IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db/db mice

PLoS ONE

Volumn 12, Issue 1, 2017, Pages

  Kolumam, Ganesh ^a,b   Wu, Xiumin ^a   Lee, Wyne P ^a   Hackney, Jason A ^a   Zavala Solorio, Jose ^a   Gandham, Vineela ^a   Danilenko, Dimitry M ^a   Arora, Puneet ^a   Wang, Xiaoting ^a,c   Ouyang, Wenjun ^a,c  

^a GENENTECH INC   (United States)

^b Calico Life Sciences LLC   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; CALGRANULIN B; FC PROTEIN; FGFR1 ANTIBODY; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 20 FC FUSION PROTEIN; INTERLEUKIN 22; INTERLEUKIN 22 FC FUSION PROTEIN; INTERLEUKIN 22 RECEPTOR; INTERLEUKIN 24; INTERLEUKIN 24 FC FUSION PROTEIN; INTERLEUKIN RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY FGFR1; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT FIBROBLAST GROWTH FACTOR; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; RECOMBINANT PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; WOUND HEALING PROMOTING AGENT; IMMUNOGLOBULIN FC FRAGMENT; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; INTERLEUKIN-22 RECEPTOR; INTERLEUKIN-24; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DB/DB MOUSE; DIABETIC FOOT; DOWN REGULATION; DRUG MECHANISM; EPITHELIZATION; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; HOST RESISTANCE; IL19 GENE; IL20 GENE; IL22 GENE; IL24 GENE; INNATE IMMUNITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN BLOOD FLOW; TISSUE REGENERATION; TISSUE REMODELING; TRANSCRIPTION INITIATION; UPREGULATION; WOUND DRESSING; WOUND HEALING; ANIMAL; COMPLICATION; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GENETICS; HUMAN; NONOBESE DIABETIC MOUSE; PATHOLOGY; WOUND INFECTION;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIABETIC FOOT; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; INTERLEUKINS; LIGANDS; MICE; MICE, INBRED NOD; RECEPTORS, INTERLEUKIN; WOUND HEALING; WOUND INFECTION;

EID: 85010904500     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0170639     Document Type: Article

References (50)

1. Monaco JL, Lawrence WT. Acute wound healing an overview. Clinics in plastic surgery. 2003; 30(1):1-12. Epub 2003/03/15. PMID: 12636211
2. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Frontiers in bioscience: a journal and virtual library. 2004; 9:283-9. Epub 2004/02/10.
3. Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clinics in dermatology. 2007; 25(1):9-18. Epub 2007/02/06. doi: 10.1016/j.clindermatol.2006.09.007 PMID: 17276196
4. Singer AJ, Clark RA. Cutaneous wound healing. The New England journal of medicine. 1999; 341 (10):738-46. Epub 1999/09/02. doi: 10.1056/NEJM199909023411006 PMID: 10471461
5. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2008; 16(5):585-601. Epub 2009/01/09.
6. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. The Journal of clinical investigation. 2007; 117(5):1219-22. Epub 2007/05/04. doi: 10.1172/JCI32169 PMID: 17476353
7. Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet. 2005; 366(9498):1719-24. Epub 2005/11/18. doi: 10.1016/S0140-6736(05)67698-2 PMID: 16291066
8. Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet. 2003; 361(9368):1545-51. Epub 2003/05/10. doi: 10.1016/S0140-6736(03)13169-8 PMID: 12737879
9. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005; 366(9498):1736-43. Epub 2005/11/18. doi: 10.1016/S0140-6736(05)67700-8 PMID: 16291068
10. Cavanagh PR, Lipsky BA, Bradbury AW, Botek G. Treatment for diabetic foot ulcers. Lancet. 2005; 366 (9498):1725-35. Epub 2005/11/18. doi: 10.1016/S0140-6736(05)67699-4 PMID: 16291067
11. Kavitha KV, Tiwari S, Purandare VB, Khedkar S, Bhosale SS, Unnikrishnan AG. Choice of wound care in diabetic foot ulcer: A practical approach. World journal of diabetes. 2014; 5(4):546-56. Epub 2014/08/16. doi: 10.4239/wjd.v5.i4.546 PMID: 25126400
12. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiological reviews. 2003; 83(3):835-70. Epub 2003/07/05. doi: 10.1152/physrev.00031.2002 PMID: 12843410
13. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. The American journal of pathology. 2004; 164(6):1935-47. Epub 2004/05/27. doi: 10.1016/S0002-9440(10)63754-6 PMID: 15161630
14. Saaristo A, Tammela T, Farkkila A, Karkkainen M, Suominen E, Yla-Herttuala S, et al. Vascular endothelial growth factor-C accelerates diabetic wound healing. The American journal of pathology. 2006; 169(3):1080-7. Epub 2006/08/29. doi: 10.2353/ajpath.2006.051251 PMID: 16936280
15. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. The American journal of pathology. 1990; 136(6):1235-46. Epub 1990/06/01. PMID: 2356856
16. LeGrand EK. Preclinical promise of becaplermin (rhPDGF-BB) in wound healing. American journal of surgery. 1998; 176(2A Suppl):48S-54S. Epub 1998/10/20. PMID: 9777972
17. Yazdanpanah L, Nasiri M, Adarvishi S. Literature review on the management of diabetic foot ulcer. World journal of diabetes. 2015; 6(1):37-53. Epub 2015/02/17. doi: 10.4239/wjd.v6.i1.37 PMID: 25685277
18. Rutz S, Wang X, Ouyang W. The IL-20 subfamily of cytokines - from host defence to tissue homeostasis. Nature reviews Immunology. 2014; 14(12):783-95. doi: 10.1038/nri3766 PMID: 25421700
19. Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 2001; 104(1):9-19. Epub 2001/02/13. PMID: 11163236
20. Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. The Journal of biological chemistry. 2002; 277(49):47517-23. Epub 2002/09/28. doi: 10.1074/jbc.M205114200 PMID: 12351624
21. Wang M, Tan Z, Zhang R, Kotenko SV, Liang P. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. The Journal of biological chemistry. 2002; 277(9):7341-7. Epub 2001/11/14. doi: 10.1074/jbc.M106043200 PMID: 11706020
22. Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of immunology. 2001; 167 (7):3545-9. Epub 2001/09/21.
23. Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. The Journal of biological chemistry. 2000; 275(40):31335-9. Epub 2000/07/06. doi: 10.1074/jbc.M005304200 PMID: 10875937
24. Sa SM, Valdez PA, Wu J, Jung K, Zhong F, Hall L, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. Journal of immunology. 2007; 178(4):2229-40.
25. Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. European journal of immunology. 2006; 36(5):1309-23. doi: 10.1002/eji.200535503 PMID: 16619290
26. McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, et al. IL-22 promotes fibroblast-mediated wound repair in the skin. The Journal of investigative dermatology. 2013; 133(5):1321-9. doi: 10.1038/jid.2012.463 PMID: 23223145
27. Avitabile S, Odorisio T, Madonna S, Eyerich S, Guerra L, Eyerich K, et al. Interleukin-22 Promotes Wound Repair in Diabetes By Improving Keratinocyte Pro-Healing Functions. The Journal of investigative dermatology. 2015. Epub 2015/07/15.
28. Sun DP, Yeh CH, So E, Wang LY, Wei TS, Chang MS, et al. Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression. Cytokine. 2013; 62(3):360-8. doi: 10.1016/j.cyto.2013.03.017 PMID: 23582717
29. Michaels Jt, Churgin SS, Blechman KM, Greives MR, Aarabi S, Galiano RD, et al. db/db mice exhibit severe wound-healing impairments compared with other murine diabetic strains in a silicone-splinted excisional wound model. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2007; 15(5):665-70. Epub 2007/11/01.
30. Wong VW, Sorkin M, Glotzbach JP, Longaker MT, Gurtner GC. Surgical approaches to create murine models of human wound healing. Journal of biomedicine & biotechnology. 2011; 2011:969618. Epub 2010/12/15.
31. Galiano RD, Michaels Jt, Dobryansky M, Levine JP, Gurtner GC. Quantitative and reproducible murine model of excisional wound healing. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2004; 12(4):485-92. Epub 2004/07/21.
32. Wang X, Ota N, Manzanillo P, Kates L, Zavala-Solorio J, Eidenschenk C, et al. Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature. 2014; 514(7521):237-41. Epub 2014/08/15. doi: 10.1038/nature13564 PMID: 25119041
33. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic acids research. 2003; 31(4):e15. PMID: 12582260
34. Bourgon R, Gentleman R, Huber W. Independent filtering increases detection power for high-throughput experiments. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(21):9546-51. doi: 10.1073/pnas.0914005107 PMID: 20460310
35. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Statistics in medicine. 1990; 9(7):811-8. PMID: 2218183
36. Falcon S, Gentleman R. Using GOstats to test gene lists for GO term association. Bioinformatics. 2007; 23(2):257-8. doi: 10.1093/bioinformatics/btl567 PMID: 17098774
37. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome research. 2003; 13 (11):2498-504. doi: 10.1101/gr.1239303 PMID: 14597658
38. Ota N, Wong K, Valdez PA, Zheng Y, Crellin NK, Diehl L, et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nature immunology. 2011; 12(10):941-8. Epub 2011/08/30. doi: 10.1038/ni.2089 PMID: 21874025
39. Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, Zavala-Solorio J, et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Science translational medicine. 2011; 3(113):113ra26. Epub 2011/12/17.
40. Perera GK, Ainali C, Semenova E, Hundhausen C, Barinaga G, Kassen D, et al. Integrative biology approach identifies cytokine targeting strategies for psoriasis. Science translational medicine. 2014; 6 (223):223ra22. Epub 2014/02/14. doi: 10.1126/scitranslmed.3007217 PMID: 24523322
41. Devalaraja RM, Nanney LB, Du J, Qian Q, Yu Y, Devalaraja MN, et al. Delayed wound healing in CXCR2 knockout mice. The Journal of investigative dermatology. 2000; 115(2):234-44. Epub 2000/08/22. doi: 10.1046/j.1523-1747.2000.00034.x PMID: 10951241
42. Kishibe M, Bando Y, Tanaka T, Ishida-Yamamoto A, Iizuka H, Yoshida S. Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2. The Journal of investigative dermatology. 2012; 132(6):1717-24. Epub 2012/02/24. doi: 10.1038/jid.2012.18 PMID: 22358061
43. Dworkin S, Jane SM, Darido C. The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair. Organogenesis. 2011; 7(3):202-8. Epub 2011/11/02. doi: 10.4161/org.7.3.18431 PMID: 22041517
44. Dowd SE, Sun Y, Secor PR, Rhoads DD, Wolcott BM, James GA, et al. Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC microbiology. 2008; 8:43. Epub 2008/03/08. doi: 10.1186/1471-2180-8-43 PMID: 18325110
45. Leung PC. Diabetic foot ulcers - a comprehensive review. The surgeon: journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 2007; 5(4):219-31. Epub 2007/09/14. PMID: 17849958
46. Boniface K, Bernard FX, Garcia M, Gurney AL, Lecron JC, Morel F. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. Journal of immunology. 2005; 174(6):3695-702. Epub 2005/03/08.
47. Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nature medicine. 2008; 14(3):282-9. Epub 2008/02/12. doi: 10.1038/nm1720 PMID: 18264109
48. Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nature medicine. 2008; 14(3):275-81. Epub 2008/02/12. doi: 10.1038/nm1710 PMID: 18264110
49. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008; 28(4):454-67. Epub 2008/04/11. doi: 10.1016/j.immuni.2008.03.004 PMID: 18400188
50. Fang RC, Galiano RD. A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers. Biologics: targets & therapy. 2008; 2(1):1-12. Epub 2008/03/01.