Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice

Journal of Neurochemistry

Volumn 130, Issue 1, 2014, Pages 115-125

  Palm, Russell ^a   Chang, Jaewon ^a   Blair, Jeffrey ^a   Garcia Mesa, Yoelvis ^a   Lee, Hyoung Gon ^a   Castellani, Rudy J ^b   Smith, Mark A ^a   Zhu, Xiongwei ^a   Casadesus, Gemma ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c KENT STATE UNIVERSITY   (United States)

Author keywords

3xTg AD; Alzheimer's disease; estrogen; GSK3 ; luteinizing hormone; ovariectomy

Indexed keywords

AMYLOID PROTEIN; BETA CATENIN; BRAIN DERIVED NEUROTROPHIC FACTOR; ESTROGEN; GLYCOGEN SYNTHASE KINASE 3BETA; GONADOTROPIN; LUTEINIZING HORMONE; MESSENGER RNA; TAU PROTEIN; BIOLOGICAL MARKER;

AGED; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN REGION; COGNITION; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; ENZYME INHIBITION; ESTROGEN THERAPY; FEMALE; FUNCTIONAL ASSESSMENT; HIPPOCAMPUS; IMMUNOFLUORESCENCE TEST; MOLECULAR PATHOLOGY; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SPATIAL MEMORY; AGING; ANIMAL; BLOOD; CELL CULTURE; METABOLISM; OVARIECTOMY; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

MUS;

AGING; ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; COGNITION; DOWN-REGULATION; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; GONADOTROPINS; HIPPOCAMPUS; LUTEINIZING HORMONE; MICE; MICE, TRANSGENIC; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84903122147     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12706     Document Type: Article

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