Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits

Journal of Neurochemistry

Volumn 112, Issue 4, 2010, Pages 870-881

  Bryan, Kathryn J ^a   Mudd, Joseph C ^a   Richardson, Sandy L ^b   Chang, Jaewon ^a   Lee, Hyoung Gon ^b   Zhu, Xiongwei ^b   Smith, Mark A ^b   Casadesus, Gemma ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Cognitive function; Estrogen replacement; Gonadotropins; Leuprolide acetate; Menopause; Ovariectomy

Indexed keywords

AROMATASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUTAMATE RECEPTOR 1; LEUPRORELIN; LUTEINIZING HORMONE; SERINE; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ESTROGEN BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; LUTEINIZING HORMONE BLOOD LEVEL; MAZE TEST; MENOPAUSE; MOLECULAR MECHANICS; MOUSE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; AROMATASE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; FERTILITY AGENTS, FEMALE; GONADOTROPINS; LEUPROLIDE; MAZE LEARNING; MENOPAUSE; MICE; MICE, INBRED C57BL; OVARIECTOMY; REACTION TIME; RECEPTORS, AMPA; RECEPTORS, ESTROGEN; RNA, MESSENGER; SERINE;

EID: 75149129708     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06502.x     Document Type: Article

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