메뉴 건너뛰기




Volumn 46, Issue 1, 2017, Pages 9-17

From Culture to High-Throughput Sequencing and Beyond: A Layperson's Guide to the “Omics” and Diagnostic Potential of the Microbiome

Author keywords

FMT; Gastrointestinal disease; Metagenome; Microbiome; Microbiota

Indexed keywords

RNA 16S; BACTERIAL DNA;

EID: 85011275777     PISSN: 08898553     EISSN: 15581942     Source Type: Journal    
DOI: 10.1016/j.gtc.2016.09.003     Document Type: Review
Times cited : (16)

References (47)
  • 1
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • 1 Eckburg, P.B., Bik, E.M., Bernstein, C.N., et al. Diversity of the human intestinal microbial flora. Science 308:5728 (2005), 1635–1638.
    • (2005) Science , vol.308 , Issue.5728 , pp. 1635-1638
    • Eckburg, P.B.1    Bik, E.M.2    Bernstein, C.N.3
  • 2
    • 85016726917 scopus 로고    scopus 로고
    • Tumour-associated and non-tumour-associated microbiota in colorectal cancer
    • [Epub ahead of print]
    • 2 Flemer, B., Lynch, D.B., Brown, J.M., et al. Tumour-associated and non-tumour-associated microbiota in colorectal cancer. Gut, 2016 [Epub ahead of print].
    • (2016) Gut
    • Flemer, B.1    Lynch, D.B.2    Brown, J.M.3
  • 3
    • 0036300743 scopus 로고    scopus 로고
    • Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces
    • 3 Zoetendal, E.G., von Wright, A., Vilpponen-Salmela, T., et al. Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces. Appl Environ Microbiol 68:7 (2002), 3401–3407.
    • (2002) Appl Environ Microbiol , vol.68 , Issue.7 , pp. 3401-3407
    • Zoetendal, E.G.1    von Wright, A.2    Vilpponen-Salmela, T.3
  • 4
    • 60549089819 scopus 로고    scopus 로고
    • Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance
    • 4 van Baarlen, P., Troost, F.J., van Hemert, S., et al. Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance. Proc Natl Acad Sci U S A 106:7 (2009), 2371–2376.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.7 , pp. 2371-2376
    • van Baarlen, P.1    Troost, F.J.2    van Hemert, S.3
  • 5
    • 84896092821 scopus 로고    scopus 로고
    • The treatment-naive microbiome in new-onset Crohn's disease
    • 5 Gevers, D., Kugathasan, S., Denson, L.A., et al. The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe 15:3 (2014), 382–392.
    • (2014) Cell Host Microbe , vol.15 , Issue.3 , pp. 382-392
    • Gevers, D.1    Kugathasan, S.2    Denson, L.A.3
  • 6
    • 84919884555 scopus 로고    scopus 로고
    • Microbiota organization is a distinct feature of proximal colorectal cancers
    • 6 Dejea, C.M., Wick, E.C., Hechenbleikner, E.M., et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci U S A 111:51 (2014), 18321–18326.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.51 , pp. 18321-18326
    • Dejea, C.M.1    Wick, E.C.2    Hechenbleikner, E.M.3
  • 7
    • 84858709310 scopus 로고    scopus 로고
    • Freezing fecal samples prior to DNA extraction affects the Firmicutes to Bacteroidetes ratio determined by downstream quantitative PCR analysis
    • 7 Bahl, M.I., Bergstrom, A., Licht, T.R., Freezing fecal samples prior to DNA extraction affects the Firmicutes to Bacteroidetes ratio determined by downstream quantitative PCR analysis. FEMS Microbiol Lett 329:2 (2012), 193–197.
    • (2012) FEMS Microbiol Lett , vol.329 , Issue.2 , pp. 193-197
    • Bahl, M.I.1    Bergstrom, A.2    Licht, T.R.3
  • 8
    • 84899898655 scopus 로고    scopus 로고
    • Comparison of methods for fecal microbiome biospecimen collection
    • 8 Dominianni, C., Wu, J., Hayes, R.B., et al. Comparison of methods for fecal microbiome biospecimen collection. BMC Microbiol, 14, 2014, 103.
    • (2014) BMC Microbiol , vol.14 , pp. 103
    • Dominianni, C.1    Wu, J.2    Hayes, R.B.3
  • 9
    • 84939179628 scopus 로고    scopus 로고
    • Temporal and technical variability of human gut metagenomes
    • 9 Voigt, A.Y., Costea, P.I., Kultima, J.R., et al. Temporal and technical variability of human gut metagenomes. Genome Biol, 16, 2015, 73.
    • (2015) Genome Biol , vol.16 , pp. 73
    • Voigt, A.Y.1    Costea, P.I.2    Kultima, J.R.3
  • 10
    • 84929119983 scopus 로고    scopus 로고
    • The effects of freezing on faecal microbiota as determined using MiSeq sequencing and culture-based investigations
    • 10 Fouhy, F., Deane, J., Rea, M.C., et al. The effects of freezing on faecal microbiota as determined using MiSeq sequencing and culture-based investigations. PLoS One, 10(3), 2015, e0119355.
    • (2015) PLoS One , vol.10 , Issue.3 , pp. e0119355
    • Fouhy, F.1    Deane, J.2    Rea, M.C.3
  • 11
    • 84996542591 scopus 로고    scopus 로고
    • Effect of room temperature transport vials on DNA quality and phylogenetic composition of faecal microbiota of elderly adults and infants
    • 11 Hill, C.J., Brown, J.R., Lynch, D.B., et al. Effect of room temperature transport vials on DNA quality and phylogenetic composition of faecal microbiota of elderly adults and infants. Microbiome, 4(1), 2016, 19.
    • (2016) Microbiome , vol.4 , Issue.1 , pp. 19
    • Hill, C.J.1    Brown, J.R.2    Lynch, D.B.3
  • 12
    • 84947460747 scopus 로고    scopus 로고
    • Sample storage conditions significantly influence faecal microbiome profiles
    • 12 Choo, J.M., Leong, L.E., Rogers, G.B., Sample storage conditions significantly influence faecal microbiome profiles. Sci Rep, 5, 2015, 16350.
    • (2015) Sci Rep , vol.5 , pp. 16350
    • Choo, J.M.1    Leong, L.E.2    Rogers, G.B.3
  • 13
    • 84893370250 scopus 로고    scopus 로고
    • Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice
    • 13 Faith, J.J., Ahern, P.P., Ridaura, V.K., et al. Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice. Sci Transl Med, 6(220), 2014, 220ra211.
    • (2014) Sci Transl Med , vol.6 , Issue.220 , pp. 220ra211
    • Faith, J.J.1    Ahern, P.P.2    Ridaura, V.K.3
  • 14
    • 84969704060 scopus 로고    scopus 로고
    • Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
    • 14 Browne, H.P., Forster, S.C., Anonye, B.O., et al. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation. Nature 533:7604 (2016), 543–546.
    • (2016) Nature , vol.533 , Issue.7604 , pp. 543-546
    • Browne, H.P.1    Forster, S.C.2    Anonye, B.O.3
  • 15
    • 84976469315 scopus 로고    scopus 로고
    • Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling
    • 15 Lau, J.T., Whelan, F.J., Herath, I., et al. Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling. Genome Med, 8(1), 2016, 72.
    • (2016) Genome Med , vol.8 , Issue.1 , pp. 72
    • Lau, J.T.1    Whelan, F.J.2    Herath, I.3
  • 16
    • 84877020842 scopus 로고    scopus 로고
    • Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut
    • 16 Petrof, E.O., Gloor, G.B., Vanner, S.J., et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut. Microbiome, 1(1), 2013, 3.
    • (2013) Microbiome , vol.1 , Issue.1 , pp. 3
    • Petrof, E.O.1    Gloor, G.B.2    Vanner, S.J.3
  • 17
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • 17 Manichanh, C., Rigottier-Gois, L., Bonnaud, E., et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 55:2 (2006), 205–211.
    • (2006) Gut , vol.55 , Issue.2 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3
  • 18
    • 84960373289 scopus 로고    scopus 로고
    • Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease
    • 18 Quevrain, E., Maubert, M.A., Michon, C., et al. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. Gut 65:3 (2016), 415–425.
    • (2016) Gut , vol.65 , Issue.3 , pp. 415-425
    • Quevrain, E.1    Maubert, M.A.2    Michon, C.3
  • 19
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • 19 Vrieze, A., Van Nood, E., Holleman, F., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:4 (2012), 913–916.e7.
    • (2012) Gastroenterology , vol.143 , Issue.4 , pp. 913-916.e7
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3
  • 20
    • 84877249773 scopus 로고    scopus 로고
    • Medicines from microbiota
    • 20 Olle, B., Medicines from microbiota. Nat Biotechnol 31:4 (2013), 309–315.
    • (2013) Nat Biotechnol , vol.31 , Issue.4 , pp. 309-315
    • Olle, B.1
  • 21
    • 77951977802 scopus 로고    scopus 로고
    • Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis
    • 21 Salonen, A., Nikkila, J., Jalanka-Tuovinen, J., et al. Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis. J Microbiol Methods 81:2 (2010), 127–134.
    • (2010) J Microbiol Methods , vol.81 , Issue.2 , pp. 127-134
    • Salonen, A.1    Nikkila, J.2    Jalanka-Tuovinen, J.3
  • 22
    • 84921532911 scopus 로고    scopus 로고
    • Choice of bacterial DNA extraction method from fecal material influences community structure as evaluated by metagenomic analysis
    • 22 Wesolowska-Andersen, A., Bahl, M.I., Carvalho, V., et al. Choice of bacterial DNA extraction method from fecal material influences community structure as evaluated by metagenomic analysis. Microbiome, 2, 2014, 19.
    • (2014) Microbiome , vol.2 , pp. 19
    • Wesolowska-Andersen, A.1    Bahl, M.I.2    Carvalho, V.3
  • 23
    • 69249109724 scopus 로고    scopus 로고
    • Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine
    • 23 Claesson, M.J., O'Sullivan, O., Wang, Q., et al. Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS One, 4(8), 2009, e6669.
    • (2009) PLoS One , vol.4 , Issue.8 , pp. e6669
    • Claesson, M.J.1    O'Sullivan, O.2    Wang, Q.3
  • 24
    • 78650453707 scopus 로고    scopus 로고
    • Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions
    • 24 Claesson, M.J., Wang, Q., O'Sullivan, O., et al. Comparison of two next-generation sequencing technologies for resolving highly complex microbiota composition using tandem variable 16S rRNA gene regions. Nucleic Acids Res, 38(22), 2010, e200.
    • (2010) Nucleic Acids Res , vol.38 , Issue.22 , pp. e200
    • Claesson, M.J.1    Wang, Q.2    O'Sullivan, O.3
  • 25
    • 84986538850 scopus 로고    scopus 로고
    • Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies
    • 25 Gohl, D.M., Vangay, P., Garbe, J., et al. Systematic improvement of amplicon marker gene methods for increased accuracy in microbiome studies. Nat Biotechnol 34:9 (2016), 942–949.
    • (2016) Nat Biotechnol , vol.34 , Issue.9 , pp. 942-949
    • Gohl, D.M.1    Vangay, P.2    Garbe, J.3
  • 26
    • 85041651856 scopus 로고    scopus 로고
    • From sample to Multi-Omics conclusions in under 48 Hours
    • e00038-16
    • 26 Quinn, R.A., Navas-Molina, J.A., Hyde, E.R., et al. From sample to Multi-Omics conclusions in under 48 Hours. mSystems, 1(2), 2016 e00038-16.
    • (2016) mSystems , vol.1 , Issue.2
    • Quinn, R.A.1    Navas-Molina, J.A.2    Hyde, E.R.3
  • 27
    • 84884127512 scopus 로고    scopus 로고
    • Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
    • 27 Langille, M.G., Zaneveld, J., Caporaso, J.G., et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol 31:9 (2013), 814–821.
    • (2013) Nat Biotechnol , vol.31 , Issue.9 , pp. 814-821
    • Langille, M.G.1    Zaneveld, J.2    Caporaso, J.G.3
  • 28
    • 84942895870 scopus 로고    scopus 로고
    • Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera
    • 28 Sun, Z., Harris, H.M., McCann, A., et al. Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera. Nat Commun, 6, 2015, 8322.
    • (2015) Nat Commun , vol.6 , pp. 8322
    • Sun, Z.1    Harris, H.M.2    McCann, A.3
  • 29
    • 84867192879 scopus 로고    scopus 로고
    • Intestinal inflammation targets cancer-inducing activity of the microbiota
    • 29 Arthur, J.C., Perez-Chanona, E., Muhlbauer, M., et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338:6103 (2012), 120–123.
    • (2012) Science , vol.338 , Issue.6103 , pp. 120-123
    • Arthur, J.C.1    Perez-Chanona, E.2    Muhlbauer, M.3
  • 30
    • 84862286169 scopus 로고    scopus 로고
    • A framework for human microbiome research
    • 30 Consortium HMP. A framework for human microbiome research. Nature 486:7402 (2012), 215–221.
    • (2012) Nature , vol.486 , Issue.7402 , pp. 215-221
  • 31
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • 31 Qin, J., Li, R., Raes, J., et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464:7285 (2010), 59–65.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3
  • 32
    • 84924026956 scopus 로고    scopus 로고
    • Potential of fecal microbiota for early-stage detection of colorectal cancer
    • 32 Zeller, G., Tap, J., Voigt, A.Y., et al. Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol Syst Biol, 10, 2014, 766.
    • (2014) Mol Syst Biol , vol.10 , pp. 766
    • Zeller, G.1    Tap, J.2    Voigt, A.Y.3
  • 33
    • 33746061683 scopus 로고    scopus 로고
    • Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB
    • 33 DeSantis, T.Z., Hugenholtz, P., Larsen, N., et al. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol 72:7 (2006), 5069–5072.
    • (2006) Appl Environ Microbiol , vol.72 , Issue.7 , pp. 5069-5072
    • DeSantis, T.Z.1    Hugenholtz, P.2    Larsen, N.3
  • 34
    • 84891787231 scopus 로고    scopus 로고
    • Ribosomal Database Project: data and tools for high throughput rRNA analysis
    • 34 Cole, J.R., Wang, Q., Fish, J.A., et al. Ribosomal Database Project: data and tools for high throughput rRNA analysis. Nucleic Acids Res 42:Database issue (2014), D633–D642.
    • (2014) Nucleic Acids Res , vol.42 , Issue.Database issue , pp. D633-D642
    • Cole, J.R.1    Wang, Q.2    Fish, J.A.3
  • 35
    • 70149090063 scopus 로고    scopus 로고
    • R: A language and environment for statistical computing
    • R Foundation for Statistical Computing Vienna (Austria)
    • 35 R Development Core Team, R: A language and environment for statistical computing. 2013, R Foundation for Statistical Computing, Vienna (Austria).
    • (2013)
    • R Development Core Team1
  • 36
    • 72949107142 scopus 로고    scopus 로고
    • Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    • 36 Schloss, P.D., Westcott, S.L., Ryabin, T., et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 75:23 (2009), 7537–7541.
    • (2009) Appl Environ Microbiol , vol.75 , Issue.23 , pp. 7537-7541
    • Schloss, P.D.1    Westcott, S.L.2    Ryabin, T.3
  • 37
    • 77952243141 scopus 로고    scopus 로고
    • QIIME allows analysis of high-throughput community sequencing data
    • 37 Caporaso, J.G., Kuczynski, J., Stombaugh, J., et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7:5 (2010), 335–336.
    • (2010) Nat Methods , vol.7 , Issue.5 , pp. 335-336
    • Caporaso, J.G.1    Kuczynski, J.2    Stombaugh, J.3
  • 38
    • 77957244650 scopus 로고    scopus 로고
    • Search and clustering orders of magnitude faster than BLAST
    • 38 Edgar, R.C., Search and clustering orders of magnitude faster than BLAST. Bioinformatics 26:19 (2010), 2460–2461.
    • (2010) Bioinformatics , vol.26 , Issue.19 , pp. 2460-2461
    • Edgar, R.C.1
  • 39
    • 84969871954 scopus 로고    scopus 로고
    • DADA2: High-resolution sample inference from Illumina amplicon data
    • 39 Callahan, B.J., McMurdie, P.J., Rosen, M.J., et al. DADA2: High-resolution sample inference from Illumina amplicon data. Nat Methods 13:7 (2016), 581–583.
    • (2016) Nat Methods , vol.13 , Issue.7 , pp. 581-583
    • Callahan, B.J.1    McMurdie, P.J.2    Rosen, M.J.3
  • 40
    • 84863105536 scopus 로고    scopus 로고
    • Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease
    • 40 Papa, E., Docktor, M., Smillie, C., et al. Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease. PLoS One, 7(6), 2012, e39242.
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e39242
    • Papa, E.1    Docktor, M.2    Smillie, C.3
  • 41
    • 84963525850 scopus 로고    scopus 로고
    • Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions
    • 41 Baxter, N.T., Ruffin, M.T., Rogers, M.A., et al. Microbiota-based model improves the sensitivity of fecal immunochemical test for detecting colonic lesions. Genome Med, 8(1), 2016, 37.
    • (2016) Genome Med , vol.8 , Issue.1 , pp. 37
    • Baxter, N.T.1    Ruffin, M.T.2    Rogers, M.A.3
  • 42
    • 84910116215 scopus 로고    scopus 로고
    • The Human Gut Microbiome as a Screening Tool for Colorectal Cancer
    • 42 Zackular, J.P., Rogers, M.A., Ruffin, M.T., et al. The Human Gut Microbiome as a Screening Tool for Colorectal Cancer. Cancer Prev Res (Phila) 7:11 (2014), 1112–1121.
    • (2014) Cancer Prev Res (Phila) , vol.7 , Issue.11 , pp. 1112-1121
    • Zackular, J.P.1    Rogers, M.A.2    Ruffin, M.T.3
  • 43
    • 84946144999 scopus 로고    scopus 로고
    • Gut mucosal microbiome across stages of colorectal carcinogenesis
    • 43 Nakatsu, G., Li, X., Zhou, H., et al. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun, 6, 2015, 8727.
    • (2015) Nat Commun , vol.6 , pp. 8727
    • Nakatsu, G.1    Li, X.2    Zhou, H.3
  • 44
    • 84942693814 scopus 로고    scopus 로고
    • Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
    • [Epub ahead of print]
    • 44 Yu, J., Feng, Q., Wong, S.H., et al. Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut, 2015 [Epub ahead of print].
    • (2015) Gut
    • Yu, J.1    Feng, Q.2    Wong, S.H.3
  • 45
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • 45 Le Chatelier, E., Nielsen, T., Qin, J., et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500:7464 (2013), 541–546.
    • (2013) Nature , vol.500 , Issue.7464 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3
  • 46
    • 84978081339 scopus 로고    scopus 로고
    • Human gut microbes impact host serum metabolome and insulin sensitivity
    • 46 Pedersen, H.K., Gudmundsdottir, V., Nielsen, H.B., et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 535:7612 (2016), 376–381.
    • (2016) Nature , vol.535 , Issue.7612 , pp. 376-381
    • Pedersen, H.K.1    Gudmundsdottir, V.2    Nielsen, H.B.3
  • 47
    • 84861578319 scopus 로고    scopus 로고
    • An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    • 47 Jeffery, I.B., O'Toole, P.W., Ohman, L., et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut 61 (2012), 997–1006.
    • (2012) Gut , vol.61 , pp. 997-1006
    • Jeffery, I.B.1    O'Toole, P.W.2    Ohman, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.