NLRC4 Inflammasome Is an Important Regulator of Interleukin-18 Levels in Patients with Acute Coronary Syndromes: Genome-Wide Association Study in the PLATelet inhibition and patient Outcomes Trial (PLATO)

Circulation: Cardiovascular Genetics

Volumn 8, Issue 3, 2015, Pages 498-506

  Johansson, Asa ^a,b   Eriksson, Niclas ^a   Becker, Richard C ^f   Storey, Robert F ^g   Himmelmann, Anders ^h   Hagström, Emil ^a,c,i   Varenhorst, Christoph ^a,c   Axelsson, Tomas ^d   Barratt, Bryan J ^j   James, Stefan K ^a,c   Katus, Hugo A ^k   Steg, Philippe Gabriel ^l,m,n,o   Syvänen, Ann Christine ^d   Wallentin, Lars ^a,c   Siegbahn, Agneta ^a,e  

^a UPPSALA CLINICAL RESEARCH CENTER   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Department of Medical Sciences Cardiology   (Sweden)

^d SCIENCE FOR LIFE LABORATORY   (Sweden)

^e UPPSALA UNIVERSITY   (Sweden)

^f UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER   (United States)

^g UNIVERSITY OF SHEFFIELD   (United Kingdom)

^h ASTRAZENECA R AND D   (Sweden)

ⁱ DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^j ASTRAZENECA   (United Kingdom)

^k UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^l INSERM   (France)

^m BICHAT HOSPITAL   (France)

ⁿ UNIVERSITÉ PARIS DESCARTES   (France)

^o ROYAL BROMPTON HOSPITAL   (United Kingdom)

more..

Author keywords

acute coronary syndrome; genome wide association study; interleukins

Indexed keywords

ANTILIPEMIC AGENT; CASPASE RECRUITMENT DOMAIN 16; CASPASE RECRUITMENT DOMAIN 17; CASPASE RECRUITMENT DOMAIN 18; CLOPIDOGREL; INFLAMMASOME; INTERLEUKIN 18; MROH6 PROTEIN; NLRC4 PROTEIN; RAD17 PROTEIN; TICAGRELOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; GENETIC MARKER; NLRC4 PROTEIN, HUMAN;

ACUTE CORONARY SYNDROME; ARTICLE; BINDING SITE; BLOOD SAMPLING; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 2; CHROMOSOME 5; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; COHORT ANALYSIS; GENETIC MARKER; GENETICS; METABOLISM; PATHOLOGY;

ACUTE CORONARY SYNDROME; CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; COHORT STUDIES; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84936950463     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.114.000724     Document Type: Article

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