Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

Molecular Cell

Volumn 65, Issue 3, 2017, Pages 460-475.e6

  Hu, Deqing ^a,b   Gao, Xin ^b   Cao, Kaixiang ^a   Morgan, Marc A ^a   Mas, Gloria ^c,d   Smith, Edwin R ^a   Volk, Andrew G ^a   Bartom, Elizabeth T ^a   Crispino, John D ^a   Di Croce, Luciano ^c,d,e   Shilatifard, Ali ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Stowers Institute for Medical Research   (United States)

^c BARCELONA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Spain)

^d UNIVERSITAT POMPEU FABRA   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

chromatin; CXXC domain; embryonic development; gene expression regulation; histone; Histone Lysine N Methyltransferase; Kmt2b; Mll2; mouse embryonic stem cell; primordial germ cell

Indexed keywords

ALANINE; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CRISPR ASSOCIATED PROTEIN; HISTONE H3; HISTONE H3 LYSINE 4; METHIONINE; METHYLTRANSFERASE; PRDM14 PROTEIN; PROTEIN; TYROSINE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HISTONE; MIXED LINEAGE LEUKEMIA PROTEIN; MLL2 PROTEIN, HUMAN; MLL2 PROTEIN, MOUSE; TUMOR PROTEIN;

ARTICLE; CATALYSIS; CHROMATIN; CPG ISLAND; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENHANCER REGION; ENZYME ACTIVE SITE; EPIGENETICS; GENE; GENE EDITING; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; HISTONE METHYLATION; HUMAN; MLL2 GENE; PRIMORDIAL GERM CELL; PROMOTER REGION; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; GERM CELL; HEK293 CELL LINE; METABOLISM; MOUSE; MOUSE EMBRYONIC STEM CELL; PROTEIN DOMAIN; SPECIES DIFFERENTIATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; GENETIC SPECIATION; GERM CELLS; HEK293 CELLS; HISTONES; HUMANS; MICE; MOUSE EMBRYONIC STEM CELLS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN DOMAINS;

EID: 85011306580     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.01.013     Document Type: Article

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