AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

Science Signaling

Volumn 10, Issue 464, 2017, Pages

  Marin, Traci L ^a,b   Gongol, Brendan ^a,b   Zhang, Fan ^c   Martin, Marcy ^a,d   Johnson, David A ^a   Xiao, Han ^a   Wang, Yinsheng ^c   Subramaniam, Shankar ^e   Chien, Shu ^d,e   Shyy, John Y J ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CYTOSINE; DNA; DNA METHYLTRANSFERASE 1; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RETINOBLASTOMA BINDING PROTEIN 7; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; DNA (CYTOSINE 5) METHYLTRANSFERASE 1; DNA BINDING PROTEIN; DNMT1 PROTEIN, HUMAN; HISTONE ACETYLTRANSFERASE TYPE B COMPLEX; MITOCHONDRIAL PROTEIN; PPARGC1A PROTEIN, HUMAN; PROTEIN BINDING; RBBP7 PROTEIN, HUMAN; TFAM PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UCP2 PROTEIN, HUMAN; UCP3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CELL FUNCTION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPIGENETICS; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL BIOGENESIS; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SHEAR STRESS; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; CELL CULTURE; DNA METHYLATION; GENETICS; IMMUNOBLOTTING; METABOLISM; ORGANELLE BIOGENESIS; PHOSPHORYLATION; TANDEM MASS SPECTROMETRY;

AMP-ACTIVATED PROTEIN KINASES; CELLS, CULTURED; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA METHYLATION; DNA-BINDING PROTEINS; HISTONE ACETYLTRANSFERASES; HUMANS; IMMUNOBLOTTING; MITOCHONDRIAL PROTEINS; NUCLEOSOMES; ORGANELLE BIOGENESIS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RETINOBLASTOMA-BINDING PROTEIN 7; TANDEM MASS SPECTROMETRY; TRANSCRIPTION FACTORS; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

EID: 85011579299     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaf7478     Document Type: Article

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