-
1
-
-
84899639879
-
Cytokines in inflammatory bowel disease
-
Neurath, M.F. Cytokines in inflammatory bowel disease. Nat. Rev. Immunol. 14, 329-342 (2014).
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 329-342
-
-
Neurath, M.F.1
-
2
-
-
77649220954
-
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
-
O'Shea, J. &Paul, W. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327, 1098-1102 (2010).
-
(2010)
Science
, vol.327
, pp. 1098-1102
-
-
O'Shea, J.1
Paul, W.2
-
3
-
-
79955563439
-
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
-
Strober, W. &Fuss, I.J. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140, 1756-1767 (2011).
-
(2011)
Gastroenterology
, vol.140
, pp. 1756-1767
-
-
Strober, W.1
Fuss, I.J.2
-
4
-
-
22144492636
-
CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa
-
Laouar, A. et al. CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat. Immunol. 6, 698-706 (2005).
-
(2005)
Nat. Immunol.
, vol.6
, pp. 698-706
-
-
Laouar, A.1
-
5
-
-
84861709318
-
Modulation of T-cell function by type i interferon
-
Tough, D.F. Modulation of T-cell function by type I interferon. Immunol. Cell Biol. 90, 492-497 (2012).
-
(2012)
Immunol. Cell Biol.
, vol.90
, pp. 492-497
-
-
Tough, D.F.1
-
6
-
-
84857415635
-
Constitutive type i interferon modulates homeostatic balance through tonic signaling
-
Gough, D.J., Messina, N.L., Clarke, C.J., Johnstone, R.W. &Levy, D.E. Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity 36, 166-174 (2012).
-
(2012)
Immunity
, vol.36
, pp. 166-174
-
-
Gough, D.J.1
Messina, N.L.2
Clarke, C.J.3
Johnstone, R.W.4
Levy, D.E.5
-
7
-
-
0037144547
-
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
-
Nguyen, K.B. et al. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 297, 2063-2066 (2002).
-
(2002)
Science
, vol.297
, pp. 2063-2066
-
-
Nguyen, K.B.1
-
8
-
-
84876311772
-
Persistent LCMV infection is controlled by blockade of type i interferon signaling
-
Teijaro, J.R. et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340, 207-211 (2013).
-
(2013)
Science
, vol.340
, pp. 207-211
-
-
Teijaro, J.R.1
-
9
-
-
84876299371
-
Blockade of chronic type i interferon signaling to control persistent LCMV infection
-
Wilson, E.B. et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 340, 202-207 (2013).
-
(2013)
Science
, vol.340
, pp. 202-207
-
-
Wilson, E.B.1
-
11
-
-
84902584152
-
The role of type i interferons in intestinal infection, homeostasis, and inflammation
-
Cho, H. &Kelsall, B.L. The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol. Rev. 260, 145-167 (2014).
-
(2014)
Immunol. Rev.
, vol.260
, pp. 145-167
-
-
Cho, H.1
Kelsall, B.L.2
-
12
-
-
79951990263
-
Localized delivery of interferon-b by Lactobacillus exacerbates experimental colitis
-
McFarland, A.P. et al. Localized delivery of interferon-b by Lactobacillus exacerbates experimental colitis. PLoS One 6, e16967 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e16967
-
-
McFarland, A.P.1
-
13
-
-
36749001082
-
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
-
Abe, K. et al. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc. Natl. Acad. Sci. USA 104, 17022-17027 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 17022-17027
-
-
Abe, K.1
-
14
-
-
59849127774
-
CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction
-
Bleich, A. et al. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology 136, 278-287 (2009).
-
(2009)
Gastroenterology
, vol.136
, pp. 278-287
-
-
Bleich, A.1
-
15
-
-
84883417081
-
Type i IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cellmediated colitis
-
Kole, A. et al. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cellmediated colitis. J. Immunol. 191, 2771-2779 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 2771-2779
-
-
Kole, A.1
-
16
-
-
84862740015
-
Type i interferons maintain foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice
-
Lee, S.E. et al. Type I interferons maintain foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice. Gastroenterology 143, 145-154 (2012).
-
(2012)
Gastroenterology
, vol.143
, pp. 145-154
-
-
Lee, S.E.1
-
17
-
-
84856837493
-
CD69 regulates type i IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential
-
Radulovic, K. et al. CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J. Immunol. 188, 2001-2013 (2012).
-
(2012)
J. Immunol.
, vol.188
, pp. 2001-2013
-
-
Radulovic, K.1
-
18
-
-
77950534540
-
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
-
Axtell, R.C. et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat. Med. 16, 406-412 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 406-412
-
-
Axtell, R.C.1
-
19
-
-
84868336049
-
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
-
Jostins, L. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012).
-
(2012)
Nature
, vol.491
, pp. 119-124
-
-
Jostins, L.1
-
20
-
-
55049113294
-
Type i interferons for induction of remission in ulcerative colitis
-
Seow, C.H., Benchimol, E.I., Griffiths, A.M. &Steinhart, A.H. Type I interferons for induction of remission in ulcerative colitis. Cochrane Database Syst. Rev. CD006790, 16 (2008).
-
(2008)
Cochrane Database Syst. Rev. CD006790
, pp. 16
-
-
Seow, C.H.1
Benchimol, E.I.2
Griffiths, A.M.3
Steinhart, A.H.4
-
21
-
-
84875425732
-
Type i interferon suppresses type II interferon-triggered human anti-mycobacterial responses
-
Teles, R.M. et al. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science 339, 1448-1453 (2013).
-
(2013)
Science
, vol.339
, pp. 1448-1453
-
-
Teles, R.M.1
-
22
-
-
0035997908
-
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
-
Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat. Immunol. 3, 549-557 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 549-557
-
-
Afkarian, M.1
-
23
-
-
0037029649
-
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
-
Neurath, M.F. et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 195, 1129-1143 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1129-1143
-
-
Neurath, M.F.1
-
24
-
-
23044440808
-
FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease
-
Kelsen, J. et al. FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. Clin. Exp. Immunol. 141, 549-557 (2005).
-
(2005)
Clin. Exp. Immunol.
, vol.141
, pp. 549-557
-
-
Kelsen, J.1
-
25
-
-
77957190532
-
T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells
-
Hofmann, C. et al. T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells. Gut 59, 1347-1354 (2010).
-
(2010)
Gut
, vol.59
, pp. 1347-1354
-
-
Hofmann, C.1
-
26
-
-
33846375082
-
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
-
Wang, J., Ioan-Facsinay, A., van der Voort, E.I., Huizinga, T.W. &Toes, R.E. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur. J. Immunol. 37, 129-138 (2007).
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 129-138
-
-
Wang, J.1
Ioan-Facsinay, A.2
Van Der Voort, E.I.3
Huizinga, T.W.4
Toes, R.E.5
-
27
-
-
84928484992
-
IFN-a/b receptor signaling promotes regulatory T cell development and function under stress conditions
-
Metidji, A. et al. IFN-a/b receptor signaling promotes regulatory T cell development and function under stress conditions. J. Immunol. 194, 4265-4276 (2015).
-
(2015)
J. Immunol.
, vol.194
, pp. 4265-4276
-
-
Metidji, A.1
-
28
-
-
0022644919
-
Deficient cell-mediated cytotoxicity and hyporesponsiveness to interferon and mitogenic lectin activation by inflammatory bowel disease peripheral blood and intestinal mononuclear cells
-
MacDermott, R.P., Bragdon, M.J., Kodner, I.J. &Bertovich, M.J. Deficient cell-mediated cytotoxicity and hyporesponsiveness to interferon and mitogenic lectin activation by inflammatory bowel disease peripheral blood and intestinal mononuclear cells. Gastroenterology 90, 6-11 (1986).
-
(1986)
Gastroenterology
, vol.90
, pp. 6-11
-
-
MacDermott, R.P.1
Bragdon, M.J.2
Kodner, I.J.3
Bertovich, M.J.4
-
29
-
-
13744249714
-
Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases
-
Mudter, J. et al. Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. Am. J. Gastroenterol. 100, 64-72 (2005).
-
(2005)
Am. J. Gastroenterol.
, vol.100
, pp. 64-72
-
-
Mudter, J.1
-
30
-
-
0038269009
-
Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease
-
Lovato, P. et al. Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J. Biol. Chem. 278, 16777-16781 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16777-16781
-
-
Lovato, P.1
-
31
-
-
44849121674
-
Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
-
Horino, J. et al. Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Int. Immunol. 20, 753-762 (2008).
-
(2008)
Int. Immunol.
, vol.20
, pp. 753-762
-
-
Horino, J.1
-
32
-
-
70449671234
-
Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function
-
Palmer, D.C. &Restifo, N.P. Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function. Trends Immunol. 30, 592-602 (2009).
-
(2009)
Trends Immunol.
, vol.30
, pp. 592-602
-
-
Palmer, D.C.1
Restifo, N.P.2
-
33
-
-
84876412015
-
Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity
-
Musch, E. et al. Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity. Inflamm. Bowel Dis. 19, 283-292 (2013).
-
(2013)
Inflamm. Bowel Dis.
, vol.19
, pp. 283-292
-
-
Musch, E.1
-
34
-
-
84922245262
-
Disease-specific alterations in the enteric virome in inflammatory bowel disease
-
Norman, J.M. et al. Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell 160, 447-460 (2015).
-
(2015)
Cell
, vol.160
, pp. 447-460
-
-
Norman, J.M.1
-
35
-
-
0034232047
-
Interferonalpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox
-
Nguyen,K.B. et al. Interferonalpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nat. Immunol. 1, 70-76 (2000).
-
(2000)
Nat. Immunol.
, vol.1
, pp. 70-76
-
-
Nguyen, K.B.1
-
36
-
-
0030872223
-
Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells
-
Mahida, Y.R. et al. Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells. Clin. Exp. Immunol. 109, 377-386 (1997).
-
(1997)
Clin. Exp. Immunol.
, vol.109
, pp. 377-386
-
-
Mahida, Y.R.1
-
37
-
-
22344448660
-
Characteristics of intestinal dendritic cells in inflammatory bowel diseases
-
Hart, A. et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 129, 50-65 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 50-65
-
-
Hart, A.1
-
38
-
-
0035871634
-
Migration and maturation of human colonic dendritic cells
-
Bell, S.J. et al. Migration and maturation of human colonic dendritic cells. J. Immunol. 166, 4958-4967 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 4958-4967
-
-
Bell, S.J.1
|