Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats

Journal of the Neurological Sciences

Volumn 361, Issue , 2016, Pages 101-111

  Ding, Yan ^a   Hou, Xuefei ^a   Chen, Li ^a   Zhou, Hua ^a   Gong, Yanju ^a   Dai, Liqun ^a   Zheng, Yu ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Chronic hypoxia; Heme oxygenase 1; Medulla oblongata; Neuroprotection; Tetramethylpyrazine; The rat

Indexed keywords

CASPASE 3; HEME OXYGENASE 1; MALONALDEHYDE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTOPORPHYRIN TIN; SUPEROXIDE DISMUTASE; TETRAMETHYLPYRAZINE; NEUROPROTECTIVE AGENT; PYRAZINE DERIVATIVE;

ADULT; AMBIGUUS NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD GAS ANALYSIS; BRAIN HYPOXIA; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; HYPOGLOSSAL NUCLEUS; IMMUNOCHEMISTRY; LIPID PEROXIDATION; MALE; MEDULLA OBLONGATA; NERVE CELL NECROSIS; NEUROPROTECTION; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SOLITARY TRACT NUCLEUS; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; HYPOXIA, BRAIN; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; HEME OXYGENASE-1; HYPOXIA, BRAIN; MALE; MALONDIALDEHYDE; MEDULLA OBLONGATA; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 84958967072     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2015.12.026     Document Type: Article

References (43)

1. W. Xu, L. Chi, B.W. Row, R. Xu, Y. Ke, B. Xu, and et al. Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea Neuroscience 126 2 2004 313 323
2. X. Shan, L. Chi, Y. Ke, C. Luo, S. Qian, D. Gozal, and et al. Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage Neurobiol. Dis. 28 2 2007 206 215
3. B.W. Row, R. Liu, W. Xu, L. Kheirandish, and D. Gozal Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat Am. J. Respir. Crit. Care Med. 167 11 2003 1548 1553
4. J.C. Smith, H.H. Ellenberger, K. Ballanyi, D.W. Richter, and J.L. Feldman Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals Science 254 5032 1991 726 729
5. J.M. Ramirez, S.W. Schwarzacher, O. Pierrefiche, B.M. Olivera, and D.W. Richter Selective lesioning of the cat pre-Botzinger complex in vivo eliminates breathing but not gasping J. Physiol. 507 Pt 3 1998 895 907
6. E. Colombari, M.A. Sato, S.L. Cravo, C.T. Bergamaschi, R.R. Campos Jr., and O.U. Lopes Role of the medulla oblongata in hypertension Hypertension 38 3 Pt 2 2001 549 554
7. A.M. Wasserman, N. Sahibzada, Y.M. Hernandez, and R.A. Gillis Specific subnuclei of the nucleus tractus solitarius play a role in determining the duration of inspiration in the rat Brain Res. 880 1-2 2000 118 130
8. C. Kaur, S. Viswanathan, and E.A. Ling Hypoxia-induced cellular and vascular changes in the nucleus tractus solitarius and ventrolateral medulla J. Neuropathol. Exp. Neurol. 70 3 2011 201 217
9. C.E. Almado, B.H. Machado, and R.M. Leao Chronic intermittent hypoxia depresses afferent neurotransmission in NTS neurons by a reduction in the number of active synapses J. Neurosci. 32 47 2012 16736 16746
10. W.D. Knight, J.T. Little, F.R. Carreno, G.M. Toney, S.W. Mifflin, and J.T. Cunningham Chronic intermittent hypoxia increases blood pressure and expression of FosB/DeltaFosB in central autonomic regions Am. J. Physiol. Regul. Integr. Comp. Physiol. 301 1 2011 R131 R139
11. F. Liao Herbs of activating blood circulation to remove blood stasis Clin. Hemorheol. Microcirc. 23 2-4 2000 127 131
12. L. Fan, K. Wang, Z. Shi, J. Die, C. Wang, and X. Dang Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury J. Vasc. Surg. 54 1 2011 192 200
13. Z. Zhang, T. Wei, J. Hou, G. Li, S. Yu, and W. Xin Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid Eur. J. Pharmacol. 467 1-3 2003 41 47
14. Z. Yang, Q. Zhang, J. Ge, and Z. Tan Protective effects of tetramethylpyrazine on rat retinal cell cultures Neurochem. Int. 52 6 2008 1176 1187
15. Y. Ding, X. Hou, L. Chen, H. Li, Y. Tang, H. Zhou, and et al. Protective action of tetramethylpyrazine on the medulla oblongata in rats with chronic hypoxia Auton. Neurosci. 173 1-2 2013 45 52
16. Y.M. Sue, C.F. Cheng, C.C. Chang, Y. Chou, C.H. Chen, and S.H. Juan Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells Nephrol. Dial. Transplant. 24 3 2008 769 777
17. M.P. Soares, and F.H. Bach Heme oxygenase-1: from biology to therapeutic potential Trends Mol. Med. 15 2 2009 50 58
18. T.S. Lee, and L.Y. Chau Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice Nat. Med. 8 3 2002 240 246
19. I. Petrache, L.E. Otterbein, J. Alam, G.W. Wiegand, and A.M. Choi Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts Am. J. Physiol. Lung Cell. Mol. Physiol. 278 2 2000 L312 L319
20. T. Tsubokawa, K. Yagi, C. Nakanishi, M. Zuka, A. Nohara, H. Ino, and et al. Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia Am. J. Physiol. Heart Circ. Physiol. 298 5 2010 H1320 H1329
21. S.-Y. Chen, G. Hsiao, H.-R. Hwang, P.-Y. Cheng, and Y.-M. Lee Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats J. Biomed. Sci. 13 5 2006 731 740
22. Z.C. Li, L. Li, H.X. Yan, H.Y. Hu, Y.Q. Ma, W.X. Yang, and et al. Effect of tetramethylpyrazine on the responses of respiration and expression of nNOS in brainstem to hypoxia in rats Sheng Li Xue Bao 57 2 2005 147 153
23. Q.F. Xue, J.M. Xie, M.G. Shao, and C.G. Hu Pulmonary hypertesion model of rats under hypoxia in normal atmospheric pressure Zhongguo Yi Xue Ke Xue Yuan Xue Bao 10 6 1988 415
24. P.N. Gueye, S.W. Borron, P. Risede, C. Monier, F. Buneaux, M. Debray, and et al. Lack of effect of single high doses of buprenorphine on arterial blood gases in the rat Toxicol. Sci. 62 1 2001 148 154
25. G. Paxions, and C. Watson The Rat Brain in Stereotaxic Coordinates fifth ed. 2005 Academic Press San Diego
26. L.C. Junqueira, and J. Carneiro Basic Histology fourth ed. 1983 Lange Medical Publications Los Altos
27. W.P. Wang, X. Guo, M.W. Koo, B.C. Wong, S.K. Lam, Y.N. Ye, and et al. Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats Am. J. Physiol. Gastrointest. Liver Physiol. 281 2 2001 G586 G594
28. R. Eyssen-Hernandez, A. Ladoux, and C. Frelin Differential regulation of cardiac heme oxygenase-1 and vascular endothelial growth factor mRNA expressions by hemin, heavy metals, heat shock and anoxia FEBS Lett. 382 3 1996 229 233
29. S.M. Keyse, and R.M. Tyrrell Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite Proc. Natl. Acad. Sci. U. S. A. 86 1 1989 99 103
30. P.J. Lee, B.H. Jiang, B.Y. Chin, N.V. Iyer, J. Alam, G.L. Semenza, and et al. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia J. Biol. Chem. 272 9 1997 5375 5381
31. C. Mancuso Heme oxygenase and its products in the nervous system Antioxid. Redox Signal. 6 5 2004 878 887
32. S.F. Yet, R. Tian, M.D. Layne, Z.Y. Wang, K. Maemura, M. Solovyeva, and et al. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice Circ. Res. 89 2 2001 168 173
33. T. Minamino, H. Christou, C.M. Hsieh, Y. Liu, V. Dhawan, N.G. Abraham, and et al. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia Proc. Natl. Acad. Sci. U. S. A. 98 15 2001 8798 8803
34. L. Guan, T. Wen, Y. Zhang, X. Wang, and J. Zhao Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning Toxicology 262 2 2009 146 152
35. P.N. Thiessen, and D.A. Cook The properties of 3,4-methylenedioxyamphetamine (MDA). I. A review of the literature Clin. Toxicol. 6 1 1973 45 52
36. I. Fridovich Superoxide dismutases Annu. Rev. Biochem. 44 1975 147 159
37. S.J. Korsmeyer, J.R. Shutter, D.J. Veis, D.E. Merry, and Z.N. Oltvai Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death Semin. Cancer Biol. 4 6 1993 327 332
38. O. Bing, L. Grundemar, L. Ny, C. Moller, and M. Heilig Modulation of carbon monoxide production and enhanced spatial learning by tin protoporphyrin Neuroreport 6 10 1995 1369 1372
39. J.A. Mark, and M.D. Maines Tin-protoporphyrin-mediated disruption in vivo of heme oxygenase-2 protein integrity and activity in rat brain Pediatr. Res. 32 3 1992 324 329
40. Y. Uchida, T. Tamaki, M. Tanaka, T. Kaizu, S. Tsuchihashi, T. Takahashi, and et al. Induction of specific stress response increases resistance of rat liver allografts to cold ischemia and reperfusion injury Transpl. Int. 16 6 2003 396 404
41. T. Dolinay, M. Szilasi, M. Liu, and A.M. Choi Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury Am. J. Respir. Crit. Care Med. 170 6 2004 613 620
42. C. Fondevila, X.D. Shen, S. Tsuchiyashi, K. Yamashita, E. Csizmadia, C. Lassman, and et al. Biliverdin therapy protects rat livers from ischemia and reperfusion injury Hepatology 40 6 2004 1333 1341
43. P.O. Berberat, M. Katori, E. Kaczmarek, D. Anselmo, C. Lassman, B. Ke, and et al. Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury FASEB J. 17 12 2003 1724 1726