메뉴 건너뛰기




Volumn 89, Issue , 2017, Pages 55-63

Luteinizing hormone acts at the hippocampus to dampen spatial memory

Author keywords

Aging; Alzheimer's disease; Estrogen; Hippocampus; Luteinizing hormone; Spatial memory

Indexed keywords

CHORIONIC GONADOTROPIN; DEGLYCOCHORIONIC GONADOTROPIN; ESTRADIOL; ITURELIX; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; HORMONE ANTAGONIST;

EID: 85008312466     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2016.11.007     Document Type: Article
Times cited : (31)

References (87)
  • 1
    • 0345826101 scopus 로고    scopus 로고
    • Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems
    • Apaja, P.M., Harju, K.T., Aatsinki, J.T., Petäjä-Repo, U.E., Rajaniemi, H.J., Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems. J. Biol. Chem. 279 (2004), 1899–1906, 10.1074/jbc.M311395200.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1899-1906
    • Apaja, P.M.1    Harju, K.T.2    Aatsinki, J.T.3    Petäjä-Repo, U.E.4    Rajaniemi, H.J.5
  • 2
    • 78049506745 scopus 로고    scopus 로고
    • Effect of chronic hCG administration on Alzheimer's-related cognition and Aβ accumulation in PS1KI mice
    • Barron, A.M., Verdile, G., Taddei, K., Bates, K.A., Martins, R.N., Effect of chronic hCG administration on Alzheimer's-related cognition and Aβ accumulation in PS1KI mice. Endocrinology 151 (2010), 5380–5388, 10.1210/en.2009-1168.
    • (2010) Endocrinology , vol.151 , pp. 5380-5388
    • Barron, A.M.1    Verdile, G.2    Taddei, K.3    Bates, K.A.4    Martins, R.N.5
  • 3
    • 43949143493 scopus 로고    scopus 로고
    • Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-β levels in female rats
    • Berry, A., Tomidokoro, Y., Ghiso, J., Thornton, J., Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-β levels in female rats. Horm. Behav. 54 (2008), 143–152, 10.1016/j.yhbeh.2008.02.006.
    • (2008) Horm. Behav. , vol.54 , pp. 143-152
    • Berry, A.1    Tomidokoro, Y.2    Ghiso, J.3    Thornton, J.4
  • 4
    • 84947866256 scopus 로고    scopus 로고
    • Luteinizing hormone: evidence for direct action in the CNS
    • Blair, J.A., Bhatta, S., McGee, H., Casadesus, G., Luteinizing hormone: evidence for direct action in the CNS. Horm. Behav., 2015, 10.1016/j.yhbeh.2015.06.020.
    • (2015) Horm. Behav.
    • Blair, J.A.1    Bhatta, S.2    McGee, H.3    Casadesus, G.4
  • 5
    • 84895768182 scopus 로고    scopus 로고
    • Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women
    • Bove, R., Secor, E., Chibnik, L.B., Barnes, L.L., Schneider, J.A., Bennett, D.A., De Jager, P.L., Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women. Neurology 82 (2014), 222–229, 10.1212/WNL.0000000000000033.
    • (2014) Neurology , vol.82 , pp. 222-229
    • Bove, R.1    Secor, E.2    Chibnik, L.B.3    Barnes, L.L.4    Schneider, J.A.5    Bennett, D.A.6    De Jager, P.L.7
  • 6
    • 0034114486 scopus 로고    scopus 로고
    • An association of elevated serum gonadotropin concentrations and Alzheimer disease?
    • (doi:jne461 [pii)
    • Bowen, R.L., Isley, J.P., Atkinson, R.L., An association of elevated serum gonadotropin concentrations and Alzheimer disease?. J. Neuroendocrinol. 12 (2000), 351–354 (doi:jne461 [pii).
    • (2000) J. Neuroendocrinol. , vol.12 , pp. 351-354
    • Bowen, R.L.1    Isley, J.P.2    Atkinson, R.L.3
  • 7
    • 84921505281 scopus 로고    scopus 로고
    • A clinical study of Lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose Lupron over 48 weeks
    • Bowen, R.L., Perry, G., Xiong, C., Smith, M.A., Atwood, C.S., A clinical study of Lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose Lupron over 48 weeks. J. Alzheimers Dis., 2014, 10.3233/JAD-141626.
    • (2014) J. Alzheimers Dis.
    • Bowen, R.L.1    Perry, G.2    Xiong, C.3    Smith, M.A.4    Atwood, C.S.5
  • 9
    • 2442515246 scopus 로고    scopus 로고
    • Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition
    • Bowen, R.L., Verdile, G., Liu, T., Parlow, A.F., Perry, G., Smith, M.A., Martins, R.N., Atwood, C.S., Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. J. Biol. Chem. 279 (2004), 20539–20545, 10.1074/jbc.M311993200.
    • (2004) J. Biol. Chem. , vol.279 , pp. 20539-20545
    • Bowen, R.L.1    Verdile, G.2    Liu, T.3    Parlow, A.F.4    Perry, G.5    Smith, M.A.6    Martins, R.N.7    Atwood, C.S.8
  • 10
    • 58149416172 scopus 로고
    • Open field behaviour of the rats as a function of age: cross sectional and longitudinal investigations
    • (World Health Organization. 2015. Dementia –341)
    • Bronstein, P.M., Open field behaviour of the rats as a function of age: cross sectional and longitudinal investigations. J. Comp. Physiol. Psychol., 80, 1972 (World Health Organization. 2015. Dementia –341).
    • (1972) J. Comp. Physiol. Psychol. , vol.80
    • Bronstein, P.M.1
  • 11
    • 75149129708 scopus 로고    scopus 로고
    • Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
    • Bryan, K.J., Mudd, J.C., Richardson, S.L., Chang, J., Lee, H.G., Zhu, X., Smith, M.A., Casadesus, G., Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits. J. Neurochem. 112 (2010), 870–881, 10.1111/j.1471-4159.2009.06502.x.
    • (2010) J. Neurochem. , vol.112 , pp. 870-881
    • Bryan, K.J.1    Mudd, J.C.2    Richardson, S.L.3    Chang, J.4    Lee, H.G.5    Zhu, X.6    Smith, M.A.7    Casadesus, G.8
  • 14
    • 33644759357 scopus 로고    scopus 로고
    • Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    • Casadesus, G., Webber, K.M., Atwood, C.S., Pappolla, M.A., Perry, G., Bowen, R.L., Smith, M.A., Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. Biochim. Biophys. Acta 1762 (2006), 447–452, 10.1016/j.bbadis.2006.01.008.
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 447-452
    • Casadesus, G.1    Webber, K.M.2    Atwood, C.S.3    Pappolla, M.A.4    Perry, G.5    Bowen, R.L.6    Smith, M.A.7
  • 15
    • 45549099937 scopus 로고    scopus 로고
    • Hypothalamic control of anterior pituitary function: a history
    • Charlton, H., Hypothalamic control of anterior pituitary function: a history. J. Neuroendocrinol. 20 (2008), 641–646, 10.1111/j.1365-2826.2008.01718.x.
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 641-646
    • Charlton, H.1
  • 16
    • 0020397276 scopus 로고
    • Characterization and biological properties of chemically deglycosylated human chorionic gonadotropin. Role of carbohydrate moieties in adenylate cyclase activation
    • Chen, H.C., Shimohigashi, Y., Dufau, M.L., Catt, K.J., Characterization and biological properties of chemically deglycosylated human chorionic gonadotropin. Role of carbohydrate moieties in adenylate cyclase activation. J. Biol. Chem. 257 (1983), 14446–14452.
    • (1983) J. Biol. Chem. , vol.257 , pp. 14446-14452
    • Chen, H.C.1    Shimohigashi, Y.2    Dufau, M.L.3    Catt, K.J.4
  • 17
    • 38349176267 scopus 로고    scopus 로고
    • A study on co-localization of FSH and its receptor in rat hippocampus
    • Chu, C., Gao, G., Huang, W., A study on co-localization of FSH and its receptor in rat hippocampus. J. Mol. Histol. 39 (2008), 49–55, 10.1007/s10735-007-9125-2.
    • (2008) J. Mol. Histol. , vol.39 , pp. 49-55
    • Chu, C.1    Gao, G.2    Huang, W.3
  • 19
    • 84875269990 scopus 로고    scopus 로고
    • Estrogen synthesis and signaling in pathways during ageing: from periphery to brain
    • Cui, J., Shen, Y., Li, R., Estrogen synthesis and signaling in pathways during ageing: from periphery to brain. Trends Mol. Med. 19 (2013), 197–209.
    • (2013) Trends Mol. Med. , vol.19 , pp. 197-209
    • Cui, J.1    Shen, Y.2    Li, R.3
  • 20
    • 0031916977 scopus 로고    scopus 로고
    • The luteinizing hormone receptor
    • Dufau, M.L., The luteinizing hormone receptor. Annu. Rev. Physiol. 60 (1998), 461–496.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 461-496
    • Dufau, M.L.1
  • 21
    • 0027475456 scopus 로고
    • Deglycosylated human chorionic gonadotropin (hCG) antagonizes hCG stimulation of 3′,5′-cyclic adenosine monophosphate accumulation through a noncompetitive interaction with recombinant human luteinizing hormone receptors
    • Dunkel, L., Jia, X.C., Nishimori, K., Boime, I., Hsueh, A.J., Deglycosylated human chorionic gonadotropin (hCG) antagonizes hCG stimulation of 3′,5′-cyclic adenosine monophosphate accumulation through a noncompetitive interaction with recombinant human luteinizing hormone receptors. Endocrinology 132 (1993), 763–769.
    • (1993) Endocrinology , vol.132 , pp. 763-769
    • Dunkel, L.1    Jia, X.C.2    Nishimori, K.3    Boime, I.4    Hsueh, A.J.5
  • 22
    • 0026440331 scopus 로고
    • Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests
    • Ennaceur, A., Meliani, K., Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests. Psychopharmacology 109 (1992), 321–330, 10.1007/BF02245880.
    • (1992) Psychopharmacology , vol.109 , pp. 321-330
    • Ennaceur, A.1    Meliani, K.2
  • 23
    • 0030977716 scopus 로고    scopus 로고
    • Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix
    • Ennaceur, A., Neave, N., Aggleton, J.P., Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Exp. Brain Res. 113 (1997), 509–519, 10.1007/PL00005603.
    • (1997) Exp. Brain Res. , vol.113 , pp. 509-519
    • Ennaceur, A.1    Neave, N.2    Aggleton, J.P.3
  • 24
    • 77949837819 scopus 로고    scopus 로고
    • Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippoxampal extracellular signal-regulated inase and phosphatidylinositol 3-kinase activation
    • Fan, L., Zhao, Z., Orr, P., Chambers, C., Lewis, M., Frick, K., Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippoxampal extracellular signal-regulated inase and phosphatidylinositol 3-kinase activation. J. Neurosci. 30 (2010), 4390–4400.
    • (2010) J. Neurosci. , vol.30 , pp. 4390-4400
    • Fan, L.1    Zhao, Z.2    Orr, P.3    Chambers, C.4    Lewis, M.5    Frick, K.6
  • 26
    • 0021118043 scopus 로고
    • Structure, expression, and evolution of the genes for the human glycoprotein hormones
    • Fiddes, J.C., Talmadge, K., Structure, expression, and evolution of the genes for the human glycoprotein hormones. Recent Prog. Horm. Res. 40 (1984), 43–78.
    • (1984) Recent Prog. Horm. Res. , vol.40 , pp. 43-78
    • Fiddes, J.C.1    Talmadge, K.2
  • 27
    • 0017188265 scopus 로고
    • Extinction of the estrogen-induced daily signal for LH release in the rat: a role for the proestrous surge of progesterone
    • Freeman, M.C., Dupke, K.C., Croteau, C.M., Extinction of the estrogen-induced daily signal for LH release in the rat: a role for the proestrous surge of progesterone. Endocrinology 99 (1976), 223–229, 10.1210/endo-99-1-223.
    • (1976) Endocrinology , vol.99 , pp. 223-229
    • Freeman, M.C.1    Dupke, K.C.2    Croteau, C.M.3
  • 28
    • 0015257793 scopus 로고
    • Effects of luteinizing hormone on multiple-unit activity in the rat hippocampus
    • Gallo, R.V., Johnson, J.H., Kalra, S.P., Whitmoyer, D.I., Sawyer, C.H., Effects of luteinizing hormone on multiple-unit activity in the rat hippocampus. Neuroendocrinology 9 (1972), 149–157, 10.1159/000122046.
    • (1972) Neuroendocrinology , vol.9 , pp. 149-157
    • Gallo, R.V.1    Johnson, J.H.2    Kalra, S.P.3    Whitmoyer, D.I.4    Sawyer, C.H.5
  • 29
    • 0036095455 scopus 로고    scopus 로고
    • Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women
    • Gill, S., Sharpless, J.L., Rado, K., Hall, J.E., Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women. J. Clin. Endocrinol. Metab. 87 (2002), 2290–2296, 10.1210/jcem.87.5.8508.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 2290-2296
    • Gill, S.1    Sharpless, J.L.2    Rado, K.3    Hall, J.E.4
  • 30
    • 84879077265 scopus 로고    scopus 로고
    • Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
    • Hebert, L.E., Weuve, J., Scherr, P.A., Evans, D.A., Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology 80 (2013), 1778–1783, 10.1212/WNL.0b013e31828726f5.
    • (2013) Neurology , vol.80 , pp. 1778-1783
    • Hebert, L.E.1    Weuve, J.2    Scherr, P.A.3    Evans, D.A.4
  • 31
    • 34247856252 scopus 로고    scopus 로고
    • Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    • Heldt, S.A., Stanek, L., Chhatwal, J.P., Ressler, K.J., Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol. Psychiatry 12 (2007), 656–670, 10.1038/sj.mp.4001957.
    • (2007) Mol. Psychiatry , vol.12 , pp. 656-670
    • Heldt, S.A.1    Stanek, L.2    Chhatwal, J.P.3    Ressler, K.J.4
  • 32
    • 9644267082 scopus 로고    scopus 로고
    • Low free testosterone is an independent risk factor for Alzheimer's disease
    • Hogervorst, E., Bandelow, S., Combrinck, M., Smith, A.D., Low free testosterone is an independent risk factor for Alzheimer's disease. Exp. Gerontol. 39 (2004), 1633–1639, 10.1016/j.exger.2004.06.019.
    • (2004) Exp. Gerontol. , vol.39 , pp. 1633-1639
    • Hogervorst, E.1    Bandelow, S.2    Combrinck, M.3    Smith, A.D.4
  • 34
    • 0028332730 scopus 로고
    • Gonadotropin-releasing hormone and its receptors in rat brain
    • Jennes, L., Conn, P.M., Gonadotropin-releasing hormone and its receptors in rat brain. Front. Neuroendocrinol. 15 (1994), 51–77, 10.1006/frne.1994.1003.
    • (1994) Front. Neuroendocrinol. , vol.15 , pp. 51-77
    • Jennes, L.1    Conn, P.M.2
  • 35
    • 0023628422 scopus 로고
    • The prevalence of dementia: a quantitative integration of the literature
    • Jorm, a.F., Korten, a.E., Henderson, a.S., The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr. Scand. 76 (1987), 465–479, 10.1111/j.1600-0447.1987.tb02906.x.
    • (1987) Acta Psychiatr. Scand. , vol.76 , pp. 465-479
    • Jorm, A.F.1    Korten, A.E.2    Henderson, A.S.3
  • 36
    • 0020683104 scopus 로고
    • Role of carbohydrate in human chorionic gonadotropin. Effect of deglycosylation on the subunit interaction and on its in vitro and in vivo biological properties
    • Kalyan, N.K., Bahl, O.P., Role of carbohydrate in human chorionic gonadotropin. Effect of deglycosylation on the subunit interaction and on its in vitro and in vivo biological properties. J. Biol. Chem. 258 (1983), 67–74.
    • (1983) J. Biol. Chem. , vol.258 , pp. 67-74
    • Kalyan, N.K.1    Bahl, O.P.2
  • 37
    • 0015911884 scopus 로고
    • Sexual differentiation of pituitary function: apparent difference between primates and rodents
    • Karsch, F.J., Dierschke, D.J., Knobil, E., Sexual differentiation of pituitary function: apparent difference between primates and rodents. Science 179:80 (1973), 484–486, 10.1126/science.179.4072.484.
    • (1973) Science , vol.179 , Issue.80 , pp. 484-486
    • Karsch, F.J.1    Dierschke, D.J.2    Knobil, E.3
  • 38
    • 0020564457 scopus 로고
    • Inhibition of implantation and termination of pregnancy in the rat by a human chorionic gonadotropin antagonist
    • Kato, K., Sairam, M.R., Manjunath, P., Inhibition of implantation and termination of pregnancy in the rat by a human chorionic gonadotropin antagonist. Endocrinology 113 (1983), 195–199.
    • (1983) Endocrinology , vol.113 , pp. 195-199
    • Kato, K.1    Sairam, M.R.2    Manjunath, P.3
  • 39
    • 0001510689 scopus 로고
    • Induction of behavioral and electroencephalographic changes in the rabbit by hormone administration or brain stimulation
    • Kawakami, M., Sawyer, C.H., Induction of behavioral and electroencephalographic changes in the rabbit by hormone administration or brain stimulation. Horm. Behav. 65 (1959), 631–643.
    • (1959) Horm. Behav. , vol.65 , pp. 631-643
    • Kawakami, M.1    Sawyer, C.H.2
  • 40
    • 0034979591 scopus 로고    scopus 로고
    • Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions
    • Kessels, R.P.C., de Haan, E.H.F., Kappelle, L.J., Postma, A., Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions. Brain Res. Rev. 35 (2001), 295–303, 10.1016/S0165-0173(01)00058-3.
    • (2001) Brain Res. Rev. , vol.35 , pp. 295-303
    • Kessels, R.P.C.1    de Haan, E.H.F.2    Kappelle, L.J.3    Postma, A.4
  • 41
    • 0015469471 scopus 로고
    • Topics in neuroendocrinology, progress in brain research
    • (Elsevier)
    • Knowles, S.F., Topics in neuroendocrinology, progress in brain research. Prog. Brain Res., 1972, 10.1016/S0079-6123(08)64278-8 (Elsevier).
    • (1972) Prog. Brain Res.
    • Knowles, S.F.1
  • 42
    • 0035852749 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH
    • Kovacs, M., Schally, A.V., Csernus, B., Rekasi, Z., Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH. Proc. Natl. Acad. Sci. U. S. A. 98 (2001), 1829–1834, 10.1073/pnas.031582398.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 1829-1834
    • Kovacs, M.1    Schally, A.V.2    Csernus, B.3    Rekasi, Z.4
  • 43
    • 84858960132 scopus 로고    scopus 로고
    • Involvement of Src family of kinases and cAMP phosphodiesterase in the luteinizing hormone/chorionic gonadotropin receptor-mediated signaling in the corpus luteum of monkey
    • Kunal, S., Killivalavan, A., Medhamurthy, R., Involvement of Src family of kinases and cAMP phosphodiesterase in the luteinizing hormone/chorionic gonadotropin receptor-mediated signaling in the corpus luteum of monkey. Reprod. Biol. Endocrinol., 10, 2010, 25, 10.1186/1477-7827-10-25.
    • (2010) Reprod. Biol. Endocrinol. , vol.10 , pp. 25
    • Kunal, S.1    Killivalavan, A.2    Medhamurthy, R.3
  • 44
    • 0016439014 scopus 로고
    • Role of estrogen as initiator of daily LH surges in the ovariectomized rat
    • Legan, S.J., Coon, G.A., Karsch, F.J., Role of estrogen as initiator of daily LH surges in the ovariectomized rat. Endocrinology 96 (1975), 50–56, 10.1210/endo-96-1-50.
    • (1975) Endocrinology , vol.96 , pp. 50-56
    • Legan, S.J.1    Coon, G.A.2    Karsch, F.J.3
  • 45
    • 0027210341 scopus 로고
    • Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain
    • Lei, Z.M., Rao, C.V., Kornyei, J.L., Licht, P., Hiatt, E.S., Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 132 (1993), 5322–5329.
    • (1993) Endocrinology , vol.132 , pp. 5322-5329
    • Lei, Z.M.1    Rao, C.V.2    Kornyei, J.L.3    Licht, P.4    Hiatt, E.S.5
  • 46
    • 0023885803 scopus 로고
    • Progressive changes in LH and FSH and LH: FSH ratio in women throughout reproductive life
    • Lenton, E.A., Sexton, L., Lee, S., Cooke, I.D., Progressive changes in LH and FSH and LH: FSH ratio in women throughout reproductive life. Maturitas 10 (1988), 35–43, 10.1016/0378-5122(88)90129-6.
    • (1988) Maturitas , vol.10 , pp. 35-43
    • Lenton, E.A.1    Sexton, L.2    Lee, S.3    Cooke, I.D.4
  • 47
    • 77649259710 scopus 로고    scopus 로고
    • Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer disease
    • Lin, J., Li, X., Yuan, F., Lin, L., Cook, C.L., Rao, C.V., Lei, Z., Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer disease. J. Neuropathol. Exp. Neurol. 69 (2010), 253–261, 10.1097/NEN.0b013e3181d072cf.
    • (2010) J. Neuropathol. Exp. Neurol. , vol.69 , pp. 253-261
    • Lin, J.1    Li, X.2    Yuan, F.3    Lin, L.4    Cook, C.L.5    Rao, C.V.6    Lei, Z.7
  • 48
    • 0028959562 scopus 로고
    • Peripheral and intracerebroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats
    • Lukacs, H., Hiatt, E.S., Lei, Z.M., Rao, C.V., Peripheral and intracerebroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats. Horm. Behav. 29 (1995), 42–58, 10.1006/hbeh.1995.1004.
    • (1995) Horm. Behav. , vol.29 , pp. 42-58
    • Lukacs, H.1    Hiatt, E.S.2    Lei, Z.M.3    Rao, C.V.4
  • 49
    • 54949084186 scopus 로고    scopus 로고
    • Beta-catenin is required for memory consolidation
    • Maguschak, K.A., Ressler, K.J., Beta-catenin is required for memory consolidation. Nat. Neurosci. 11 (2008), 1319–1326, 10.1038/nn.2198.
    • (2008) Nat. Neurosci. , vol.11 , pp. 1319-1326
    • Maguschak, K.A.1    Ressler, K.J.2
  • 50
    • 0023889961 scopus 로고
    • The pathological association between down syndrome and Alzheimer disease
    • Mann, D.M.A., The pathological association between down syndrome and Alzheimer disease. Mech. Ageing Dev. 43 (1988), 99–136, 10.1016/0047-6374(88)90041-3.
    • (1988) Mech. Ageing Dev. , vol.43 , pp. 99-136
    • Mann, D.M.A.1
  • 51
    • 0027447726 scopus 로고
    • Epidemiology of Alzheimer's presenile dementia in Scotland, 1974–88
    • McGonigal, G., Thomas, B., McQuade, C., Starr, J.M., MacLennan, W.J., Whalley, L.J., Epidemiology of Alzheimer's presenile dementia in Scotland, 1974–88. BMJ 306 (1993), 680–683, 10.1136/bmj.306.6879.680.
    • (1993) BMJ , vol.306 , pp. 680-683
    • McGonigal, G.1    Thomas, B.2    McQuade, C.3    Starr, J.M.4    MacLennan, W.J.5    Whalley, L.J.6
  • 52
    • 0036244335 scopus 로고    scopus 로고
    • Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
    • Mumby, D.G., Gaskin, S., Glenn, M.J., Schramek, T.E., Lehmann, H., Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn. Mem. 9 (2002), 49–57, 10.1101/lm.41302.
    • (2002) Learn. Mem. , vol.9 , pp. 49-57
    • Mumby, D.G.1    Gaskin, S.2    Glenn, M.J.3    Schramek, T.E.4    Lehmann, H.5
  • 54
    • 0022614193 scopus 로고
    • Down's syndrome and Alzheimer's disease: a review
    • Oliver, C., Holland, A.J., Down's syndrome and Alzheimer's disease: a review. Psychol. Med. 16 (1986), 307–322, 10.1017/S0033291700009120.
    • (1986) Psychol. Med. , vol.16 , pp. 307-322
    • Oliver, C.1    Holland, A.J.2
  • 55
    • 0017683650 scopus 로고
    • Hypothalamic-pituitary vasculature: evidence for retrograde blood flow in the pituitary stalk
    • Oliver, C., Mical, R.S., Porter, J.C., Hypothalamic-pituitary vasculature: evidence for retrograde blood flow in the pituitary stalk. Endocrinology 101 (1977), 598–604, 10.1210/endo-101-2-598.
    • (1977) Endocrinology , vol.101 , pp. 598-604
    • Oliver, C.1    Mical, R.S.2    Porter, J.C.3
  • 56
    • 84903122147 scopus 로고    scopus 로고
    • Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice
    • Palm, R., Chang, J., Blair, J., Garcia-Mesa, Y., Lee, H.-G., Castellani, R.J., Smith, M.A., Zhu, X., Casadesus, G., Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. J. Neurochem. 130 (2014), 115–125, 10.1111/jnc.12706.
    • (2014) J. Neurochem. , vol.130 , pp. 115-125
    • Palm, R.1    Chang, J.2    Blair, J.3    Garcia-Mesa, Y.4    Lee, H.-G.5    Castellani, R.J.6    Smith, M.A.7    Zhu, X.8    Casadesus, G.9
  • 57
    • 84995946949 scopus 로고    scopus 로고
    • The Rat Brain in Stereotaxic Coordinates Sixth Edition
    • Acad. Press
    • Paxinos, G., Watson, C., The Rat Brain in Stereotaxic Coordinates Sixth Edition. vol. 170, 2006, Acad. Press, 547612, 10.1016/0143-4179(83)90049-5.
    • (2006) , vol.170 , pp. 547612
    • Paxinos, G.1    Watson, C.2
  • 58
    • 0025993361 scopus 로고
    • BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
    • Phillips, H.S., Hains, J.M., Armanini, M., Laramee, G.R., Johnson, S.A., Winslow, J.W., BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7 (1991), 695–702, 10.1016/0896-6273(91)90273-3.
    • (1991) Neuron , vol.7 , pp. 695-702
    • Phillips, H.S.1    Hains, J.M.2    Armanini, M.3    Laramee, G.R.4    Johnson, S.A.5    Winslow, J.W.6
  • 59
    • 0027102043 scopus 로고
    • Effects of estrogen on memory function in surgically menopausal women
    • Phillips, S.M., Sherwin, B.B., Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 17 (1992), 485–495, 10.1016/0306-4530(92)90007-T.
    • (1992) Psychoneuroendocrinology , vol.17 , pp. 485-495
    • Phillips, S.M.1    Sherwin, B.B.2
  • 61
    • 1242340464 scopus 로고    scopus 로고
    • Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory
    • Pothuizen, H.H.J., Zhang, W.N., Jongen-Rêlo, A.L., Feldon, J., Yee, B.K., Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory. Eur. J. Neurosci. 19 (2004), 705–712, 10.1111/j.0953-816X.2004.03170.x.
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 705-712
    • Pothuizen, H.H.J.1    Zhang, W.N.2    Jongen-Rêlo, A.L.3    Feldon, J.4    Yee, B.K.5
  • 62
    • 38749095857 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis
    • Prange-Kiel, J., Jarry, H., Schoen, M., Kohlmann, P., Lohse, C., Zhou, L., Rune, G.M., Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis. J. Cell Biol. 180 (2008), 417–426, 10.1083/jcb.200707043.
    • (2008) J. Cell Biol. , vol.180 , pp. 417-426
    • Prange-Kiel, J.1    Jarry, H.2    Schoen, M.3    Kohlmann, P.4    Lohse, C.5    Zhou, L.6    Rune, G.M.7
  • 63
    • 0028801626 scopus 로고
    • A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density
    • Rannevik, G., Jeppsson, S., Johnell, O., Bjerre, B., Laurell-Borulf, Y., Svanberg, L., A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density. Maturitas 21 (1995), 103–113, 10.1016/0378-5122(94)00869-9.
    • (1995) Maturitas , vol.21 , pp. 103-113
    • Rannevik, G.1    Jeppsson, S.2    Johnell, O.3    Bjerre, B.4    Laurell-Borulf, Y.5    Svanberg, L.6
  • 64
    • 0018742636 scopus 로고
    • Differential properties of human chorionic gonadotrophin and human luteinizing hormone binding to plasma membranes of bovine corpora lutea
    • Rao, C.V., Differential properties of human chorionic gonadotrophin and human luteinizing hormone binding to plasma membranes of bovine corpora lutea. Acta Endocrinol. 90 (1979), 696–710, 10.1530/acta.0.0900696.
    • (1979) Acta Endocrinol. , vol.90 , pp. 696-710
    • Rao, C.V.1
  • 65
    • 0021341423 scopus 로고
    • Inhibitory action of chemically deglycosylated human chorionic gonadotrophin on hormone-induced steroid production by dispersed cells from human corpus luteum
    • Richardson, M.C., Masson, G.M., Sairam, M.R., Inhibitory action of chemically deglycosylated human chorionic gonadotrophin on hormone-induced steroid production by dispersed cells from human corpus luteum. J. Endocrinol. 101 (1984), 327–332, 10.1677/joe.0.1010327.
    • (1984) J. Endocrinol. , vol.101 , pp. 327-332
    • Richardson, M.C.1    Masson, G.M.2    Sairam, M.R.3
  • 66
    • 84860220560 scopus 로고    scopus 로고
    • Hysterectomy, oophorectomy, estrogen, and the risk of dementia
    • Rocca, W.a., Grossardt, B.R., Shuster, L.T., Stewart, E.a., Hysterectomy, oophorectomy, estrogen, and the risk of dementia. Neurodegener. Dis. 10 (2012), 175–178, 10.1159/000334764.
    • (2012) Neurodegener. Dis. , vol.10 , pp. 175-178
    • Rocca, W.A.1    Grossardt, B.R.2    Shuster, L.T.3    Stewart, E.A.4
  • 68
    • 0014292996 scopus 로고
    • The concentration of HCG in the plasma and spinal fluid of patients with trophoblastic tumours in the central nervous system
    • Rushworth, A.G., Orr, A.H., Bagshawe, K.D., The concentration of HCG in the plasma and spinal fluid of patients with trophoblastic tumours in the central nervous system. Br. J. Cancer 22 (1968), 253–257.
    • (1968) Br. J. Cancer , vol.22 , pp. 253-257
    • Rushworth, A.G.1    Orr, A.H.2    Bagshawe, K.D.3
  • 69
    • 0020699583 scopus 로고
    • Hormonal antagonistic properties of chemically deglycosylated human choriogonadotropin
    • Sairam, M.R., Manjunath, P., Hormonal antagonistic properties of chemically deglycosylated human choriogonadotropin. J. Biol. Chem. 258 (1983), 445–449.
    • (1983) J. Biol. Chem. , vol.258 , pp. 445-449
    • Sairam, M.R.1    Manjunath, P.2
  • 72
    • 80655148219 scopus 로고    scopus 로고
    • Early initiation of hormone therapy in menopausal women is associated with increased hippocampal and posterior cingulate cholinergic activity
    • Smith, Y.R., Bowen, L., Love, T.M., Berent-Spillson, A., Frey, K.A., Persad, C.C., Reame, N.K., Koeppe, R.A., Zubieta, J.-K., Early initiation of hormone therapy in menopausal women is associated with increased hippocampal and posterior cingulate cholinergic activity. J. Clin. Endocrinol. Metab. 96 (2011), E1761–E1770, 10.1210/jc.2011-0351.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. E1761-E1770
    • Smith, Y.R.1    Bowen, L.2    Love, T.M.3    Berent-Spillson, A.4    Frey, K.A.5    Persad, C.C.6    Reame, N.K.7    Koeppe, R.A.8    Zubieta, J.-K.9
  • 73
    • 0023935114 scopus 로고
    • Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone
    • Spratt, D.I., O'Dea, L.S., Schoenfeld, D., Butler, J., Rao, P.N., Crowley, W.F., Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone. Am. J. Phys. 254 (1988), E658–E666.
    • (1988) Am. J. Phys. , vol.254 , pp. E658-E666
    • Spratt, D.I.1    O'Dea, L.S.2    Schoenfeld, D.3    Butler, J.4    Rao, P.N.5    Crowley, W.F.6
  • 74
    • 67349134666 scopus 로고    scopus 로고
    • Effects of the LHRH antagonist Cetrorelix on the brain function in mice
    • Telegdy, G., Tanaka, M., Schally, A.V., Effects of the LHRH antagonist Cetrorelix on the brain function in mice. Neuropeptides 43 (2009), 229–234, 10.1016/j.npep.2009.03.001.
    • (2009) Neuropeptides , vol.43 , pp. 229-234
    • Telegdy, G.1    Tanaka, M.2    Schally, A.V.3
  • 75
    • 77249109792 scopus 로고    scopus 로고
    • Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease
    • Toledo, E.M., Inestrosa, N.C., Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Mol. Psychiatry, 15(272–85), 2010, 228, 10.1038/mp.2009.72.
    • (2010) Mol. Psychiatry , vol.15 , Issue.272-85 , pp. 228
    • Toledo, E.M.1    Inestrosa, N.C.2
  • 76
    • 0028826267 scopus 로고
    • The relative importance of the oligosaccharide units in human chorionic gonadotropin (CG) for LH/CG receptor activation in rat Leydig cells and mouse Leydig tumor cells
    • Van Loenen, H.J., van Gelderen-Boele, S., Flinterman, J.F., Merz, W.E., Rommerts, F.F., The relative importance of the oligosaccharide units in human chorionic gonadotropin (CG) for LH/CG receptor activation in rat Leydig cells and mouse Leydig tumor cells. J. Endocrinol. 147 (1995), 367–375, 10.1677/joe.0.1470367.
    • (1995) J. Endocrinol. , vol.147 , pp. 367-375
    • Van Loenen, H.J.1    van Gelderen-Boele, S.2    Flinterman, J.F.3    Merz, W.E.4    Rommerts, F.F.5
  • 79
    • 0027159773 scopus 로고
    • Comparison of the antigonadotropic activity of three GnRH antagonists (Nal-Glu, Antide and Cetrorelix) in a non-human primate model (Macaca fascicularis)
    • Weinbauer, G.F., Nieschlag, E., Comparison of the antigonadotropic activity of three GnRH antagonists (Nal-Glu, Antide and Cetrorelix) in a non-human primate model (Macaca fascicularis). Andrologia 25 (1993), 141–147, 10.1111/j.1439-0272.1993.tb02698.x.
    • (1993) Andrologia , vol.25 , pp. 141-147
    • Weinbauer, G.F.1    Nieschlag, E.2
  • 80
    • 80053482654 scopus 로고    scopus 로고
    • Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial
    • Wharton, W., Baker, L.D., Gleason, C.E., Dowling, M., Barnet, J.H., Johnson, S., Carlsson, C., Craft, S., Asthana, S., Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial. J. Alzheimers Dis. 26 (2011), 495–505, 10.3233/JAD-2011-110341.
    • (2011) J. Alzheimers Dis. , vol.26 , pp. 495-505
    • Wharton, W.1    Baker, L.D.2    Gleason, C.E.3    Dowling, M.4    Barnet, J.H.5    Johnson, S.6    Carlsson, C.7    Craft, S.8    Asthana, S.9
  • 81
    • 78651406687 scopus 로고    scopus 로고
    • Measures of menopause driven differences in levels of blood lipids, follicle-stimulating hormone, and luteinizing hormone in women aged 35 to 60 years: national health and nutrition examination survey III and national health and nutrition examination Surv
    • Wiacek, M., Hagner, W., Zubrzycki, I.Z., Measures of menopause driven differences in levels of blood lipids, follicle-stimulating hormone, and luteinizing hormone in women aged 35 to 60 years: national health and nutrition examination survey III and national health and nutrition examination Surv. Menopause 18 (2011), 60–66, 10.1097/gme.0b013e3181e7060b.
    • (2011) Menopause , vol.18 , pp. 60-66
    • Wiacek, M.1    Hagner, W.2    Zubrzycki, I.Z.3
  • 82
    • 36048982949 scopus 로고    scopus 로고
    • Leuprolide acetate: a drug of diverse clinical applications
    • Wilson, A.C., Meethal, S.V., Bowen, R.L., Atwood, C.S., Leuprolide acetate: a drug of diverse clinical applications. Expert Opin. Investig. Drugs 16 (2007), 1851–1863, 10.1517/13543784.16.11.1851.
    • (2007) Expert Opin. Investig. Drugs , vol.16 , pp. 1851-1863
    • Wilson, A.C.1    Meethal, S.V.2    Bowen, R.L.3    Atwood, C.S.4
  • 83
    • 0018865717 scopus 로고
    • Effect of ovariectomy on plasma LH, FSH, estradiol, and progesterone and medial basal hypothalamic LHRH concentrations old and young rats
    • Wise, P.M., Ratner, A., Effect of ovariectomy on plasma LH, FSH, estradiol, and progesterone and medial basal hypothalamic LHRH concentrations old and young rats. Neuroendocrinology 30 (1980), 15–19.
    • (1980) Neuroendocrinology , vol.30 , pp. 15-19
    • Wise, P.M.1    Ratner, A.2
  • 84
    • 84945342551 scopus 로고    scopus 로고
    • Dementia Fact Sheet
    • World Health Organization, Dementia Fact Sheet. 2015 (www.who.int/mediacentre/factsheets/fs362/en/).
    • (2015)
    • World Health Organization1
  • 85
    • 0014385194 scopus 로고
    • Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man
    • Yen, S., Llerena, O., Little, B., Pearson, O., Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man. J. Clin. Endocrinol. Metab. 28 (1968), 1763–1767.
    • (1968) J. Clin. Endocrinol. Metab. , vol.28 , pp. 1763-1767
    • Yen, S.1    Llerena, O.2    Little, B.3    Pearson, O.4
  • 86
    • 78349310108 scopus 로고    scopus 로고
    • Low luteinizing hormone enhances spatial memory and has protective effects on memory loss in rats
    • Ziegler, S.G., Thornton, J.E., Low luteinizing hormone enhances spatial memory and has protective effects on memory loss in rats. Horm. Behav. 58 (2010), 705–713, 10.1016/j.yhbeh.2010.07.002.
    • (2010) Horm. Behav. , vol.58 , pp. 705-713
    • Ziegler, S.G.1    Thornton, J.E.2
  • 87
    • 0033536570 scopus 로고    scopus 로고
    • Immortalized hippocampal cells contain functional luteinizing hormone/human chorionic gonadotropin receptors
    • Zhang, W., Lei, Z.M., Rao, C.V., Immortalized hippocampal cells contain functional luteinizing hormone/human chorionic gonadotropin receptors. Life Sci. 65 (1999), 2083–2098, 10.1016/S0024-3205(99)00474-9.
    • (1999) Life Sci. , vol.65 , pp. 2083-2098
    • Zhang, W.1    Lei, Z.M.2    Rao, C.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.