Tetramethylpyrazine ameliorated disuse-induced gastrocnemius muscle atrophy in hindlimb unloading rats through suppression of Ca2+/ROS-mediated apoptosis

Applied Physiology, Nutrition and Metabolism

Volumn 42, Issue 2, 2017, Pages 117-127

  Hu, Nai Fei ^a   Chang, Hui ^a   Du, Bei ^b   Zhang, Quan Wang ^a   Arfat, Yasir ^a   Dang, Kai ^a   Gao, Yun Fang ^a  

^a NORTHWEST UNIVERSITY   (China)

^b Shaanxi Institute of International Trade Commerce   (China)

Author keywords

Apoptosis; Cytosolic calcium overload; Disuse atrophy; Oxidative stress; Tetramethylpyrazine

Indexed keywords

ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; BMI1 PROTEIN; PYRAZINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RING1 PROTEIN, RAT; TETRAMETHYLPYRAZINE; UBIQUITIN PROTEIN LIGASE; VASODILATOR AGENT;

ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CALCIUM SIGNALING; DRUG EFFECTS; ENZYME REPRESSION; FAST MUSCLE FIBER; FEMALE; IMMOBILIZATION; METABOLISM; MUSCULAR DISORDERS, ATROPHIC; OXIDATIVE STRESS; PATHOLOGY; PROTEIN DEGRADATION; RANDOMIZATION; SKELETAL MUSCLE; SLOW MUSCLE FIBER; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BIOMARKERS; CALCIUM SIGNALING; ENZYME REPRESSION; FEMALE; HINDLIMB SUSPENSION; MUSCLE FIBERS, FAST-TWITCH; MUSCLE FIBERS, SLOW-TWITCH; MUSCLE, SKELETAL; MUSCULAR DISORDERS, ATROPHIC; OXIDATIVE STRESS; PLATELET AGGREGATION INHIBITORS; POLYCOMB REPRESSIVE COMPLEX 1; PROTEOLYSIS; PYRAZINES; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; UBIQUITIN-PROTEIN LIGASES; VASODILATOR AGENTS;

EID: 85011349860     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2016-0363     Document Type: Article

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