PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

Stem Cell Reports

Volumn 8, Issue 2, 2017, Pages 264-277

  Wang, Liheng ^a   Sui, Lina ^a   Panigrahi, Sunil K ^a   Meece, Kana ^a   Xin, Yurong ^b   Kim, Jinrang ^b   Gromada, Jesper ^b   Doege, Claudia A ^a   Wardlaw, Sharon L ^a   Egli, Dieter ^a,c   Leibel, Rudolph L ^a  

^a Columbia University ^*  (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c New York Stem Cell Foundation Laboratory   (United States)

Author keywords

hESC; hypothalamic neurons; obesity; PC1 3 deficiency; POMC processing

Indexed keywords

ALPHA MELANIN DISPERSING HORMONE; CRISPR ASSOCIATED PROTEIN; FURIN; INTERMEDIN; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN RECEPTOR; PROLINE CARBOXYPEPTIDASE; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 1; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ALPHA INTERMEDIN; CORTICOTROPIN; PROPROTEIN CONVERTASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; ENZYME DEFICIENCY; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; HYPOTHALAMUS; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CRISPR CAS SYSTEM; CYTOLOGY; DEFICIENCY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; PROTEIN DEGRADATION; PYRAMIDAL NERVE CELL; SECRETION (PROCESS);

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; CRISPR-CAS SYSTEMS; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GENE TARGETING; HUMAN EMBRYONIC STEM CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MUTATION; NEURONS; PRO-OPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; PROTEOLYSIS; PYRAMIDAL CELLS;

EID: 85010876882     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2016.12.021     Document Type: Article

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