An association of elevated serum gonadotropin concentrations and Alzheimer disease?

Journal of Neuroendocrinology

Volumn 12, Issue 4, 2000, Pages 351-354

  Bowen, Richard L ^a,d   Isley, J P ^b   Atkinson, R L ^c  

^a Private Practice   (United States)

^b Private Practice   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d NONE   (United States)

Author keywords

Alzheimer; Follicle stimulating hormone; Hormone; Luteinizing hormone; Oestrogen

Indexed keywords

FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MALE; PRIORITY JOURNAL;

ALZHEIMER DISEASE; CASE-CONTROL STUDIES; CELLS, CULTURED; ESTROGEN REPLACEMENT THERAPY; FEMALE; GONADOTROPINS; HUMANS; MALE;

EID: 0034114486     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2000.00461.x     Document Type: Article

References (35)

1. Ernst RL, Hay JW. The US economic and social costs of Alzheimer disease revisited. Am J Public Health 1994; 84: 1261.
2. Evans DA, Funkenstein HH, Albert MS, Scherr PA, Cook NR, Chown MJ, Hebert LE, Hennekens CH, Taylor JO. Prevalence of Alzheimer disease in a community population of older persons. Higher than previously reported. JAMA 1989: 262: 2551-2556.
3. Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B. Very old women at highest risk of dementia and Alzheimer disease: incidence data from the Kungsholmen Project. Neurology 1997; 48: 132-138.
4. Visser FE, Aldenkamp AP, van Huffelen AC, Kuilman M, Overweg J, van Wijk J. Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. Am J Mental Retardation 1997; 101: 400-412.
5. de la Monte SM, Ghanbari K, Frey WH, Wands JR. Characterization of the Ad7C-NTPcDNA expression in Alzheimer disease and measurement of a 41-kD protein in cerebrospinal fluid. J Clin Invest 1997; 100: 3093-3104.
6. Folstein MK, Folstein SE, McHugh PR. 'Mini-Mental State': a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
7. Grummer RR, Carroll DJ, A. review of lipoprotein cholesterol metabolism: importance to ovarian function. J Anim Sci 1988; 66: 3160-3173.
8. Beisiegel U, Weber W, Ihrke G, Herz J, Stanley KK. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 1989; 14: 162-164.
9. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer disease. Neurology 1993; 43: 1467-1472.
10. Nalbantoglu J, Gilfix BM, Bertrand P, Robitaille Y, Gauthier S et al. Poirier J. Predictive value of apolipoprotein E genotyping in Alzheimer disease: results of an autopsy series and an analysis of several combined studies. Ann Neur 1994; 36: 889-895.
11. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988; 240: 622-630.
12. Weisgraber KH, Innerarity TL, Rall SC Jr, Mahley RW, Apolipoprotein E. receptor binding properties. Adv Exp Med Biol 1985; 183: 159-171.
13. Azhar S, Tsai L, Reaven E. Uptake and utilization of lipoprotein cholesterol esters by rat granulosa cells. Biochim Biophys Acta 1990; 1047: 148-160.
14. Pillot T, Goethals M, Najib J, Labeur C, Lins L, Chambaz J, Brasseur R, Vandekerckhove J, Rosseneu M. Beta-amloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E. relevance to Alzheimer disease. J Neurochem 1999; 72: 230-237.
15. Rebeck GW, Herr SD, Strickland DK, Hyman BT. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein. Ann Neurol 1995; 37: 211-217.
16. Foster JD, Strauss JF III, Paavola LG. Cellular events involved in hormonal control of receptor-mediated endocytosis: regulation occurs at multiple sites in the low density lipoprotein pathway, including steps beyond the receptor. Endocrinology 1993; 132: 337-350.
17. Lukacs H, Hiatt ES, Lei ZM. Peripheral and intracerbroventricular administration of human chorionic gonadotropin alters several hippocampus-associated behaviors in cycling female rats. Hormones Behav 1995; 29: 42-58.
18. Lei ZM, Rao CV, Kornyei JL, Licht P, Hiatt ES. Novel expression of human chorionic gonadotropin/luteinizing hormone receptor gene in brain. Endocrinology 1993; 132: 2262-2270.
19. Al-Hader AA, Lei ZM, Rap CV. Neurons from fetal rat brains contain functional luteinizing hormone/chorionic gonadotropin receptors. Biol Reprod 1997; 56: 1071-1076.
20. Al-Hader AA, Lei ZM, Rao CN. Novel expression of functional luteinizing hormone/chononic gonadotropin receptors in cultured glial cells from neonatal rat brains. Biol Reprod 1997; 56: 501-507.
21. Smalheiser NR, Swanson DR. Linking estrogen to Alzheimer disease: an informatics approach. Neurology 1996; 47: 809-810.
22. Paganini-Hill A, Henderson VW. Estrogen deficiency and risk of Alzheimer disease in women. Am J Epidemiol 1994; 140: 256-261.
23. Ravaglia G, Forti P, Maioli F, Scali RC, Boschi F, Pratelli L, Pizzoferrato A, Gasbarrini G. Hormonal changes in male subjects over-ninety. Bollettino: Societa Italiana Biologia Sperimentale 1995; 71: 133-139.
24. Schellenberg GD. Progress in Aszheimer's disease genetics. Curr Opinion Neurol 1995; 8: 262-267.
25. Lancelet L. Genetics of Alzheimer disease. Acta Neuralgic Scand 1996: 168(Suppl): 25-27.
26. Schupf N, Kapell D, Nightingale B, Rodriguez A, Tycko B. Earlier onset of Alzheimer disease in men with. Down Syndrome Neurol 1998; 50: 991-995.
27. Hasen J, Boyar RM, Shapiro LR. Gonadal Function in Trisomy 21. Hormone Res 1980; 12: 345-350.
28. Hsiang YH, Berkovitz GD, Bland GL, Migeon CJ, Warren AC. Gonadal function in patients with Down syndrome. Am J Med Genet 1987: 27: 449-458.
29. Campbell WA, Lowther J, Mckenzie I, Price W. Serum gonadotropins in Down syndrome. J Med Genetics 1982; 19: 98-99.
30. Hestnes A, Stovner LJ, Husoy O, Folling I, Fougner KJ. Hormonal and biochemical disturbances in Down syndrome. J Mental Deficiency Res 1991; 35: 179-193.
31. McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer disease: a review of 17 epidemiologic studies. Neurology 1996; 47: 425-432.
32. Spector TD, Ollier W, Perry LA, Silman AJ, Thompson PW, edwards A. Free serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls. Clin Rheumatol 1989; 8: 37-41.
33. Kobayashi S, Yamamoto S, Tanaka M, Hashimoto H, Hirose S. Klinefelter's syndrome and rheumatoid arthritis: report of a case and review of the literature Clin. Rheumatol 1994; 13: 500-503.
34. Hall GM, Larbre JP, Spector TD, Perry LA, Da Silva JA. A randomized trial of testosterone therapy in males with rheumatoid arthritis. Br J Rheum 1996;35:568-573.
35. Gudbjornsson B, Skogseid B, Oberh K, Wide L, Hallgren R. Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis: effect of glucocorticoids. Rheumatology 1996; 23: 596-602.