메뉴 건너뛰기




Volumn 13, Issue 11, 2012, Pages 1083-1091

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PROTEIN BCL 6;

EID: 84867709361     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2428     Document Type: Article
Times cited : (379)

References (58)
  • 1
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen, C.D., Okada, T. & Cyster, J.G. Germinal-center organization and cellular dynamics. Immunity 27, 190-202 (2007).
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1    Okada, T.2    Cyster, J.G.3
  • 4
    • 84866320759 scopus 로고    scopus 로고
    • Identification of human germinal center light and dark zone cells and their relationship to human B cell lymphomas
    • published online, doi:10.1182/blood-2012-03-415380 (26 June)
    • Victora, G.D. et al. Identification of human germinal center light and dark zone cells and their relationship to human B cell lymphomas. Blood (published online, doi:10.1182/blood-2012-03-415380 (26 June 2012)).
    • (2012) Blood
    • Victora, G.D.1
  • 5
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen, C.D., Okada, T., Tang, H.L. & Cyster, J.G. Imaging of germinal center selection events during affinity maturation. Science 315, 528-531 (2007).
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 6
    • 78149477766 scopus 로고    scopus 로고
    • Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
    • Victora, G.D. et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143, 592-605 (2010).
    • (2010) Cell , vol.143 , pp. 592-605
    • Victora, G.D.1
  • 7
    • 0031154831 scopus 로고    scopus 로고
    • Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts
    • Oprea, M. & Perelson, A.S. Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts. J. Immunol. 158, 5155-5162 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 5155-5162
    • Oprea, M.1    Perelson, A.S.2
  • 8
    • 0034802541 scopus 로고    scopus 로고
    • Signatures of the immune response
    • Shaffer, A.L. et al. Signatures of the immune response. Immunity 15, 375-385 (2001).
    • (2001) Immunity , vol.15 , pp. 375-385
    • Shaffer, A.L.1
  • 9
    • 0344953578 scopus 로고    scopus 로고
    • Transcriptional analysis of the B cell germinal center reaction
    • Klein, U. et al. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA 100, 2639-2644 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2639-2644
    • Klein, U.1
  • 10
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    • Dent, A.L., Shaffer, A.L., Yu, X., Allman, D. & Staudt, L.M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276, 589-592 (1997).
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 11
    • 17144439800 scopus 로고    scopus 로고
    • The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    • Ye, B.H. et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 16, 161-170 (1997).
    • (1997) Nat. Genet. , vol.16 , pp. 161-170
    • Ye, B.H.1
  • 12
    • 0029967024 scopus 로고    scopus 로고
    • B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
    • Schubart, D.B., Rolink, A., Kosco-Vilbois, M.H., Botteri, F. & Matthias, P. B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature 383, 538-542 (1996).
    • (1996) Nature , vol.383 , pp. 538-542
    • Schubart, D.B.1    Rolink, A.2    Kosco-Vilbois, M.H.3    Botteri, F.4    Matthias, P.5
  • 13
    • 84859715609 scopus 로고    scopus 로고
    • Roles of BCL6 in normal and transformed germinal center B cells
    • Basso, K. & Dalla-Favera, R. Roles of BCL6 in normal and transformed germinal center B cells. Immunol. Rev. 247, 172-183 (2012).
    • (2012) Immunol. Rev. , vol.247 , pp. 172-183
    • Basso, K.1    Dalla-Favera, R.2
  • 14
    • 77649222742 scopus 로고    scopus 로고
    • Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells
    • Basso, K. et al. Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood 115, 975-984 (2010).
    • (2010) Blood , vol.115 , pp. 975-984
    • Basso, K.1
  • 15
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang, C.V. MYC on the path to cancer. Cell 149, 22-35 (2012).
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 16
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers, M. & Eisenman, R.N. Myc's broad reach. Genes Dev. 22, 2755-2766 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 18
    • 67049097382 scopus 로고    scopus 로고
    • The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL
    • Ci, W. et al. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood 113, 5536-5548 (2009).
    • (2009) Blood , vol.113 , pp. 5536-5548
    • Ci, W.1
  • 19
    • 80054093403 scopus 로고    scopus 로고
    • Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC
    • Nahar, R. et al. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood 118, 4174-4178 (2011).
    • (2011) Blood , vol.118 , pp. 4174-4178
    • Nahar, R.1
  • 20
    • 42249101428 scopus 로고    scopus 로고
    • Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse
    • Huang, C.Y., Bredemeyer, A.L., Walker, L.M., Bassing, C.H. & Sleckman, B.P. Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur. J. Immunol. 38, 342-349 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 342-349
    • Huang, C.Y.1    Bredemeyer, A.L.2    Walker, L.M.3    Bassing, C.H.4    Sleckman, B.P.5
  • 21
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • Jacob, J. & Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176, 679-687 (1992).
    • (1992) J. Exp. Med. , vol.176 , pp. 679-687
    • Jacob, J.1    Kelsoe, G.2
  • 22
    • 79958255209 scopus 로고    scopus 로고
    • A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center
    • Schwickert, T.A. et al. A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J. Exp. Med. 208, 1243-1252 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1243-1252
    • Schwickert, T.A.1
  • 23
    • 0032479526 scopus 로고    scopus 로고
    • Visualization of specific B and T lymphocyte interactions in the lymph node
    • Garside, P. et al. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281, 96-99 (1998).
    • (1998) Science , vol.281 , pp. 96-99
    • Garside, P.1
  • 24
    • 0036228846 scopus 로고    scopus 로고
    • Role of antigen receptor affinity in T cell-independent antibody responses in vivo
    • Shih, T.A., Roederer, M. & Nussenzweig, M.C. Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat. Immunol. 3, 399-406 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 399-406
    • Shih, T.A.1    Roederer, M.2    Nussenzweig, M.C.3
  • 25
    • 0036073140 scopus 로고    scopus 로고
    • Role of BCR affinity in T cell dependent antibody responses in vivo
    • Shih, T.A., Meffre, E., Roederer, M. & Nussenzweig, M.C. Role of BCR affinity in T cell dependent antibody responses in vivo. Nat. Immunol. 3, 570-575 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 570-575
    • Shih, T.A.1    Meffre, E.2    Roederer, M.3    Nussenzweig, M.C.4
  • 26
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano, M. et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34, 961-972 (2011).
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1
  • 27
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 28
    • 0034628560 scopus 로고    scopus 로고
    • How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
    • Glynne, R. et al. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis. Nature 403, 672-676 (2000).
    • (2000) Nature , vol.403 , pp. 672-676
    • Glynne, R.1
  • 29
    • 0026746043 scopus 로고
    • Inducible cell contact signals regulate early activation gene expression during B-T lymphocyte collaboration
    • Klaus, S.J. & Parker, D.C Inducible cell contact signals regulate early activation gene expression during B-T lymphocyte collaboration. J. Immunol. 149, 1867-1875 (1992).
    • (1992) J. Immunol. , vol.149 , pp. 1867-1875
    • Klaus, S.J.1    Parker, D.C.2
  • 30
    • 0021888368 scopus 로고
    • Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice
    • Cumano, A. & Rajewsky, K. Structure of primary anti-(4-hydroxy-3- nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice. Eur. J. Immunol. 15, 512-520 (1985).
    • (1985) Eur. J. Immunol. , vol.15 , pp. 512-520
    • Cumano, A.1    Rajewsky, K.2
  • 31
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of the antibody repertoire in the mouse
    • Rajewsky, K., Forster, I. & Cumano, A. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238, 1088-1094 (1987).
    • (1987) Science , vol.238 , pp. 1088-1094
    • Rajewsky, K.1    Forster, I.2    Cumano, A.3
  • 32
    • 0035942781 scopus 로고    scopus 로고
    • B cells acquire antigen from target cells after synapse formation
    • Batista, F.D., Iber, D. & Neuberger, M.S. B cells acquire antigen from target cells after synapse formation. Nature 411, 489-494 (2001).
    • (2001) Nature , vol.411 , pp. 489-494
    • Batista, F.D.1    Iber, D.2    Neuberger, M.S.3
  • 33
    • 65349144269 scopus 로고    scopus 로고
    • Timing and tuning of CD27-CD70 interactions: The impact of signal strength in setting the balance between adaptive responses and immunopathology
    • Nolte, M.A., van Olffen, R.W., van Gisbergen, K.P. & van Lier, R.A. Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol. Rev. 229, 216-231 (2009).
    • (2009) Immunol. Rev. , vol.229 , pp. 216-231
    • Nolte, M.A.1    Van Olffen, R.W.2    Van Gisbergen, K.P.3    Van Lier, R.A.4
  • 34
    • 18844364782 scopus 로고    scopus 로고
    • CD27 and CD70 in T cell and B cell activation
    • Borst, J., Hendriks, J. & Xiao, Y. CD27 and CD70 in T cell and B cell activation. Curr. Opin. Immunol. 17, 275-281 (2005).
    • (2005) Curr. Opin. Immunol. , vol.17 , pp. 275-281
    • Borst, J.1    Hendriks, J.2    Xiao, Y.3
  • 35
    • 34250877785 scopus 로고    scopus 로고
    • In vivo imaging studies shed light on germinal-centre development
    • Hauser, A.E., Shlomchik, M.J. & Haberman, A.M. In vivo imaging studies shed light on germinal-centre development. Nat. Rev. Immunol. 7, 499-504 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 499-504
    • Hauser, A.E.1    Shlomchik, M.J.2    Haberman, A.M.3
  • 36
    • 0032511987 scopus 로고    scopus 로고
    • Design and properties of a Myc derivative that efficiently homodimerizes
    • Soucek, L. et al. Design and properties of a Myc derivative that efficiently homodimerizes. Oncogene 17, 2463-2472 (1998).
    • (1998) Oncogene , vol.17 , pp. 2463-2472
    • Soucek, L.1
  • 37
    • 53349103292 scopus 로고    scopus 로고
    • Modelling Myc inhibition as a cancer therapy
    • Soucek, L. et al. Modelling Myc inhibition as a cancer therapy. Nature 455, 679-683 (2008).
    • (2008) Nature , vol.455 , pp. 679-683
    • Soucek, L.1
  • 38
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin, K.Y. et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436, 1048-1052 (2005).
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1
  • 39
    • 79960623998 scopus 로고    scopus 로고
    • The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy
    • Savino, M. et al. The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. PLoS ONE 6, e22284 (2011).
    • (2011) PLoS ONE , vol.6
    • Savino, M.1
  • 40
    • 79952696452 scopus 로고    scopus 로고
    • A rapid and scalable system for studying gene function in mice using conditional RNA interference
    • Premsrirut, P.K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145-158 (2011).
    • (2011) Cell , vol.145 , pp. 145-158
    • Premsrirut, P.K.1
  • 41
    • 0030791583 scopus 로고    scopus 로고
    • C-myc proto-oncogene expression by germinal center B cells isolated from human tonsils
    • Cutrona, G. et al. c-myc proto-oncogene expression by germinal center B cells isolated from human tonsils. Ann. NY Acad. Sci. 815, 436-439 (1997).
    • (1997) Ann. NY Acad. Sci. , vol.815 , pp. 436-439
    • Cutrona, G.1
  • 42
    • 0029917123 scopus 로고    scopus 로고
    • Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2
    • Martinez-Valdez, H. et al. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J. Exp. Med. 183, 971-977 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 971-977
    • Martinez-Valdez, H.1
  • 43
    • 84858706847 scopus 로고    scopus 로고
    • Molecular mechanisms that control the expression and activity of Bcl-6 in T(H)1 cells to regulate flexibility with a TFH-like gene profile
    • Oestreich, K.J., Mohn, S.E. & Weinmann, A.S. Molecular mechanisms that control the expression and activity of Bcl-6 in T(H)1 cells to regulate flexibility with a TFH-like gene profile. Nat. Immunol. 13, 405-411 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 405-411
    • Oestreich, K.J.1    Mohn, S.E.2    Weinmann, A.S.3
  • 44
    • 84867730760 scopus 로고    scopus 로고
    • The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
    • doi:10/1038.ni2418 (this issue)
    • Calado, D.P. et al. The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat. Immunol. doi:10/1038.ni2418 (this issue).
    • Nat. Immunol.
    • Calado, D.P.1
  • 45
    • 77951920690 scopus 로고    scopus 로고
    • C-Myc regulates transcriptional pause release
    • Rahl, P.B. et al. c-Myc regulates transcriptional pause release. Cell 141, 432-445 (2010).
    • (2010) Cell , vol.141 , pp. 432-445
    • Rahl, P.B.1
  • 46
    • 77957239251 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
    • Pavri, R. et al. Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 143, 122-133 (2010).
    • (2010) Cell , vol.143 , pp. 122-133
    • Pavri, R.1
  • 47
    • 0036898253 scopus 로고    scopus 로고
    • Acetylation inactivates the transcriptional repressor BCL6
    • Bereshchenko, O.R., Gu, W. & Dalla-Favera, R. Acetylation inactivates the transcriptional repressor BCL6. Nat. Genet. 32, 606-613 (2002).
    • (2002) Nat. Genet. , vol.32 , pp. 606-613
    • Bereshchenko, O.R.1    Gu, W.2    Dalla-Favera, R.3
  • 48
    • 33750502877 scopus 로고    scopus 로고
    • High affinity germinal center B cells are actively selected into the plasma cell compartment
    • Phan, T.G. et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 203, 2419-2424 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2419-2424
    • Phan, T.G.1
  • 49
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Küppers, R. Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 5, 251-262 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 251-262
    • Küppers, R.1
  • 50
    • 77950955761 scopus 로고    scopus 로고
    • Origin of chromosomal translocations in lymphoid cancer
    • Nussenzweig, A. & Nussenzweig, M.C. Origin of chromosomal translocations in lymphoid cancer. Cell 141, 27-38 (2010).
    • (2010) Cell , vol.141 , pp. 27-38
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 51
    • 0027460507 scopus 로고
    • Quantitative analysis of molecules which distinguish functional compartments within germinal centers
    • Hardie, D.L., Johnson, G.D., Khan, M. & MacLennan, I.C. Quantitative analysis of molecules which distinguish functional compartments within germinal centers. Eur. J. Immunol. 23, 997-1004 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 997-1004
    • Hardie, D.L.1    Johnson, G.D.2    Khan, M.3    MacLennan, I.C.4
  • 52
    • 33646596305 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells
    • Cattoretti, G. et al. Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells. Blood 107, 3967-3975 (2006).
    • (2006) Blood , vol.107 , pp. 3967-3975
    • Cattoretti, G.1
  • 53
    • 0033818104 scopus 로고    scopus 로고
    • A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells
    • Guo, M. et al. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum. Immunol. 61, 729-738 (2000).
    • (2000) Hum. Immunol. , vol.61 , pp. 729-738
    • Guo, M.1
  • 54
    • 0029009977 scopus 로고
    • The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    • Jiang, W. et al. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375, 151-155 (1995).
    • (1995) Nature , vol.375 , pp. 151-155
    • Jiang, W.1
  • 55
    • 50249133616 scopus 로고    scopus 로고
    • Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
    • Gurel, B. et al. Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis. Mod. Pathol. 21, 1156-1167 (2008).
    • (2008) Mod. Pathol. , vol.21 , pp. 1156-1167
    • Gurel, B.1
  • 56
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • Phan, R.T. & Dalla-Favera, R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature 432, 635-639 (2004).
    • (2004) Nature , vol.432 , pp. 635-639
    • Phan, R.T.1    Dalla-Favera, R.2
  • 58
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • Klein, U. et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J. Exp. Med. 194, 1625-1638 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1625-1638
    • Klein, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.