14. Horton AA, Fairhurst S (1987). Lipid peroxidation and mechanisms of toxicity. Crit Rev Toxicol, 18, 27-79.
15. Jia R, Cao L, Xu P, et al (2012). In vitro and in vivo hepatoprotective and antioxidant effects of Astragalus polysaccharides against carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem, 38, 871-81.
16. Joerger M (2014). Metabolism of the taxanes including nab-paclitaxel. Expert Opin Drug Metab Toxicol, 1-12 [Epub ahead of print].
17. Kebieche M, Lakroun Z, Lahouel M, et al (2009). Evaluation of epirubicin-induced acute oxidative stress toxicity in rat liver cells and mitochondria, and the prevention of toxicity through quercetin administration. Exp Toxicol Pathol, 61, 161-7.
18. King PD, Perry MC (2001). Hepatotoxicity of chemotherapy. Oncologist, 6, 162-76.
19. Liu X, Yang Y, Zhang X, et al (2010). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2 cell. J Gastroenterol Hepatol, 25, 420-6.
20. Lu AF, Qi MJ, Li ZL, et al (2010). Callus cultivation and determination of flavonoids from Tetrastigma hemsleyanum. Zhong Yao Cai, 33, 1042-5.
21. Lubgan D, Marczak A, Walczak M, et al (2006). Pharmacological mechanisms of Doxorubicin activity (DOX)-current state of knowledge. Przegl Lek, 63, 782-8.
22. Ma B, Yeo W, Hui P, et al (2002a). Acute toxicity of adjuvant doxorubicin and cyclophosphamide for early breast cancer-a retrospective review of Chinese patients and comparison with an historic Western series. Radiother Oncol, 62, 185-9.
23. Ma XQ, Shi Q, Duan JA, et al (2002b). Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem, 50, 4861-6.
24. Matovina-Brko G, Ruzic M, Fabri M, et al (2014). Treatment of acute hepatitis C in breast cancer patient: a case report. J Chemother, 26, 180-3.
25. McDonald GB, Slattery JT, Bouvier ME, et al (2003). Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation. Blood, 101, 2043-8.
26. McQuade JL, Meng Z, Chen Z, et al (2012). Utilization of and Attitudes towards Traditional Chinese Medicine Therapies in a Chinese Cancer Hospital: A Survey of Patients and Physicians. Evid Based Complement Alternat Med, 2012, 504507.
27. Murialdo R, Gallo M, Boy D, et al (2014). Sequential dose-dense 5-fluorouracil, epirubicin and cyclophosphamide followed by docetaxel in patients with early breast cancer with four or more positive lymph nodes. Tumori, 100, 128-35.
28. Na D, Liu FN, Miao ZF, et al (2009). Astragalus extract inhibits destruction of gastric cancer cells to mesothelial cells by anti-apoptosis. World J Gastroenterol, 15, 570-7.
29. Naume B, Synnestvedt M, Falk RS, et al (2014). Clinical outcome with correlation to disseminated tumor cell (DTC) status after DTC-guided secondary adjuvant treatment with docetaxel in early breast cancer. J Clin Oncol, 32, 3848-57.
30. Ozben T (2007). Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci, 96, 2181-96.
31. Peng X, Chen B, Lim CC, et al (2005). The cardiotoxicology of anthracycline chemotherapeutics: translating molecular mechanism into preventative medicine. Mol Interv, 5, 163-71.
32. Shin HJ, Lee HS, Kim YI, et al (2014). Hepatotoxicity of anti-tuberculosis chemotherapy in patients with liver cirrhosis. Int J Tuberc Lung Dis, 18, 347-51.
33. Shokrzadeh M, Naghshvar F, Ahmadi A, et al (2014). The potential ameliorative effects of melatonin against cyclophosphamide-induced DNA damage in murine bone marrow cells. Eur Rev Med Pharmacol Sci, 18, 605-11.
34. Thatishetty AV, Agresti N, O'Brien CB (2013). Chemotherapy-induced hepatotoxicity. Clin Liver Dis, 17, 671-86.
35. Tian QE, Li HD, Yan M, et al (2012). Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice. World J Gastroenterol, 18, 7079-86.
36. Varbiro G, Veres B, Gallyas F, et al (2001). Direct effect of Taxol on free radical formation and mitochondrial permeability transition. Free Radic Biol Med, 31, 548-58.
37. Wang XH, Jia HL, Deng L, et al (2014). Astragalus polysaccharides mediated preventive effects on bronchopulmonary dysplasia in rats. Pediatr Res, 76, 347-54.
38. Yang B, Xiao B, Sun T (2013). Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice. Int J Biol Macromol, 62, 287-90.
39. Yeo W, Mok TS, Tse KK, et al (2002). Phase II study of docetaxel and epirubicin in Chinese patients with metastatic breast cancer. Anticancer Drugs, 13, 655-62.
40. Zhao LH, Ma ZX, Zhu J, et al (2011). Characterization of polysaccharide from Astragalus radix as the macrophage stimulator. Cell Immunol, 271, 329-34.