Determinants of Platelet Activation in Human Essential Hypertension

Hypertension

Volumn 43, Issue 1, 2004, Pages 64-70

  Minuz, Pietro ^a,c,d   Patrignani, Paola ^b   Gaino, Stefania ^a   Seta, Francesca ^b   Capone, Marta L ^b   Tacconelli, Stefania ^b   Degan, Maurizio ^a   Faccini, Giovanni ^a   Fornasiero, Anna ^a   Talamini, Giorgio ^a   Tommasoli, Rosamaria ^a   Arosio, Enrico ^a   Santonastaso, Clara Lechi ^a   Lechi, Alessandro ^a   Patrono, Carlo ^b,c  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d Medicina Interna C   (Italy)

Author keywords

Hypertension, essential; Oxidative stress; Platelets; Thromboxanes; Urine

Indexed keywords

11 OXOTHROMBOXANE B2; 8 ISOPROSTAGLANDIN F2 ALPHA; ALPHA TOCOPHEROL; ANTITHROMBOCYTIC AGENT; ASCORBIC ACID; FIBRINOGEN; HOMOCYSTEINE;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; ESSENTIAL HYPERTENSION; FEMALE; FIBRINOGEN BLOOD LEVEL; HUMAN; HYPERTENSION RETINOPATHY; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; URINARY EXCRETION; VASCULAR LESION; VITAMIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; DINOPROST; F2-ISOPROSTANES; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OXIDATIVE STRESS; PLATELET ACTIVATION; THROMBOXANE B2;

EID: 9144242591     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000105109.44620.1B     Document Type: Article

References (34)

1. 2α. Hypertension. 1999;33:424-428.
2. Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension. 1999;33:1353-1358.
3. Zalba G, Beaumont FJ, San Jose G, Fortuno A, Fortuno MA, Etayo JC, Diez J. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension. 2000;35:1055-1061.
4. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 1998;97:2222-2229.
5. Solzbach U, Hornig B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation. 1997;96:1513-1519.
6. Guzik TJ, West NE, Black E, McDonald D, Ratnatunga C, Pillai R, Channon KM. Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors. Circ Res. 2000;86:e85-e90.
7. 2α is increased in hypercholesterolemia. Arterioscler Thromb Vasc Biol. 1997;17:3230-3235.
8. Davi G, Di Minno G, Coppola A, Andria G, Cerbone AM, Madonna P, Tufano A, Falco A, Marchesani P, Ciabattoni G, Patrono C. Oxidative stress and platelet activation in homozygous homocystinuria. Circulation. 2001;104:1124-1128.
9. Davi G, Guagnano MT, Ciabattoni G, Basili S, Falco A, Marinopiccoli M, Nutini M, Sensi S, Patrono C. Platelet activation in obese women: role of inflammation and oxidant stress. JAMA. 2002;288:2008-2014.
10. 2α and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation. 1999;99:224-229.
11. Patrono C, FitzGerald GA. Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arterioscler Thromb Vasc Biol. 1997;17:2309-2315.
12. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation. 1995;91:1981-1987.
13. 1999 World Health Organization-International Society of Hypertension guidelines for the management of hypertension. Guidelines Subcommittee. J Hypertens. 1999;17:151-183.
14. Walsh JB. Hypertensive retinopathy: description, classification, and prognosis. Ophthalmology. 1982;89:1127-1131.
15. 2α excretion in man. J Pharmacol Exp Ther. 1995;275:94-100.
16. 2 in human plasma and urine. Biochim Biophys Acta. 1987;918:293-297.
17. Minuz P, Barrow SE, Cockcroft JR, Ritter JM. Prostacyclin and thromboxane biosynthesis in mild essential hypertension. Hypertension. 1990;15:469-474.
18. Minuz P, Patrignani P, Gaino S, Degan M, Menapace L, Tommasoli R, Seta F, Capone ML, Tacconelli S, Palatresi S, Bencini C, Del Vecchio C, Mansueto G, Arosio E, Santonastaso CL, Lechi A, Morganti A, Patrono C. Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. Circulation. 2002;106:2800-2805.
19. 2 synthesis in pregnancy-induced hypertension. Lancet. 1990;335:751-754.
20. Davi G, Gresele P, Violi F, Basili S, Catalano M, Giammarresi C, Volpato R, Nenci GG, Ciabattoni G, Patrono C. Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo: evidence derived from the study of peripheral arterial disease. Circulation. 1997;96:69-75.
21. McIntyre M, Bohr DF, Dominiczak AF. Endothelial function in hypertension: the role of superoxide anion. Hypertension 1999;34:539-545.
22. Cracowski JL, Baguet JP, Ormezzano O, Bessard J, Stanke-Labesque F, Bessard G, Mallion JM. Lipid peroxidation is not increased in patients with untreated mild-to-moderate hypertension. Hypertension. 2003;41:286-288.
23. Brennan LA, Steinhorn RH, Wedgwood S, Mata-Greenwood E, Roark EA, Russell JA, Black SM. Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res. 2003;92:683-691.
24. Kunsch C, Medford RM. Oxidative stress as a regulator of gene expression in the vasculature. Circ Res. 1999;85:753-766.
25. Sechi LA, Zingaro L, Catena C, Casaccio D, De Marchi S. Relationship of fibrinogen levels and hemostatic abnormalities with organ damage in hypertension. Hypertension. 2000;36:978-985.
26. 2 receptors. J Clin Invest. 1992;90:136-141.
27. 2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol. 1993;264:C1619-C1624.
28. 2α is not mediated by thromboxane receptor isoforms. J Biol Chem. 1996;271:14916-14924.
29. 2α increases platelet adhesion and reduces the antiadhesive and antiaggregatory effects of NO. Arterioscler Thromb Vasc Biol. 1998;18:1248-1256.
30. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042-1050.
31. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest. 1996;98:5-7.
32. Ma J, Hennekens CH, Ridker PM, Stampfer MJ. A prospective study of fibrinogen and risk of myocardial infarction in the Physicians' Health Study. J Am Coll Cardiol. 1999;33:1347-1352.
33. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 2000;101:1767-1772.
34. Engstrom G, Janzon L, Berglund G, Lind P, Stavenow L, Hedblad B, Lindgarde F. Blood pressure increase and incidence of hypertension in relation to inflammation-sensitive plasma proteins. Arterioscler Thromb Vasc Biol. 2002;22:2054-2058.