GABAB(1) receptor subunit isoforms differentially regulate stress resilience

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages 15232-15237

  O'Leary, Olivia F ^a,b   Felice, Daniela ^a   Galimberti, Stefano ^a   Savignac, Hélène M ^a,h   Bravo, Javier A ^a,i   Crowley, Tadhg ^a   El Yacoubi, Malika ^c,d   Vaugeois, Jean Marie ^e,f   Gassmann, Martin ^g   Bettler, Bernhard ^g   Dinan, Timothy G ^a,b   Cryan, John F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITÉ LYON 1   (France)

^d LYON NEUROSCIENCE RESEARCH CENTER   (France)

^e UNIVERSITÉ DE ROUEN   (France)

^f Envtl   (France)

^g UNIVERSITY OF BASEL   (Switzerland)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

Author keywords

Antidepressant; Anxiety; Depression; Neurogenesis

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; RECEPTOR SUBUNIT; CORTICOSTERONE; ISOPROTEIN; PROTEIN C FOS;

ADULT; ADULTHOOD; ANHEDONIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DEPRESSION; EARLY LIFE STRESS; FEMALE; HIPPOCAMPUS; MALE; MENTAL STRESS; MOUSE; NONHUMAN; ONCOGENE C FOS; PHENOTYPE; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; RISK FACTOR; SWIMMING; TRANSGENIC MOUSE;

ANHEDONIA; ANIMALS; BEHAVIOR, ANIMAL; CELL PROLIFERATION; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; MICE; MICE, TRANSGENIC; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GABA-B; RISK FACTORS; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 84908081526     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404090111     Document Type: Article

References (41)

1. Feder A, Nestler EJ, Charney DS (2009) Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 10(6):446-457.
2. Russo SJ, Murrough JW, Han MH, Charney DS, Nestler EJ (2012) Neurobiology of resilience. Nat Neurosci 15(11):1475-1484.
3. Cryan JF, Kaupmann K (2005) Don't worry 'B' happy!: A role for GABA(B) receptors in anxiety and depression. Trends Pharmacol Sci 26(1):36-43.
4. Ghose S, Winter MK, McCarson KE, Tamminga CA, Enna SJ (2011) The GABAB receptor as a target for antidepressant drug action. Br J Pharmacol 162(1):1-17.
5. Pilc A, Nowak G (2005) GABAergic hypotheses of anxiety and depression: Focus on GABA-B receptors. Drugs Today (Barc) 41(11):755-766.
6. Gassmann M, Bettler B (2012) Regulation of neuronal GABA(B) receptor functions by subunit composition. Nat Rev Neurosci 13(6):380-394.
7. Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF (2007) Specific roles of GABA (B(1)) receptor isoforms in cognition. Behav Brain Res 181(1):158-162.
8. Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF (2006) GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. J Neurosci 26(34):8800-8803.
9. Vigot R, et al. (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50(4):589-601.
10. Shaban H, et al. (2006) Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nat Neurosci 9(8):1028-1035.
11. Klempan TA, et al. (2009) Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry 14(2):175-189.
12. Levinson AJ, et al. (2010) Evidence of cortical inhibitory deficits in major depressive disorder. Biol Psychiatry 67(5):458-464.
13. Croarkin PE, et al. (2014) Evidence for pretreatment LICI deficits among depressed children and adolescents with nonresponse to fluoxetine. Brain Stimul 7(2):243-251.
14. Mombereau C, et al. (2004) Genetic and pharmacological evidence of a role for GABA (B) receptors in the modulation of anxiety- and antidepressant-like behavior. Neuropsychopharmacology 29(6):1050-1062.
15. Mombereau C, et al. (2005) Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. Neuroreport 16(3):307-310.
16. Felice D, O'Leary OF, Pizzo RC, Cryan JF (2012) Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: Relevance to antidepressant action. Neuropharmacology 63(8):1380-1388.
17. Slattery DA, Desrayaud S, Cryan JF (2005) GABAB receptor antagonist-mediated an-tidepressant- like behavior is serotonin-dependent. J Pharmacol Exp Ther 312(1):290-296.
18. Nowak G, et al. (2006) Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol 149(5):581-590.
19. Henningsen K, et al. (2012) Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression. Behav Pharmacol 23(8):735-743.
20. Jacobson LH, Bettler B, Kaupmann K, Cryan JF (2007) Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology (Berl) 190(4):541-553.
21. O'Mahony CM, Sweeney FF, Daly E, Dinan TG, Cryan JF (2010) Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour. Behav Brain Res 213(2):148-154.
22. Jacobson L, Sapolsky R (1991) The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 12(2):118-134.
23. Brown ES, Rush AJ, McEwen BS (1999) Hippocampal remodeling and damage by corticosteroids: Implications for mood disorders. Neuropsychopharmacology 21(4):474-484.
24. El Yacoubi M, et al. (2003) Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. Proc Natl Acad Sci USA 100(10):6227-6232.
25. Surget A, et al. (2011) Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry 16(12):1177-1188.
26. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011) Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476(7361):458-461.
27. Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10(9):1110-1115.
28. O'Leary OF, O'Connor RM, Cryan JF (2012) Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice. Neuropharmacology 62(1):247-255.
29. Tanti A, Belzung C (2013) Neurogenesis along the septo-temporal axis of the hippocampus: Are depression and the action of antidepressants region-specific? Neuroscience 252:234-252.
30. Bannerman DM, et al. (2004) Regional dissociations within the hippocampus - Memory and anxiety. Neurosci Biobehav Rev 28(3):273-283.
31. Sands SA, Reisman SA, Enna SJ (2004) Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus. Biochem Pharmacol 68(8):1489-1495.
32. Warner-Schmidt JL, Duman RS (2006) Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment. Hippocampus 16(3):239-249.
33. BoldriniM, et al. (2009) Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34(11):2376-2389.
34. B receptors. Development 141(1):83-90.
35. B receptors in reward processes. Adv Pharmacol 58:315-371.
36. Takahashi A, Shimamoto A, Boyson CO, DeBold JF, Miczek KA (2010) GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice. J Neurosci 30(35):11771-11780.
37. Challis C, et al. (2013) Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. J Neurosci 33(35):13978-13988, 13988a.
38. B receptor function in dorsal raphé neurons upon chronic fluoxetine treatment of socially stressed rats. J Neurophysiol 98(1):196-204.
39. B receptors. Proc Natl Acad Sci USA 109(30):12171-12176.
40. Savignac HM, et al. (2011) Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain. Neuroscience 192:524-536.
41. Bravo JA, et al. (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 108(38):16050-16055.