Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms

Psychopharmacology

Volumn 234, Issue 9-10, 2017, Pages 1511-1523

  Jacobson, Laura H ^a,b   Hoyer, Daniel ^a,b,c   Fehlmann, Dominique ^d   Bettler, Bernhard ^e   Kaupmann, Klemens ^d   Cryan, John F ^f,g  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

^f UNIVERSITY COLLEGE CORK   (Ireland)

^g UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

5 HT1A receptor; 8 OH DPAT; GABAB1 receptor subunit isoforms

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B1A RECEPTOR; 4 AMINOBUTYRIC ACID B1B RECEPTOR; CORTICOSTERONE; CORTICOTROPIN; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; GABA TYPE B RECEPTOR, SUBUNIT 1; ISOPROTEIN; PROTEIN BINDING; SEROTONIN AGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DEPRESSION; FEMALE; FORCED SWIM TEST; GENOTYPE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEROTONINERGIC SYSTEM; ANIMAL; BRAIN; DEFICIENCY; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PSYCHOLOGY;

ANIMALS; ANTIDEPRESSIVE AGENTS; BODY TEMPERATURE; BRAIN; CORTICOSTERONE; DEPRESSION; FEMALE; GABA ANTAGONISTS; MALE; MICE; MICE, KNOCKOUT; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, GABA-B; SEROTONIN RECEPTOR AGONISTS;

EID: 85008601725     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-016-4521-5     Document Type: Article

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