A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance

Molecular Cell

Volumn 65, Issue 1, 2017, Pages 154-167

  Jeong, Ji Hak ^a   Park, Sun Jin ^a   Dickinson, Shohreh Iravani ^b   Luo, Jun Li ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

advanced prostate cancer; androgen deprivation therapy; castration resistance; castration resistant prostate cancer; constitutively activated inflammatory signaling; Meis2; miR 196b 3p; NF B; PPP3CC; stem cell transcription factors; tumorigenicity

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BIOLOGICAL MARKER; CALCINEURIN; CD49F PROTEIN; CELASTROL; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; MEIS2 PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 196B; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATASE; PHOSPHATASE 3CC; SC 514; STEM CELL ANTIGEN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SOX2; TWIST RELATED PROTEIN 2; UNCLASSIFIED DRUG; ANTIANDROGEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; HOMEODOMAIN PROTEIN; MEIS2 PROTEIN, HUMAN; MIRN196 MICRORNA, HUMAN; MIRN196 MICRORNA, MOUSE; MRG1 PROTEIN, MOUSE; NFKBIA PROTEIN, HUMAN; NFKBIA PROTEIN, MOUSE; PPP3CC PROTEIN, HUMAN; PPP3CC PROTEIN, MOUSE; RAG-1 PROTEIN; RELA PROTEIN, HUMAN; RELA PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STEM CELL; CASTRATION RESISTANT PROSTATE CANCER; COCARCINOGENESIS; CONTROLLED STUDY; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CELL PROLIFERATION; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; INFLAMMATION; METABOLISM; ONCOGENE MYC; PATHOLOGY; PHENOTYPE; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RNA INTERFERENCE; TIME FACTOR; TRANSGENIC MOUSE; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR VOLUME;

ANDROGEN ANTAGONISTS; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CALCINEURIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HOMEODOMAIN PROTEINS; HUMANS; INFLAMMATION; MALE; MICE, TRANSGENIC; MICRORNAS; NEOPLASTIC STEM CELLS; NF-KAPPAB INHIBITOR ALPHA; PHENOTYPE; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR BURDEN; TUMOR CELLS, CULTURED;

EID: 85009444669     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.11.034     Document Type: Article

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