메뉴 건너뛰기




Volumn 18, Issue 3, 2017, Pages 303-312

Gsk3 is a metabolic checkpoint regulator in B cells

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 4; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYC PROTEIN; PROTEIN S6; REACTIVE OXYGEN METABOLITE; CD19 ANTIGEN; CD40 LIGAND; GLYCOGEN SYNTHASE KINASE 3BETA; GSK3B PROTEIN, MOUSE;

EID: 85010868621     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3664     Document Type: Article
Times cited : (227)

References (37)
  • 1
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora, G. D. et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143, 592-605 (2010).
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1
  • 2
    • 84867730760 scopus 로고    scopus 로고
    • The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
    • Calado, D. P. et al. The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat. Immunol. 13, 1092-1100 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 1092-1100
    • Calado, D.P.1
  • 3
    • 84867709361 scopus 로고    scopus 로고
    • The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
    • Dominguez-Sola, D. et al. The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat. Immunol. 13, 1083-1091 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 1083-1091
    • Dominguez-Sola, D.1
  • 4
    • 33744462050 scopus 로고    scopus 로고
    • Antigen-receptor-mediated changes in glucose metabolism in B lymphocytes: Role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    • Doughty, C. A. et al. Antigen-receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107, 4458-4465 (2006).
    • (2006) Blood , vol.107 , pp. 4458-4465
    • Doughty, C.A.1
  • 5
    • 38349158386 scopus 로고    scopus 로고
    • Multiple signaling pathways promote B lymphocyte stimulator-dependent B cell growth and survival
    • Woodland, R. T. et al. Multiple signaling pathways promote B lymphocyte stimulator-dependent B cell growth and survival. Blood 111, 750-760 (2008).
    • (2008) Blood , vol.111 , pp. 750-760
    • Woodland, R.T.1
  • 6
    • 38449099803 scopus 로고    scopus 로고
    • Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism
    • Dufort, F. J. et al. Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism. J. Immunol. 179, 4953-4957 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 4953-4957
    • Dufort, F.J.1
  • 7
    • 84923265392 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 (GSK3): Regulation, actions and diseases
    • Beurel, E., Grieco, S. F. & Jope, R. S. Glycogen synthase kinase 3 (GSK3): regulation, actions and diseases. Pharmacol. Ther. 148, 114-131 (2015).
    • (2015) Pharmacol. Ther. , vol.148 , pp. 114-131
    • Beurel, E.1    Grieco, S.F.2    Jope, R.S.3
  • 8
    • 79959233776 scopus 로고    scopus 로고
    • What are the bona fide GSK3 substrates
    • Sutherland, C. What are the bona fide GSK3 substrates Int. J. Alzheimers Dis. 2011, 505607 (2011).
    • (2011) Int. J. Alzheimers Dis. , vol.2011 , pp. 505607
    • Sutherland, C.1
  • 9
    • 77952954695 scopus 로고    scopus 로고
    • When pathways collide: Collaboration and connivance among signaling proteins in development
    • McNeill, H. & Woodgett, J. R. When pathways collide: collaboration and connivance among signaling proteins in development. Nat. Rev. Mol. Cell Biol. 11, 404-413 (2010).
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 404-413
    • McNeill, H.1    Woodgett, J.R.2
  • 10
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase 3 by insulin-mediated by protein kinase B
    • Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M. & Hemmings, B. A. Inhibition of glycogen synthase kinase 3 by insulin-mediated by protein kinase B. Nature 378, 785-789 (1995).
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 11
    • 12944250922 scopus 로고    scopus 로고
    • Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    • Fang, X. et al. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. USA 97, 11960-11965 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11960-11965
    • Fang, X.1
  • 12
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase 3 by phosphorylation: New kinase connections in insulin and growth-factor signaling
    • Sutherland, C., Leighton, I. A. & Cohen, P. Inactivation of glycogen synthase kinase 3 by phosphorylation: new kinase connections in insulin and growth-factor signaling. Biochem. J. 296, 15-19 (1993).
    • (1993) Biochem. J. , vol.296 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 13
    • 34250179471 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 and 3 mediate a glucose-sensitive anti-apoptotic signaling pathway to stabilize Mcl-1
    • Zhao, Y. et al. Glycogen synthase kinase 3 and 3 mediate a glucose-sensitive anti-apoptotic signaling pathway to stabilize Mcl-1. Mol. Cell. Biol. 27, 4328-4339 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4328-4339
    • Zhao, Y.1
  • 14
    • 84862276453 scopus 로고    scopus 로고
    • GSK-3: A bifunctional role in cell death pathways
    • Jacobs, K. M. et al. GSK-3: A bifunctional role in cell death pathways. Int. J. Cell Biol. 2012, 930710 (2012).
    • (2012) Int. J. Cell Biol. , vol.2012 , pp. 930710
    • Jacobs, K.M.1
  • 15
    • 78751688466 scopus 로고    scopus 로고
    • Cyclin D3 is selectively required for proliferative expansion of germinal center B cells
    • Cato, M. H., Chintalapati, S. K., Yau, I. W., Omori, S. A. & Rickert, R. C. Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol. Cell. Biol. 31, 127-137 (2011).
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 127-137
    • Cato, M.H.1    Chintalapati, S.K.2    Yau, I.W.3    Omori, S.A.4    Rickert, R.C.5
  • 16
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G. L., Roth, P. H., Fang, H. M. & Wang, G. L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 17
    • 84880880724 scopus 로고    scopus 로고
    • New insights into pre-BCR and BCR signaling with relevance to B cell malignancies
    • Rickert, R. C. New insights into pre-BCR and BCR signaling with relevance to B cell malignancies. Nat. Rev. Immunol. 13, 578-591 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 578-591
    • Rickert, R.C.1
  • 18
    • 84880280631 scopus 로고    scopus 로고
    • ViSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
    • Amir, A. D. et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat. Biotechnol. 31, 545-552 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 545-552
    • Amir, A.D.1
  • 19
    • 34249311572 scopus 로고    scopus 로고
    • Functional redundancy of GSK-3 and GSK-3 in Wnt-catenin signaling shown by using an allelic series of embryonic stem cell lines
    • Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K. & Woodgett, J. R. Functional redundancy of GSK-3 and GSK-3 in Wnt-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev. Cell 12, 957-971 (2007).
    • (2007) Dev. Cell , vol.12 , pp. 957-971
    • Doble, B.W.1    Patel, S.2    Wood, G.A.3    Kockeritz, L.K.4    Woodgett, J.R.5
  • 20
    • 0030818183 scopus 로고    scopus 로고
    • Lymphocyte-specific, Cre-mediated mutagenesis in mice
    • Rickert, R. C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25, 1317-1318 (1997).
    • (1997) Nucleic Acids Res , vol.25 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.B.3
  • 21
    • 84861692916 scopus 로고    scopus 로고
    • Cell receptor signal transduction in the GC is short-circuited by high phosphatase activity
    • Khalil, A. M., Cambier, J. C. & Shlomchik, M. J. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science 336, 1178-1181 (2012).
    • (2012) Science , vol.336 , pp. 1178-1181
    • Khalil, A.M.1    Cambier, J.C.2    Shlomchik, M.J.B.3
  • 22
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
    • (2001) BMC Dev. Biol. , vol.1 , pp. 4
    • Srinivas, S.1
  • 23
    • 0025339171 scopus 로고
    • The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bone marrow
    • Förster, I. & Rajewsky, K. The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc. Natl. Acad. Sci. USA 87, 4781-4784 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4781-4784
    • Förster, I.1    Rajewsky, K.2
  • 24
    • 80052643363 scopus 로고    scopus 로고
    • In vitro-derived germinal center B cells differentially generate memory B or plasma cells in vivo
    • Nojima, T. et al. In vitro-derived germinal center B cells differentially generate memory B or plasma cells in vivo. Nat. Commun. 2, 465 (2011).
    • (2011) Nat. Commun. , vol.2 , pp. 465
    • Nojima, T.1
  • 25
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors and stress
    • Sengupta, S., Peterson, T. R. & Sabatini, D. M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors and stress. Mol. Cell 40, 310-322 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 26
    • 0347695988 scopus 로고    scopus 로고
    • Phosphorylation by glycogen synthase kinase 3 controls c-Myc proteolysis and subnuclear localization
    • Gregory, M. A., Qi, Y. & Hann, S. R. Phosphorylation by glycogen synthase kinase 3 controls c-Myc proteolysis and subnuclear localization. J. Biol. Chem. 278, 51606-51612 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 51606-51612
    • Gregory, M.A.1    Qi, Y.2    Hann, S.R.3
  • 27
    • 84865114403 scopus 로고    scopus 로고
    • Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis
    • Sander, S. et al. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell 22, 167-179 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 167-179
    • Sander, S.1
  • 29
    • 84862818143 scopus 로고    scopus 로고
    • Mitochondria-ROS cross-talk in the control of cell death and aging
    • Marchi, S. et al. Mitochondria-ROS cross-talk in the control of cell death and aging. J. Signal Transduct. 2012, 329635 (2012).
    • (2012) J. Signal Transduct. , vol.2012 , pp. 329635
    • Marchi, S.1
  • 30
    • 84986575883 scopus 로고    scopus 로고
    • Germinal center hypoxia and regulation of antibody qualities by a hypoxia response system
    • Cho, S. H. et al. Germinal center hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537, 234-238 (2016).
    • (2016) Nature , vol.537 , pp. 234-238
    • Cho, S.H.1
  • 31
    • 84994472525 scopus 로고    scopus 로고
    • Germinal center hypoxia potentiates immunoglobulin class switch recombination
    • Abbott, R. K. et al. Germinal center hypoxia potentiates immunoglobulin class switch recombination. J. Immunol. 197, 4014-4020 (2016).
    • (2016) J. Immunol. , vol.197 , pp. 4014-4020
    • Abbott, R.K.1
  • 32
    • 84898606445 scopus 로고    scopus 로고
    • Metabolic reprogramming is required for antibody production that is suppressed in anergic, but exaggerated in, chronically BAFF-exposed B cells
    • Caro-Maldonado, A. et al. Metabolic reprogramming is required for antibody production that is suppressed in anergic, but exaggerated in, chronically BAFF-exposed B cells. J. Immunol. 192, 3626-3636 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 3626-3636
    • Caro-Maldonado, A.1
  • 33
  • 34
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of c-MYC activity
    • Zhang, H. et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of c-MYC activity. Cancer Cell 11, 407-420 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1
  • 35
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki, K. et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-968 (2006).
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1
  • 36
    • 84940602638 scopus 로고    scopus 로고
    • Combined regulation of mTORC1 and lysosomal acidification by GSK3 suppresses autophagy and contributes to cancer cell growth
    • Azoulay-Alfaguter, I., Elya, R., Avrahami, L., Katz, A. & Eldar-Finkelman, H. Combined regulation of mTORC1 and lysosomal acidification by GSK3 suppresses autophagy and contributes to cancer cell growth. Oncogene 34, 4613-4623 (2015).
    • (2015) Oncogene , vol.34 , pp. 4613-4623
    • Azoulay-Alfaguter, I.1    Elya, R.2    Avrahami, L.3    Katz, A.4    Eldar-Finkelman, H.5
  • 37
    • 84940416372 scopus 로고    scopus 로고
    • GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signaling
    • Stretton, C. et al. GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signaling. Biochem. J. 470, 207-221 (2015).
    • (2015) Biochem. J. , vol.470 , pp. 207-221
    • Stretton, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.