The Late Endosome and Its Lipid BMP Act as Gateways for Efficient Cytosolic Access of the Delivery Agent dfTAT and Its Macromolecular Cargos

Cell Chemical Biology

Volumn 23, Issue 5, 2016, Pages 598-607

  Erazo Oliveras, Alfredo ^a   Najjar, Kristina ^a   Truong, Dat ^a   Wang, Ting Yi ^a   Brock, Dakota J ^a   Prater, Austin R ^a   Pellois, Jean Philippe ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

cellular delivery; endosomal escape; figubis(monoacylglycero)phosphate; late endosomes; membrane leakage

Indexed keywords

BIS(MONOACYLGLYCERO)PHOSPHATE; CALCEIN; CELL PENETRATING PEPTIDE; DISULFIDE BOND FLUOROPHORE TETRAMETHYLRHODAMINE; LIPOSOME; PHOSPHOLIPID DERIVATIVE; TETRAMETHYLRHODAMINE; UNCLASSIFIED DRUG; BIS(MONOACYLGLYCERYL)PHOSPHATE; LIPID; LYSOPHOSPHOLIPID; MACROMOLECULE; MONOACYLGLYCEROL;

ARTICLE; CELL LYSATE; CELL MATURATION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DISULFIDE BOND; ENDOCYTOSIS; ENDOSOME; EXPERIMENTAL STUDY; FLUORESCENCE MICROSCOPY; GEL FILTRATION; GENETIC TRANSFECTION; IN VITRO STUDY; LATE ENDOSOME; LIPID COMPOSITION; LYSOSOME; MACROMOLECULE; MICELLE; PHOSPHOLIPID BILAYER; PHOTON CORRELATION SPECTROSCOPY; PROTEIN LIPID INTERACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TRANS GOLGI NETWORK; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; METABOLISM;

CELL-PENETRATING PEPTIDES; CYTOSOL; DRUG DELIVERY SYSTEMS; ENDOSOMES; HUMANS; LIPIDS; LYSOPHOSPHOLIPIDS; MACROMOLECULAR SUBSTANCES; MONOGLYCERIDES;

EID: 84975063117     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.03.016     Document Type: Article

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