Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

Nature Communications

Volumn 8, Issue , 2017, Pages

  Ozaki, Taro ^a,e   Yamashita, Kona ^a   Goto, Yuki ^b   Shimomura, Morito ^a   Hayashi, Shohei ^a,f   Asamizu, Shumpei ^a   Sugai, Yoshinori ^a   Ikeda, Haruo ^c   Suga, Hiroaki ^b   Onaka, Hiroyasu ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KITASATO UNIVERSITY   (Japan)

^d TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

^f SHIMANE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GOADSPORIN; GODD PEPTIDE; GODE PEPTIDE; GODF PEPTIDE; GODH PEPTIDE; NATURAL PRODUCT; PEPTIDE; PYRROLE DERIVATIVE; RECOMBINANT PROTEIN; SYNTHETIC DNA; TRANSFER RNA; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN;

DNA; ENZYME ACTIVITY; GENE EXPRESSION; MUTATION; PEPTIDE; PROTEIN; SECONDARY METABOLITE;

ARTICLE; BIOSYNTHESIS; DNA SEQUENCE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME RECONSTITUTION; ESCHERICHIA COLI; IN VITRO STUDY; IN VIVO STUDY; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ONE POT SYNTHESIS; PROTEIN PROCESSING; STREPTOMYCES; TANDEM MASS SPECTROMETRY; CHEMISTRY; ENZYMOLOGY; GENETICS; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RIBOSOME; SITE DIRECTED MUTAGENESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBOSOMES; STREPTOMYCES;

EID: 85011857408     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14207     Document Type: Article

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