NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

Nature

Volumn 529, Issue 7586, 2016, Pages 403-407

  Murakami, Kazuhiro ^a,b,c,d   Günesdogan, Ufuk ^a,b   Zylicz, Jan J ^a,b   Tang, Walfred W C ^a,b   Sengupta, Roopsha ^a,b   Kobayashi, Toshihiro ^a,b   Kim, Shinseog ^a,b   Butler, Richard ^a   Dietmann, Sabine ^b   Surani, M Azim ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c RIKEN   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; B LYMPHOCYTE INDUCED MATURATION PROTEIN 14; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TFAP2C; UNCLASSIFIED DRUG; ACTIVIN; BMP4 PROTEIN, MOUSE; CHROMATIN; HOMEODOMAIN PROTEIN; NANOG PROTEIN, MOUSE; PRDM1 PROTEIN, MOUSE; PRDM14 PROTEIN, MOUSE; PROTEIN BINDING; SOX2 PROTEIN, MOUSE; TFAP2C PROTEIN, MOUSE; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SOX;

CELLS AND CELL COMPONENTS; GENOME; GERM CELL; GROWTH RATE; HORMONE; MORPHOGENESIS; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; ECTODERM; ECTOPIC EXPRESSION; EMBRYONIC STEM CELL; ENHANCER REGION; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; GERM CELL; GERM LINE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CHROMATIN; CYTOLOGY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; GENOME; GERM LAYER; MALE; METABOLISM; MOUSE EMBRYONIC STEM CELL; PLURIPOTENT STEM CELL;

MUS;

ACTIVINS; ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CHROMATIN; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME; GERM CELLS; GERM LAYERS; HOMEODOMAIN PROTEINS; MALE; MICE; MOUSE EMBRYONIC STEM CELLS; NANOG HOMEOBOX PROTEIN; PLURIPOTENT STEM CELLS; PROTEIN BINDING; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS;

EID: 84955479249     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16480     Document Type: Article

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