Astragalus polysaccharides repress myocardial lipotoxicity in a PPARalpha-dependent manner in vitro and in vivo in mice

Journal of Diabetes and its Complications

Volumn 29, Issue 2, 2015, Pages 164-175

  Chen, Wei ^a   Lai, Yanni ^a   Wang, Liying ^a   Xia, Yanping ^a   Chen, Wenjie ^a   Zhao, Xuelan ^a   Yu, Maohua ^a   Li, Yiming ^a   Zhang, Yu ^a   Ye, Hongying ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cardiomyocytes; Cardiomyopathy; H9c2; Lipid metabolism; Lipotoxity; PPAR

Indexed keywords

ASTRAGALUS POLYSACCHARIDE; FATTY ACID; GLUCOSE; HERBACEOUS AGENT; MYOSIN HEAVY CHAIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CARDIOTONIC AGENT; FENOFIBRATE; HYBRID PROTEIN; POLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DRUG INHIBITION; ECHOCARDIOGRAPHY; EMBRYO; GENE ACTIVATION; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIPOTOXICITY; MALE; MOUSE; MYOCARDIAL LIPOTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; TRANSGENIC MOUSE; AGONISTS; ANIMAL; ASTRAGALUS MEMBRANACEUS; C57BL MOUSE; CARDIAC MUSCLE; CELL LINE; CHEMISTRY; DIABETIC CARDIOMYOPATHIES; DIETARY SUPPLEMENT; DRUG EFFECTS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; HEART; LIPID METABOLISM; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PLANT ROOT;

ANIMALS; ASTRAGALUS MEMBRANACEUS; CARDIOTONIC AGENTS; CELL LINE; DIABETIC CARDIOMYOPATHIES; DIETARY SUPPLEMENTS; ENERGY METABOLISM; FENOFIBRATE; GENE EXPRESSION REGULATION; HEART; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; MYOSIN HEAVY CHAINS; PLANT ROOTS; POLYSACCHARIDES; PPAR ALPHA; RECOMBINANT FUSION PROTEINS;

EID: 84923036782     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2014.11.007     Document Type: Article

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