메뉴 건너뛰기




Volumn 795, Issue , 2017, Pages 160-168

Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats

Author keywords

Egr1; MAPKs; Nrf2; PI3K; Sinusoidal obstruction syndrome; TLRs NF B

Indexed keywords

BAICALEIN; EARLY GROWTH RESPONSE FACTOR 1; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCROTALINE; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; QUERCETIN; SERINE PROTEINASE INHIBITOR; THROMBOPLASTIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; EGR1 PROTEIN, RAT; FLAVANONE DERIVATIVE; NFE2L2 PROTEIN, RAT; PROTEIN KINASE B; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR NRF2;

EID: 85008873231     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.12.015     Document Type: Article
Times cited : (44)

References (47)
  • 1
    • 0036964978 scopus 로고    scopus 로고
    • Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations
    • Aljada, A., Ghanim, H., Mohanty, P., Kapur, N., Dandona, P., Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J. Clin. Endocrinol. Metab. 87 (2002), 1419–1422.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1419-1422
    • Aljada, A.1    Ghanim, H.2    Mohanty, P.3    Kapur, N.4    Dandona, P.5
  • 2
    • 0023724778 scopus 로고    scopus 로고
    • IkappaB: a specific inhibitor of the NF-kappaB transcription factor
    • Baeuerle, P.A., Baltimore, D., IkappaB: a specific inhibitor of the NF-kappaB transcription factor. Science 242 (1998), 540–546.
    • (1998) Science , vol.242 , pp. 540-546
    • Baeuerle, P.A.1    Baltimore, D.2
  • 3
    • 0028174061 scopus 로고
    • Function and activation of NF-kappaB in the immune system
    • Baeuerle, P.A., Henkel, T., Function and activation of NF-kappaB in the immune system. Annu. Rev. Immunol. 12 (1994), 141–179.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 4
    • 80052365243 scopus 로고    scopus 로고
    • Role of Toll-like receptors in liver health and disease
    • Broering, R., Lu, M., Schlaak, J.F., Role of Toll-like receptors in liver health and disease. Clin. Sci. 121 (2011), 415–426.
    • (2011) Clin. Sci. , vol.121 , pp. 415-426
    • Broering, R.1    Lu, M.2    Schlaak, J.F.3
  • 5
    • 84874111758 scopus 로고    scopus 로고
    • The Nrf2 cell defence pathway: keap1-dependent and -independent mechanisms of regulation
    • Bryan, H.K., Olayanju, A., Goldring, C.E., Park, B.K., The Nrf2 cell defence pathway: keap1-dependent and -independent mechanisms of regulation. Biochem. Pharmacol. 85 (2013), 705–717.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 705-717
    • Bryan, H.K.1    Olayanju, A.2    Goldring, C.E.3    Park, B.K.4
  • 6
    • 84923093541 scopus 로고    scopus 로고
    • How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation
    • Carreras, E., How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation. Br. J. Haematol. 168 (2015), 481–491.
    • (2015) Br. J. Haematol. , vol.168 , pp. 481-491
    • Carreras, E.1
  • 7
    • 84938683897 scopus 로고    scopus 로고
    • Comparison of the anti-inflammatory active constituents and hepatotoxic pyrrolizidine alkaloids in two Senecio plants and their preparations by LC-UV and LC-MS
    • Chen, P.H., Wang, Y., Chen, L.L., Jiang, W., Niu, Y., Shao, Q., Comparison of the anti-inflammatory active constituents and hepatotoxic pyrrolizidine alkaloids in two Senecio plants and their preparations by LC-UV and LC-MS. J. Pharm. Biomed. 115 (2015), 260–271.
    • (2015) J. Pharm. Biomed. , vol.115 , pp. 260-271
    • Chen, P.H.1    Wang, Y.2    Chen, L.L.3    Jiang, W.4    Niu, Y.5    Shao, Q.6
  • 8
    • 79955917684 scopus 로고    scopus 로고
    • Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum
    • Chen, Z., Huo, J.R., Yang, L., Zhu, H.Y., Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum. J. Gastroenterol. Hepatol. 26 (2011), 1016–1021.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 1016-1021
    • Chen, Z.1    Huo, J.R.2    Yang, L.3    Zhu, H.Y.4
  • 9
    • 0029958822 scopus 로고    scopus 로고
    • Alpha-melanocyte- stimulating hormone reduces endotoxin-induced liver inflammation
    • Chiao, H., Foster, S., Thomas, R., Lipton, J., Star, R.A., Alpha-melanocyte- stimulating hormone reduces endotoxin-induced liver inflammation. J. Clin. Invest. 97 (1996), 2038–2044.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2038-2044
    • Chiao, H.1    Foster, S.2    Thomas, R.3    Lipton, J.4    Star, R.A.5
  • 10
    • 84897381050 scopus 로고    scopus 로고
    • A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats
    • Conotte, R., Colet, J.M., A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats. Toxicol. Appl. Pharmacol. 276 (2014), 147–156.
    • (2014) Toxicol. Appl. Pharmacol. , vol.276 , pp. 147-156
    • Conotte, R.1    Colet, J.M.2
  • 12
    • 34247598767 scopus 로고    scopus 로고
    • Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature
    • Dai, N., Yu, Y.C., Ren, T.H., Wu, J.G., Jiang, Y., Shen, L.G., Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature. World J. Gastroenterol. 13 (2007), 1628–1631.
    • (2007) World J. Gastroenterol. , vol.13 , pp. 1628-1631
    • Dai, N.1    Yu, Y.C.2    Ren, T.H.3    Wu, J.G.4    Jiang, Y.5    Shen, L.G.6
  • 14
    • 0036125693 scopus 로고    scopus 로고
    • Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease)
    • DeLeve, L.D., Shulman, H.M., McDonald, G.B., Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin. Liver Dis. 22 (2002), 27–42.
    • (2002) Semin. Liver Dis. , vol.22 , pp. 27-42
    • DeLeve, L.D.1    Shulman, H.M.2    McDonald, G.B.3
  • 15
    • 0042825692 scopus 로고    scopus 로고
    • Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition
    • Deleve, L.D., Wang, X., Tsai, J., Kanel, G., Strasberg, S., Tokes, Z.A., Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology 125 (2003), 882–890.
    • (2003) Gastroenterology , vol.125 , pp. 882-890
    • Deleve, L.D.1    Wang, X.2    Tsai, J.3    Kanel, G.4    Strasberg, S.5    Tokes, Z.A.6
  • 17
    • 84861972788 scopus 로고    scopus 로고
    • The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats
    • Ezzat, T., van, den, Broek, M.A., Davies, N., Dejong, C.H., Bast, A., Malaqo, M., The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats. J. Surg. Oncol. 106 (2012), 72–78.
    • (2012) J. Surg. Oncol. , vol.106 , pp. 72-78
    • Ezzat, T.1    van, den, Broek, M.A.2    Davies, N.3    Dejong, C.H.4    Bast, A.5    Malaqo, M.6
  • 18
    • 0242363201 scopus 로고    scopus 로고
    • Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury
    • Hanumegowda, U.M., Copple, B.L., Shibuya, M., Malle, E., Ganey, P.E., Roth, R.A., Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury. Toxicol. Sci. 76 (2003), 237–246.
    • (2003) Toxicol. Sci. , vol.76 , pp. 237-246
    • Hanumegowda, U.M.1    Copple, B.L.2    Shibuya, M.3    Malle, E.4    Ganey, P.E.5    Roth, R.A.6
  • 19
    • 33644914519 scopus 로고    scopus 로고
    • Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome
    • Helmy, A., Review article: updates in the pathogenesis and therapy of hepatic sinusoidal obstruction syndrome. Aliment. Pharmacol. Ther. 23 (2006), 11–25.
    • (2006) Aliment. Pharmacol. Ther. , vol.23 , pp. 11-25
    • Helmy, A.1
  • 20
    • 0032819772 scopus 로고    scopus 로고
    • Dietary flavonoids: intake, health effects and bioavailability
    • Hollman, P.C.H., Katan, M.B., Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 37 (1999), 937–942.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 937-942
    • Hollman, P.C.H.1    Katan, M.B.2
  • 21
    • 84873926649 scopus 로고    scopus 로고
    • Hepatoprotective effects of baicalein against CCl(4)-induced acute liver injury in mice
    • Huang, H.L., Wang, Y.J., Zhang, Q.Y., Liu, B., Wang, F.Y., Li, J.J., Hepatoprotective effects of baicalein against CCl(4)-induced acute liver injury in mice. World J. Gastroenterol. 18 (2012), 6605–6613.
    • (2012) World J. Gastroenterol. , vol.18 , pp. 6605-6613
    • Huang, H.L.1    Wang, Y.J.2    Zhang, Q.Y.3    Liu, B.4    Wang, F.Y.5    Li, J.J.6
  • 22
    • 0037387892 scopus 로고    scopus 로고
    • Role of plasminogen activator inhibitor-1 (PAI-1) levels in the diagnosis of BMT-associated hepatic veno-occlusive disease and monitoring of subsequent therapy with defibrotide (DF)
    • Kaleelrahman, M., Eatonm, J.D., Leeming, D., Bowyer, K., Taberner, D., Chang, J., Role of plasminogen activator inhibitor-1 (PAI-1) levels in the diagnosis of BMT-associated hepatic veno-occlusive disease and monitoring of subsequent therapy with defibrotide (DF). Hematology 8 (2003), 91–95.
    • (2003) Hematology , vol.8 , pp. 91-95
    • Kaleelrahman, M.1    Eatonm, J.D.2    Leeming, D.3    Bowyer, K.4    Taberner, D.5    Chang, J.6
  • 23
    • 84911492218 scopus 로고    scopus 로고
    • Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation
    • Keating, G.M., Defibrotide: a review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation. Clin. Drug Investig. 34 (2014), 895–904.
    • (2014) Clin. Drug Investig. , vol.34 , pp. 895-904
    • Keating, G.M.1
  • 24
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: friend and foe
    • Klebanoff, S.J., Myeloperoxidase: friend and foe. J. Leukoc. Biol. 77 (2005), 598–625.
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 598-625
    • Klebanoff, S.J.1
  • 25
    • 18544367609 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide
    • Lee, J.H., Lee, K.H., Lee, J.H., Kim, S., Seol, M., Park, C.J., Plasminogen activator inhibitor-1 is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide. Br. J. Haematol. 118 (2002), 1087–1094.
    • (2002) Br. J. Haematol. , vol.118 , pp. 1087-1094
    • Lee, J.H.1    Lee, K.H.2    Lee, J.H.3    Kim, S.4    Seol, M.5    Park, C.J.6
  • 26
    • 0030429532 scopus 로고    scopus 로고
    • EGR-1, the reluctant suppression factor: EGR-1 is known to function in the regulation of growth, differentiation, and also significant tumor suppressor activity and a mechanism involving the induction of TGF-beta1 is postulated to account for this suppressor activity
    • Liu, C., Calogero, A., Ragona, G., Adamson, E., Mercola, D., EGR-1, the reluctant suppression factor: EGR-1 is known to function in the regulation of growth, differentiation, and also significant tumor suppressor activity and a mechanism involving the induction of TGF-beta1 is postulated to account for this suppressor activity. Crit. Rev. Oncog. 7 (1996), 101–125.
    • (1996) Crit. Rev. Oncog. , vol.7 , pp. 101-125
    • Liu, C.1    Calogero, A.2    Ragona, G.3    Adamson, E.4    Mercola, D.5
  • 27
    • 0017146061 scopus 로고
    • A case of veno-occlusive disease of the liver in Britain associated with herbal tea consumption
    • McGee, J., Patrick, R.S., Wood, C.B., Blumqart, L.H., A case of veno-occlusive disease of the liver in Britain associated with herbal tea consumption. J. Clin. Pathol. 29 (1976), 788–794.
    • (1976) J. Clin. Pathol. , vol.29 , pp. 788-794
    • McGee, J.1    Patrick, R.S.2    Wood, C.B.3    Blumqart, L.H.4
  • 28
    • 0027813823 scopus 로고
    • MAP kinase kinase: a node connecting multiple pathways
    • Mordret, G., MAP kinase kinase: a node connecting multiple pathways. Biol. Cell 79 (1993), 193–207.
    • (1993) Biol. Cell , vol.79 , pp. 193-207
    • Mordret, G.1
  • 29
    • 84867575484 scopus 로고    scopus 로고
    • Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9
    • Nakamura, K., Hatano, E., Narita, M., Miyaqawa-Hayashino, A., Koyama, Y., Naqata, H., Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9. J. Hepatol. 57 (2012), 1037–1043.
    • (2012) J. Hepatol. , vol.57 , pp. 1037-1043
    • Nakamura, K.1    Hatano, E.2    Narita, M.3    Miyaqawa-Hayashino, A.4    Koyama, Y.5    Naqata, H.6
  • 32
    • 80955165973 scopus 로고    scopus 로고
    • Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9
    • Periasamy, S., Hsu, D.Z., Chen, S.Y., Yang, S.S., Chandrasekaran, V.R., Liu, M.Y., Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9. Cell Biochem. Biophys. 61 (2011), 327–336.
    • (2011) Cell Biochem. Biophys. , vol.61 , pp. 327-336
    • Periasamy, S.1    Hsu, D.Z.2    Chen, S.Y.3    Yang, S.S.4    Chandrasekaran, V.R.5    Liu, M.Y.6
  • 33
    • 84880271807 scopus 로고    scopus 로고
    • Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model
    • Robinson, S.M., Mann, J., Vasilaki, A., Mathers, J., Burt, A.D., Oakley, F., Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. J. Hepatol. 59 (2013), 318–326.
    • (2013) J. Hepatol. , vol.59 , pp. 318-326
    • Robinson, S.M.1    Mann, J.2    Vasilaki, A.3    Mathers, J.4    Burt, A.D.5    Oakley, F.6
  • 34
    • 11144354740 scopus 로고    scopus 로고
    • Severe hepatic sinusoidal obstruction associated with oxaliplatin based chemotherapy in patients with metastatic colorectal cancer
    • Rubbia-Brandt, L., Audard, V., Sartoretti, P., Roth, A.D., Brezault, C., Le, Charpentier, M., Severe hepatic sinusoidal obstruction associated with oxaliplatin based chemotherapy in patients with metastatic colorectal cancer. Ann. Oncol. 15 (2004), 460–466.
    • (2004) Ann. Oncol. , vol.15 , pp. 460-466
    • Rubbia-Brandt, L.1    Audard, V.2    Sartoretti, P.3    Roth, A.D.4    Brezault, C.5    Le, Charpentier, M.6
  • 35
    • 84934926046 scopus 로고    scopus 로고
    • Sesquiterpenes, flavonoids, shikimic acid derivatives and pyrrolizidine alkaloids from Senecio kingii Hook
    • Ruiz-Vasquez, L., Reina, M., Lopez-Rodriguez, M., Gimenez, C., Cabrera, R., Cuadra, P., Sesquiterpenes, flavonoids, shikimic acid derivatives and pyrrolizidine alkaloids from Senecio kingii Hook. Phytochemistry 117 (2015), 245–253.
    • (2015) Phytochemistry , vol.117 , pp. 245-253
    • Ruiz-Vasquez, L.1    Reina, M.2    Lopez-Rodriguez, M.3    Gimenez, C.4    Cabrera, R.5    Cuadra, P.6
  • 36
    • 84907470481 scopus 로고    scopus 로고
    • Ant-inflammatory and antioxidant activities of the methanol extract of Gynura segetum leaf
    • Seow, L.J., Beh, H.K., Umar, M.I., Sadikun, A., Asmawi, M.Z., Ant-inflammatory and antioxidant activities of the methanol extract of Gynura segetum leaf. Int. Immunopharm. 23 (2014), 186–191.
    • (2014) Int. Immunopharm. , vol.23 , pp. 186-191
    • Seow, L.J.1    Beh, H.K.2    Umar, M.I.3    Sadikun, A.4    Asmawi, M.Z.5
  • 38
    • 84896269207 scopus 로고    scopus 로고
    • Quercetin attenuates chronic ethanol hepatotoxicity: implication of “free” iron uptake and release
    • Tang, Y., Li, Y., Yu, H., Gao, C., Liu, L., Xing, M., Quercetin attenuates chronic ethanol hepatotoxicity: implication of “free” iron uptake and release. Food Chem. Toxicol. 67 (2014), 131–138.
    • (2014) Food Chem. Toxicol. , vol.67 , pp. 131-138
    • Tang, Y.1    Li, Y.2    Yu, H.3    Gao, C.4    Liu, L.5    Xing, M.6
  • 39
    • 0142043984 scopus 로고    scopus 로고
    • Redox signaling and the MAP kinase pathways
    • Torres, M., Forman, H.J., Redox signaling and the MAP kinase pathways. Biofactors 17 (2003), 287–296.
    • (2003) Biofactors , vol.17 , pp. 287-296
    • Torres, M.1    Forman, H.J.2
  • 40
    • 84867277240 scopus 로고    scopus 로고
    • Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K
    • Troutman, T.D., Bazan, J.F., Pasare, C., Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K. Cell Cycle 11 (2012), 3559–3567.
    • (2012) Cell Cycle , vol.11 , pp. 3559-3567
    • Troutman, T.D.1    Bazan, J.F.2    Pasare, C.3
  • 41
    • 84941801683 scopus 로고    scopus 로고
    • Interplay of inflammation and endothelial dysfunction in bone marrow transplantation: Focus on hepatic veno-occlusive disease
    • Vion, A.C., Rautou, P.E., Durand, F., Boulanger, C.M., Valla, D.C., Interplay of inflammation and endothelial dysfunction in bone marrow transplantation: Focus on hepatic veno-occlusive disease. Semin. Thromb. Hemost. 41 (2015), 629–643.
    • (2015) Semin. Thromb. Hemost. , vol.41 , pp. 629-643
    • Vion, A.C.1    Rautou, P.E.2    Durand, F.3    Boulanger, C.M.4    Valla, D.C.5
  • 42
    • 0242267092 scopus 로고    scopus 로고
    • Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment
    • Wadleigh, M., Ho, V., Momtaz, P., Richardson, P., Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment. Curr. Opin. Hematol. 10 (2003), 451–462.
    • (2003) Curr. Opin. Hematol. , vol.10 , pp. 451-462
    • Wadleigh, M.1    Ho, V.2    Momtaz, P.3    Richardson, P.4
  • 43
    • 84882253698 scopus 로고    scopus 로고
    • Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity
    • Wang, D.W., Huang, L.F., Chen, S.L., Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity. J. Ethnopharmacol. 149 (2013), 1–23.
    • (2013) J. Ethnopharmacol. , vol.149 , pp. 1-23
    • Wang, D.W.1    Huang, L.F.2    Chen, S.L.3
  • 44
    • 84893903102 scopus 로고    scopus 로고
    • Tusanqi and hepatic sinusoidal syndrome
    • Wang, J.Y., Gao, H., Tusanqi and hepatic sinusoidal syndrome. J. Dig. Dis. 15 (2014), 105–107.
    • (2014) J. Dig. Dis. , vol.15 , pp. 105-107
    • Wang, J.Y.1    Gao, H.2
  • 45
    • 84940052159 scopus 로고    scopus 로고
    • Tusanqi-related sinusoidal obstruction syndrome in China: a systematic review of the literatures
    • Wang, X., Qi, X., Guo, X., Tusanqi-related sinusoidal obstruction syndrome in China: a systematic review of the literatures. Medicine, 94, 2015, e942.
    • (2015) Medicine , vol.94 , pp. e942
    • Wang, X.1    Qi, X.2    Guo, X.3
  • 46
    • 50749103437 scopus 로고
    • Senecio disease, or cirrhosis of the liver due to senecio poisoning
    • Willmot, F.C., Robertson, G.W., Senecio disease, or cirrhosis of the liver due to senecio poisoning. Lancet 196 (1920), 848–849.
    • (1920) Lancet , vol.196 , pp. 848-849
    • Willmot, F.C.1    Robertson, G.W.2
  • 47
    • 77649272110 scopus 로고    scopus 로고
    • A systems biology perspective on Nrf2-mediated antioxidant response
    • Zhang, Q., Pi, J.B., Wood, C.G., Andersen, M.E., A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol. Appl. Pharmacol. 244 (2010), 84–97.
    • (2010) Toxicol. Appl. Pharmacol. , vol.244 , pp. 84-97
    • Zhang, Q.1    Pi, J.B.2    Wood, C.G.3    Andersen, M.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.