Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

Nature Cell Biology

Volumn 18, Issue 5, 2016, Pages 549-560

  Nielsen, Sebastian R ^a   Quaranta, Valeria ^a   Linford, Andrea ^a   Emeagi, Perpetua ^a   Rainer, Carolyn ^a   Santos, Almudena ^a   Ireland, Lucy ^a   Sakai, Takao ^a   Sakai, Keiko ^a   Kim, Yong Sam ^b,c   Engle, Dannielle ^d,e   Campbell, Fiona ^a   Palmer, Daniel ^a   Ko, Jeong Heon ^c   Tuveson, David A ^d,e,f   Hirsch, Emilio ^g   Mielgo, Ainhoa ^a   Schmid, Michael C ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

^d Simons Center for Quantitative Biology   (United States)

^e Lustgarten Foundation Pancreatic Cancer Laboratory at Cold Spring Harbor   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULIN; GROWTH FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; GRANULIN PRECURSOR PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER FIBROSIS; LIVER METASTASIS; MACROPHAGE; METASTASIS ASSOCIATED MACROPHAGE; MONOCYTE; MOUSE; MYOFIBROBLAST; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STELLATE CELL; TUMOR GROWTH; ADENOCARCINOMA; ANIMAL; CELL PROLIFERATION; HEPATIC STELLATE CELL; INFLAMMATION; LIVER CIRRHOSIS; LIVER TUMOR; METABOLISM; METASTASIS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; SECONDARY; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL PROLIFERATION; HEPATIC STELLATE CELLS; HUMANS; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MACROPHAGES; MICE; MONOCYTES; MYOFIBROBLASTS; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS;

EID: 84964329471     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3340     Document Type: Article

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