An L- to D-amino acid conversion in an endosomolytic analog of the cell-penetrating peptide TAT influences proteolytic stability, endocytic uptake, and endosomal escape

Journal of Biological Chemistry

Volumn 292, Issue 3, 2017, Pages 847-861

  Najjar, Kristina ^a   Erazo Oliveras, Alfredo ^a   Brock, Dakota J ^a   Wang, Ting Yi ^a   Pellois, Jean Philippe ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHIRALITY; CYTOLOGY; ENZYME ACTIVITY;

ANTI-PROLIFERATIVE ACTIVITIES; CELL PENETRATING PEPTIDES (CPPS); CELL-PENETRATING PEPTIDE; CELLULAR UPTAKE; ENDOSOMAL ESCAPES; INTRACELLULAR PROCESS; PROTEOLYTIC DEGRADATION; PROTEOLYTIC STABILITY;

PEPTIDES;

AMINO ACID; CRE RECOMBINASE; DEXTRO AMINO ACID; LEVO AMINO ACID; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; CELL PENETRATING PEPTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL ACTIVITY; CELL FUNCTION; CELL PROLIFERATION; CELLULAR PENETRATION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CHIRALITY; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOMAL ESCAPE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRACELLULAR ACTIVITY; MOLECULAR BIOLOGY; PROTEASE RESISTANCE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; CHEMISTRY; ENDOSOME; HELA CELL LINE; METABOLISM; MOLECULAR MODEL;

AMINO ACIDS; CELL-PENETRATING PEPTIDES; ENDOSOMES; HELA CELLS; HUMANS; MODELS, MOLECULAR;

EID: 85010447475     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.759837     Document Type: Article

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