Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles

Chemistry and Biology

Volumn 21, Issue 5, 2014, Pages 679-688

  Hayashi, Shohei ^a   Ozaki, Taro ^a   Asamizu, Shumpei ^a   Ikeda, Haruo ^b   Omura, Satoshi ^b   Oku, Naoya ^c   Igarashi, Yasuhiro ^c   Tomoda, Hiroshi ^b   Onaka, Hiroyasu ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c TOYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; LACTAZOLE A; LACTAZOLE B; LACTAZOLE C; LACTAZOLE DERIVATIVE; MACROCYCLIC COMPOUND; PEPTIDE DERIVATIVE; PYRIDINE; PYRROLE; UNCLASSIFIED DRUG; CYCLOPEPTIDE; PEPTIDE; THIAZOLE DERIVATIVE; THIOL DERIVATIVE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BIOSYNTHESIS; CANDIDA ALBICANS; CYCLIZATION; ESCHERICHIA COLI; GENE; GENE CLUSTER; GENE INACTIVATION; GENETIC ENGINEERING; HETEROLOGOUS EXPRESSION; LAZA GENE; LAZB GENE; LAZC GENE; LAZD GENE; LAZE GENE; LAZF GENE; MICROCOCCUS LUTEUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PENICILLIUM CHRYSOGENUM; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STREPTOMYCES LACTACYSTINAEUS; STREPTOMYCES LIVIDANS; BACTERIAL GENE; BACTERIAL GENOME; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MULTIGENE FAMILY;

BIOSYNTHETIC PATHWAYS; GENES, BACTERIAL; GENETIC ENGINEERING; GENOME, BACTERIAL; MACROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; MULTIGENE FAMILY; PEPTIDES; PEPTIDES, CYCLIC; STREPTOMYCES; SULFHYDRYL COMPOUNDS; THIAZOLES;

EID: 84901428333     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.03.008     Document Type: Article

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