Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography

Molecular Immunology

Volumn 83, Issue , 2017, Pages 92-99

  Obmolova, Galina ^a   Teplyakov, Alexey ^a   Malia, Thomas J ^a   Wunderler, Nicole ^a   Kwok, Deborah ^a   Barone, Linda ^a   Sweet, Raymond ^a   Ort, Tatiana ^a   Scully, Michael ^a   Gilliland, Gary L ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Antibody; CD27; Crystal structure; Epitope; Mechanism

Indexed keywords

ANTIBODY; CD27 ANTIGEN; EPITOPE; I KAPPA B; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; CD70 ANTIGEN; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG CLEARANCE; FEMALE; HUMAN; HUMAN CELL; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTIBODY AFFINITY; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; HALF LIFE TIME; IMMUNOLOGY; MACACA FASCICULARIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; ANTIGENS, CD27; ANTIGENS, CD70; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; HALF-LIFE; HUMANS; MACACA FASCICULARIS; MICE;

EID: 85009973175     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2017.01.005     Document Type: Article

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