Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

Journal of Clinical Investigation

Volumn 127, Issue 1, 2017, Pages 132-136

  Wang, Ping Yuan ^a   Li, Jie ^a   Walcott, Farzana L ^b,c   Kang, Ju Gyeong ^a   Starost, Matthew F ^d   Talagala, S Lalith ^e   Zhuang, Jie ^a   Park, Ji Hoon ^a   Huffstutler, Rebecca D ^a   Bryla, Christina M ^b   Mai, Phuong L ^b   Pollak, Michael ^f   Annunziata, Christina M ^b   Savage, Sharon A ^b   Fojo, Antonio Tito ^g   Hwang, Paul M ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^f MCGILL UNIVERSITY   (Canada)

^g Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; MUTANT PROTEIN; PROTEIN P53; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CANCER INHIBITION; CARCINOGENESIS; CELL DISRUPTION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FAMILIAL CANCER; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; THYMUS; ADULT; ANIMAL; DRUG EFFECTS; FEMALE; GENETICS; JURKAT CELL LINE; LI-FRAUMENI SYNDROME; MALE; METABOLISM; MIDDLE AGED; MITOCHONDRION; MUTANT MOUSE STRAIN; NEOPLASMS, EXPERIMENTAL; OXYGEN CONSUMPTION; PATHOLOGY; PILOT STUDY; SIGNAL TRANSDUCTION;

ADULT; ANIMALS; CELL PROLIFERATION; FEMALE; HUMANS; JURKAT CELLS; LI-FRAUMENI SYNDROME; MALE; METFORMIN; MICE; MICE, MUTANT STRAINS; MIDDLE AGED; MITOCHONDRIA; NEOPLASMS, EXPERIMENTAL; OXYGEN CONSUMPTION; PILOT PROJECTS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85008311686     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI88668     Document Type: Article

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