CpG Motifs of Bacterial DNA Exert Protective Effects in Mouse Models of IBD by Antigen-Independent Tolerance Induction

Gastroenterology

Volumn 136, Issue 1, 2009, Pages 278-287

  Bleich, Andre ^a   Janus, Lydia M ^a   Smoczek, Anna ^a   Westendorf, Astrid M ^b   Strauch, Ulrike ^c   Mähler, Michael ^a   Hedrich, Hans J ^a   Fichtner Feigl, Stefan ^c   Schölmerich, Jürgen ^c   Falk, Werner ^c   Hofmann, Claudia ^c   Obermeier, Florian ^c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIAL DNA; BETA INTERFERON; CD4 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; OLIGODEOXYNUCLEOTIDE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; BACTERIAL ANTIGEN; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; CYTOKINE; INTERLEUKIN 10; OLIGODEOXYRIBONUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; ENTERITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; GERMFREE ANIMAL; IMMUNOLOGICAL TOLERANCE; PHYSIOLOGY; REGULATORY T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, BACTERIAL; CYTOKINES; GERM-FREE LIFE; IMMUNE TOLERANCE; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; L-SELECTIN; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 59849127774     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.09.022     Document Type: Article

References (38)

1. Andus T., and Gross V. Etiology and pathophysiology of inflammatory bowel disease--environmental factors. Hepatogastroenterology 47 (2000) 29-43
2. Sartor R.B. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am J Gastroenterol 92 (1997) 5S-11S
3. Bleich A., and Mähler M. Environment as a critical factor for the pathogenesis and outcome of gastrointestinal disease: experimental and human inflammatory bowel disease and Helicobacter-induced gastritis. Pathobiology 72 (2005) 293-307
4. Cong Y., Brandwein S.L., McCabe R.P., et al. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 187 (1998) 855-864
5. Inohara N., Ogura Y., Fontalba A., et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278 (2003) 5509-5512
6. Girardin S.E., Boneca I.G., Viala J., et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278 (2003) 8869-8872
7. Ogura Y., Bonen D.K., Inohara N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411 (2001) 603-606
8. Krieg A.M. Now I know my CpGs. Trends Microbiol 9 (2001) 249-252
9. Krieg A.M., Yi A.K., Matson S., et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
10. Hemmi H., Takeuchi O., Kawai T., et al. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
11. Bauer S., and Wagner H. Bacterial CpG-DNA licenses TLR9. Curr Top Microbiol Immunol 270 (2002) 145-154
12. O'Hagan D.T., MacKichan M.L., and Singh M. Recent developments in adjuvants for vaccines against infectious diseases. Biomol Eng 18 (2001) 69-85
13. Krieg A.M. From bugs to drugs: therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA. Antisense Nucleic Acid Drug Dev 11 (2001) 181-188
14. Metzger W.J., and Nyce J.W. Oligonucleotide therapy of allergic asthma. J Allergy Clin Immunol 104 (1999) 260-266
15. Creticos P.S., Schroeder J.T., Hamilton R.G., et al. Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 355 (2006) 1445-1455
16. Katakura K., Sato Y., and Sato N. CpG motifs in plasmid DNA exacerbate inflammation in experimental colitis. Gastroenterology 120 (2001) A.518
17. Obermeier F., Dunger N., Strauch U.G., et al. Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis. Clin Exp Immunol 134 (2003) 217-224
18. Rachmilewitz D., Karmeli F., Takabayashi K., et al. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology 122 (2002) 1428-1441
19. Obermeier F., Strauch U.G., Dunger N., et al. In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis. Gut 54 (2005) 1428-1436
20. Nicklas W., Baneux P., Boot R., et al. Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 36 (2002) 20-42
21. Sparwasser T., Koch E.S., Vabulas R.M., et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28 (1998) 2045-2054
22. Kawade Y., and Watanabe Y. Characterization of rat monoclonal antibodies to mouse interferon a and b. Proceedings of the Third International TNO Meeting on the Biology of the Interferon System. In: Cantell K., and Schellekens H. (Eds). The Biology of the Interferon System (1987), Martinus Nijhoff, Dordrecht 197-201
23. Fuss I.J., Boirivant M., Lacy B., et al. The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis. J Immunol 168 (2002) 900-908
24. Bleich A., Mähler M., Most C., et al. Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome 15 (2004) 865-871
25. Moolenbeek C., and Ruitenberg E.J. The "Swiss roll": a simple technique for histological studies of the rodent intestine. Lab Anim 15 (1981) 57-59
26. de Buhr M.F., Mähler M., Geffers R., et al. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics 25 (2006) 426-434
27. Katakura K., Lee J., Rachmilewitz D., et al. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 115 (2005) 695-702
28. Levings M.K., Sangregorio R., Galbiati F., et al. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 166 (2001) 5530-5539
29. Bilsborough J., George T.C., Norment A., et al. Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology 108 (2003) 481-492
30. Yamagiwa S., Gray J.D., Hashimoto S., et al. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol 166 (2001) 7282-7289
31. Chen W., Jin W., Hardegen N., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198 (2003) 1875-1886
32. Moseman E.A., Liang X., Dawson A.J., et al. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. J Immunol 173 (2004) 4433-4442
33. Strauch U.G., Obermeier F., Grunwald N., et al. Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut 54 (2005) 1546-1552
34. Mudter J., and Neurath M.F. Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance. Inflamm Bowel Dis 13 (2007) 1016-1023
35. Rose S., Lichtenheld M., Foote M.R., et al. Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function. J Immunol 178 (2007) 2667-2678
36. Sudo N., Sawamura S., Tanaka K., et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 159 (1997) 1739-1745
37. Fort M., Lesley R., Davidson N., et al. IL-4 exacerbates disease in a Th1 cell transfer model of colitis. J Immunol 166 (2001) 2793-2800
38. Roers A., Siewe L., Strittmatter E., et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med 200 (2004) 1289-1297