Identification of a diverse synthetic abietane diterpenoid library for anticancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 27, Issue 3, 2017, Pages 505-510

  Xu, Hongtao ^a,b   Liu, Lili ^a   Fan, Xiaoting ^a,d   Zhang, Guanjun ^c   Li, Yuanchao ^b   Jiang, Biao ^a  

^a SHANGHAITECH UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Abietic acid; Anticancer; Diverse; Natural product like; Triptophenolide

Indexed keywords

ABIETIC ACID; ABIETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; DEHYDROABIETIC ACID; DEHYDROABIETIC ACID DERIVATIVE; DITERPENOID; FLUOROURACIL; TRIPTOLIDE; TRIPTOPHENOLIDE DERIVATIVE; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE;

A-549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; PC 3 CELL LINE; SKOV 3 CELL LINE; TUMOR CELL LINE; TUNEL ASSAY; WESTERN BLOTTING; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85008177116     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.12.032     Document Type: Article

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