-
1
-
-
84892805731
-
Cancer Statistics, 2014
-
24399786
-
Siegel R, Ma J, Zou Z, Jemal A. Cancer Statistics, 2014. CA Cancer J Clin 2014; 64:9-29; PMID:24399786; http://dx.doi.org/10.3322/caac.21208
-
(2014)
CA Cancer J Clin
, vol.64
, pp. 9-29
-
-
Siegel, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
2
-
-
80052653226
-
Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors
-
21765634
-
Miller CP, Singh MM, Rivera-Del Valle N, Manton CA, Chandra J. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors. J Biomed Biotechnol 2011; 2011:514261; PMID:21765634; http://dx.doi.org/10.1155/2011/514261.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 514261
-
-
Miller, C.P.1
Singh, M.M.2
Rivera-Del Valle, N.3
Manton, C.A.4
Chandra, J.5
-
3
-
-
80053144962
-
The next 10 years — Timeline: A decade of exploring the cancer epigenome — biological and translational implications
-
Baylin SB, Jones PA. The next 10 years — Timeline:A decade of exploring the cancer epigenome — biological and translational implications. Nat Rev Cancer 2011; 11:726-34; http://dx.doi.org/10.1038/nrc3130.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
4
-
-
33847076849
-
Chromatin Modifications and Their Function
-
17320507
-
Kouzarides T. Chromatin Modifications and Their Function. Cell 2007; 128:693-705; PMID:17320507; http://dx.doi.org/10.1016/j.cell.2007.02.005
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
5
-
-
79952534189
-
Regulation of chromatin by histone modifications
-
21321607
-
Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications. Cell Res 2011; 21:381-95; PMID:21321607; http://dx.doi.org/10.1038/cr.2011.22
-
(2011)
Cell Res
, vol.21
, pp. 381-395
-
-
Bannister, A.J.1
Kouzarides, T.2
-
6
-
-
0345357773
-
Gene Silencing in Cancer in Association with Promoter Hypermethylation
-
14627790
-
Herman JG, Baylin SB. Gene Silencing in Cancer in Association with Promoter Hypermethylation. N Engl J Med 2003; 349:2042-54; PMID:14627790; http://dx.doi.org/10.1056/NEJMra023075
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
7
-
-
84946912433
-
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
-
Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 2015; 527:1-16; http://dx.doi.org/10.1038/527S1a
-
(2015)
Nature
, vol.527
, pp. 1-16
-
-
Peng, D.1
Kryczek, I.2
Nagarsheth, N.3
Zhao, L.4
Wei, S.5
Wang, W.6
Sun, Y.7
Zhao, E.8
Vatan, L.9
Szeliga, W.10
-
8
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
16955068
-
Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006; 5:769-84; PMID:16955068; http://dx.doi.org/10.1038/nrd2133
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
9
-
-
84892732599
-
Romidepsin for the treatment of relapsed/refractory peripheral T-cell lymphoma: pivotal study update demonstrates durable responses
-
24456586
-
Coiffier B, Pro B, Prince HM, Foss F, Sokol L, Greenwood M, Caballero D, Morschhauser F, Wilhelm M, Pinter-Brown L, et al. Romidepsin for the treatment of relapsed/refractory peripheral T-cell lymphoma:pivotal study update demonstrates durable responses. J Hematol Oncol 2014; 7:11; PMID:24456586; http://dx.doi.org/10.1186/1756-8722-7-11
-
(2014)
J Hematol Oncol
, vol.7
, pp. 11
-
-
Coiffier, B.1
Pro, B.2
Prince, H.M.3
Foss, F.4
Sokol, L.5
Greenwood, M.6
Caballero, D.7
Morschhauser, F.8
Wilhelm, M.9
Pinter-Brown, L.10
-
10
-
-
84940697848
-
Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma
-
Shi Y, Dong M, Hong X, Zhang W, Feng J, Zhu J, Yu L, Ke X, Huang H, Shen Z, et al. Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma. Ann Oncol 2015; 26:1766-71; http://dx.doi.org/10.1093/annonc/mdv237.
-
(2015)
Ann Oncol
, vol.26
, pp. 1766-1771
-
-
Shi, Y.1
Dong, M.2
Hong, X.3
Zhang, W.4
Feng, J.5
Zhu, J.6
Yu, L.7
Ke, X.8
Huang, H.9
Shen, Z.10
-
11
-
-
85011850847
-
Belinostat for the treatment of relapsed or refractory peripheral T-cell lymphoma
-
Campbell P, Thomas CM. Belinostat for the treatment of relapsed or refractory peripheral T-cell lymphoma. J Oncol Pharm Pr 2016; http://dx.doi.org/10.1177/1078155216634178.
-
(2016)
J Oncol Pharm Pr
-
-
Campbell, P.1
Thomas, C.M.2
-
12
-
-
84954203949
-
Panobinostat PK/PD in combination with bortezomib and dexamethasone in patients withrelapsed and relapsed/ refractory multiple myeloma (RRMM)
-
Mu S, Tajima T, Corrado C, Suzuki K, Hino M, Kuroda Y, Shibayama H, Lin R, Waldron E, Binlich F. Panobinostat PK/PD in combination with bortezomib and dexamethasone in patients withrelapsed and relapsed/ refractory multiple myeloma (RRMM). Clin Pharmacol Ther 2015; 97:S49; http://dx.doi.org/10.1007/s00228-015-1967-z
-
(2015)
Clin Pharmacol Ther
, vol.97
, pp. S49
-
-
Mu, S.1
Tajima, T.2
Corrado, C.3
Suzuki, K.4
Hino, M.5
Kuroda, Y.6
Shibayama, H.7
Lin, R.8
Waldron, E.9
Binlich, F.10
-
13
-
-
84869871771
-
The role of histone demethylases in cancer therapy
-
22902149
-
Hoffmann I, Roatsch M, Schmitt ML, Carlino L, Pippel M, Sippl W, Jung M. The role of histone demethylases in cancer therapy. Mol Oncol 2012; 6:683-703; PMID:22902149; http://dx.doi.org/10.1016/j.molonc.2012.07.004
-
(2012)
Mol Oncol
, vol.6
, pp. 683-703
-
-
Hoffmann, I.1
Roatsch, M.2
Schmitt, M.L.3
Carlino, L.4
Pippel, M.5
Sippl, W.6
Jung, M.7
-
14
-
-
84994908511
-
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
-
Morera L, Lübbert M, Jung M. Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy. Clin Epigenet 2016
-
(2016)
Clin Epigenet
-
-
Morera, L.1
Lübbert, M.2
Jung, M.3
-
15
-
-
84859480637
-
Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer
-
22493729
-
Lv T, Yuan D, Miao X, Lv Y, Zhan P, Shen X, Song Y. Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. PLoS One 2012; 7:e35065; PMID:22493729; http://dx.doi.org/10.1371/journal.pone.0035065
-
(2012)
PLoS One
, vol.7
, pp. e35065
-
-
Lv, T.1
Yuan, D.2
Miao, X.3
Lv, Y.4
Zhan, P.5
Shen, X.6
Song, Y.7
-
16
-
-
84859837026
-
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
-
22464800
-
Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y, Ciceri F, Blaser JG, Greystoke BF, Jordan AM, et al. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 2012; 21:473-87; PMID:22464800; http://dx.doi.org/10.1016/j.ccr.2012.03.014
-
(2012)
Cancer Cell
, vol.21
, pp. 473-487
-
-
Harris, W.J.1
Huang, X.2
Lynch, J.T.3
Spencer, G.J.4
Hitchin, J.R.5
Li, Y.6
Ciceri, F.7
Blaser, J.G.8
Greystoke, B.F.9
Jordan, A.M.10
-
17
-
-
84862777766
-
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
-
22406747
-
Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 2012; 18:605-11; PMID:22406747; http://dx.doi.org/10.1038/nm.2661
-
(2012)
Nat Med
, vol.18
, pp. 605-611
-
-
Schenk, T.1
Chen, W.C.2
Göllner, S.3
Howell, L.4
Jin, L.5
Hebestreit, K.6
Klein, H.U.7
Popescu, A.C.8
Burnett, A.9
Mills, K.10
-
18
-
-
84926475466
-
Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date
-
Mould DP, McGonagle AE, Wiseman DH, Williams EL, Jordan AM. Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia:Clinical Significance and Progress to Date. Med Res Rev 2014; 35:586-618; http://dx.doi.org/10.1002/med.21334.
-
(2014)
Med Res Rev
, vol.35
, pp. 586-618
-
-
Mould, D.P.1
McGonagle, A.E.2
Wiseman, D.H.3
Williams, E.L.4
Jordan, A.M.5
-
19
-
-
84867401194
-
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells
-
Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer 2012; 29:997-1003; http://dx.doi.org/10.1016/j.lungcan.2012.08.003
-
(2012)
Lung Cancer
, vol.29
, pp. 997-1003
-
-
Kikuchi, J.1
Takashina, T.2
Kinoshita, I.3
Kikuchi, E.4
Shimizu, Y.5
Sakakibara-Konishi, J.6
Oizumi, S.7
Marquez, V.E.8
Nishimura, M.9
Dosaka-Akita, H.10
-
20
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
-
19230772
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, Schoch R, Gattermann N, Sanz G, List A, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes:a randomised, open-label, phase III study. Lancet Oncol 2009; 10:223-32; PMID:19230772; http://dx.doi.org/10.1016/S1470-2045(09)70003-8
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
Santini, V.4
Finelli, C.5
Giagounidis, A.6
Schoch, R.7
Gattermann, N.8
Sanz, G.9
List, A.10
-
21
-
-
84937804118
-
International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts
-
25987659
-
Dombret H, Seymour JF, Butrym A, Wierzbowska A, Selleslag D, Jang JH, Kumar R, Cavenagh J, Schuh AC, Candoni A, et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts. Blood 2015; 126:291-300; PMID:25987659; http://dx.doi.org/10.1182/blood-2015-01-621664
-
(2015)
Blood
, vol.126
, pp. 291-300
-
-
Dombret, H.1
Seymour, J.F.2
Butrym, A.3
Wierzbowska, A.4
Selleslag, D.5
Jang, J.H.6
Kumar, R.7
Cavenagh, J.8
Schuh, A.C.9
Candoni, A.10
-
22
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes
-
[Internet], 16532500
-
Kantarjian H, Issa J-PJ, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, Klimek V, Slack J, de Castro C, Ravandi F, et al. Decitabine improves patient outcomes in myelodysplastic syndromes. Cancer [Internet] 2006; 106:1794-803; PMID:16532500; http://dx.doi.org/10.1002/cncr.21792
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.-P.J.2
Rosenfeld, C.S.3
Bennett, J.M.4
Albitar, M.5
DiPersio, J.6
Klimek, V.7
Slack, J.8
de Castro, C.9
Ravandi, F.10
-
23
-
-
79956294708
-
Low-Dose Decitabine Versus Best Supportive Care in Elderly Patients With Intermediate- or High-Risk Myelodysplastic Syndrome (MDS) Ineligible for Intensive Chemotherapy: Final Results of the Randomized Phase III Study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS
-
21483003
-
Lübbert M, Suciu S, Baila L, Rüter BH, Platzbecker U, Giagounidis A, Selleslag D, Labar B, Germing U, Salih HR, et al. Low-Dose Decitabine Versus Best Supportive Care in Elderly Patients With Intermediate- or High-Risk Myelodysplastic Syndrome (MDS) Ineligible for Intensive Chemotherapy:Final Results of the Randomized Phase III Study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS. J Clin Oncol 2011; 29:1987-96; PMID:21483003; http://dx.doi.org/10.1200/JCO.2010.30.9245
-
(2011)
J Clin Oncol
, vol.29
, pp. 1987-1996
-
-
Lübbert, M.1
Suciu, S.2
Baila, L.3
Rüter, B.H.4
Platzbecker, U.5
Giagounidis, A.6
Selleslag, D.7
Labar, B.8
Germing, U.9
Salih, H.R.10
-
24
-
-
77952140672
-
Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
-
20368434
-
Blum W, Garzon R, Klisovic RB, Schwind S, Walker A, Geyer S, Liu S, Havelange V, Becker H, Schaaf L, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci U S A 2010; 107:7473-8; PMID:20368434; http://dx.doi.org/10.1073/pnas.1002650107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7473-7478
-
-
Blum, W.1
Garzon, R.2
Klisovic, R.B.3
Schwind, S.4
Walker, A.5
Geyer, S.6
Liu, S.7
Havelange, V.8
Becker, H.9
Schaaf, L.10
-
25
-
-
84961411072
-
Clinical Results of Hypomethylating Agents in AML Treatment
-
26237015
-
Cruijsen M, Lübbert M, Wijermans P, Huls G. Clinical Results of Hypomethylating Agents in AML Treatment. J Clin Med 2014; 4:1-17; PMID:26237015; http://dx.doi.org/10.3390/jcm4010001
-
(2014)
J Clin Med
, vol.4
, pp. 1-17
-
-
Cruijsen, M.1
Lübbert, M.2
Wijermans, P.3
Huls, G.4
-
26
-
-
84864063679
-
Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia
-
[Internet]
-
Kantarjian HM, Thomas XG, Dmoszynska A, Wierzbowska A, Mazur G, Mayer J, Gau JP, Chou WC, Buckstein R, Cermak J, et al. Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia. J Clin Oncol [Internet] 2012; 30:1-10; http://dx.doi.org/10.1200/JCO.2011.38.9429.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1-10
-
-
Kantarjian, H.M.1
Thomas, X.G.2
Dmoszynska, A.3
Wierzbowska, A.4
Mazur, G.5
Mayer, J.6
Gau, J.P.7
Chou, W.C.8
Buckstein, R.9
Cermak, J.10
-
27
-
-
84908133944
-
Panobinostat plus bortezomib and dexamethasone vs. placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial
-
25242045
-
San-Miguel JF, Hungria VTM, Yoon SS, Beksac M, Dimopoulos MA, Elghandour A, Jedrzejczak WW, Günther A, Nakorn TN, Siritanaratkul N, et al. Panobinostat plus bortezomib and dexamethasone vs. placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma:a multicentre, randomised, double-blind phase 3 trial. Lancet Oncol 2014; 15:1195-206; PMID:25242045; http://dx.doi.org/10.1016/S1470-2045(14)70440-1
-
(2014)
Lancet Oncol
, vol.15
, pp. 1195-1206
-
-
San-Miguel, J.F.1
Hungria, V.T.M.2
Yoon, S.S.3
Beksac, M.4
Dimopoulos, M.A.5
Elghandour, A.6
Jedrzejczak, W.W.7
Günther, A.8
Nakorn, T.N.9
Siritanaratkul, N.10
-
28
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
7585152
-
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995; 1:686-92; PMID:7585152; http://dx.doi.org/10.1038/nm0795-686
-
(1995)
Nat Med
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
Baylin, S.B.7
Sidransky, D.8
-
29
-
-
84897056300
-
Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung
-
24360395
-
Gomes A, Reis-Silva M, Alarcão A, Couceiro P, Sousa V, Carvalho L. Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung. Rev Port Pneumol 2014; 20:20-30; PMID:24360395; http://dx.doi.org/10.1016/j.rppneu.2013.07.003
-
(2014)
Rev Port Pneumol
, vol.20
, pp. 20-30
-
-
Gomes, A.1
Reis-Silva, M.2
Alarcão, A.3
Couceiro, P.4
Sousa, V.5
Carvalho, L.6
-
30
-
-
2942548985
-
Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer
-
15146565
-
Grote HJ, Schmiemann V, Kiel S, Böcking A, Kappes R, Gabbert HE, Sarbia M. Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer. Int J Cancer 2004; 110:751-5; PMID:15146565; http://dx.doi.org/10.1002/ijc.20196
-
(2004)
Int J Cancer
, vol.110
, pp. 751-755
-
-
Grote, H.J.1
Schmiemann, V.2
Kiel, S.3
Böcking, A.4
Kappes, R.5
Gabbert, H.E.6
Sarbia, M.7
-
31
-
-
0034674916
-
Promoter methylation and silencing of the retinoic acid receptor-β gene in lung carcinomas
-
10944551
-
Virmani AK, Rathi A, Zöchbauer-Müller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, et al. Promoter methylation and silencing of the retinoic acid receptor-β gene in lung carcinomas. J Natl Cancer Inst 2000; 92:1303-7; PMID:10944551; http://dx.doi.org/10.1093/jnci/92.16.1303
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1303-1307
-
-
Virmani, A.K.1
Rathi, A.2
Zöchbauer-Müller, S.3
Sacchi, N.4
Fukuyama, Y.5
Bryant, D.6
Maitra, A.7
Heda, S.8
Fong, K.M.9
Thunnissen, F.10
-
32
-
-
84894768842
-
A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma
-
24569633
-
Do H, Wong NC, Murone C, John T, Solomon B, Mitchell PL, Dobrovic A. A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. Sci Rep 2014; 4:4186; PMID:24569633; http://dx.doi.org/10.1038/srep04186
-
(2014)
Sci Rep
, vol.4
, pp. 4186
-
-
Do, H.1
Wong, N.C.2
Murone, C.3
John, T.4
Solomon, B.5
Mitchell, P.L.6
Dobrovic, A.7
-
33
-
-
84922765422
-
Unmasking the Lung Cancer Epigenome
-
25668024
-
Belinsky SA. Unmasking the Lung Cancer Epigenome. Annu Rev Physiol 2015; 77:453-74; PMID:25668024; http://dx.doi.org/10.1146/annurev-physiol-021014-072018
-
(2015)
Annu Rev Physiol
, vol.77
, pp. 453-474
-
-
Belinsky, S.A.1
-
34
-
-
80053627793
-
Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung
-
21466904
-
Minamiya Y, Ono T, Saito H, Takahashi N, Ito M, Mitsui M, Motoyama S, Ogawa J. Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Lung Cancer 2011; 74:300-4; PMID:21466904; http://dx.doi.org/10.1016/j.lungcan.2011.02.019
-
(2011)
Lung Cancer
, vol.74
, pp. 300-304
-
-
Minamiya, Y.1
Ono, T.2
Saito, H.3
Takahashi, N.4
Ito, M.5
Mitsui, M.6
Motoyama, S.7
Ogawa, J.8
-
35
-
-
84862792039
-
Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients
-
22360506
-
Song JS, Kim YS, Kim DK, Park S, Il Jang SJ. Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients. Pathol Int 2012; 62:182-90; PMID:22360506; http://dx.doi.org/10.1111/j.1440-1827.2011.02776.x
-
(2012)
Pathol Int
, vol.62
, pp. 182-190
-
-
Song, J.S.1
Kim, Y.S.2
Kim, D.K.3
Park, S.4
Il Jang, S.J.5
-
36
-
-
35348862421
-
Global histone modifications predict prognosis of resected non-small-cell lung cancer
-
Barlési F, Giaccone G, Gallegos-Ruiz MI, Loundou A, Span SW, Lefesvre P, Kruyt FA, Rodriguez JA. Global histone modifications predict prognosis of resected non-small-cell lung cancer. J Clin Oncol 2007; 25:4358-64; http://dx.doi.org/10.1200/JCO.2007.11.2599
-
(2007)
J Clin Oncol
, vol.25
, pp. 4358-4364
-
-
Barlési, F.1
Giaccone, G.2
Gallegos-Ruiz, M.I.3
Loundou, A.4
Span, S.W.5
Lefesvre, P.6
Kruyt, F.A.7
Rodriguez, J.A.8
-
37
-
-
84891801684
-
A prognostic DNA methylation signature for stage I non-small-cell lung cancer
-
24081945
-
Sandoval J, Mendez-Gonzalez J, Nadal E, Chen G, Carmona FJ, Sayols S, Moran S, Heyn H, Vizoso M, Gomez A, et al. A prognostic DNA methylation signature for stage I non-small-cell lung cancer. J Clin Oncol 2013; 31:4140-7; PMID:24081945; http://dx.doi.org/10.1200/JCO.2012.48.5516
-
(2013)
J Clin Oncol
, vol.31
, pp. 4140-4147
-
-
Sandoval, J.1
Mendez-Gonzalez, J.2
Nadal, E.3
Chen, G.4
Carmona, F.J.5
Sayols, S.6
Moran, S.7
Heyn, H.8
Vizoso, M.9
Gomez, A.10
-
38
-
-
84891073380
-
Epigenetic therapy of non-small cell lung cancer using decitabine (5-aza-2′-deoxycytidine)
-
23908969
-
Momparler RL. Epigenetic therapy of non-small cell lung cancer using decitabine (5-aza-2′-deoxycytidine). Front Oncol 2013; 3:188; PMID:23908969; http://dx.doi.org/10.3389/fonc.2013.00188
-
(2013)
Front Oncol
, vol.3
, pp. 188
-
-
Momparler, R.L.1
-
39
-
-
50349086621
-
The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer
-
18424067
-
Gridelli C, Rossi A, Maione P. The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer. Crit Rev Oncol Hematol 2008; 68:29-36; PMID:18424067; http://dx.doi.org/10.1016/j.critrevonc.2008.03.002
-
(2008)
Crit Rev Oncol Hematol
, vol.68
, pp. 29-36
-
-
Gridelli, C.1
Rossi, A.2
Maione, P.3
-
40
-
-
84867401194
-
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells
-
22925699
-
Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer 2012; 78:138-43; PMID:22925699; http://dx.doi.org/10.1016/j.lungcan.2012.08.003
-
(2012)
Lung Cancer
, vol.78
, pp. 138-143
-
-
Kikuchi, J.1
Takashina, T.2
Kinoshita, I.3
Kikuchi, E.4
Shimizu, Y.5
Sakakibara-Konishi, J.6
Oizumi, S.7
Marquez, V.E.8
Nishimura, M.9
Dosaka-Akita, H.10
-
41
-
-
50249095068
-
Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
-
18425418
-
Vansteenkiste J, Van Cutsem E, Dumez H, Chen C, Ricker JL, Randolph SS, Schoeffski P. Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest New Drugs 2008; 26:483-8; PMID:18425418; http://dx.doi.org/10.1007/s10637-008-9131-6
-
(2008)
Invest New Drugs
, vol.26
, pp. 483-488
-
-
Vansteenkiste, J.1
Van Cutsem, E.2
Dumez, H.3
Chen, C.4
Ricker, J.L.5
Randolph, S.S.6
Schoeffski, P.7
-
42
-
-
84655163371
-
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
-
22586682
-
Juergens RA, Wrangle J, Vendetti FP, Murphy SC, Zhao M, Coleman B, Sebree R, Rodgers K, Hooker CM, Franco N, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov 2011; 1:598-607; PMID:22586682; http://dx.doi.org/10.1158/2159-8290.CD-11-0214
-
(2011)
Cancer Discov
, vol.1
, pp. 598-607
-
-
Juergens, R.A.1
Wrangle, J.2
Vendetti, F.P.3
Murphy, S.C.4
Zhao, M.5
Coleman, B.6
Sebree, R.7
Rodgers, K.8
Hooker, C.M.9
Franco, N.10
-
43
-
-
33644856123
-
Epigenetic therapy of cancer: past, present and future
-
16485345
-
Yoo CB, Jones PA. Epigenetic therapy of cancer:past, present and future. Nat Rev Drug Discov 2006; 5:37-50; PMID:16485345; http://dx.doi.org/10.1038/nrd1930
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
44
-
-
84881095514
-
Erlotinib resistance in lung cancer: current progress and future perspectives
-
23407898
-
Tang J, Salama R, Gadgeel SM, Sarkar FH, Ahmad A. Erlotinib resistance in lung cancer:current progress and future perspectives. Front Pharmacol 2013; 4:15; PMID:23407898; http://dx.doi.org/10.3389/fphar.2013.00015
-
(2013)
Front Pharmacol
, vol.4
, pp. 15
-
-
Tang, J.1
Salama, R.2
Gadgeel, S.M.3
Sarkar, F.H.4
Ahmad, A.5
-
45
-
-
84921906992
-
5-Azacytidine enhances efficacy of multiple chemotherapy drugs in AML and lung cancer with modulation of CpG methylation
-
25501798
-
Füller M, Klein M, Schmidt E, Rohde C, Göllner S, Schulze I, Qianli J, Berdel W, Edemir B, Müller-Tidow C, et al. 5-Azacytidine enhances efficacy of multiple chemotherapy drugs in AML and lung cancer with modulation of CpG methylation. Int J Oncol 2014; 46:1192-204; PMID:25501798; http://dx.doi.org/10.3892/ijo.2014.2792.
-
(2014)
Int J Oncol
, vol.46
, pp. 1192-1204
-
-
Füller, M.1
Klein, M.2
Schmidt, E.3
Rohde, C.4
Göllner, S.5
Schulze, I.6
Qianli, J.7
Berdel, W.8
Edemir, B.9
Müller-Tidow, C.10
-
46
-
-
84876231994
-
Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells
-
23440266
-
Li XY, Wu JZ, Cao HX, Ma R, Wu JQ, Zhong YJ, Feng JF. Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells. Oncol Rep 2013; 29:1975-82; PMID:23440266; http://dx.doi.org/10.3892/or.2013.2298.
-
(2013)
Oncol Rep
, vol.29
, pp. 1975-1982
-
-
Li, X.Y.1
Wu, J.Z.2
Cao, H.X.3
Ma, R.4
Wu, J.Q.5
Zhong, Y.J.6
Feng, J.F.7
-
47
-
-
84862828219
-
DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity
-
22429326
-
Kim HJ, Kim JH, Chie EK, Park DY, Kim IA, Kim IH. DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity. Radiat Oncol 2012; 7:39; PMID:22429326; http://dx.doi.org/10.1186/1748-717X-7-39
-
(2012)
Radiat Oncol
, vol.7
, pp. 39
-
-
Kim, H.J.1
Kim, J.H.2
Chie, E.K.3
Park, D.Y.4
Kim, I.A.5
Kim, I.H.6
-
48
-
-
83355172959
-
Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo
-
Zuco V, de Cesare M, Cincinelli R, Nannei R, Pisano C, Zaffaroni N, Zunino F. Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo. PLoS One 2011; 6:1-12; http://dx.doi.org/10.1371/journal.pone.0029085
-
(2011)
PLoS One
, vol.6
, pp. 1-12
-
-
Zuco, V.1
de Cesare, M.2
Cincinelli, R.3
Nannei, R.4
Pisano, C.5
Zaffaroni, N.6
Zunino, F.7
-
50
-
-
84908092488
-
Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer
-
Del Bufalo D, Desideri M, De Luca T, Di Martile M, Gabellini C, Monica V, Busso S, Eramo A, De Maria R, Milella M, et al. Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer. Mol Cancer 2014; 13:230; http://dx.doi.org/10.1186/1476-4598-13-230.
-
(2014)
Mol Cancer
, vol.13
, pp. 230
-
-
Del Bufalo, D.1
Desideri, M.2
De Luca, T.3
Di Martile, M.4
Gabellini, C.5
Monica, V.6
Busso, S.7
Eramo, A.8
De Maria, R.9
Milella, M.10
-
51
-
-
65649134414
-
Histone Deacetylase Inhibitor Romidepsin Enhances Anti-Tumor Effect of Erlotinib in Non-small Cell Lung Cancer (NSCLC)
-
Frenkel EP. Histone Deacetylase Inhibitor Romidepsin Enhances Anti-Tumor Effect of Erlotinib in Non-small Cell Lung Cancer (NSCLC). Cell Lines 2009; 4:161-6; http://dx.doi.org/10.1097/JTO.0b013e318194fae7.
-
(2009)
Cell Lines
, vol.4
, pp. 161-166
-
-
Frenkel, E.P.1
-
52
-
-
31544452076
-
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
-
16424029
-
Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, Helfrich B, Dziadziuszko R, Chan DC, Sugita M, et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006; 66:944-50; PMID:16424029; http://dx.doi.org/10.1158/0008-5472.CAN-05-1988
-
(2006)
Cancer Res
, vol.66
, pp. 944-950
-
-
Witta, S.E.1
Gemmill, R.M.2
Hirsch, F.R.3
Coldren, C.D.4
Hedman, K.5
Ravdel, L.6
Helfrich, B.7
Dziadziuszko, R.8
Chan, D.C.9
Sugita, M.10
-
53
-
-
84959122182
-
-
Greve G, Schiffmann I, Pfeifer D, Pantic M, Schüler J, Lübbert M. The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells. BMC Cancer. 2015;15(1):947; http://dx.doi.org/10.1186/s12885-015-1967-5.
-
-
-
-
54
-
-
84946480845
-
Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid
-
26008188
-
Greve G, Schiffmann I, Lübbert M. Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid. J Cancer Res Clin Oncol 2015; 141:2171-80; PMID:26008188; http://dx.doi.org/10.1007/s00432-015-1987-1.
-
(2015)
J Cancer Res Clin Oncol
, vol.141
, pp. 2171-2180
-
-
Greve, G.1
Schiffmann, I.2
Lübbert, M.3
-
55
-
-
78149491383
-
Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids
-
21079797
-
Han S, Fukazawa T, Yamatsuji T, Matsuoka J, Miyachi H, Maeda Y, Durbin M, Naomoto Y. Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors:SL142 or SL325 and retinoic acids. PLoS One 2010; 5:e13834; PMID:21079797; http://dx.doi.org/10.1371/journal.pone.0013834
-
(2010)
PLoS One
, vol.5
, pp. e13834
-
-
Han, S.1
Fukazawa, T.2
Yamatsuji, T.3
Matsuoka, J.4
Miyachi, H.5
Maeda, Y.6
Durbin, M.7
Naomoto, Y.8
-
56
-
-
84916199010
-
Sodium Valproate, a Histone Deacetylase Inhibitor, Enhances the Efficacy of Vinorelbine-Cisplatin- based Chemoradiation in Non-small Cell Lung Cancer Cells
-
Gavrilov V, Lavrenkov K, Ariad S. Sodium Valproate, a Histone Deacetylase Inhibitor, Enhances the Efficacy of Vinorelbine-Cisplatin- based Chemoradiation in Non-small Cell Lung Cancer Cells. Anticancer Res 2014; 34:6572
-
(2014)
Anticancer Res
, vol.34
, pp. 6572
-
-
Gavrilov, V.1
Lavrenkov, K.2
Ariad, S.3
-
57
-
-
68149170764
-
Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells
-
19270532
-
Zhang F, Zhang T, Teng ZH, Zhang R, Wang JB, Mei QB. Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther 2009; 8:823-31; PMID:19270532; http://dx.doi.org/10.4161/cbt.8.9.8143
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 823-831
-
-
Zhang, F.1
Zhang, T.2
Teng, Z.H.3
Zhang, R.4
Wang, J.B.5
Mei, Q.B.6
-
58
-
-
84927547043
-
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
-
25629630
-
Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, Lin YJ, Zhang H, Marquez VE, Hammerman PS, Wong KK, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature 2015; 520:239-42; PMID:25629630; http://dx.doi.org/10.1038/nature14122
-
(2015)
Nature
, vol.520
, pp. 239-242
-
-
Fillmore, C.M.1
Xu, C.2
Desai, P.T.3
Berry, J.M.4
Rowbotham, S.P.5
Lin, Y.J.6
Zhang, H.7
Marquez, V.E.8
Hammerman, P.S.9
Wong, K.K.10
-
59
-
-
84878964098
-
Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
-
23354309
-
Vasilatos SN, Katz TA, Oesterreich S, Wan Y, Davidson NE, Huang Y. Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells. Carcinogenesis 2013; 34:1196-207; PMID:23354309; http://dx.doi.org/10.1093/carcin/bgt033
-
(2013)
Carcinogenesis
, vol.34
, pp. 1196-1207
-
-
Vasilatos, S.N.1
Katz, T.A.2
Oesterreich, S.3
Wan, Y.4
Davidson, N.E.5
Huang, Y.6
-
60
-
-
70449701913
-
Epigenetic cross-talk between DNA methylation and histone modifications in human cancers
-
19718392
-
Kondo Y. Epigenetic cross-talk between DNA methylation and histone modifications in human cancers. Yonsei Med J 2009; 50:455-63; PMID:19718392; http://dx.doi.org/10.3349/ymj.2009.50.4.455
-
(2009)
Yonsei Med J
, vol.50
, pp. 455-463
-
-
Kondo, Y.1
-
61
-
-
79953760389
-
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation
-
Guillemette B, Drogaris P, Lin HH, Armstrong H, Hiragami-Hamada K, Imhof A, Bonneil E, Thibault P, Verreault A, Festenstein RJ. H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet 2011; 7:e1001354; http://dx.doi.org/10.1371/journal.pgen.1001354.
-
(2011)
PLoS Genet
, vol.7
, pp. e1001354
-
-
Guillemette, B.1
Drogaris, P.2
Lin, H.H.3
Armstrong, H.4
Hiragami-Hamada, K.5
Imhof, A.6
Bonneil, E.7
Thibault, P.8
Verreault, A.9
Festenstein, R.J.10
-
62
-
-
85008242925
-
Abstract 5162: Effects of combined epigenetic therapy with histone methyltransferase EZH2 inhibitor 3-deazaneplanocin and histone deacetylase inhibitor SAHA on non-small cell lung cancer cells
-
Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Konishi JS, Oizumi S, Nishimura M, Akita HD. Abstract 5162:Effects of combined epigenetic therapy with histone methyltransferase EZH2 inhibitor 3-deazaneplanocin and histone deacetylase inhibitor SAHA on non-small cell lung cancer cells. Cancer Res 2014; 74:5162-2; http://dx.doi.org/10.1158/1538-7445.AM2014-5162
-
(2014)
Cancer Res
, vol.74
, pp. 5162
-
-
Takashina, T.1
Kinoshita, I.2
Kikuchi, J.3
Shimizu, Y.4
Konishi, J.S.5
Oizumi, S.6
Nishimura, M.7
Akita, H.D.8
-
63
-
-
78751512281
-
Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model
-
21224363
-
Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, Channell MM, Liu Y, Casero RA, Baylin SB, et al. Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Res 2011; 71:454-62; PMID:21224363; http://dx.doi.org/10.1158/0008-5472.CAN-10-3184
-
(2011)
Cancer Res
, vol.71
, pp. 454-462
-
-
Belinsky, S.A.1
Grimes, M.J.2
Picchi, M.A.3
Mitchell, H.D.4
Stidley, C.A.5
Tesfaigzi, Y.6
Channell, M.M.7
Liu, Y.8
Casero, R.A.9
Baylin, S.B.10
-
64
-
-
84921329779
-
Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer
-
25474141
-
Vendetti FP, Topper M, Huang P, Dobromilskaya I, Easwaran H, Wrangle J, Baylin SB, Poirier JT, Rudin CM. Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget 2015; 6:56-70; PMID:25474141; http://dx.doi.org/10.18632/oncotarget.2695.
-
(2015)
Oncotarget
, vol.6
, pp. 56-70
-
-
Vendetti, F.P.1
Topper, M.2
Huang, P.3
Dobromilskaya, I.4
Easwaran, H.5
Wrangle, J.6
Baylin, S.B.7
Poirier, J.T.8
Rudin, C.M.9
-
65
-
-
0030974771
-
Pilot phase I-II study on 5-aza-2′deoxycytidine (Decitabine) in patients with metastatic lung cancer
-
9074840
-
Momparler RL. Pilot phase I-II study on 5-aza-2′deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anti-Cander Drugs 1997; 53:358-68; PMID:9074840; http://dx.doi.org/10.1097/00001813-199704000-00008
-
(1997)
Anti-Cander Drugs
, vol.53
, pp. 358-368
-
-
Momparler, R.L.1
-
66
-
-
33750326078
-
Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura
-
17020984
-
Schrump DS, Fischette MR, Nguyen DM, Zhao M, Li X, Kunst TF, Hancox A, Hong JA, Chen GA, Pishchik V, et al. Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. Clin Cancer Res 2006; 12:5777-85; PMID:17020984; http://dx.doi.org/10.1158/1078-0432.CCR-06-0669
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5777-5785
-
-
Schrump, D.S.1
Fischette, M.R.2
Nguyen, D.M.3
Zhao, M.4
Li, X.5
Kunst, T.F.6
Hancox, A.7
Hong, J.A.8
Chen, G.A.9
Pishchik, V.10
-
67
-
-
67649399669
-
Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study
-
19347984
-
Traynor AM, Dubey S, Eickhoff JC, Kolesar JM, Schell K, Huie MS, Groteluschen DL, Marcotte SM, Hallahan CM, Weeks HR, et al. Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer:a Wisconsin Oncology Network phase II study. J Thorac Oncol 2009; 4:522-6; PMID:19347984; http://dx.doi.org/10.1097/JTO.0b013e3181952478
-
(2009)
J Thorac Oncol
, vol.4
, pp. 522-526
-
-
Traynor, A.M.1
Dubey, S.2
Eickhoff, J.C.3
Kolesar, J.M.4
Schell, K.5
Huie, M.S.6
Groteluschen, D.L.7
Marcotte, S.M.8
Hallahan, C.M.9
Weeks, H.R.10
-
68
-
-
80053444581
-
Phase II study of the HDAC inhibitor romidepsin in relapsed small cell lung cancer
-
Otterson GA, Hodgson L, Pang H, Vokes EE. Phase II study of the HDAC inhibitor romidepsin in relapsed small cell lung cancer. Changes 2012; 29:997-1003; http://dx.doi.org/10.1016/j.biotechadv.2011.08.021.
-
(2012)
Changes
, vol.29
, pp. 997-1003
-
-
Otterson, G.A.1
Hodgson, L.2
Pang, H.3
Vokes, E.E.4
-
69
-
-
84856718345
-
A phase I study of 5-azacytidine and erlotinib in advanced solid tumor malignancies
-
21901396
-
Bauman J, Verschraegen C, Belinsky S, Muller C, Rutledge T, Fekrazad M, Ravindranathan M, Lee SJ, Jones D. A phase I study of 5-azacytidine and erlotinib in advanced solid tumor malignancies. Cancer Chemother Pharmacol 2012; 69:547-54; PMID:21901396; http://dx.doi.org/10.1007/s00280-011-1729-2
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 547-554
-
-
Bauman, J.1
Verschraegen, C.2
Belinsky, S.3
Muller, C.4
Rutledge, T.5
Fekrazad, M.6
Ravindranathan, M.7
Lee, S.J.8
Jones, D.9
-
70
-
-
0034106513
-
A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
-
10830142
-
Schwartsmann G, Schunemann H, Gorini CN, Filho AF, Garbino C, Sabini G, Muse I, DiLeone L, Mans DR. A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Invest New Drugs 2000; 18:83-91; PMID:10830142; http://dx.doi.org/10.1023/A:1006388031954
-
(2000)
Invest New Drugs
, vol.18
, pp. 83-91
-
-
Schwartsmann, G.1
Schunemann, H.2
Gorini, C.N.3
Filho, A.F.4
Garbino, C.5
Sabini, G.6
Muse, I.7
DiLeone, L.8
Mans, D.R.9
-
71
-
-
84867899520
-
Phase I Trial of Induction Histone Deacetylase and Proteasome Inhibition Followed by Surgery in Non-small Cell Lung Cancer
-
Jones DR, Moskaluk CA, Gillenwater HH, Petroni R, Burks SG, Philips J, Rehm PK, Kozower BD, Bao Y. Phase I Trial of Induction Histone Deacetylase and Proteasome Inhibition Followed by Surgery in Non-small Cell Lung Cancer. J Thorac Oncol 2012; 7:1683-90; http://dx.doi.org/10.1097/JTO.0b013e318267928d.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1683-1690
-
-
Jones, D.R.1
Moskaluk, C.A.2
Gillenwater, H.H.3
Petroni, R.4
Burks, S.G.5
Philips, J.6
Rehm, P.K.7
Kozower, B.D.8
Bao, Y.9
-
72
-
-
84873097735
-
A phase i study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer
-
22415798
-
Dasari A, Gore L, Messersmith WA, Diab S, Jimeno A, Weekes CD, Lewis KD, Drabkin HA, Flaig TW, Camidge DR. A phase i study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer. Invest New Drugs 2013; 31:115-25; PMID:22415798; http://dx.doi.org/10.1007/s10637-012-9812-z
-
(2013)
Invest New Drugs
, vol.31
, pp. 115-125
-
-
Dasari, A.1
Gore, L.2
Messersmith, W.A.3
Diab, S.4
Jimeno, A.5
Weekes, C.D.6
Lewis, K.D.7
Drabkin, H.A.8
Flaig, T.W.9
Camidge, D.R.10
-
73
-
-
84896502954
-
A phase I, pharmacokinetic and pharmacodynamic study of panobinostat, an HDAC inhibitor, combined with erlotinib in patients with advanced aerodigestive tract tumors
-
Internet, [cited 2014 Feb 5]
-
Gray J, Haura EB, Chiappori A, Tanvetyanon T, Williams CC, Pinder-Schenk M, Kish JA, Kreahling JM, Lush RM, Neuger AM, et al. A phase I, pharmacokinetic and pharmacodynamic study of panobinostat, an HDAC inhibitor, combined with erlotinib in patients with advanced aerodigestive tract tumors. Clin Cancer Res [Internet] 2014 [cited 2014 Feb 5]; 20:1644-55; http://dx.doi.org/10.1158/1078-0432.CCR-13-2235.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1644-1655
-
-
Gray, J.1
Haura, E.B.2
Chiappori, A.3
Tanvetyanon, T.4
Williams, C.C.5
Pinder-Schenk, M.6
Kish, J.A.7
Kreahling, J.M.8
Lush, R.M.9
Neuger, A.M.10
-
74
-
-
84899471596
-
Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression
-
24636848
-
Reguart N, Rosell R, Cardenal F, Cardona AF, Isla D, Palmero R, Moran T, Rolfo C, Pallarès MC, Insa A, et al. Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression. Lung Cancer 2014; 84:161-7; PMID:24636848; http://dx.doi.org/10.1016/j.lungcan.2014.02.011
-
(2014)
Lung Cancer
, vol.84
, pp. 161-167
-
-
Reguart, N.1
Rosell, R.2
Cardenal, F.3
Cardona, A.F.4
Isla, D.5
Palmero, R.6
Moran, T.7
Rolfo, C.8
Pallarès, M.C.9
Insa, A.10
-
75
-
-
84864004796
-
Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy
-
22508830
-
Witta SE, Jotte RM, Konduri K, Neubauer MA, Spira AI, Ruxer RL, Varella-Garcia M, Bunn PA, Hirsch FR. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy. J Clin Oncol 2012; 30:2248-55; PMID:22508830; http://dx.doi.org/10.1200/JCO.2011.38.9411
-
(2012)
J Clin Oncol
, vol.30
, pp. 2248-2255
-
-
Witta, S.E.1
Jotte, R.M.2
Konduri, K.3
Neubauer, M.A.4
Spira, A.I.5
Ruxer, R.L.6
Varella-Garcia, M.7
Bunn, P.A.8
Hirsch, F.R.9
-
76
-
-
73949140461
-
Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer
-
19933908
-
Ramalingam SS, Maitland ML, Frankel P, Argiris AE, Koczywas M, Gitlitz B, Thomas S, Espinoza-Delgado I, Vokes EE, Gandara DR, et al. Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer. J Clin Oncol 2010; 28:56-62; PMID:19933908; http://dx.doi.org/10.1200/JCO.2009.24.9094
-
(2010)
J Clin Oncol
, vol.28
, pp. 56-62
-
-
Ramalingam, S.S.1
Maitland, M.L.2
Frankel, P.3
Argiris, A.E.4
Koczywas, M.5
Gitlitz, B.6
Thomas, S.7
Espinoza-Delgado, I.8
Vokes, E.E.9
Gandara, D.R.10
-
77
-
-
84872316231
-
Phase i study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small-cell lung cancer
-
23053268
-
Chu BF, Karpenko MJ, Liu Z, Aimiuwu J, Villalona-Calero MA, Chan KK, Grever MR, Otterson GA. Phase i study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small-cell lung cancer. Cancer Chemother Pharmacol 2013; 71:115-21; PMID:23053268; http://dx.doi.org/10.1007/s00280-012-1986-8
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, pp. 115-121
-
-
Chu, B.F.1
Karpenko, M.J.2
Liu, Z.3
Aimiuwu, J.4
Villalona-Calero, M.A.5
Chan, K.K.6
Grever, M.R.7
Otterson, G.A.8
-
78
-
-
85008264475
-
-
http://clinicaltrials.gov/show/NCT01628471
-
-
-
-
79
-
-
85008258005
-
-
http://clinicaltrials.gov/show/NCT00978250
-
-
-
-
80
-
-
85008255509
-
-
http://clinicaltrials.gov/show/NCT00423449
-
-
-
-
81
-
-
85008244819
-
-
https://clinicaltrials.gov/ct2/show/record/NCT00473889
-
-
-
-
82
-
-
85008255338
-
-
http://clinicaltrials.gov/show/NCT01090830
-
-
-
-
83
-
-
85008244826
-
-
http://clinicaltrials.gov/show/NCT01188707
-
-
-
-
84
-
-
85008246455
-
-
https://clinicaltrials.gov/ct2/show/record/NCT01935947
-
-
-
-
85
-
-
85008264824
-
-
http://clinicaltrials.gov/show/NCT00387465
-
-
-
-
86
-
-
84937429405
-
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
-
26175415
-
Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, Schneck JL, Carson JD, Liu Y, Butticello M, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell 2015; 28:57-69; PMID:26175415; http://dx.doi.org/10.1016/j.ccell.2015.06.002
-
(2015)
Cancer Cell
, vol.28
, pp. 57-69
-
-
Mohammad, H.P.1
Smitheman, K.N.2
Kamat, C.D.3
Soong, D.4
Federowicz, K.E.5
Van Aller, G.S.6
Schneck, J.L.7
Carson, J.D.8
Liu, Y.9
Butticello, M.10
-
87
-
-
85008249676
-
-
https://clinicaltrials.gov/ct2/show/NCT02034123?term#61501;GSK2879552rank1501;1
-
-
-
-
88
-
-
84890130945
-
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine
-
[Internet], 24162015
-
Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, Vancriekinge W, Demeyer T, Du Z, Parsana P, et al. Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine. Oncotarget [Internet] 2013; 4:2067-79; PMID:24162015; http://dx.doi.org/10.18632/oncotarget.1542
-
(2013)
Oncotarget
, vol.4
, pp. 2067-2079
-
-
Wrangle, J.1
Wang, W.2
Koch, A.3
Easwaran, H.4
Mohammad, H.P.5
Vendetti, F.6
Vancriekinge, W.7
Demeyer, T.8
Du, Z.9
Parsana, P.10
-
89
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
[Internet], 22658128
-
Brahmer JR, Tykodi SS, Chow LQM, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med [Internet] 2012; 366:2455-65; PMID:22658128; http://dx.doi.org/10.1056/NEJMoa1200694
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.M.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
Drake, C.G.7
Camacho, L.H.8
Kauh, J.9
Odunsi, K.10
-
90
-
-
77953691179
-
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
-
20525993
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al. Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer. N Engl J Med 2010; 362:2251-9; PMID:20525993; http://dx.doi.org/10.1056/NEJMoa0912614
-
(2010)
N Engl J Med
, vol.362
, pp. 2251-2259
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
-
91
-
-
84940381273
-
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
-
[Internet]
-
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell [Internet] 2015; 162:974-86. Available from:http://dx.doi.org/10.1016/j.cell.2015.07.011
-
(2015)
Cell
, vol.162
, pp. 974-986
-
-
Chiappinelli, K.B.1
Strissel, P.L.2
Desrichard, A.3
Li, H.4
Henke, C.5
Akman, B.6
Hein, A.7
Rote, N.S.8
Cope, L.M.9
Snyder, A.10
-
92
-
-
84940403834
-
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
-
[Internet]
-
Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen SY, Han H, Liang G, Jones PA, Pugh TJ, et al. DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell [Internet] 2015; 162:961-73. Available from:http://dx.doi.org/10.1016/j.cell.2015.07.056
-
(2015)
Cell
, vol.162
, pp. 961-973
-
-
Roulois, D.1
Loo Yau, H.2
Singhania, R.3
Wang, Y.4
Danesh, A.5
Shen, S.Y.6
Han, H.7
Liang, G.8
Jones, P.A.9
Pugh, T.J.10
-
93
-
-
85008251335
-
-
https://clinicaltrials.gov/ct2/show/NCT01928576
-
-
-
-
94
-
-
84936791837
-
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
-
Brahmer J, Reckamp KL, Baas P, Crin∫ L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 2015; 373:1-13; http://dx.doi.org/10.1056/NEJMoa1504627.
-
(2015)
N Engl J Med
, vol.373
, pp. 1-13
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crin, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
Antonia, S.7
Pluzanski, A.8
Vokes, E.E.9
Holgado, E.10
-
95
-
-
85008264906
-
-
https://clinicaltrials.gov/ct2/show/NCT02546986
-
-
-
-
96
-
-
85008251959
-
-
https://clinicaltrials.gov/show/NCT02437136
-
-
-
-
97
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
9916800
-
Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999; 21:103-7; PMID:9916800; http://dx.doi.org/10.1038/5047
-
(1999)
Nat Genet
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myöhänen, S.3
Herman, J.G.4
Baylin, S.B.5
-
98
-
-
84856230241
-
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells
-
21452019
-
Huang Y, Vasilatos SN, Boric L, Shaw PG, Davidson NE. Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells. Breast Cancer Res Treat 2012; 131:777-89; PMID:21452019; http://dx.doi.org/10.1007/s10549-011-1480-8
-
(2012)
Breast Cancer Res Treat
, vol.131
, pp. 777-789
-
-
Huang, Y.1
Vasilatos, S.N.2
Boric, L.3
Shaw, P.G.4
Davidson, N.E.5
-
99
-
-
84869850999
-
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies
-
22214283
-
Fahy J, Jeltsch A, Arimondo PB. DNA methyltransferase inhibitors in cancer:a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat 2012; 22:1-16; PMID:22214283; http://dx.doi.org/10.1517/13543776.2012.729579
-
(2012)
Expert Opin Ther Pat
, vol.22
, pp. 1-16
-
-
Fahy, J.1
Jeltsch, A.2
Arimondo, P.B.3
-
100
-
-
78649947871
-
Inhibition of class IIb histone deacetylase significantly improves cloning efficiency in mice
-
[Internet]
-
Ono T, Li C, Mizutani E, Terashita Y, Yamagata K, Wakayama T. Inhibition of class IIb histone deacetylase significantly improves cloning efficiency in mice. Biol Reprod [Internet] 2010; 83:929-37; http://dx.doi.org/10.1095/biolreprod.110.085282.
-
(2010)
Biol Reprod
, vol.83
, pp. 929-937
-
-
Ono, T.1
Li, C.2
Mizutani, E.3
Terashita, Y.4
Yamagata, K.5
Wakayama, T.6
-
101
-
-
84881059186
-
Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms
-
[Internet], 23887629
-
Ali A, Bluteau O, Messaoudi K, Palazzo A, Boukour S, Lordier L, Lecluse Y, Rameau P, Kraus-Berthier L, Jacquet-Bescond A, et al. Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms. Cell Death Dis [Internet] 2013; 4:e738; PMID:23887629; http://dx.doi.org/10.1038/cddis.2013.260
-
(2013)
Cell Death Dis
, vol.4
, pp. e738
-
-
Ali, A.1
Bluteau, O.2
Messaoudi, K.3
Palazzo, A.4
Boukour, S.5
Lordier, L.6
Lecluse, Y.7
Rameau, P.8
Kraus-Berthier, L.9
Jacquet-Bescond, A.10
-
102
-
-
9244234991
-
Desmoplastic small round-cell tumor: Prolonged progression-free survival with aggressive multimodality therapy
-
8622067
-
Kushner BH, LaQuaglia MP, Wollner N, Meyers PA, Lindsley KL, Ghavimi F, Merchant TE, Boulad F, Cheung NK, Bonilla MA, et al. Desmoplastic small round-cell tumor:Prolonged progression-free survival with aggressive multimodality therapy. J Clin Oncol 1996; 14:1526-31; PMID:8622067; http://dx.doi.org/10.1002/pbc.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1526-1531
-
-
Kushner, B.H.1
LaQuaglia, M.P.2
Wollner, N.3
Meyers, P.A.4
Lindsley, K.L.5
Ghavimi, F.6
Merchant, T.E.7
Boulad, F.8
Cheung, N.K.9
Bonilla, M.A.10
-
103
-
-
85008263641
-
Initial Testing (Stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program
-
Carol H, Gorlick R, Kolb EA, Morton CL, Manesh DM, Keir ST, Reynolds CP, Kang MH, Maris JM, Wozniak A, et al. Initial Testing (Stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2010; 199:1442-8; http://dx.doi.org/10.1086/597422.
-
(2010)
Pediatr Blood Cancer
, vol.199
, pp. 1442-1448
-
-
Carol, H.1
Gorlick, R.2
Kolb, E.A.3
Morton, C.L.4
Manesh, D.M.5
Keir, S.T.6
Reynolds, C.P.7
Kang, M.H.8
Maris, J.M.9
Wozniak, A.10
-
104
-
-
77951685547
-
The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells
-
20201941
-
Mandl-Weber S, Meinel FG, Jankowsky R, Oduncu F, Schmidmaier R, Baumann P. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol 2010; 149:518-28; PMID:20201941; http://dx.doi.org/10.1111/j.1365-2141.2010.08124.x
-
(2010)
Br J Haematol
, vol.149
, pp. 518-528
-
-
Mandl-Weber, S.1
Meinel, F.G.2
Jankowsky, R.3
Oduncu, F.4
Schmidmaier, R.5
Baumann, P.6
-
105
-
-
84938866474
-
Phenylbutyrate - a pan-HDAC inhibitor that suppresses proliferation of glioblastoma LN-229 cell line
-
Kusaczuk M, Krętowski R, Bartoszewicz M, Cechowska-Pasko M. Phenylbutyrate - a pan-HDAC inhibitor that suppresses proliferation of glioblastoma LN-229 cell line. Tumor Biol 2016; 37:931-42; http://dx.doi.org/10.1007/s13277-015-3781-8
-
(2016)
Tumor Biol
, vol.37
, pp. 931-942
-
-
Kusaczuk, M.1
Krętowski, R.2
Bartoszewicz, M.3
Cechowska-Pasko, M.4
-
106
-
-
33847657556
-
Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
-
[Internet], 17334228
-
Kim DH, Shin J, Kwon HJ. Psammaplin A is a natural prodrug that inhibits class I histone deacetylase. Exp Mol Med [Internet] 2007; 39:47-55. PMID:17334228; http://dx.doi.org/10.1038/emm.2007.6
-
(2007)
Exp Mol Med
, vol.39
, pp. 47-55
-
-
Kim, D.H.1
Shin, J.2
Kwon, H.J.3
|