Novel genetic loci associated with hippocampal volume

Nature Communications

Volumn 8, Issue , 2017, Pages

  Hibar, Derrek P ^a   Adams, Hieab H H ^b   Jahanshad, Neda ^a   Chauhan, Ganesh ^c   Stein, Jason L ^a,d   Hofer, Edith ^e   Renteria, Miguel E ^f   Bis, Joshua C ^g   Arias Vasquez, Alejandro ^h,i   Ikram, M Kamran ^b,j,k,l,m   Desrivières, Sylvane ⁿ   Vernooij, Meike W ^b   Abramovic, Lucija ^o   Alhusaini, Saud ^p,q   Amin, Najaf ^b   Andersson, Micael ^r   Arfanakis, Konstantinos ^s,t,u   Aribisala, Benjamin S ^v,w   Armstrong, Nicola J ^x,y   Athanasiu, Lavinia ^z,aa   Axelsson, Tomas ^ab   Beecham, Ashley H ^ac   Beiser, Alexa ^ad,ae,af   Bernard, Manon ^ag   Blanton, Susan H ^ac   Bohlken, Marc M ^o   Boks, Marco P ^o   Bralten, Janita ^h,i   Brickman, Adam M ^ah   Carmichael, Owen ^ai   Chakravarty, M Mallar ^aj,ak   Chen, Qiang ^al   Ching, Christopher R K ^a,am   Chouraki, Vincent ^ad,af,an   Cuellar Partida, Gabriel ^f   Crivello, Fabrice ^c   Den Braber, Anouk ^ao   Doan, Nhat Trung ^z   Ehrlich, Stefan ^ap,aq   Giddaluru, Sudheer ^ar,as   Goldman, Aaron L ^al   Gottesman, Rebecca F ^at   Grimm, Oliver ^au   Griswold, Michael E ^av   Guadalupe, Tulio ^aw,ax   Gutman, Boris A ^a   Hass, Johanna ^ay   Haukvik, Unn K ^z,az   Hoehn, David ^ba   Holmes, Avram J ^aq,bb   Hoogman, Martine ^h,i   Janowitz, Deborah ^bc   Jia, Tianye ⁿ   Jørgensen, Kjetil N ^z,az   Karbalai, Nazanin ^ba   Kasperaviciute, Dalia ^bd,be   Kim, Sungeun ^bf   Klein, Marieke ^h,i   Kraemer, Bernd ^au   Lee, Phil H ^aq,bg,bh   Liewald, David C M ^v   Lopez, Lorna M ^v   Luciano, Michelle ^v   MacAre, Christine ⁿ   Marquand, Andre F ^i,bi   Matarin, Mar ^bd,bj   Mather, Karen A ^x   Mattheisen, Manuel ^bk,bl   McKay, David R ^bm,bn   Milaneschi, Yuri ^bo   Muñoz Maniega, Susana ^v   Nho, Kwangsik ^bf   Nugent, Allison C ^bp   Nyquist, Paul ^bq   Loohuis, Loes M Olde ^br   Oosterlaan, Jaap ^bs   Papmeyer, Martina ^v,bt   Pirpamer, Lukas ^e   Pütz, Benno ^ba   Ramasamy, Adaikalavan ^n,bj,bu   Richards, Jennifer S ^h,i,bv   Risacher, Shannon L ^bf   Roiz Santiañez, Roberto ^bw,bx   Rommelse, Nanda ^h,i,bv   Ropele, Stefan ^e   Rose, Emma J ^by   Royle, Natalie A ^v,bz   Rundek, Tatjana ^ac   Sämann, Philipp G ^ba   Saremi, Arvin ^a   Satizabal, Claudia L ^ad,af   Schmaal, Lianne ^bo,ca,cb   Schork, Andrew J ^cc,cd   Shen, Li ^bf   Shin, Jean ^ag   Shumskaya, Elena ^h,i,bi   Smith, Albert V ^ce,cf   Sprooten, Emma ^bm,bn,cg   Strike, Lachlan T ^f,ch   Teumer, Alexander ^bc   Tordesillas Gutierrez, Diana ^bx,ci   Toro, Roberto ^cj   Trabzuni, Daniah ^bj,ck   Trompet, Stella ^cl   Vaidya, Dhananjay ^at   Van Der Grond, Jeroen ^cl   Van Der Lee, Sven J ^b   Van Der Meer, Dennis ^cm   Van Donkelaar, Marjolein M J ^h,i   Van Eijk, Kristel R ^o   Van Erp, Theo G M ^cn   Van Rooij, Daan ^h,i,cm   Walton, Esther ^ap,co   Westlye, Lars T ^aa,co   Whelan, Christopher D ^a,q   Windham, Beverly G ^z   Winkler, Anderson M ^bm,cp   Wittfeld, Katharina ^bc,cq   Woldehawariat, Girma ^bp   Wolf, Christiane ^cr   Wolfers, Thomas ^h,i   Yanek, Lisa R ^at   Yang, Jingyun ^t,cs   Zijdenbos, Alex ^u   Zwiers, Marcel P ^i,bi   Agartz, Ingrid ^z,az,ct   Almasy, Laura ^cu,cv,cw   Ames, David ^cx,cy   Amouyel, Philippe ^an   Andreassen, Ole A ^z,aa   Arepalli, Sampath ^cz   Assareh, Amelia A ^x   Barral, Sandra ^ah   Bastin, Mark E ^v,bz   Becker, Diane M ^at   Becker, James T ^da   Bennett, David A ^t,cs   Blangero, John ^cu   Van Bokhoven, Hans ^h,i   Boomsma, Dorret I ^ao   Brodaty, Henry ^x,db   Brouwer, Rachel M ^o   Brunner, Han G ^h,i,x   Buckner, Randy L ^aq,dc   Buitelaar, Jan K ^h,i,bv   Bulayeva, Kazima B ^dd   Cahn, Wiepke ^o   Calhoun, Vince D ^de,df   Cannon, Dara M ^bp,dg   Cavalleri, Gianpiero L ^q   Cheng, Ching Yu ^j,k,dh   Cichon, Sven ^di,dj,dk   Cookson, Mark R ^cz   Corvin, Aiden ^by   Crespo Facorro, Benedicto ^bw,bx   Curran, Joanne E ^cu   Czisch, Michael ^ba   Dale, Anders M ^dl,dm   Davies, Gareth E ^dm   De Craen, Anton J M ^dn   De Geus, Eco J C ^ao   De Jager, Philip L ^bg,bh,cl,do   De Zubicaray, Greig I ^bh   Deary, Ian J ^v   Debette, Stéphanie ^c,ad,dp   Decarli, Charles ^dq   Delanty, Norman ^q,dr   Depondt, Chantal ^ds   Destefano, Anita ^ae,af   Dillman, Allissa ^cz   Djurovic, Srdjan ^ar,dt   Donohoe, Gary ^aa,dh   Drevets, Wayne C ^bp,by   Duggirala, Ravi ^cu   Dyer, Thomas D ^cu   Enzinger, Christian ^e   Erk, Susanne ^du   Espeseth, Thomas ^aa,co   Fedko, Iryna O ^ao   Fernández, Guillén ^h,i   Ferrucci, Luigi ^dv   Fisher, Simon E ^i,aw   Fleischman, Debra A ^t,da   Ford, Ian ^u   Fornage, Myriam ^dw   Foroud, Tatiana M ^bf,dx   Fox, Peter T ^bf   Francks, Clyde ^i,aw   Fukunaga, Masaki ^dy   Gibbs, J Raphael ^bj,cz   Glahn, David C ^bm,bn   Gollub, Randy L ^aq,bg   Göring, Harald H H ^cu   Green, Robert C ^bg,dz   Gruber, Oliver ^au   Gudnason, Vilmundur ^ce,cf   Guelfi, Sebastian ^bj   Håberg, Asta K ^do,ea   Hansell, Narelle K ^f,ch   Hardy, John ^bj   Hartman, Catharina A ^cm   Hashimoto, Ryota ^eb,ec   Hegenscheid, Katrin ^ed   Heinz, Andreas ^du   Le Hellard, Stephanie ^ar,as   Hernandez, Dena G ^bc,bj,ce   Heslenfeld, Dirk J ^cr   Ho, Beng Choon ^bs   Hoekstra, Pieter J ^cm   Hoffmann, Wolfgang ^bc,cq   Hofman, Albert ^ef   Holsboer, Florian ^ba,ee   Homuth, Georg ^ef   Hosten, Norbert ^ed   Hottenga, Jouke Jan ^ao   Huentelman, Matthew ^eg   Pol, Hilleke E Hulshoff ^o   Ikeda, Masashi ^bc   Jack, Clifford R ^eh   Jenkinson, Mark ^cp   Johnson, Robert ^ei   Jönsson, Erik G ^z,ct   Jukema, J Wouter ^cl   Kahn, René S ^o   Kanai, Ryota ^ej,ek,el   Kloszewska, Iwona ^em   Knopman, David S ^en   Kochunov, Peter ^eo   Kwok, John B ^ej,ep   Lawrie, Stephen M ^v   Lemaître, Hervé ^eq   Liu, Xinmin ^bp,er   Longo, Dan L ^es   Lopez, Oscar L ^et   Lovestone, Simon ^da,db   Martinez, Oliver ^dq   Martinot, Jean Luc ^eq   Mattay, Venkata S ^al,at,cq   McDonald, Colm ^dg   McIntosh, Andrew M ^v   McMahon, Francis J ^bp   McMahon, Katie L ^at   Mecocci, Patrizia ^ch   Melle, Ingrid ^z,aa   Meyer Lindenberg, Andreas ^au   Mohnke, Sebastian ^du   Montgomery, Grant W ^f   Morris, Derek W ^aa   Mosley, Thomas H ^z   Mühleisen, Thomas W ^dj,dk   Müller Myhsok, Bertram ^ba,eu,ev   Nalls, Michael A ^cz   Nauck, Matthias ^bc,ew   Nichols, Thomas E ^cp,ex   Niessen, Wiro J ^b,ey   Nöthen, Markus M ^dj,ez   Nyberg, Lars ^r   Ohi, Kazutaka ^eb   Olvera, Rene L ^bf   Ophoff, Roel A ^o,br   Pandolfo, Massimo ^ds   Paus, Tomas ^dk,fa   Pausova, Zdenka ^ag,fb   Penninx, Brenda W J H ^bo   Pike, G Bruce ^fa,fc   Potkin, Steven G ^cn   Psaty, Bruce M ^fc   Reppermund, Simone ^x,fd   Rietschel, Marcella ^au   Roffman, Joshua L ^aq   Romanczuk Seiferth, Nina ^du   Rotter, Jerome I ^er   Ryten, Mina ^n,bj   Sacco, Ralph L ^ac,fe   Sachdev, Perminder S ^x,ac   Saykin, Andrew J ^bf,dx   Schmidt, Reinhold ^e   Schmidt, Helena ^ff   Schofield, Peter R ^ej,ep   Sigursson, Sigurdur ^ce   Simmons, Andrew ^e,n   Singleton, Andrew ^cz   Sisodiya, Sanjay M ^bd   Smith, Colin ^fg   Smoller, Jordan W ^aq,bg,bh   Soininen, Hilkka ^bz,fh   Steen, Vidar M ^ar,as   Stott, David J ^fi   Sussmann, Jessika E ^v   Thalamuthu, Anbupalam ^x   Toga, Arthur W ^dw   Traynor, Bryan J ^cz   Troncoso, Juan ^a   Tsolaki, Magda ^at   Tzourio, Christophe ^c,fj   Uitterlinden, Andre G ^b,c   Hernández, Maria C Valdés ^v,bz   Van Der Brug, Marcel ^b   Van Der Lugt, Aad ^b   Van Der Wee, Nic J A ^fk   Van Haren, Neeltje E M ^o   Van 'T Ent, Dennis ^ao   Van Tol, Marie Jose ^cl   Vardarajan, Badri N ^ah   Vellas, Bruno ^cm   Veltman, Dick J ^bo   Völzke, Henry ^bc   Walter, Henrik ^du   Wardlaw, Joanna M ^v,bz   Wassink, Thomas H ^fl   Weale, Michael E ⁿ   Weinberger, Daniel R ^al,ee   Weiner, Michael W ^at   Wen, Wei ^x,ac   Westman, Eric ^fm   White, Tonya ^b,cu   Wong, Tien Y ^j,k,dh   Wright, Clinton B ^ac,fe   Zielke, Ronald H ^ei   Zonderman, Alan B ^fn   Martin, Nicholas G ^f   Van Duijn, Cornelia M ^b   Wright, Margaret J ^at,ch   Longstreth, W T ^da   Schumann, Gunter ⁿ   Grabe, Hans J ^bc   Franke, Barbara ^h,i   Launer, Lenore J ^fd   Medland, Sarah E ^f   Seshadri, Sudha ^ad,af   Thompson, Paul M ^a   Ikram, M Arfan ^b,da   more..

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^h RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ RADBOUD UNIVERSITY   (Netherlands)

^j Academy of Medicine Singapore   (Singapore)

^k SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^l NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^m NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

ⁿ KING'S COLLEGE LONDON   (United Kingdom)

^o UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^p MCGILL UNIVERSITY   (Canada)

^q ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^r UMEÅ UNIVERSITY   (Sweden)

^s Illinois Institute of Technology   (United States)

^t RUSH UNIVERSITY MEDICAL CENTER   (United States)

^u RUSH UNIVERSITY MEDICAL CENTER   (United States)

^v UNIVERSITY OF EDINBURGH   (United Kingdom)

^w LAGOS STATE UNIVERSITY   (Nigeria)

^x UNIVERSITY OF NEW SOUTH WALES   (Australia)

^y MURDOCH UNIVERSITY   (Australia)

^z UNIVERSITY OF OSLO   (Norway)

^aa OSLO UNIVERSITY HOSPITAL   (Norway)

^ab UPPSALA UNIVERSITY   (Sweden)

^ac UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^ad BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ae BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^af FRAMINGHAM HEART STUDY   (United States)

^ag HOSPITAL FOR SICK CHILDREN   (Canada)

^ah Department of Epidemiology   (United States)

^ai PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^aj DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^ak MCGILL UNIVERSITY   (Canada)

^al LIEBER INSTITUTE FOR BRAIN DEVELOPMENT   (United States)

^am UNIVERSITY OF CALIFORNIA   (United States)

^an UNIV LILLE   (France)

^ao VU University   (Netherlands)

^ap DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^aq MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ar UNIVERSITY OF BERGEN   (Norway)

^as HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^at JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^au UNIVERSITY OF HEIDELBERG   (Germany)

^av UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^aw MAX PLANCK INSTITUTE FOR PSYCHOLINGUISTICS   (Netherlands)

^ax Radboud University Nijmegen and International Max Planck Research School for Language Sciences   (Netherlands)

^ay DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^az DIAKONHJEMMET HOSPITAL   (Norway)

^ba MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^bb YALE UNIVERSITY   (United States)

^bc UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^bd EPILEPSY SOCIETY   (United Kingdom)

^be IMPERIAL COLLEGE LONDON   (United Kingdom)

^bf INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bg HARVARD MEDICAL SCHOOL   (United States)

^bh BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^bi RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^bj UNIVERSITY COLLEGE LONDON   (United Kingdom)

^bk AARHUS UNIVERSITY   (Denmark)

^bl H LUNDBECK A S   (Denmark)

^bm YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bn Olin Neuropsychiatric Research Center   (United States)

^bo VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^bp NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^bq JOHNS HOPKINS UNIVERSITY   (United States)

^br UNIVERSITY OF CALIFORNIA   (United States)

^bs VU UNIVERSITY AMSTERDAM   (Netherlands)

^bt UNIVERSITY OF BERN   (Switzerland)

^bu UNIVERSITY OF OXFORD   (United Kingdom)

^bv RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^bw HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^bx CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^by TRINITY COLLEGE DUBLIN   (Ireland)

^bz UNIVERSITY OF EDINBURGH   (United Kingdom)

^ca THE NATIONAL CENTRE OF EXCELLENCE IN YOUTH MENTAL HEALTH   (Australia)

^cb UNIVERSITY OF MELBOURNE   (Australia)

^cc UNIVERSITY OF CALIFORNIA   (United States)

^cd UNIVERSITY OF CALIFORNIA   (United States)

^ce ICELANDIC HEART ASSOCIATION   (Iceland)

^cf UNIVERSITY OF ICELAND   (Iceland)

^cg MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ch UNIVERSITY OF QUEENSLAND   (Australia)

^ci Biomedical Research Institute (IDIVAL)   (Spain)

^cj INSTITUT PASTEUR   (France)

^ck KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^cl LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^cm UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^cn UNIVERSITY OF CALIFORNIA   (United States)

^co GEORGIA STATE UNIVERSITY   (United States)

^cp UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^cq UNIVERSITY OF OXFORD   (United Kingdom)

^cr GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^cs UNIVERSITY OF WÜRZBURG   (Germany)

^ct INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^cu KAROLINSKA INSTITUTE   (Sweden)

^cv One West University Blvd   (United States)

^cw UNIVERSITY OF PENNSYLVANIA   (United States)

^cx CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^cy ROYAL MELBOURNE HOSPITAL   (Australia)

^cz UNIVERSITY OF MELBOURNE   (Australia)

^da NATIONAL INSTITUTE ON AGING   (United States)

^db UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^dc MAASTRICHT UNIVERSITY   (Netherlands)

^dd HARVARD UNIVERSITY   (United States)

^de DAGESTAN STATE UNIVERSITY   (Russian Federation)

^df MIND RESEARCH NETWORK   (United States)

^dg UNIVERSITY OF NEW MEXICO   (United States)

^dh NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^di NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^dj UNIVERSITY OF BASEL   (Switzerland)

^dk UNIVERSITY OF BONN   (Germany)

^dl FORSCHUNGSZENTRUM JÜLICH   (Germany)

^dm UNIVERSITY OF CALIFORNIA   (United States)

^dn Avera Health   (United States)

^do BRIGHAM AND WOMEN S HOSPITAL   (United States)

^dp QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^dq BORDEAUX UNIVERSITY HOSPITAL   (France)

^dr UNIVERSITY OF CALIFORNIA   (United States)

^ds BEAUMONT HOSPITAL   (Ireland)

^dt ERASME HOSPITAL   (Belgium)

^du JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^dv CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^dw UNIVERSITY OF GLASGOW   (United Kingdom)

^dx UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^dy UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^dz NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^ea NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^eb TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^ec OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^ed OSAKA UNIVERSITY   (Japan)

^ee UNIVERSITY OF IOWA   (United States)

^ef HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^eg HMNC Brain Health   (Germany)

^eh TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^ei FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^ej MAYO CLINIC   (United States)

^ek UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^el UNIVERSITY OF SUSSEX   (United Kingdom)

^em UNIVERSITY COLLEGE LONDON   (United Kingdom)

^en ARAYA INC   (Japan)

^eo MEDICAL UNIVERSITY OF LODZ   (Poland)

^ep MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

^eq NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^er UNIVERSITY OF NEW SOUTH WALES   (Australia)

^es INSERM   (France)

^et New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^eu UNIVERSITY OF PERUGIA   (Italy)

^ev Partner Site Greifswald ^*  (Germany)

^ew UNIVERSITY OF LIVERPOOL   (United Kingdom)

^ex DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^ey UNIVERSITY OF WARWICK   (United Kingdom)

^ez DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^fa UNIVERSITY OF TORONTO   (Canada)

^fb CHILD MIND INSTITUTE   (United States)

^fc UNIVERSITY OF CALGARY   (Canada)

^fd UNIVERSITY OF WASHINGTON   (United States)

^fe HARBOR UCLA MEDICAL CENTER   (United States)

^ff PRINCE OF WALES HOSPITAL   (Australia)

^fg King's College London   (United Kingdom)

^fh UNIVERSITY OF EASTERN FINLAND   (Finland)

^fi KUOPIO UNIVERSITY HOSPITAL   (Finland)

^fj ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^fk GENENTECH INC   (United States)

^fl UNIVERSITÉ DE TOULOUSE   (France)

^fm UNIVERSITY OF CALIFORNIA   (United States)

^fn SOPHIA CHILDREN S HOSPITAL   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; GENE; GENETIC ANALYSIS; GENETIC VARIATION; GENOME; MENTAL HEALTH; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; VOLUME;

ALZHEIMER DISEASE; ARTICLE; ASTN2 GENE; BRAIN SIZE; CAUCASIAN; DENTATE GYRUS; DPP4 GENE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC RISK; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HUMAN; MAST4 GENE; MSRB3 GENE; NUCLEAR MAGNETIC RESONANCE IMAGING; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SUBICULUM; ADOLESCENT; ADULT; AGED; CHILD; COHORT ANALYSIS; FEMALE; GENETIC PREDISPOSITION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; META ANALYSIS; MIDDLE AGED; ORGAN SIZE; PATHOPHYSIOLOGY; VERY ELDERLY; YOUNG ADULT;

ASTN2 PROTEIN, HUMAN; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; GLYCOPROTEIN; MAST4 PROTEIN, HUMAN; METHIONINE SULFOXIDE REDUCTASE; MICROTUBULE ASSOCIATED PROTEIN; MSRB3 PROTEIN, HUMAN; NERVE PROTEIN; PROTEIN SERINE THREONINE KINASE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CHILD; COHORT STUDIES; DIPEPTIDYL PEPTIDASE 4; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GLYCOPROTEINS; HIPPOCAMPUS; HUMANS; MALE; METHIONINE SULFOXIDE REDUCTASES; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; ORGAN SIZE; PROTEIN-SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 85010190069     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13624     Document Type: Article

References (55)

1. Van Paesschen, W. et al. Quantitative hippocampal MRI and intractable temporal lobe epilepsy. Neurology 45, 2233-2240 (1995).
2. Kim, G. H. et al Hippocampal volume and shape in pure subcortical vascular dementia. Neurobiol. Aging 36, 485-491 (2015).
3. Thompson, P. M. et al Mapping hippocampal and ventricular change in Alzheimer disease. NeuroImage 22, 1754-1766 (2004).
4. Schmaal, L. et al Subcortical brain alterations in major depressive disorder: findings from the ENIGMA major depressive disorder working group. Mol Psychiatry 21, 806-812 (2015).
5. Hibar, D. P. et al Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 21, 1710-1716 (2016).
6. van Erp, T. G. et al Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry 21, 547-553 (2015).
7. Smith, M. E. Bilateral hippocampal volume reduction in adults with posttraumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus 15, 798-807 (2005).
8. Bliss, T. V. & Collingridge, G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39 (1993).
9. Maguire, E. A. et al Knowing where and getting there: a human navigation network. Science 280, 921-924 (1998).
10. Vinogradova, O. S. Hippocampus as comparator: role of the two input and two output systems of the hippocampus in selection and registration of information. Hippocampus 11, 578-598 (2001).
11. McEwen, B. S., Eiland, L., Hunter, R. G. & Miller, M. M. Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 62, 3-12 (2012).
12. Coras, R. et al Differential influence of hippocampal subfields to memory formation: insights from patients with temporal lobe epilepsy. Brain 137, 1945-1957 (2014).
13. Newmark, R. E., Schon, K., Ross, R. S. & Stern, C. E. Contributions of the hippocampal subfields and entorhinal cortex to disambiguation during working memory. Hippocampus 23, 467-475 (2013).
14. Navratilova, Z. & Battaglia, F. P. CA2: it's about time-and episodes. Neuron 85, 8-10 (2015).
15. Hitti, F. L. & Siegelbaum, S. A. The hippocampal CA2 region is essential for social memory. Nature 508, 88-92 (2014).
16. McCormick, C, St-Laurent, M., Ty, A., Valiante, T. A. & McAndrews, M. P. Functional and effective hippocampal-neocortical connectivity during construction and elaboration of autobiographical memory retrieval. Cereb. Cortex. 25, 1297-1305 (2015).
17. Strange, B. A., Witter, M. P., Lein, E. S. & Moser, E. I. Functional organization of the hippocampal longitudinal axis. Nat. Rev. Neurosci. 15, 655-669 (2014).
18. Lupien, S. J., McEwen, B. S., Gunnar, M. R. & Heim, C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 10, 434-445 (2009).
19. Renteria, M. E. et al. Genetic architecture of subcortical brain regions: common and region-specific genetic contributions. Genes Brain Behav. 13, 821-830 (2014).
20. Kremen, W. S. et al Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study. NeuroImage 49, 1213-1223 (2010).
21. den Braber, A. et al Heritability of subcortical brain measures: a perspective for future genome-wide association studies. NeuroImage 83, 98-102 (2013).
22. Hibar, D. P. et al Common genetic variants influence human subcortical brain structures. Nature 520, 224-229 (2015).
23. Stein, J. L. et al Identification of common variants associated with human hippocampal and intracranial volumes. Nat. Genet. 44, 552-561 (2012).
24. Bis, J. C. et al Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat. Genet. 44, 545 (2012).
25. Bulik-Sullivan, B. K. et al LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 47, 291-295 (2015).
26. Finucane, H. K. et al Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228-1235 (2015).
27. Bulik-Sullivan, B. et al An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
28. Wilson, P. M., Fryer, R. H., Fang, Y. & Astn2, Hatten M. E. a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration. J. Neurosci. 30, 8529-8540 (2010).
29. Lionel A. C., et al. Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes. Hum. Mol. Genet. 23, 2752-2768 (2014).
30. Freilinger, T. et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat. Genet. 44, 777-U205 (2012).
31. Pratley, R. E. & Salsali, A. Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes. Curr. Med. Res. Opin. 23, 919-931 (2007).
32. Pratley, R. E., Jauffret-Kamel, S., Galbreath, E. & Holmes, D. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm. Metab. Res. 38, 423-428 (2006).
33. Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427 (2014).
34. Dessaud, E., McMahon, A. P. & Briscoe, J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135, 2489-2503 (2008).
35. Ramasamy, A. et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat. Neurosci. 17, 1418-1428 (2014).
36. Shrestha, S. et al. A genome-wide association study of carotid atherosclerosis in HIV-infected men. AIDS 24, 583-592 (2010).
37. Martins-de-Souza, D. et al. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. J. Proteome. Res. 11, 2533-2543 (2012).
38. Garcia-Verdugo, J. M. et al. The proliferative ventricular zone in adult vertebrates: a comparative study using reptiles, birds, and mammals. Brain Res. Bull. 57, 765-775 (2002).
39. Apostolova, L. G. et al. Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps. Arch. Neurol. 63, 693-699 (2006).
40. Mueller, S. G. & Weiner, M. W. Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields. Hippocampus 19, 558-564 (2009).
41. Huang, Y. et al. Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study. Biol. Psychiatry 74, 62-68 (2013).
42. Haukvik, U. K. et al. In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder. Biol. Psychiatry 77, 581-588 (2015).
43. Schoene-Bake, J. C. et al. In vivo mapping of hippocampal subfields in mesial temporal lobe epilepsy: relation to histopathology. Hum. Brain Mapp. 35, 4718-4728 (2014).
44. Erickson, K. I. et al. Exercise training increases size of hippocampus and improves memory. Proc. Natl Acad. Sci. USA 108, 3017-3022 (2011).
45. Styner, M., Lieberman, J. A., Pantazis, D. & Gerig, G. Boundary and medial shape analysis of the hippocampus in schizophrenia. Med. Image Anal. 8, 197-203 (2004).
46. Maller, J. J. et al. Hippocampal volumetrics in treatment-resistant depression and schizophrenia: the devil's in de-tail. Hippocampus 22, 9-16 (2012).
47. Patenaude, B., Smith, S. M., Kennedy, D. N. & Jenkinson, M. A Bayesian model of shape and appearance for subcortical brain segmentation. NeuroImage 56, 907-922 (2011).
48. Fischl, B. et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341-355 (2002).
49. WillerLi, C. J. & Abecasis, Y. GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190-2191 (2010).
50. Lambert, J. C. et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 45, 1452-1458 (2013).
51. Li, M. X., Gui, H. S., Kwan, J. S. & Sham, P. C. GATES: a rapid and powerful gene-based association test using extended Simes procedure. Am. J. Hum. Genet. 88, 283-293 (2011).
52. Li, M. X., Kwan, J. S. & Sham, P. C. HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis. Am. J. Hum. Genet. 91, 478-488 (2012).
53. Roadmap Epigenomics, C. et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317-330 (2015).
54. Iglesias, J. E. et al. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI. NeuroImage 115, 117-137 (2015).
55. Cuellar-Partida, G., Renteria, M. E. & MacGregor, S. LocusTrack: integrated visualization of GWAS results and genomic annotation. Source Code Biol. Med. 10, 1 (2015).