microRNA-454 shows anti-angiogenic and anti-metastatic activity in pancreatic ductal adenocarcinoma by targeting LRP6

American Journal of Cancer Research

Volumn 7, Issue 1, 2017, Pages 139-147

  Fan, Yue ^a   Shi, Chenye ^a   Li, Tianyu ^a   Kuang, Tiantao ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Angiogenesis; Growth; LRP6; Metastasis; MicroRNA 454; Pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MICRORNA 454; UNCLASSIFIED DRUG; VASCULOTROPIN; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL INVASION; COLONY FORMATION; CONTROLLED STUDY; DRUG TARGETING; G2 PHASE CELL CYCLE CHECKPOINT; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LRP6 GENE; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PROTEIN EXPRESSION; TUMOR INVASION; TUMOR VASCULARIZATION; WNT SIGNALING PATHWAY;

EID: 85009921629     PISSN: None     EISSN: 21566976     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Michl P, Gress TM. Current concepts and novel targets in advanced pancreatic cancer. Gut 2013; 62: 317-326.
2. Popescu AM, Purcaru SO, Alexandru O, Dricu A. New perspectives in glioblastoma antiangiogenic therapy. Contemp Oncol (Pozn) 2016; 20: 109-118.
3. Georgiadou D, Sergentanis TN, Sakellariou S, Filippakis GM, Zagouri F, Vlachodimitropoulos D, Psaltopoulou T, Lazaris AC, Patsouris E, Zografos GC. VEGF and Id-1 in pancreatic adenocarcinoma: prognostic significance and impact on angiogenesis. Eur J Surg Oncol 2014; 40: 1331-1337.
4. Solorzano CC, Baker CH, Bruns CJ, Killion JJ, Ellis LM, Wood J, Fidler IJ. Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother Radiopharm 2001; 16: 359-370.
5. Fukasawa M, Korc M. Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin Cancer Res 2004; 10: 3327-3332.
6. Srivastava S, Tsongalis GJ, Kaur P. Role of microRNAs in regulation of the TNF/TNFR gene superfamily in chronic lymphocytic leukemia. Clin Biochem 2016; 49: 1307-1310.
7. Wang C, Liu P, Wu H, Cui P, Li Y, Liu Y, Liu Z, Gou S. MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3. Oncotarget 2016; 7: 14912-14924.
8. Fan P, Liu L, Yin Y, Zhao Z, Zhang Y, Amponsah PS, Xiao X, Bauer N, Abukiwan A, Nwaeburu CC, Gladkich J, Gao C, Schemmer P, Gross W, Herr I. MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer. Cancer Lett 2016; 373: 130-137.
9. Sun L, Wang Q, Gao X, Shi D, Mi S, Han Q. MicroRNA-454 functions as an oncogene by regulating PTEN in uveal melanoma. FEBS Lett 2015; 589: 2791-2796.
10. Zhu DY, Li XN, Qi Y, Liu DL, Yang Y, Zhao J, Zhang CY, Wu K, Zhao S. MiR-454 promotes the progression of human non-small cell lung cancer and directly targets PTEN. Biomed Pharmacother 2016; 81: 79-85.
11. Fan Y, Xu LL, Shi CY, Wei W, Wang DS, Cai DF. MicroRNA-454 regulates stromal cell derived factor-1 in the control of the growth of pancreatic ductal adenocarcinoma. Sci Rep 2016; 6: 22793.
12. Tang XD, Zhou X, Zhou KY. Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1alpha protein accumulation and vascular endothelial growth factor expression in human breast cancer cells. Acta Pharmacol Sin 2009; 30: 605-616.
13. Duan Y, Wu X, Zhao Q, Gao J, Huo D, Liu X, Ye Z, Dong X, Fu Z, Shang Y, Xuan C. DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1. Oncotarget 2016; 7: 69674-69687.
14. Anderson M, Marayati R, Moffitt R, Yeh JJ. Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer. Oncotarget 2016; [Epub ahead of print].
15. Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V. CD44 functions in Wnt signaling by regulating LRP6 localization and activation. Cell Death Differ 2015; 22: 677-689.
16. Nielsen SR, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakai T, Sakai K, Kim YS, Engle D, Campbell F, Palmer D, Ko JH, Tuveson DA, Hirsch E, Mielgo A, Schmid MC. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol 2016; 18: 549-560.
17. Miyake M, Hori S, Morizawa Y, Tatsumi Y, Nakai Y, Anai S, Torimoto K, Aoki K, Tanaka N, Shimada K, Konishi N, Toritsuka M, Kishimoto T, Rosser CJ, Fujimoto K. CXCL1-mediated interaction of cancer cells with tumor-associated macrophages and cancer-associated fibro blasts promotes tumor progression in human bladder cancer. Neoplasia 2016; 18: 636-646.
18. He T, Qi F, Jia L, Wang S, Wang C, Song N, Fu Y, Li L, Luo Y. Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p. Cancer Lett 2015; 368: 115-125.
19. Cao Z, Ding BS, Guo P, Lee SB, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Rafii A, Scandura JM, Rafii S. Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell 2014; 25: 350-365.
20. Ren DN, Chen J, Li Z, Yan H, Yin Y, Wo D, Zhang J, Ao L, Chen B, Ito TK, Chen Y, Liu Z, Li Y, Yang J, Lu X, Peng Y, Pan L, Zhao Y, Liu S, Zhu W. LRP5/6 directly bind to frizzled and prevent frizzled-regulated tumour metastasis. Nat Commun 2015; 6: 6906.
21. Wen Q, Zhao J, Bai L, Wang T, Zhang H, Ma Q. miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6. Oncol Rep 2015; 34: 2202-2210.
22. Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. Calcipotriol targets LRP6 to inhibit Wnt signaling in pancreatic cancer. Mol Cancer Res 2015; 13: 1509-1519
23. Niu G, Li B, Sun J, Sun L. miR-454 is down-regulated in osteosarcomas and suppresses cell proliferation and invasion by directly targeting c-Met. Cell Prolif 2015; 48: 348-355.
24. Wang L, Bai YY, Yang Y, Hu F, Wang Y, Yu Z, Cheng Z. Diabetes mellitus stimulates pancreatic cancer growth and epithelial-mesenchymal transition-mediated metastasis via a p38 MAPK pathway. Oncotarget 2016; 7: 38539-38550.