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3
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Mechanistic links between oxidative stress and disuse muscle atrophy
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This ia a review that summarizes the biological signaling connections between ROS and disuse muscle atrophy
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Powers SK, Smuder AJ, Criswell DS. Mechanistic links between oxidative stress and disuse muscle atrophy. Antioxid Redox Signal 2011;15:2519-2528. This ia a review that summarizes the biological signaling connections between ROS and disuse muscle atrophy.
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Powers, S.K.1
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Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness
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Powers SK, Hudson MB, Nelson WB, et al. Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness. Crit Care Med 2011;39:1749-1759. This is the first study to demonstrate that mitochondria are an important source of ROS in diaphragm muscle during disuse and that mitochondrial-targeted antioxidants can protect diaphragm muscle from atrophy during prolonged mechanical ventilation.
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Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy
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This study concludes that mitochondria are an important source of ROS in inactive locomotor skeletal muscle and that mitochondrial-targeted antioxidants can protect inactive fibers from atrophy
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Min K, Smuder AJ, Kwon OS, et al. Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy. J Appl Physiol 2011;111:1459-1466. This study concludes that mitochondria are an important source of ROS in inactive locomotor skeletal muscle and that mitochondrial-targeted antioxidants can protect inactive fibers from atrophy.
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Mechanical ventilation promotes redox status alterations in the diaphragm
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Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production
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Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
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Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction
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Whidden MA, McClung JM, Falk DJ, et al. Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction. J Appl Physiol 2009;106:385-394.
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Ros-mediated activation of NF-kappaB and Foxo during muscle disuse
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Dodd SL, Gagnon BJ, Senf SM, et al. Ros-mediated activation of NF-kappaB and Foxo during muscle disuse. Muscle Nerve 2010;41:110-113. This study is demonstrating that ROS can activate both NF-kB and FoxO signaling in inactive skeletal muscles.
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Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm
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Whidden MA, Smuder AJ, Wu M, et al. Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm. J Appl Physiol 2010;108:1376-1382.
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P38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting
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McClung JM, Judge AR, Powers SK, Yan Z. p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell Physiol 2010;298:C542-C549.
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Oxidation enhances myofibrillar protein degradation via calpain and caspase-3
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Redox homeostasis, oxidative stress and disuse muscle atrophy
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This is a review article that discusses the role that redox homeostasis and oxidants play in disuse muscle atrophy
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Pellegrino MA, Desaphy JF, Brocca L, et al. Redox homeostasis, oxidative stress and disuse muscle atrophy. J Physiol 2011;589(Pt 9):2147-2160. This is a review article that discusses the role that redox homeostasis and oxidants play in disuse muscle atrophy.
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Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1
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