Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 3, 2012, Pages 298-305

  Makino, Fumihiko ^a   Ito, Jun ^a   Abe, Yoshiyuki ^a   Harada, Norihiro ^a   Kamachi, Fumitaka ^a   Yagita, Hideo ^a   Takahashi, Kazuhisa ^a   Okumura, Ko ^a   Akiba, Hisaya ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD27; CD70; Costimulation; Lung inflammation; Th2 development

Indexed keywords

CD27 ANTIGEN; CD70 MONOCLONAL ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MONOCLONAL ANTIBODY; OVALBUMIN; UNCLASSIFIED DRUG;

AEROSOL; ALLERGIC PNEUMONITIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY REACTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; FEMALE; IMMUNIZATION; LUNG LAVAGE; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; TH2 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD27; ANTIGENS, CD70; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HYPERSENSITIVITY; MICE; MICE, INBRED BALB C; PNEUMONIA;

MURINAE; MUS; RATTUS;

EID: 84865816256     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0354OC     Document Type: Article

References (37)

1. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999;17:255-281. (Pubitemid 29241125)
2. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326: 298-304.
3. Hogan SP, Mould A, Kikutani H, Ramsay AJ, Foster PS. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins. J Clin Invest 1997;99:1329-1339. (Pubitemid 27142771)
4. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 1996;183:195-201. (Pubitemid 26028759)
5. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261. (Pubitemid 29004074)
6. Janeway CA Jr, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994;76:275-285. (Pubitemid 24046690)
7. Jenkins MK. The ups and downs of T cell costimulation. Immunity 1994; 1:443-446.
8. Nolte MA, van Olffen RW, van Gisbergen KP, van Lier RA. Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol Rev 2009;229:216-231.
9. Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009;9:271-285.
10. Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, et al. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-κB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-κB-inducing kinase. J Biol Chem 1998; 273:13353-13358. (Pubitemid 28246911)
11. Gravestein LA, Amsen D, Boes M, Calvo CR, Kruisbeek AM, Borst J. The TNF receptor family member CD27 signals to Jun N-terminal kinase via TRAF-2. Eur J Immunol 1998;28:2208-2216. (Pubitemid 28321305)
12. Hintzen RQ, Lens SM, Beckmann MP, Goodwin RG, Lynch D, van Lier RA. Characterization of the human CD27 ligand, a novel member of the TNF gene family. J Immunol 1994;152:1762-1773. (Pubitemid 24075708)
13. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997;186:1407-1418. (Pubitemid 27479800)
14. Oshima H, Nakano H, Nohara C, Kobata T, Nakajima A, Jenkins NA, Gilbert DJ, Copeland NG, Muto T, Yagita H, et al. Characterization of murine CD70 by molecular cloning and mAb. Int Immunol 1998;10: 517-526. (Pubitemid 28182109)
15. Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, Matsuda H, Aoki T, Yagita H, Okumura K. Critical contribution of OX40 ligand to T helper cell Type 2 differentiation in experimental leishmaniasis. J Exp Med 2000;191:375-380. (Pubitemid 30060926)
16. Nakajima A, Oshima H, Nohara C, Morimoto S, Yoshino S, Kobata T, Yagita H, Okumura K. Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis. J Neuroimmunol 2000;109:188-196.
17. Manocha M, Rietdijk S, Laouar A, Liao G, Bhan A, Borst J, Terhorst C, Manjunath N. Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis. J Immunol 2009;183:270-276.
18. Oflazoglu E, Boursalian TE, Zeng W, Edwards AC, Duniho S, McEarchern JA, Law CL, Gerber HP, Grewal IS. Blocking of CD27- CD70 pathway by anti-CD70 antibody ameliorates joint disease in murine collagen-induced arthritis. J Immunol 2009;183:3770-3777.
19. Shiroki F, Matsuda S, Doi T, Fujiwara M, Mochizuki Y, Kadowaki T, Suzuki H, Koyasu S. The p85α regulatory subunit of Class IA phosphoinositide 3-kinase regulates β-selection in thymocyte development. J Immunol 2007;178:1349-1356. (Pubitemid 46154604)
20. Nagashima O, Harada N, Usui Y, Yamazaki T, Yagita H, Okumura K, Takahashi K, Akiba H. B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma. J Immunol 2008; 181:4062-4071.
21. Mattes J, Yang M, Siqueira A, Clark K, MacKenzie J, McKenzie AN, Webb DC, Matthaei KI, Foster PS. IL-13 induces airways hyperreactivity independently of the IL-4R α chain in the allergic lung. J Immunol 2001;167:1683-1692. (Pubitemid 32703171)
22. Oyoshi MK, Bryce P, Goya S, Pichavant M, Umetsu DT, Oettgen HC, Tsitsikov EN. TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation. J Immunol 2008;180:1878-1885.
23. Behrendt AK, Hansen G. CD27 costimulation is not critical for the development of asthma and respiratory tolerance in a murine model. Immunol Lett 2010;133:19-27.
24. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I, Kroczek RA. ICOS is an inducible T-cell costimulator structurally and functionally related to CD28. Nature 1999; 397:263-266.
25. Yoshinaga SK, Whoriskey JS, Khare SD, Sarmiento U, Guo J, Horan T, Shih G, Zhang M, Coccia MA, Kohno T, et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature 1999;402:827-832. (Pubitemid 129638129)
26. Hoshino A, Tanaka Y, Akiba H, Asakura Y, Mita Y, Sakurai T, Takaoka A, Nakaike S, Ishii N, Sugamura K, et al. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol 2003;33:861-869. (Pubitemid 36546673)
27. Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, Croft M. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med 2003;198:315-324. (Pubitemid 36987856)
28. Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, Ma J, Tezuka K, Yagita H, Okumura K. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 2005;175: 2340-2348. (Pubitemid 41113843)
29. van Oosterwijk MF, Juwana H, Arens R, Tesselaar K, van Oers MH, Eldering E, van Lier RA. CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development. Int Immunol 2007;19:713-718. (Pubitemid 47078715)
30. Soares H, Waechter H, Glaichenhaus N, Mougneau E, Yagita H,Mizenina O, Dudziak D, Nussenzweig MC, Steinman RM. A subset of dendritic cells induces CD4+ T cells to produce IFN-γ by an IL-12-independent but CD70-dependent mechanism in vivo . J Exp Med 2007;204: 1095-1106. (Pubitemid 46798153)
31. Hashimoto-Okada M, Kitawaki T, Kadowaki N, Iwata S, Morimoto C, Hori T, Uchiyama T. The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4+ T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans. Int Immunol 2009;21:891-904.
32. Wambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. J Allergy Clin Immunol 2012;129:544-551.
33. Laouar A, Haridas V, Vargas D, Zhinan X, Chaplin D, van Lier RA, Manjunath N. CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa. Nat Immunol 2005;6:698-706. (Pubitemid 41716743)
34. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 1995;375:151-155.
35. Nussenzweig MC, Steinman RM, Witmer MD, Gutchinov B. A monoclonal antibody specific for mouse dendritic cells. Proc Natl Acad Sci USA 1982;79:161-165. (Pubitemid 12181506)
36. Hendriks J, Gravestein LA, Tesselaar K, van Lier RA, Schumacher TN, Borst J. CD27 is required for generation and long-term maintenance of T cell immunity. Nat Immunol 2000;1:433-440.
37. Hendriks J, Xiao Y, Borst J. CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. J Exp Med 2003;198:1369-1380. (Pubitemid 37392482)